摘要:
A method for treating adult respiratory distress syndrome (ARDS) and sepsis in a patient in need thereof which comprises administering to said patient an antibody to complement component C5a or the des Arg derivative thereof in an amount effective to treat ARDS and sepsis.
摘要:
Coupling members for coupling an earth-boring drill tool to a drill string, drilling tools including a coupling member attached to a body of an earth-boring drill tool, methods for forming drilling tools including a coupling member, and methods for forming coupling members are disclosed. A coupling member may include a distal region comprising a first material composition and a proximal region comprising a second, different material composition. A drilling tool may include a body that is attached to a coupling member with a varied material composition for coupling the body to a drill string.
摘要:
The subject invention relates to a valve replacement system together with methods of preparation and use, are provided for endovascular replacement of a heart valve in a host. The valve replacement system includes up to five components: a prosthetic valve device, a valve introducer device, an intraluminal procedure device, a procedure device capsule, and a tissue cutter. The system provides for endovascular removal of a malfunctioning valve and subsequent replacement with a permanent prosthetic heart valve.
摘要:
A composite includes a porous matrix that includes a molybdenum-silicon-boron (Mo—Si—B) alloy that has a plurality of pores with a lubricant in contact with the Mo—Si—B alloy, a hydrophobic compound in contact with the Mo—Si—B alloy, or a combination thereof. A method for preparing a porous composite includes disposing a porous matrix comprising a Mo—Si—B alloy on a substrate, the Mo—Si—B alloy comprising a plurality of pores; disposing a lubricant on a surface of the porous matrix; and disposing a hydrophobic compound on a surface of the porous matrix to form the porous composite.
摘要:
Displacement members for use in forming a bit body of an earth-boring rotary drill bit include a body having an exterior surface, at least a portion of which is configured to define at least one surface of the bit body as the bit body is formed around the displacement member. In some embodiments, the body may be hollow and/or porous. Methods for forming earth-boring rotary drill bits include positioning such a displacement member in a mold and forming a bit body around the displacement member in the mold. Additional methods include pressing a plurality of particles to form a body, forming at least one recess in the body, positioning such a displacement member in the recess, and sintering the body to form a bit body.
摘要:
Earth-boring tools for drilling subterranean formations include a particle-matrix composite material comprising a plurality of silicon carbide particles dispersed throughout a matrix material, such as, for example, an aluminum or aluminum-based alloy. In some embodiments, the silicon carbide particles comprise an ABC-SiC material. Methods of manufacturing such tools include providing a plurality of silicon carbide particles within a matrix material. Optionally, the silicon carbide particles may comprise ABC-SiC material, and the ABC-SiC material may be toughened to increase a fracture toughness exhibited by the ABC-SiC material. In some methods, at least one of an infiltration process and a powder compaction and consolidation process may be employed.
摘要:
Methods of forming at least a portion of an earth-boring tool include providing particulate matter comprising a hard material in a mold cavity, melting a metal and the hard material to form a molten composition comprising a eutectic or near-eutectic composition of the metal and the hard material, casting the molten composition to form the at least a portion of an earth-boring tool within the mold cavity, and adjusting a stoichiometry of at least one hard material phase of the at least a portion of the earth-boring tool. Methods of forming a roller cone of an earth-boring rotary drill bit comprise forming a molten composition, casting the molten composition within a mold cavity, solidifying the molten composition to form the roller cone, and converting an eta-phase region within the roller cone to at least one of WC and W2C.
摘要:
Methods for forming bodies of earth-boring drill bits and other tools include milling a plurality of hard particles and a plurality of particles comprising a matrix material to form a mill product comprising powder particles, separating the particles into a plurality of particle size fractions. Some of the particles from the fractions may be combined to form a powder mixture, which may be pressed to form a green body. Additional methods include mixing a plurality of hard particles and a plurality of particles comprising a matrix material to form a powder mixture, and pressing the powder mixture with pressure having an oscillating magnitude to form a green body. In yet additional methods a powder mixture may be pressed within a deformable container to form a green body and drainage of liquid from the container is enabled as the powder mixture is pressed.
摘要:
Earth-boring rotary drill bits include bit bodies comprising a composite material including a plurality of hard phase regions or particles dispersed throughout a titanium or titanium-based alloy matrix material. The bits further include a cutting structure disposed on a face of the bit body. In some embodiments, the bit bodies may include a plurality of regions having differing material compositions. For example, the bit bodies may include a first region comprising a plurality of hard phase regions or particles dispersed throughout a titanium or titanium-based alloy matrix material, and a second region comprising a titanium or a titanium-based alloy material. Methods for forming such drill bits include at least partially sintering a plurality of hard particles and a plurality of particles comprising titanium or a titanium-based alloy material to form a bit body comprising a particle-matrix composite material. A shank may be attached directly to the bit body.
摘要:
Geometric compensation techniques are used to improve the accuracy by which features may be located on drill bits formed using particle compaction and sintering processes. In some embodiments, a positional error to be exhibited by at least one feature in a less than fully sintered bit body upon fully sintering the bit body is predicted and the at least one feature is formed on the less than fully sintered bit body at a location at least partially determined by the predicted positional error. In other embodiments, bit bodies of earth-boring rotary drill bits are designed to include a design drilling profile and a less than fully sintered bit body is formed including a drilling profile having a shape differing from a shape of the design drilling profile. Less than fully sintered bit bodies of earth-boring rotary drill bits are formed using such methods.