公开(公告)号：US10676557B2

公开(公告)日：2020-06-09

申请号：US16255043

申请日：2019-01-23

Applicant: Novartis AG

Inventor： Frank Chang ,  Ryan DeSousa ,  Jinyu Huang

IPC: C08L101/14 ,  C08L83/04 ,  C08F290/06 ,  G02B1/04 ,  C08G77/20 ,  C08G77/14 ,  C08G77/38 ,  C08G77/12

Abstract: The invention provides a hydrophilized polydiorganosiloxane vinylic crosslinker which comprises (1) a polydiorganosiloxane polymer chain comprising dimethylsiloxane units and hydrophilized siloxane unit having one methyl substituent and one monovalent C10-C50 organic substituent having two or three carboxy groups, wherein the molar ratio of the hydrophilized siloxane units to the dimethylsiloxane units is from about 0.035 to about 0.25, and (2) two terminal (meth)acryloyl groups. The hydrophilized polydiorganosiloxane vinylic crosslinker has a number average molecular weight of greater than 3000 Daltons. The present invention is also related to a silicone hydrogel contact lens, which comprises repeating units derived from a hydrophilized polydiorganosiloxane vinylic crosslinker of the invention. In addition, the invention provides a method for making silicone hydrogel contact lenses using a lens-forming formulation comprising hydrophilized polydiorganosiloxane vinylic crosslinker of the invention.

公开(公告)号：US10598825B2

公开(公告)日：2020-03-24

申请号：US16398607

申请日：2019-04-30

Applicant: Novartis AG

Inventor： Xinming Qian ,  Frank Chang ,  Yasuo Matsuzawa ,  Venkat Shankar

IPC: G02B1/04 ,  A61L27/18 ,  A61L27/34 ,  A61F2/14 ,  C08L83/04 ,  A61F2/16 ,  A61F9/007 ,  A61L12/04 ,  C08G77/12 ,  C08G77/20

Abstract: The invention is related to a medical device comprising a core material made of a crosslinked silicone material and a hydrogel coating which is thermodynamically stable. The invention is also related to a method for producing such a medical device, especially a soft contact lens.

公开(公告)号：US10597479B2

公开(公告)日：2020-03-24

申请号：US16175904

申请日：2018-10-31

Applicant: Novartis AG

Inventor： Frank Chang ,  Jinyu Huang ,  Troy Vernon Holland

IPC: C08L101/14 ,  C08L83/04 ,  C08F290/06 ,  G02B1/04 ,  C08G77/20 ,  C08F283/12 ,  C08F220/40

Abstract: The invention provides a class of amphiphilic branched macromers and the uses thereof. An amphiphilic branched polydiorganosiloxane macromer of the invention is produced from an α,ω-dimethacryloyl-terminated polydiorganosiloxane vinylic crosslinker comprising one or more ATRP-containing siloxane units having one substituent having an ATRP initiator by ATRP polymerization of one or more hydrophilic vinylic monomers. It comprises at least two polydiorganosiloxane polymer chains each having at most two terminal methacryloxy groups, dangling hydrophilic polymer chains each having a polymerizable or non-polymerizable terminal group, and one or more hydrophilic polymer chains as linkages between two polydiorganosiloxane chains. The present invention is also related to a silicone hydrogel contact lens, which comprises units derived from a polydiorganosiloxane-containing amphiphilic branched macromer of the invention.

公开(公告)号：US10527757B2

公开(公告)日：2020-01-07

申请号：US15792807

申请日：2017-10-25

Applicant: Novartis AG

Inventor： Frank Chang ,  Feng Jing ,  Fei Cheng ,  Ying Zheng

IPC: G02B1/04 ,  C08G77/20 ,  C08G77/28 ,  C08J3/075 ,  C08L25/06 ,  C08L33/10 ,  C08L83/08 ,  B29D11/00 ,  C08F283/12 ,  C08F290/06 ,  C08F299/08 ,  C08J3/24

Abstract: The invention provides a class of amphiphilic branched polydiorganosiloxane macromers and the uses thereof. Such a macromer comprises a polydiorganosiloxane polymer chain and two terminal groups free of any ethylenically unsaturated group, wherein the polydiorganosiloxane polymer chain comprises (1) at least 5 dimethylsiloxane units in a consecutive sequence, (2) at least two first siloxane units each having methyl as one of the two substituents of each first siloxane unit and one first organic radical having one sole (meth)acryloyl group as the other substituent, (3) at least one second siloxane unit having methyl as one of the two substituents of the second siloxane unit and one second organic radical, which is free of any ethylenically unsaturated group and comprises one or more hydrophilic groups or polymer chains, as the other substituent.

公开(公告)号：US10465047B2

公开(公告)日：2019-11-05

申请号：US15727674

申请日：2017-10-09

Applicant: Novartis AG

Inventor： Feng Jing ,  Frank Chang

IPC: C08G77/442 ,  C08G77/38 ,  G02C7/04 ,  C08F20/06 ,  C08F26/10 ,  C08F299/08 ,  C08G77/20 ,  C08G77/46

Abstract: The invention provides a polymerizable polydimethylsiloxane-polyoxyalkylene block copolymer which comprises (1) a linear polymer chain comprising at least two polydimethylsiloxane segments, one hydrophilic polyoxyalkylene segment between each pair of polydimethylsiloxane segments, and one amide-rich linker between each pair of one polydimethylsiloxane segment and one hydrophilic polyoxyalkylene segment, and (2) two terminal (meth)acryloyl groups. The hydrophilized polydiorganosiloxane vinylic crosslinker has a weight average molecular weight of at least 3000 Daltons. The invention is also related to a silicone hydrogel contact lens produced from a polymerizable polydimethylsiloxane-polyoxyalkylene block copolymer of the invention.

公开(公告)号：US20190256455A1

公开(公告)日：2019-08-22

申请号：US16401193

申请日：2019-05-02

Applicant: Novartis AG

Inventor： Frank Chang ,  Ryan DeSousa ,  Troy Vernon Holland ,  Walter R. Laredo

IPC: C07C225/22 ,  B29D11/00 ,  G02C7/10 ,  G02C7/04 ,  C07C225/10 ,  C08F116/06 ,  C07D249/20 ,  G02B1/04

Abstract: Described herein are dimethyl acetal-containing UV-absorbing compounds and their uses in preparing UV-absorbing polyvinyl alcohol prepolymers suitable for producing UV-absorbing contact lenses capable of blocking ultra-violet (“UV”) radiation and optionally (but preferably) violet radiation with wavelengths from 380 nm to 440 nm, thereby protecting eyes to some extent from damages caused by UV radiation and potentially from violet radiation. This invention also provides a UV-absorbing polyvinyl alcohol prepolymer.

公开(公告)号：US10322993B2

公开(公告)日：2019-06-18

申请号：US15352132

申请日：2016-11-15

Applicant: Novartis AG

Inventor： Frank Chang ,  Ryan DeSousa ,  Troy Vernon Holland ,  Walter R. Laredo

IPC: C07D249/20 ,  C07C225/22 ,  C07C225/10 ,  C08F116/06 ,  G02B1/04 ,  G02C7/04 ,  G02C7/10 ,  B29D11/00

Abstract: Described herein are dimethyl acetal-containing UV-absorbing compounds and their uses in preparing UV-absorbing polyvinyl alcohol prepolymers suitable for producing UV-absorbing contact lenses capable of blocking ultra-violet (“UV”) radiation and optionally (but preferably) violet radiation with wavelengths from 380 nm to 440 nm, thereby protecting eyes to some extent from damages caused by UV radiation and potentially from violet radiation. This invention also provides a UV-absorbing polyvinyl alcohol prepolymer.

公开(公告)号：US10287370B2

公开(公告)日：2019-05-14

申请号：US15730780

申请日：2017-10-12

Applicant: Novartis AG

Inventor： Frank Chang ,  Troy Vernon Holland ,  Thomas M. Moy

IPC: C08F28/02 ,  C08F20/56 ,  C08F22/38 ,  C08F2/38 ,  C08F220/56 ,  C08F230/02 ,  C08F8/34 ,  G02B1/04

Abstract: The invention is related to a class of hydrophilic polymers each comprising one sole thiol-containing terminal group. The hydrophilic polymers are highly reactive towards azetidinium groups of an azetidinium-containing polymer upon heating and can find particular use in for producing water-soluble highly-branched hydrophilic polymeric material useful for producing water gradient contact lenses.

公开(公告)号：US10254567B2

公开(公告)日：2019-04-09

申请号：US15434105

申请日：2017-02-16

Applicant: Novartis AG

Inventor： Frank Chang ,  Ryan DeSousa ,  Troy Vernon Holland ,  John Dallas Pruitt ,  Jared Nelson

IPC: C07D249/20 ,  G02C7/10 ,  C08F220/70 ,  C08F230/08 ,  G02B1/04 ,  G02C7/04 ,  B29D11/00 ,  C08F20/36 ,  G02B5/20 ,  G02B5/22 ,  C07C233/38 ,  B29K105/00

Abstract: Described herein are water-soluble UV-absorbing vinylic monomers and their uses in preparing UV-absorbing contact lenses capable of blocking ultra-violet (“UV”) radiation and optionally (but preferably) violet radiation with wavelengths from 380 nm to 440 nm, thereby protecting eyes to some extent from damages caused by UV radiation and potentially from violet radiation. This invention also provides a UV-absorbing contact lens.

公开(公告)号：US20190023935A1

公开(公告)日：2019-01-24

申请号：US16036988

申请日：2018-07-17

Applicant: Novartis AG

Inventor： Frank Chang ,  Feng Jing ,  Troy Vernon Holland ,  Chung-Yuan Chiang ,  John Dallas Pruitt

IPC: C09D133/26 ,  C08F220/56 ,  C08F220/28 ,  C08F220/38 ,  C09D133/14 ,  C09D179/08 ,  C09D5/02 ,  G02B1/04

Abstract: The invention is related to a class of hydrophilic poly(meth)acrylamide-based copolymers each comprising dangling (i.e., pendant) reactive chains each terminated with a carboxyl group groups and at least 50% by mole of (meth)acrylamide repeating units relative to all repeating units of the hydrophilic poly(meth)acrylamide-based copolymer. The hydrophilic copolymers have a relatively high affinity to a base coating of a polyanionic polymer on a medical device or contact lens and are highly reactive towards azetidinium groups of an azetidinium-containing polymer upon heating. They can find particular use in producing water-soluble highly-branched hydrophilic polymeric material and in producing water gradient contact lenses.