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120 条记录 (耗时 0.066 秒)

    Leishmania antigens for use in the therapy and diagnosis of leishmaniasis
    84.
    发明授权
    Leishmania antigens for use in the therapy and diagnosis of leishmaniasis 失效
    利什曼原虫抗原用于治疗和诊断利什曼病

    公开(公告)号：US06709661B1

    公开(公告)日：2004-03-23

    申请号：US08798841

    申请日：1997-02-12

    申请人： Steven G. Reed ,  Antonio Campos-Neto ,  John R. Webb ,  Davin C. Dillon ,  Yasir A. W. Skeiky

    发明人： Steven G. Reed ,  Antonio Campos-Neto ,  John R. Webb ,  Davin C. Dillon ,  Yasir A. W. Skeiky

    IPC分类号： A61K39008

    CPC分类号： C07K14/44 ,  A61K38/00 ,  A61K39/00 ,  Y02A50/41 ,  Y10S530/806

    摘要： Compositions and methods for preventing, treating and detecting leishmaniasis and stimulating immune responses in patients are disclosed. The compounds provided include polypeptides that contain at least an immunogenic portion of one or more Leishmania antigens, or a variant thereof. Vaccines and pharmaceutical compositions comprising such polypeptides, or DNA molecules encoding such polypeptides, are also provided and may be used, for example, for the prevention and therapy of leishmaniasis, as well as for the detection of Leishmania infection.

    摘要翻译： 公开了用于预防，治疗和检测利什曼病并刺激患者免疫应答的组合物和方法。 提供的化合物包括含有至少一种或多种利什曼原虫抗原的免疫原性部分或其变体的多肽。 还提供包含这些多肽的疫苗和药物组合物，或编码这些多肽的DNA分子，并且可以用于例如预防和治疗利什曼病以及利什曼原虫感染的检测。

    Compounds for therapy and diagnosis of lung cancer and methods for their use
    85.
    发明授权
    Compounds for therapy and diagnosis of lung cancer and methods for their use 失效
    用于治疗和诊断肺癌的化合物及其使用方法

    公开(公告)号：US06444425B1

    公开(公告)日：2002-09-03

    申请号：US09370838

    申请日：1999-08-09

    申请人： Steven G. Reed ,  Michael J. Lodes ,  Raodoh Mohamath ,  Heather Secrist

    发明人： Steven G. Reed ,  Michael J. Lodes ,  Raodoh Mohamath ,  Heather Secrist

    IPC分类号： C12Q168

    CPC分类号： C07K14/47 ,  A61K38/00 ,  A61K39/00

    摘要： Compositions and methods for the therapy and diagnosis of cancer, such as lung cancer, are disclosed. Compositions may comprise one or more lung tumor proteins, immunogenic portions thereof, or polynucleotides that encode such portions. Alternatively, a therapeutic composition may comprise an antigen presenting cell that expresses a lung tumor protein, or a T cell that is specific for cells expressing such a protein. Such compositions may be used, for example, for the prevention and treatment of diseases such as lung cancer. Diagnostic methods based on detecting a lung tumor protein, or mRNA encoding such a protein, in a sample are also provided.

    摘要翻译： 公开了用于治疗和诊断癌症的组合物和方法，例如肺癌。 组合物可以包含一种或多种肺肿瘤蛋白，其免疫原性部分，或编码这些部分的多核苷酸。 或者，治疗组合物可以包含表达肺肿瘤蛋白的抗原呈递细胞，或表达这种蛋白质的细胞特异的T细胞。 这样的组合物可以用于例如预防和治疗诸如肺癌的疾病。 还提供了基于检测样品中的肺肿瘤蛋白或编码这种蛋白质的mRNA的诊断方法。

    Compounds for immunotherapy of breast cancer and methods for their use
    86.
    发明授权
    Compounds for immunotherapy of breast cancer and methods for their use 失效
    用于乳腺癌免疫治疗的化合物及其使用方法

    公开(公告)号：US06379951B1

    公开(公告)日：2002-04-30

    申请号：US09118627

    申请日：1998-07-17

    申请人： Steven G. Reed ,  Jiangchun Xu

    发明人： Steven G. Reed ,  Jiangchun Xu

    IPC分类号： C07H2104

    CPC分类号： C07K14/82 ,  A61K38/00 ,  A61K39/00

    摘要： Compounds and methods for treating breast cancer are provided. The inventive compounds include polypeptides containing at least a portion of a breast tumor protein. Vaccines and pharmaceutical compositions for immunotherapy of breast cancer comprising such polypeptides, or DNA molecules encoding such polypeptides, are also provided, together with DNA molecules for preparing the inventive polypeptides.

    摘要翻译： 提供了治疗乳腺癌的化合物和方法。 本发明化合物包括含有至少一部分乳腺肿瘤蛋白质的多肽。 还提供了包含此类多肽的乳腺癌免疫治疗用疫苗和药物组合物，或编码此类多肽的DNA分子，以及用于制备本发明多肽的DNA分子。

    Compositions and methods for the prevention and treatment of M. tuberculosis infection
    87.
    发明授权
    Compositions and methods for the prevention and treatment of M. tuberculosis infection 失效
    预防和治疗结核分枝杆菌感染的组合物和方法

    公开(公告)号：US06350456B1

    公开(公告)日：2002-02-26

    申请号：US09056556

    申请日：1998-04-07

    申请人： Steven G. Reed ,  Yasir A. W. Skeiky ,  Davin C. Dillon

    发明人： Steven G. Reed ,  Yasir A. W. Skeiky ,  Davin C. Dillon

    IPC分类号： A61K304

    CPC分类号： C07K14/35 ,  A61K38/00 ,  A61K39/00 ,  A61K2039/51 ,  C07K2319/00

    摘要： Compositions and methods for treatment and vaccination against tuberculosis are disclosed. In one aspect the compositions provided include at least two polypeptides that contain an immunogenic portion of a M. tuberculosis antigen or at least two DNA molecules encoding such polypeptides. In a second aspect, the compositions provided include a fusion protein comprising at least two polypeptides that contain an immunogenic portion of a M. tuberculosis antigen. Such compositions may be formulated into vaccines and/or pharmaceutical compositions for immunization against M. tuberculosis infection, or may be used for the diagnosis of tuberculosis.

    摘要翻译： 公开了治疗和接种针对结核病的组合物和方法。 在一个方面，所提供的组合物包括至少两种含有结核分枝杆菌抗原的免疫原性部分或至少两种编码这种多肽的DNA分子的多肽。 在第二方面，提供的组合物包括包含至少两种含有结核分枝杆菌抗原的免疫原性部分的多肽的融合蛋白。 这样的组合物可以配制成针对结核分枝杆菌感染免疫的疫苗和/或药物组合物，或可用于诊断结核病。

    Compounds and methods for the diagnosis and treatment of Ehrlichia infection
    89.
    发明授权
    Compounds and methods for the diagnosis and treatment of Ehrlichia infection 有权
    用于诊断和治疗艾滋病感染的化合物和方法

    公开(公告)号：US06277381B1

    公开(公告)日：2001-08-21

    申请号：US09295028

    申请日：1999-04-20

    申请人： Steven G. Reed ,  Michael J. Lodes ,  Raymond L. Houghton ,  Patricia D. McNeill

    发明人： Steven G. Reed ,  Michael J. Lodes ,  Raymond L. Houghton ,  Patricia D. McNeill

    IPC分类号： A61K3902

    CPC分类号： C07K14/29 ,  A61K38/00 ,  C07K2319/00 ,  Y02A50/401 ,  Y02A50/402

    摘要： Compounds and methods for the diagnosis and treatment of Ehrlichia infection, in particular human granulocytic ehrlichiosis, are disclosed. The compounds provided include polypeptides that contain at least one antigenic portion of an Ehrlichia antigen and DNA sequences encoding such polypeptides. Pharmaceutical compositions an vaccines comprising such polypeptides or DNA sequences are also provided. Diagnostic kits containing such polypeptides or DNA sequences and a suitable detection reagent may be used for the detection of Ehrlichia infection in patients and biologiacal samples. Antibodies directed against such polypeptides are also provided.

    摘要翻译： 公开了用于诊断和治疗埃里巴病毒感染，特别是人粒细胞性肾病的化合物和方法。 提供的化合物包括含有至少一种抗原部分的埃里希抗原的多肽和编码这种多肽的DNA序列。 药物组合物还提供了包含这种多肽或DNA序列的疫苗。 含有此类多肽或DNA序列的诊断试剂盒和合适的检测试剂可用于检测患者和生物样品中的埃氏体感染。 还提供了针对这种多肽的抗体。

    Compounds and methods for diagnosis of lung cancer
    90.
    发明授权
    Compounds and methods for diagnosis of lung cancer 失效
    化合物和肺癌诊断方法

    公开(公告)号：US06210883B1

    公开(公告)日：2001-04-03

    申请号：US09040984

    申请日：1998-03-18

    申请人： Steven G. Reed ,  Tong Tong Wang

    发明人： Steven G. Reed ,  Tong Tong Wang

    IPC分类号： C12Q168

    CPC分类号： C12Q1/6809 ,  A61K38/00 ,  C07K14/47 ,  Y10S435/81

    摘要： Compounds and methods for treating lung cancer are provided. The inventive compounds include polypeptides containing at least a portion of a lung tumor protein. Vaccines and pharmaceutical compositions for immunotherapy of lung cancer comprising such polypeptides, or DNA molecules encoding such polypeptides, are also provided, together with DNA molecules for preparing the inventive polypeptides.

    摘要翻译： 提供了治疗肺癌的化合物和方法。 本发明化合物包括含有至少一部分肺肿瘤蛋白的多肽。 还提供包含这种多肽的肺癌免疫治疗用疫苗和药物组合物，或编码这些多肽的DNA分子，以及用于制备本发明多肽的DNA分子。