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公开(公告)号：US08138142B2
公开(公告)日：2012-03-20
申请号：US12657146
申请日：2010-01-13
Applicant: Jasbir Seehra , Ravindra Kumar , Jennifer Lachey , Alan Koncarevic
Inventor： Jasbir Seehra , Ravindra Kumar , Jennifer Lachey , Alan Koncarevic
CPC classification number: C07K16/40 , A61K31/00 , A61K31/7088 , A61K38/179 , A61K2039/505 , C07K14/705 , C07K16/22 , C07K2317/24 , C07K2317/31 , C07K2317/54 , C07K2317/55 , C07K2317/622 , C07K2317/76 , C07K2319/30
Abstract: In certain aspects, the present invention provides compositions and methods for increasing adiponectin in a patient in need thereof by administering an antagonist of an ActRIIB signaling pathway. Examples of such antagonists include ActRIIB polypeptides, anti-ActRIIB antibodies, anti-activin A and/or B antibodies, anti-myostatin antibodies, anti-GDF3 antibodies, and anti-BMP7 antibodies. Also provided are methods for ameliorating one or more undesired effects of anti-androgen therapy, including muscle loss, bone loss, increased adiposity, and/or increased insulin resistance. A variety of disorders may be treated by causing an increase in circulating adiponectin concentrations.
Abstract translation: 在某些方面，本发明提供了通过施用ActRIIB信号通路的拮抗剂来增加有需要的患者中的脂连蛋白的组合物和方法。 此类拮抗剂的实例包括ActRIIB多肽，抗ActRIIB抗体，抗激活素A和/或B抗体，抗肌生成抑制素抗体，抗GDF3抗体和抗BMP7抗体。 还提供了用于改善一种或多种不期望的抗雄激素治疗效果的方法，包括肌肉损失，骨丢失，增加的肥胖和/或增加的胰岛素抵抗。 可以通过引起循环中脂联素浓度的增加来治疗多种疾病。
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公开(公告)号：US20120015877A1
公开(公告)日：2012-01-19
申请号：US13247748
申请日：2011-09-28
Applicant: Jasbir Seehra , Robert Scott Pearsall , Ravindra Kumar
Inventor： Jasbir Seehra , Robert Scott Pearsall , Ravindra Kumar
CPC classification number: C12N9/12 , A61K38/179 , A61K38/1796 , C07K14/47 , C07K14/475 , C07K2319/30 , C12Q1/6897 , C12Y207/1103
Abstract: In certain aspects, the present invention provides compositions and methods for increasing red blood cell and/or hemoglobin levels in vertebrates, including rodents and primates, and particularly in humans.
Abstract translation: 在某些方面，本发明提供用于增加脊椎动物（包括啮齿动物和灵长类动物，特别是人）中红细胞和/或血红蛋白水平的组合物和方法。
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83.发明申请PLATELET GLYCOPROTEIN IB ALPHA VARIANT FUSION POLYPEPTIDES AND METHODS OF USE THEREOF 审中-公开PLATELET GLYCOPROTEIN IB ALPHA VARIANT FUSION POLYPEPTIDES及其使用方法公开(公告)号：US20110039780A1
公开(公告)日：2011-02-17
申请号：US12621887
申请日：2009-11-19
Applicant: Gray Shaw , Dianne Sako , Ravindra Kumar , Jin Xu
Inventor： Gray Shaw , Dianne Sako , Ravindra Kumar , Jin Xu
CPC classification number: C07K14/705 , A61K38/00 , C07K2319/00
Abstract: The present invention provides compositions and methods for treating or preventing vascular-associated disorders.
Abstract translation: 本发明提供了用于治疗或预防血管相关疾病的组合物和方法。
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84.发明授权Platelet glycoprotein Ib alpha variant fusion polypeptides and methods of use thereof 失效血小板糖蛋白Ibα变体融合多肽及其使用方法公开(公告)号：US07727535B2
公开(公告)日：2010-06-01
申请号：US10868371
申请日：2004-06-14
Applicant: Gray Shaw , Dianne Sako , Ravindra Kumar , Jin Xu
Inventor： Gray Shaw , Dianne Sako , Ravindra Kumar , Jin Xu
CPC classification number: C07K14/705 , A61K38/00 , C07K2319/00
Abstract: The present invention provides compositions and methods for treating or preventing vascular-associated disorders.
Abstract translation: 本发明提供了用于治疗或预防血管相关疾病的组合物和方法。
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公开(公告)号：US20100068215A1
公开(公告)日：2010-03-18
申请号：US12583177
申请日：2009-08-13
Applicant: Jasbir Seehra , Robert Scott Pearsall , Ravindra Kumar
Inventor： Jasbir Seehra , Robert Scott Pearsall , Ravindra Kumar
IPC: A61K39/395 , A61K38/00 , A61P7/06 , C07K16/00 , C12N5/10
CPC classification number: C12N9/12 , A61K38/179 , A61K38/1796 , C07K14/47 , C07K14/475 , C07K2319/30 , C12Q1/6897 , C12Y207/1103
Abstract: In certain aspects, the present invention provides compositions and methods for increasing red blood cell and/or hemoglobin levels in vertebrates, including rodents and primates, and particularly in humans.
Abstract translation: 在某些方面，本发明提供用于增加脊椎动物（包括啮齿动物和灵长类动物，特别是人）中红细胞和/或血红蛋白水平的组合物和方法。
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Patent Agency Ranking
公开(公告)号：US07615363B2
公开(公告)日：2009-11-10
申请号：US11467135
申请日：2006-08-24
Applicant: Lidia Mosyak , Thomas Saltmarsh Rush, III , Xiaotian Zhong , Thomas E. McDonagh , Katy E. Georgiadis , Phaik-Eng Sum , Edward R. LaVallie , Lisa A. Collins-Racie , Christopher John Corcoran , Ravindra Kumar , Tracy Hebert , Stephane Hubert Olland , Stewart Andrews Mackie
Inventor： Lidia Mosyak , Thomas Saltmarsh Rush, III , Xiaotian Zhong , Thomas E. McDonagh , Katy E. Georgiadis , Phaik-Eng Sum , Edward R. LaVallie , Lisa A. Collins-Racie , Christopher John Corcoran , Ravindra Kumar , Tracy Hebert , Stephane Hubert Olland , Stewart Andrews Mackie
CPC classification number: C12N9/6421 , C07K2299/00 , C07K2319/00
Abstract: This invention relates to aggrecanase polypeptides and aggrecanase polypeptide/ligand complexes, crystals of aggrecanase and aggrecanase polypeptide/ligand complexes, and related methods and software systems.
Abstract translation: 本发明涉及聚集蛋白聚糖酶多肽和聚集蛋白聚糖蛋白聚糖酶多肽/配体复合物，聚集蛋白聚糖蛋白聚糖酶和聚集蛋白聚糖酶多肽/配体复合物的晶体，以及相关的方法和软件系统。
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87.发明授权公开(公告)号：US07049128B2
公开(公告)日：2006-05-23
申请号：US10382758
申请日：2003-03-06
Applicant: Gray D. Shaw , Dianne S. Sako , Ravindra Kumar , Francis Sullivan , Tom McDonagh
Inventor： Gray D. Shaw , Dianne S. Sako , Ravindra Kumar , Francis Sullivan , Tom McDonagh
CPC classification number: C07K14/705 , A61K38/1709 , C07K2319/00
Abstract: The present invention provides compositions and methods for treating or preventing vascular-associated disorders.
Abstract translation: 本发明提供了用于治疗或预防血管相关疾病的组合物和方法。
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88.发明授权公开(公告)号：US06991796B2
公开(公告)日：2006-01-31
申请号：US10068426
申请日：2002-02-06
Applicant: Gray D. Shaw , Dianne S. Sako , Ravindra Kumar , Francis Sullivan , Tom McDonagh
Inventor： Gray D. Shaw , Dianne S. Sako , Ravindra Kumar , Francis Sullivan , Tom McDonagh
CPC classification number: C07K14/705 , A61K38/1709 , C07K2319/00
Abstract: The present invention provides compositions and methods for treating or preventing vascular-associated disorders.
Abstract translation: 本发明提供了用于治疗或预防血管相关疾病的组合物和方法。
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公开(公告)号：US20050148006A1
公开(公告)日：2005-07-07
申请号：US11012286
申请日：2004-12-16
Applicant: Francis Sullivan , Ronald Kriz , Ravindra Kumar
Inventor： Francis Sullivan , Ronald Kriz , Ravindra Kumar
IPC: A61P29/00 , C12N1/21 , C12N9/88 , C12N15/60 , C12Q1/68 , C07H21/04 , C08B37/00 , C12N9/24 , C12P19/04
CPC classification number: C12N9/88
Abstract: The invention provides a novel GDP-mannose 4,6-dehydratase.
Abstract translation: 本发明提供了一种新的GDP-甘露糖4,6-脱水酶。
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公开(公告)号：US5942228A
公开(公告)日：1999-08-24
申请号：US149674
申请日：1998-09-09
Applicant: Francis Sullivan , Ronald Kriz , Ravindra Kumar
Inventor： Francis Sullivan , Ronald Kriz , Ravindra Kumar
CPC classification number: C12N9/88
Abstract: The invention provides a novel GDP-mannose 4,6-dehydratase.
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