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公开(公告)号：US20160357031A1
公开(公告)日：2016-12-08
申请号：US15168697
申请日：2016-05-31
Applicant: Novartis AG
Inventor： Troy Vernon Holland , Frank Chang , Ryan DeSousa
CPC classification number: G02C7/108 , B29D11/00038 , B29D11/00134 , B29D11/00519 , B29K2083/00 , B29K2105/0061 , B29K2995/0062 , C07F7/30 , C07F9/098 , C08F2/48 , C08F2/50 , C08F26/06 , C08F220/54 , G02B1/04 , G02B1/043 , G02C7/049
Abstract: Described herein are acyl germanium photoinitiator for cost-effective and time-efficient method for producing UV-absorbing contact lenses capable of blocking ultra-violet (“UV”) radiation and optionally (but preferably) violet radiation with wavelengths from 380 nm to 440 nm, thereby protecting eyes to some extent from damages caused by UV radiation and potentially from violet radiation. This invention also provides a method for making UV-absorbing contact lenses made by using an acyl germanium photoinitiator of the invention.
Abstract translation: 本文描述的是用于生产能够阻挡紫外线（“UV”）辐射的UV吸收隐形眼镜的成本有效和时间有效的方法的酰基锗光引发剂，以及波长为380nm至440nm的任选（但优选）紫外线辐射 从而在一定程度上保护眼睛免受紫外线辐射和紫外线辐射造成的损害。 本发明还提供了通过使用本发明的酰基锗光引发剂制造紫外线吸收隐形眼镜的方法。
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公开(公告)号：US20150092155A1
公开(公告)日：2015-04-02
申请号：US14496492
申请日：2014-09-25
Applicant: Novartis AG
Inventor： Frank Chang , Jinyu Huang , Ryan DeSousa
CPC classification number: G02B1/043 , B29D11/00134 , B29K2083/005 , B29K2105/0005 , B29K2105/0061 , B29K2105/24 , C08L83/04 , C08L33/26
Abstract: The invention provides silicone hydrogel ophthalmic lenses (in particular contact lenses) having relatively-long thermal stability and methods for making such ophthalmic lenses.
Abstract translation: 本发明提供具有相当长的热稳定性的硅酮水凝胶眼用透镜（特别是隐形眼镜）以及制造这种眼科镜片的方法。
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公开(公告)号：US11111327B2
公开(公告)日：2021-09-07
申请号：US16250003
申请日：2019-01-17
Applicant: Novartis AG
Inventor： Ryan DeSousa , Troy Vernon Holland , Frank Chang
IPC: C08F216/06 , B29D11/00 , C08K5/17 , G02B1/04 , B29C35/08 , C08J3/24 , C08K5/3435 , C08L29/06 , C08L83/04 , G02C7/04 , B29K29/00 , B29K105/00 , B29K105/24
Abstract: Described herein is a cast-molding process for producing contact lenses in a relatively-short curing time from a lens-forming composition, which comprises (a) at least one thiol-containing compound or component, (b) at least one metal scavenger, and (c) at least one free radical scavenger and which has a pH of from about 2.5 to about 5. The addition of a chain-transfer agent into a lens-forming composition can reduce not only the curing time of the lens-forming composition but also reduce the elastic modulus of resultant crosslinked materials (e.g., contact lenses) from the lens-forming composition. The lower pH and the addition of metal scavenger and the free radical scavenger into the lens-forming composition can ensure that the lens-forming composition to have a shelf life of at least three days.
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公开(公告)号：US10676557B2
公开(公告)日：2020-06-09
申请号：US16255043
申请日：2019-01-23
Applicant: Novartis AG
Inventor： Frank Chang , Ryan DeSousa , Jinyu Huang
IPC: C08L101/14 , C08L83/04 , C08F290/06 , G02B1/04 , C08G77/20 , C08G77/14 , C08G77/38 , C08G77/12
Abstract: The invention provides a hydrophilized polydiorganosiloxane vinylic crosslinker which comprises (1) a polydiorganosiloxane polymer chain comprising dimethylsiloxane units and hydrophilized siloxane unit having one methyl substituent and one monovalent C10-C50 organic substituent having two or three carboxy groups, wherein the molar ratio of the hydrophilized siloxane units to the dimethylsiloxane units is from about 0.035 to about 0.25, and (2) two terminal (meth)acryloyl groups. The hydrophilized polydiorganosiloxane vinylic crosslinker has a number average molecular weight of greater than 3000 Daltons. The present invention is also related to a silicone hydrogel contact lens, which comprises repeating units derived from a hydrophilized polydiorganosiloxane vinylic crosslinker of the invention. In addition, the invention provides a method for making silicone hydrogel contact lenses using a lens-forming formulation comprising hydrophilized polydiorganosiloxane vinylic crosslinker of the invention.
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公开(公告)号：US20190256455A1
公开(公告)日：2019-08-22
申请号：US16401193
申请日：2019-05-02
Applicant: Novartis AG
Inventor： Frank Chang , Ryan DeSousa , Troy Vernon Holland , Walter R. Laredo
IPC: C07C225/22 , B29D11/00 , G02C7/10 , G02C7/04 , C07C225/10 , C08F116/06 , C07D249/20 , G02B1/04
Abstract: Described herein are dimethyl acetal-containing UV-absorbing compounds and their uses in preparing UV-absorbing polyvinyl alcohol prepolymers suitable for producing UV-absorbing contact lenses capable of blocking ultra-violet (“UV”) radiation and optionally (but preferably) violet radiation with wavelengths from 380 nm to 440 nm, thereby protecting eyes to some extent from damages caused by UV radiation and potentially from violet radiation. This invention also provides a UV-absorbing polyvinyl alcohol prepolymer.
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Patent Agency Ranking
公开(公告)号：US10322993B2
公开(公告)日：2019-06-18
申请号：US15352132
申请日：2016-11-15
Applicant: Novartis AG
Inventor： Frank Chang , Ryan DeSousa , Troy Vernon Holland , Walter R. Laredo
IPC: C07D249/20 , C07C225/22 , C07C225/10 , C08F116/06 , G02B1/04 , G02C7/04 , G02C7/10 , B29D11/00
Abstract: Described herein are dimethyl acetal-containing UV-absorbing compounds and their uses in preparing UV-absorbing polyvinyl alcohol prepolymers suitable for producing UV-absorbing contact lenses capable of blocking ultra-violet (“UV”) radiation and optionally (but preferably) violet radiation with wavelengths from 380 nm to 440 nm, thereby protecting eyes to some extent from damages caused by UV radiation and potentially from violet radiation. This invention also provides a UV-absorbing polyvinyl alcohol prepolymer.
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公开(公告)号：US10254567B2
公开(公告)日：2019-04-09
申请号：US15434105
申请日：2017-02-16
Applicant: Novartis AG
Inventor： Frank Chang , Ryan DeSousa , Troy Vernon Holland , John Dallas Pruitt , Jared Nelson
IPC: C07D249/20 , G02C7/10 , C08F220/70 , C08F230/08 , G02B1/04 , G02C7/04 , B29D11/00 , C08F20/36 , G02B5/20 , G02B5/22 , C07C233/38 , B29K105/00
Abstract: Described herein are water-soluble UV-absorbing vinylic monomers and their uses in preparing UV-absorbing contact lenses capable of blocking ultra-violet (“UV”) radiation and optionally (but preferably) violet radiation with wavelengths from 380 nm to 440 nm, thereby protecting eyes to some extent from damages caused by UV radiation and potentially from violet radiation. This invention also provides a UV-absorbing contact lens.
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公开(公告)号：US10823983B2
公开(公告)日：2020-11-03
申请号：US16280084
申请日：2019-02-20
Applicant: Novartis AG
Inventor： Frank Chang , Ryan DeSousa , Troy Vernon Holland , John Dallas Pruitt , Jared Nelson
IPC: G02C7/10 , C07D249/20 , C08F230/08 , G02B1/04 , G02C7/04 , B29D11/00 , C08F20/36 , G02B5/20 , G02B5/22 , C07C233/38 , C08F220/60 , C08F220/70 , B29K105/00
Abstract: Described herein are water-soluble UV-absorbing vinylic monomers and their uses in preparing UV-absorbing contact lenses capable of blocking ultra-violet (“UV”) radiation and optionally (but preferably) violet radiation with wavelengths from 380 nm to 440 nm, thereby protecting eyes to some extent from damages caused by UV radiation and potentially from violet radiation. This invention also provides a UV-absorbing contact lens.
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公开(公告)号：US10472319B2
公开(公告)日：2019-11-12
申请号：US16401193
申请日：2019-05-02
Applicant: Novartis AG
Inventor： Frank Chang , Ryan DeSousa , Troy Vernon Holland , Walter R. Laredo
IPC: G02B1/04 , C07C225/22 , B29D11/00 , G02C7/10 , C07C225/10 , C08F116/06 , C07D249/20 , G02C7/04
Abstract: Described herein are dimethyl acetal-containing UV-absorbing compounds and their uses in preparing UV-absorbing polyvinyl alcohol prepolymers suitable for producing UV-absorbing contact lenses capable of blocking ultra-violet (“UV”) radiation and optionally (but preferably) violet radiation with wavelengths from 380 nm to 440 nm, thereby protecting eyes to some extent from damages caused by UV radiation and potentially from violet radiation. This invention also provides a UV-absorbing polyvinyl alcohol prepolymer.
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公开(公告)号：US10268053B2
公开(公告)日：2019-04-23
申请号：US15434098
申请日：2017-02-16
Applicant: Novartis AG
Inventor： Troy Vernon Holland , Frank Chang , Walter R. Laredo , Xuwei Jiang , Ryan DeSousa
IPC: C07C233/23 , G02C7/10 , C07C233/33 , C08F283/12 , G02B1/04 , G02C7/04 , C07C225/22 , C07C237/32 , C07C237/34
Abstract: Described herein are UV-absorbing vinylic monomers and their uses in preparing UV-absorbing contact lenses capable of blocking ultra-violet (“UV”) radiation and violet radiation with wavelengths from 380 nm to 440 nm, thereby protecting eyes to some extent from damages caused by UV radiation and potentially from violet radiation.
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