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    POLYMERIZABLE POLYSILOXANES WITH HYDROPHILIC SUBSTITUENTS
    1.
    发明申请
    POLYMERIZABLE POLYSILOXANES WITH HYDROPHILIC SUBSTITUENTS 审中-公开

    公开(公告)号：US20190153141A1

    公开(公告)日：2019-05-23

    申请号：US16255043

    申请日：2019-01-23

    Applicant: Novartis AG

    Inventor： Frank Chang ,  Ryan DeSousa ,  Jinyu Huang

    IPC: C08F290/06 ,  C08G77/38 ,  C08G77/14 ,  G02B1/04 ,  C08G77/20

    CPC classification number: C08F290/068 ,  C08G77/12 ,  C08G77/14 ,  C08G77/20 ,  C08G77/38 ,  C08G2210/00 ,  G02B1/043 ,  C08L101/14 ,  C08L83/04

    Abstract: The invention provides a hydrophilized polydiorganosiloxane vinylic crosslinker which comprises (1) a polydiorganosiloxane polymer chain comprising dimethylsiloxane units and hydrophilized siloxane unit having one methyl substituent and one monovalent C10-C50 organic substituent having two or three carboxy groups, wherein the molar ratio of the hydrophilized siloxane units to the dimethylsiloxane units is from about 0.035 to about 0.25, and (2) two terminal (meth)acryloyl groups. The hydrophilized polydiorganosiloxane vinylic crosslinker has a number average molecular weight of greater than 3000 Daltons. The present invention is also related to a silicone hydrogel contact lens, which comprises repeating units derived from a hydrophilized polydiorganosiloxane vinylic crosslinker of the invention. In addition, the invention provides a method for making silicone hydrogel contact lenses using a lens-forming formulation comprising hydrophilized polydiorganosiloxane vinylic crosslinker of the invention.

    Hydrophilized polydiorganosiloxane vinylic crosslinkers and uses thereof
    2.
    发明授权
    Hydrophilized polydiorganosiloxane vinylic crosslinkers and uses thereof 有权

    公开(公告)号：US10246543B2

    公开(公告)日：2019-04-02

    申请号：US16110194

    申请日：2018-08-23

    Applicant: Novartis AG

    Inventor： Jinyu Huang ,  Frank Chang ,  Steve Yun Zhang ,  Feng Jing

    IPC: C08L101/14 ,  C08L83/04 ,  C08F290/06 ,  C08G77/20 ,  C08G77/16 ,  C08G77/392 ,  G02B1/04 ,  C08G77/12

    Abstract: The invention provides a hydrophilized polydiorganosiloxane vinylic crosslinker which comprises (1) a polydiorganosiloxane polymer chain comprising dimethylsiloxane units and hydrophilized siloxane units each having one methyl substituent and one monovalent C4-C40 organic radical substituent having two to six hydroxyl groups, wherein the molar ratio of the hydrophilized siloxane units to the dimethylsiloxane units is from about 0.035 to about 0.15, and (2) two terminal (meth)acryloyl groups. The hydrophilized polydiorganosiloxane vinylic crosslinker has a number average molecular weight of from about 3000 Daltons to about 80,000 Daltons. The present invention is also related to a silicone hydrogel contact lens, which comprises repeating units derived from a hydrophilized polydiorganosiloxane vinylic crosslinker of the invention.

    Carbosiloxane vinylic monomers
    3.
    发明授权
    Carbosiloxane vinylic monomers 有权
    碳硅氧烷乙烯基单体

    公开(公告)号：US09329306B2

    公开(公告)日：2016-05-03

    申请号：US14694590

    申请日：2015-04-23

    Applicant: Novartis AG

    Inventor： Jinyu Huang ,  Frank Chang

    IPC: C08F230/08 ,  C08F30/08 ,  C08L83/04 ,  G02B1/04 ,  C07F7/18 ,  C07F7/08

    CPC classification number: G02B1/043 ,  C07F7/0838 ,  C07F7/1804 ,  C08F30/08 ,  C08F230/08 ,  C08G77/12 ,  C08G77/26 ,  C08L83/04 ,  C08L101/14

    Abstract: The invention provides a carbosiloxane vinylic monomer which comprises one sole ethylenically unsaturated group, one sole terminal butyl group; and one oligo(carbosiloxane)-containing linkage between the ethylenically unsaturated terminal group and the terminal butyl group. The present invention is also related to a polymer, an actinically-crosslinkable silicone-containing prepolymer, a silicone hydrogel polymeric material, or a silicone hydrogel contact lens, which comprises monomeric units derived from a carbosiloxane vinylic monomer of the invention.

    Abstract translation: 本发明提供一种碳硅氧烷乙烯基单体，其包含一个唯一的烯键式不饱和基团，一个唯一的末端丁基基团; 和烯键式不饱和端基和末端丁基之间的一个低聚（碳硅氧烷）键。 本发明还涉及包含衍生自本发明的碳硅氧烷乙烯基单体的单体单元的聚合物，可光化交联的含硅氧烷的预聚物，硅氧烷水凝胶聚合物材料或硅氧水凝胶隐形眼镜。

    CARBOSILOXANE VINYLIC MONOMERS
    4.
    发明申请
    CARBOSILOXANE VINYLIC MONOMERS 有权
    碳硅氧烷单体

    公开(公告)号：US20150309211A1

    公开(公告)日：2015-10-29

    申请号：US14694590

    申请日：2015-04-23

    Applicant: Novartis AG

    Inventor： Jinyu Huang ,  Frank Chang

    IPC: G02B1/04 ,  C08F230/08 ,  C07F7/18 ,  C08F30/08

    CPC classification number: G02B1/043 ,  C07F7/0838 ,  C07F7/1804 ,  C08F30/08 ,  C08F230/08 ,  C08G77/12 ,  C08G77/26 ,  C08L83/04 ,  C08L101/14

    Abstract: The invention provides a carbosiloxane vinylic monomer which comprises one sole ethylenically unsaturated group, one sole terminal butyl group; and one oligo(carbosiloxane)-containing linkage between the ethylenically unsaturated terminal group and the terminal butyl group. The present invention is also related to a polymer, an actinically-crosslinkable silicone-containing prepolymer, a silicone hydrogel polymeric material, or a silicone hydrogel contact lens, which comprises monomeric units derived from a carbosiloxane vinylic monomer of the invention.

    Abstract translation: 本发明提供一种碳硅氧烷乙烯基单体，其包含一个唯一的烯键式不饱和基团，一个唯一的末端丁基基团; 和烯键式不饱和端基和末端丁基之间的一个低聚（碳硅氧烷）键。 本发明还涉及包含衍生自本发明的碳硅氧烷乙烯基单体的单体单元的聚合物，可光化交联的含硅氧烷的预聚物，硅氧烷水凝胶聚合物材料或硅氧水凝胶隐形眼镜。

    AMPHIPHILIC BRANCHED POLYDIORGANOSILOXANE MACROMERS
    5.
    发明申请
    AMPHIPHILIC BRANCHED POLYDIORGANOSILOXANE MACROMERS 审中-公开

    公开(公告)号：US20190062485A1

    公开(公告)日：2019-02-28

    申请号：US16175904

    申请日：2018-10-31

    Applicant: Novartis AG

    Inventor： Frank Chang ,  Jinyu Huang ,  Troy Vernon Holland

    IPC: C08F290/06 ,  G02B1/04 ,  C08F283/12 ,  C08G77/20 ,  C08F222/10 ,  C08F220/40 ,  C08F222/38

    Abstract: The invention provides a class of amphiphilic branched macromers and the uses thereof. An amphiphilic branched polydiorganosiloxane macromer of the invention is produced from an α,ω-dimethacryloyl-terminated polydiorganosiloxane vinylic crosslinker comprising one or more ATRP-containing siloxane units having one substituent having an ATRP initiator by ATRP polymerization of one or more hydrophilic vinylic monomers. It comprises at least two polydiorganosiloxane polymer chains each having at most two terminal methacryloxy groups, dangling hydrophilic polymer chains each having a polymerizable or non-polymerizable terminal group, and one or more hydrophilic polymer chains as linkages between two polydiorganosiloxane chains. The present invention is also related to a silicone hydrogel contact lens, which comprises units derived from a polydiorganosiloxane-containing amphiphilic branched macromer of the invention.

    AMPHIPHILIC BRANCHED POLYDIORGANOSILOXANE MACROMERS
    8.
    发明申请
    AMPHIPHILIC BRANCHED POLYDIORGANOSILOXANE MACROMERS 审中-公开

    公开(公告)号：US20170166675A1

    公开(公告)日：2017-06-15

    申请号：US15376707

    申请日：2016-12-13

    Applicant: Novartis AG

    Inventor： Frank Chang ,  Jinyu Huang ,  Troy Vernon Holland

    IPC: C08F290/06 ,  C08G77/20 ,  G02B1/04

    CPC classification number: C08F290/068 ,  C08F283/124 ,  C08F2438/01 ,  C08G77/20 ,  C08G2210/00 ,  C08L2312/06 ,  G02B1/043 ,  C08F222/1006 ,  C08F220/40 ,  C08F222/38

    Abstract: The invention provides a class of amphiphilic branched macromers and the uses thereof. An amphiphilic branched polydiorganosiloxane macromer of the invention is produced from an α,ω-dimethacryloyl-terminated polydiorganosiloxane vinylic crosslinker comprising one or more ATRP-containing siloxane units having one substituent having an ATRP initiator by ATRP polymerization of one or more hydrophilic vinylic monomers. It comprises at least two polydiorganosiloxane polymer chains each having at most two terminal methacryloxy groups, dangling hydrophilic polymer chains each having a polymerizable or non-polymerizable terminal group, and one or more hydrophilic polymer chains as linkages between two polydiorganosiloxane chains. The present invention is also related to a silicone hydrogel contact lens, which comprises units derived from a polydiorganosiloxane-containing amphiphilic branched macromer of the invention.

    POLYMERIZABLE POLYSILOXANES WITH HYDROPHILIC SUBSTITUENTS
    10.
    发明申请
    POLYMERIZABLE POLYSILOXANES WITH HYDROPHILIC SUBSTITUENTS 有权
    具有疏水性取代基的聚合多羟基硅烷

    公开(公告)号：US20160090432A1

    公开(公告)日：2016-03-31

    申请号：US14859486

    申请日：2015-09-21

    Applicant: Novartis AG

    Inventor： Frank Chang ,  Jinyu Huang ,  Venkat Shankar

    IPC: C08F230/08 ,  G02B1/04

    CPC classification number: G02B1/043 ,  B29D11/00134 ,  B29D11/00192 ,  B29K2083/00 ,  B29K2105/0061 ,  C08F220/00 ,  C08F220/58 ,  C08F230/08 ,  C08F290/068 ,  C08F2220/585 ,  C08G77/20 ,  C08G77/26 ,  C08G77/28 ,  C08G77/38 ,  C08G77/42 ,  C08G77/442 ,  C08G77/445 ,  C08G77/48 ,  C08G2210/00 ,  C08J3/03 ,  C08J3/075 ,  C08J3/28 ,  C08L51/085 ,  C08L83/06 ,  C08L83/10 ,  C08L83/14 ,  G02C7/04 ,  C08L83/04 ,  C08L101/14

    Abstract: The invention provides an actinically-polymerizable amphiphilic polysiloxane which comprises a polysiloxane polymer chain comprising a polylsiloxane segments comprising at least one siloxane unit having a low molecular weight hydrophilic polymer chain connected with a silicone atom of the siloxane unit, and (meth)acrylamido groups each covalently bonded to one of the ends of the polysiloxane polymer chain and/or to the end of one of low molecular weight hydrophilic polymer chains each connected with one silicone atom. The present invention is also related to a polymer, an actinically-crosslinkable silicone-containing prepolymer, a silicone hydrogel polymeric material, or a silicone hydrogel contact lens, which comprises repeating units derived from an actinically-polymerizable amphiphilic polysiloxane of the invention. In addition, the invention provides a method for making silicone hydrogel contact lenses using a water-based lens-forming formulation comprising an actinically-polymerizable amphiphilic polysiloxane of the invention and/or an actinically-crosslinkable silicone-containing prepolymer of the invention.

    Abstract translation: 本发明提供了一种光聚合性两亲性聚硅氧烷，其包含聚硅氧烷聚合物链，其包含聚硅氧烷链段，该聚硅氧烷链段包含至少一个硅氧烷单元，该硅氧烷单元具有与硅氧烷单元的硅氧烷原子连接的低分子量亲水性聚合物链和各自的（甲基）丙烯酰胺基 共价键合到聚硅氧烷聚合物链的一个端部和/或每个与一个硅氧烷原子连接的低分子量亲水聚合物链之一的末端。 本发明还涉及聚合物，可光化交联的含硅氧烷的预聚物，硅氧烷水凝胶聚合物材料或硅氧水凝胶隐形眼镜，其包含衍生自本发明的可光化聚合的两亲聚硅氧烷的重复单元。 此外，本发明提供了使用包含本发明的可自由基聚合的两亲性聚硅氧烷和/或本发明的可光化交联的含硅氧烷预聚物的水性透镜形成剂制备硅酮水凝胶隐形眼镜的方法。

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