公开(公告)号：US20050209580A1

公开(公告)日：2005-09-22

申请号：US11086867

申请日：2005-03-22

申请人： Toby Freyman

发明人： Toby Freyman

IPC分类号： A61F2/958 ,  A61M25/00 ,  A61M31/00

CPC分类号： A61M25/0075 ,  A61F2/2403 ,  A61F2/2412 ,  A61F2/2424 ,  A61F2/2433 ,  A61F2/2496 ,  A61F2250/0059 ,  A61M25/0029 ,  A61M25/007 ,  A61M25/1002 ,  A61M25/1011 ,  A61M2025/0034 ,  A61M2025/0076 ,  A61M2025/1047 ,  A61M2025/105 ,  A61M2025/1072

摘要： The invention provides a catheter for insertion into a biological passage which contains a first flowing fluid, the catheter including a tubular member having a proximal end and a distal end; a fluid delivery lumen contained within the tubular member; an inflatable balloon assembly disposed at the distal end of the tubular member, the balloon assembly including an inflatable balloon member having an uninflated state and an inflated state, the balloon assembly including apertures in communication with the fluid delivery lumen; an inflation lumen in communication with the balloon member; and a valve contained within the inflatable balloon assembly. The inflatable balloon is assembly configured such that when the balloon member is in the inflated state: (i) sections of the balloon member contact the biological passage defining at least one containment pocket; (ii) the apertures are disposed in the containment pocket, (iii) a flow lumen is defined through the balloon member to allow the first fluid to flow through the balloon member; and (iv) the valve functions to allow the first flowing fluid to flow through the flow lumen in a physiologic direction, while blocking backflow of the first fluid through the flow lumen.

公开(公告)号：US20050096636A1

公开(公告)日：2005-05-05

申请号：US10700569

申请日：2003-11-05

申请人： Toby Freyman ,  Maria Palasis

发明人： Toby Freyman ,  Maria Palasis

IPC分类号： A61M1/10 ,  A61M5/142 ,  A61M25/00 ,  A61M25/16

CPC分类号： A61M25/00 ,  A61M5/14228 ,  A61M2025/0057

摘要： An apparatus and method for delivering a viscous liquid therapeutic material fluid through a lumen in a catheter that selectively narrows the lumen at a plurality of axial locations along the lumen.

摘要翻译： 一种用于通过导管中的内腔递送粘性液体治疗物质流体的装置和方法，所述导管在沿着内腔的多个轴向位置选择性地缩小内腔。

公开(公告)号：US08790920B2

公开(公告)日：2014-07-29

申请号：US12021625

申请日：2008-01-29

申请人： Toby Freyman

发明人： Toby Freyman

IPC分类号： C12N5/00

CPC分类号： A61L27/3683 ,  A61K35/28 ,  A61K38/00 ,  A61L27/28 ,  A61L27/3633 ,  A61L31/08

摘要： The invention is directed to compositions comprising decellularized bone marrow extracellular matrix and uses thereof. Methods for repairing or regenerating defective, diseased, damaged or ischemic tissues or organs in a subject, preferably a human, using the decellularized bone marrow extracellular matrix of the invention are also provided. The invention is further directed to a medical device, preferably a stent or an artificial heart, and biocompatible materials, preferably a tissue regeneration scaffold, comprising decellularized bone marrow extracellular matrix for implantation into a subject.

摘要翻译： 本发明涉及包含脱细胞的骨髓细胞外基质及其用途的组合物。 还提供了使用本发明的脱细胞化骨髓细胞外基质修复或再生受治疗者，优选人的有缺陷，患病，损伤或缺血组织或器官的方法。 本发明进一步涉及医疗装置，优选支架或人造心脏，以及生物相容性材料，优选组织再生支架，其包括用于植入受试者的脱细胞骨髓细胞外基质。

公开(公告)号：US08114049B2

公开(公告)日：2012-02-14

申请号：US12399548

申请日：2009-03-06

申请人： Toby Freyman ,  Gordon Kocur ,  Daniel Horn

发明人： Toby Freyman ,  Gordon Kocur ,  Daniel Horn

IPC分类号： A61M31/00 ,  A61M37/00 ,  A61M29/00

CPC分类号： A61M25/1029 ,  A61L29/085 ,  A61L29/16 ,  A61L2300/416 ,  A61M25/0045 ,  A61M25/10 ,  A61M2025/0056 ,  A61M2025/1031 ,  A61M2025/105 ,  B29L2009/005 ,  C08L53/02

摘要： Catheter devices having an expandable balloon for delivering a therapeutic agent to a body site. The balloon has one or more folds which serve as a reservoir for containing the therapeutic agent. The fold may have any of various configurations to hold the therapeutic agent. In some cases, the balloon comprises one or more lobes that forms the fold(s). The therapeutic agent may be provided in various ways. For example, the therapeutic agent may be contained in packets that rupture upon expansion of the balloon, or as a plurality of discrete bulk masses, or sealed within compartments.

摘要翻译： 具有用于将治疗剂递送到身体部位的可膨胀气囊的导管装置。 气囊具有一个或多个折叠，其用作容纳治疗剂的储存器。 折叠可以具有保持治疗剂的各种构造中的任何一种。 在一些情况下，气囊包括形成褶皱的一个或多个凸起。 治疗剂可以以各种方式提供。 例如，治疗剂可以包含在囊膨胀时破裂的包装中，或者作为多个离散的体积块，或者密封在隔室内。

公开(公告)号：US07972295B2

公开(公告)日：2011-07-05

申请号：US11077117

申请日：2005-03-11

申请人： Toby Freyman ,  Inas Khayal ,  Wendy Naimark

发明人： Toby Freyman ,  Inas Khayal ,  Wendy Naimark

IPC分类号： A61M31/00

CPC分类号： A61M37/0069

摘要： Apparatus and method utilizing fluid to deliver a bolus of therapeutic material through a lumen to a delivery or discharge control portion of the apparatus, where the bolus may be discharged or delivered to a desired location.

摘要翻译： 使用流体的药物和方法将治疗材料的药丸通过内腔输送到装置的输送或排出控制部分，其中推注可以排出或输送到期望的位置。

公开(公告)号：US20090138074A1

公开(公告)日：2009-05-28

申请号：US12363358

申请日：2009-01-30

申请人： Toby Freyman ,  Wendy Naimark ,  Maria Palasis

发明人： Toby Freyman ,  Wendy Naimark ,  Maria Palasis

IPC分类号： A61F2/82 ,  A61M25/00

CPC分类号： A61L27/3683 ,  A61K35/12 ,  A61L27/3633 ,  A61L2430/40 ,  C12N5/0679 ,  C12N2510/00

摘要： The invention is directed to an apparatus, such as a medical device, having a surface coated or covered with a decellularized extracellular matrix or having a component comprising the decellularized extracellular matrix for implantation into a subject, preferably a human. In one embodiment of the invention, a decellularized extracellular matrix is used to form a bodily implant such as a vein, an artery, an esophagus, or a ventricular restraining device. In some embodiments of the invention, the decellularized extracellular matrix is configured to be a time released therapeutic. In another embodiment of the invention, a decellularized extracellular matrix forms an aneurysm treatment device, such as an aneurysm coil, a seal, a pouch, or a filler. In a further embodiment of the invention, decellularized extracellular matrix is used to embolize lesions, tumors, or vessels. Methods for making the tissue regeneration scaffold and methods for manufacturing a coated or covered medical device having a component comprising decellularized extracellular matrix of body tissues are also provided.

摘要翻译： 本发明涉及一种诸如医疗装置的装置，其具有被脱细胞的细胞外基质包被或覆盖的表面，或具有包含用于植入受试者，优选人的脱细胞的细胞外基质的组分。 在本发明的一个实施方案中，使用脱细胞的细胞外基质形成诸如静脉，动脉，食管或心室抑制装置的身体植入物。 在本发明的一些实施方案中，脱细胞的细胞外基质被配置为时间释放的治疗剂。 在本发明的另一个实施方案中，脱细胞的细胞外基质形成动脉瘤治疗装置，例如动脉瘤线圈，密封件，小袋或填充物。 在本发明的另一个实施方案中，脱细胞的细胞外基质用于栓塞病变，肿瘤或血管。 还提供了用于制备组织再生支架的方法和用于制造具有包含身体组织的脱细胞的细胞外基质的组分的涂覆或覆盖的医疗装置的方法。

公开(公告)号：US07470252B2

公开(公告)日：2008-12-30

申请号：US10942046

申请日：2004-09-16

申请人： Timothy J. Mickley ,  Maria Palasis ,  Toby Freyman

发明人： Timothy J. Mickley ,  Maria Palasis ,  Toby Freyman

IPC分类号： A61M29/00 ,  A61M31/00 ,  A61M37/00

CPC分类号： A61M25/104 ,  A61M25/10 ,  A61M2025/105 ,  A61M2025/1072

摘要： The present invention provides a systems that delivers therapeutic to the inner lumens, chambers, cavities, and vessels of the body. A therapeutic delivery device for delivery of therapeutic to a target site within the body of a patient is provided. This device may include a catheter, an expandable multi-port housing fluidly coupled to the catheter and a sheath. The multi-port housing in this device may be sized to travel within a lumen of a patient and may be adapted to expand from a first configuration to a second configuration. The multi-port housing may also contain at least two ejection ports coupled to an internal lumen of the multi-port housing.

摘要翻译： 本发明提供了将治疗剂递送到身体的内腔，腔室，空腔和血管的系统。 提供了用于将治疗剂递送到患者体内的靶位点的治疗递送装置。 该装置可以包括导管，可流体地联接到导管的可扩展多端口壳体和护套。 该装置中的多端口壳体的尺寸可以设计成在患者的内腔内行进，并且可以适于从第一构型扩展到第二构造。 多端口壳体还可以包含联接到多端口壳体的内腔的至少两个喷射端口。

公开(公告)号：US20080183143A1

公开(公告)日：2008-07-31

申请号：US12022413

申请日：2008-01-30

申请人： Maria Palasis ,  Timothy J. Mickley ,  Toby Freyman ,  Wendy Naimark

发明人： Maria Palasis ,  Timothy J. Mickley ,  Toby Freyman ,  Wendy Naimark

IPC分类号： A61M31/00 ,  A61M29/00

CPC分类号： A61M31/002 ,  A61F2/24 ,  A61F2250/0067

摘要： The present invention relates to implantable medical devices and methods that employ these medical devices to treat heart valves. In one embodiment, a medical device is provided comprising a body. The body may have a portion thereof including therapeutic agent and can be configured to support the device proximate a heart valve. Methods in accordance with embodiments of the present invention may also include providing a medical device having a body with at least a portion thereof including a therapeutic agent. These methods may also include positioning the medical device in a location proximate to a downstream surface of the heart valve and securing the device. The therapeutic agent released may then be delivered to the heart valve.

摘要翻译： 本发明涉及使用这些医疗装置来治疗心脏瓣膜的可植入医疗装置和方法。 在一个实施例中，提供了包括身体的医疗装置。 身体可以具有其一部分，包括治疗剂，并且可被构造成在靠近心脏瓣膜的位置支撑装置。 根据本发明的实施例的方法还可以包括提供具有身体的医疗装置，其中至少一部分包括治疗剂。 这些方法还可以包括将医疗装置定位在靠近心脏瓣膜的下游表面的位置并固定装置。 然后释放的治疗剂可以被递送到心脏瓣膜。

公开(公告)号：US07338468B2

公开(公告)日：2008-03-04

申请号：US10673430

申请日：2003-09-30

申请人： Toby Freyman

发明人： Toby Freyman

IPC分类号： A61M29/00

CPC分类号： A61M25/1002 ,  A61M25/0075 ,  A61M25/10 ,  A61M2025/105 ,  A61M2025/1086

摘要： The present invention relates to a device and method for endoluminal delivery of fluid, such as therapeutic fluid, into the vessel wall that minimizes loss of the fluid. In one embodiment, a catheter for delivering fluid or therapeutic into a vessel wall is provided, wherein the catheter has at least one injector for delivering fluid and a sealing mechanism for preventing or minimizing passage of fluid through an unengaged injector.

摘要翻译： 本发明涉及一种用于将流体（例如治疗性流体）腔内输送到容器壁中以最小化流体损失的装置和方法。 在一个实施例中，提供了用于将流体或治疗剂输送到血管壁中的导管，其中所述导管具有用于输送流体的至少一个注射器和用于防止或最小化流体通过未注入注射器的通道的密封机构。

公开(公告)号：US20060206056A1

公开(公告)日：2006-09-14

申请号：US11432398

申请日：2006-05-12

申请人： Toby Freyman ,  Wendy Naimark ,  Tim Mickley ,  Samuel Epstein

发明人： Toby Freyman ,  Wendy Naimark ,  Tim Mickley ,  Samuel Epstein

IPC分类号： A61M5/178

CPC分类号： A61M5/1582

摘要： Injection devices are provided, which reduce potential outflow of therapeutic agents from an injection site. Devices are provided having at least a first lumen containing one or more therapeutic agents and a second lumen containing a second material for injection into tissue. Other devices are provided having an inner lumen with an injection needle to inject a therapeutic agent and an outer lumen that provides a vacuum seal between the injection needle and the needle track. Further provided are methods of delivering a therapeutic agent to tissue.