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123 条记录 (耗时 0.068 秒)

    Compounds, composition, methods, targets for cancer therapy
    81.
    发明授权
    Compounds, composition, methods, targets for cancer therapy 失效
    化合物，组成，方法，癌症治疗目标

    公开(公告)号：US08680129B2

    公开(公告)日：2014-03-25

    申请号：US12667687

    申请日：2010-01-04

    申请人： Ming Yu

    发明人： Ming Yu

    IPC分类号： A01N43/64 ,  A61K31/41

    CPC分类号： C12N15/113 ,  A61K31/21 ,  A61K31/33 ,  A61K31/353 ,  A61K31/41 ,  A61K31/47 ,  A61K31/713 ,  A61K45/06 ,  C07D257/04 ,  C12N2310/14 ,  C12N2320/30 ,  A61K2300/00

    摘要： This invention describes methods and pharmaceutical compositions for combinational cancer treatments that are capable of inducing JNK phosphorylation and induce programmed cell death. It also identified genes as target for anti-cancer drug development and enhancement of the chemotherapeutic drug effect for the treatment of cancer. This invention points to a novel method and principle for a new avenue of developing more efficient and low or non cytotoxic cancer treatment.

    摘要翻译： 本发明描述了能够诱导JNK磷酸化并诱导程序性细胞死亡的组合癌症治疗的方法和药物组合物。 它还将基因鉴定为抗癌药物开发的目标，并提高治疗癌症的化疗药物作用。 本发明指出了开发更有效和低或非细胞毒性癌症治疗的新途径的新方法和原理。

    Dual mode cavity filter assembly operating in a TE22N mode
    82.
    发明授权
    Dual mode cavity filter assembly operating in a TE22N mode 有权
    双模腔式过滤器组件以TE22N模式运行

    公开(公告)号：US08665039B2

    公开(公告)日：2014-03-04

    申请号：US12886168

    申请日：2010-09-20

    申请人： Bahram Yassini ,  Ming Yu

    发明人： Bahram Yassini ,  Ming Yu

    IPC分类号： H01P1/207

    CPC分类号： H01P1/2082 ,  H01P7/06

    摘要： A microwave cavity filter is configured for operation in the dual TE22N mode to realize a very high Q factor at very high frequency ranges. The microwave filter is formed from using one or more cylindrical cavities in which two orthogonal field polarizations of the TE22N mode are excited and coupled together by means of a coupling element. Different combinations of inter-cavity irises provide for both direct and cross-coupling of aligned field polarizations in adjacent cavities, as required, to realize complex filter functions. The irises may be formed in either a side or end wall of the cavities for both collinear and planar mount configuration. Negative mode coupling also allows for transmission zeros to be realized on either side of the filter passband.

    摘要翻译： 微波空腔滤波器配置为在双TE22N模式下工作，以在非常高的频率范围内实现非常高的Q因子。 微波滤波器由使用一个或多个圆柱形空腔形成，其中TE22N模式的两个正交场偏振被激发并通过耦合元件耦合在一起。 腔间虹膜的不同组合根据需要提供相邻腔中的对准场偏振的直接和交叉耦合，以实现复杂的滤波器功能。 虹膜可以形成在空腔的侧壁或端壁中，用于共线和平面安装配置。 负模耦合还允许在滤波器通带的任一侧实现传输零点。

    Handheld computing device
    83.
    发明授权
    Handheld computing device 有权
    手持式计算设备

    公开(公告)号：US08345410B2

    公开(公告)日：2013-01-01

    申请号：US12694085

    申请日：2010-01-26

    申请人： John P. Ternus ,  Stephen R. McClure ,  Joshua D. Banko ,  Ming Yu

    发明人： John P. Ternus ,  Stephen R. McClure ,  Joshua D. Banko ,  Ming Yu

    IPC分类号： H05K5/03

    CPC分类号： G06F1/1633 ,  G06F1/1613 ,  G06F1/1626 ,  G06F1/1643 ,  G06F1/1656 ,  H01Q1/2266 ,  H04M1/0252 ,  H04M1/0266 ,  H04M1/0277 ,  H05K1/0281 ,  H05K1/118 ,  H05K1/147 ,  H05K5/03 ,  Y10T29/49995

    摘要： A portable computing device is disclosed. The portable computing device can take many forms such as a laptop computer, a tablet computer, and so on. The portable computing device can include at least a single piece housing. The single piece housing including a plurality of steps. The plurality of mounting steps is formed by at least removing a preselected amount of housing material at predetermined locations on the interior surface. At least some of the mounting steps are used to mount at least some of the plurality of internal operating components to the housing.

    摘要翻译： 公开了一种便携式计算设备。 便携式计算设备可以采用许多形式，例如膝上型计算机，平板计算机等。 便携式计算装置可以包括至少一个单件壳体。 单件壳体包括多个台阶。 多个安装步骤通过在内表面上的预定位置处至少去除预选量的壳体材料而形成。 至少一些安装步骤用于将多个内部操作部件中的至少一些安装到壳体。

    System for increasing imaging quality
    84.
    发明授权
    System for increasing imaging quality 有权
    提高成像质量的系统

    公开(公告)号：US08167210B2

    公开(公告)日：2012-05-01

    申请号：US12211941

    申请日：2008-09-17

    申请人： Rong Liu ,  Vladimir Gurevich ,  Ming Yu

    发明人： Rong Liu ,  Vladimir Gurevich ,  Ming Yu

    IPC分类号： G02B5/00

    CPC分类号： G06K7/10831

    摘要： A method and apparatus for improving the image quality obtained by an imaging-based scanner comprising a housing supporting one or more protective windows. The apparatus further comprises at least one scanning arrangement, the scanning arrangement comprising illumination and imaging optics. The illumination and imaging optics form a respective field of view for imaging a target object. A light baffle is attached to the scanning arrangement. The light baffle has an aperture corresponding to each of the illumination and imaging optics such that stray light reflected from the protective windows is absorbed by the light baffle, improving the image quality of the imaging-based scanner.

    摘要翻译： 一种用于改善由基于成像的扫描仪获得的图像质量的方法和装置，其包括支撑一个或多个保护窗的壳体。 该装置还包括至少一个扫描装置，扫描装置包括照明和成像光学元件。 照明和成像光学器件形成用于对目标物体成像的相应视场。 轻型挡板附着在扫描装置上。 光挡板具有对应于每个照明和成像光学器件的孔径，使得从保护窗口反射的杂散光被光挡板吸收，从而提高了基于成像的扫描仪的图像质量。

    Monitoring a rechargeable battery with multiple parameter update rates
    85.
    发明申请
    Monitoring a rechargeable battery with multiple parameter update rates 有权
    监控具有多个参数更新率的可充电电池

    公开(公告)号：US20120049802A1

    公开(公告)日：2012-03-01

    申请号：US12807130

    申请日：2010-08-27

    申请人： Yevgen P. Barsukov ,  Jinrong Qian ,  Peter Fundaro ,  Ming Yu

    发明人： Yevgen P. Barsukov ,  Jinrong Qian ,  Peter Fundaro ,  Ming Yu

    IPC分类号： H02J7/00

    CPC分类号： G01R31/3651 ,  G01R31/362 ,  G01R31/3662

    摘要： Monitoring a state of a rechargeable battery involves repeatedly obtaining at least one measured value related to the battery during discharge of the battery; repeatedly calculating the state of the battery during discharge of the battery based on a previously calculated state of the battery, the measured value and at least one parameter of the battery; before the state of the battery passes a threshold value, updating the parameter of the battery at a first rate; after the state of the battery passes the threshold value, updating the parameter of the battery at a second rate, faster than the first rate; and correcting the state of the battery in response to each update of the parameter.

    摘要翻译： 监视可充电电池的状态包括在电池放电期间重复地获得与电池相关的至少一个测量值; 基于电池的先前计算状态，测量值和电池的至少一个参数，重复地计算电池放电期间电池的状态; 在电池的状态通过阈值之前，以第一速率更新电池的参数; 在电池的状态通过阈值之后，以比第一速率更快的第二速率更新电池的参数; 以及响应于参数的每次更新来校正电池的状态。

    Dielectric resonator and filter with low permittivity material
    86.
    发明授权
    Dielectric resonator and filter with low permittivity material 有权
    介电谐振器和低介电常数材料的滤波器

    公开(公告)号：US08031036B2

    公开(公告)日：2011-10-04

    申请号：US12252076

    申请日：2008-10-15

    申请人： Antonio Panariello ,  Ming Yu ,  Mihai Vladimirescu ,  William A. Fitzpatrick

    发明人： Antonio Panariello ,  Ming Yu ,  Mihai Vladimirescu ,  William A. Fitzpatrick

    IPC分类号： H01P7/10

    CPC分类号： H01P7/10 ,  H01P1/2053

    摘要： A resonator cavity for supporting a plurality of resonant modes and filtering electromagnetic energy includes a cavity and a resonator element with a mounting flange. The cavity is defined by a top end wall, a bottom end wall and a sidewall and has a longitudinal axis along its length is defined. The resonator element is positioned within the cavity along the longitudinal axis and includes a mounting flange. The resonator element is only in physical contact with the cavity through the mounting flange at a mounting location and where at least one resonant mode of the electromagnetic energy exhibits a local minima. The dimensions of the cavity and the resonator element are selected so that the associated electromagnetic energy is defined by an electromagnetic field pattern that substantially repeats itself at least twice along the length of the resonator.

    摘要翻译： 用于支撑多个谐振模式和滤波电磁能的谐振器腔包括腔和具有安装凸缘的谐振元件。 空腔由顶端壁，底端壁和侧壁限定，并且具有沿其长度的纵向轴线被限定。 谐振器元件沿着纵向轴线定位在腔内，并且包括安装凸缘。 谐振器元件仅在安装位置处通过安装凸缘与空腔物理接触，并且其中电磁能的至少一个谐振模式表现出局部最小值。 选择空腔和谐振器元件的尺寸，使得相关联的电磁能量由沿着谐振器的长度基本上重复其自身至少两次的电磁场图案限定。

    LIGANDS FOR IMAGING CARDIAC INNERVATION
    89.
    发明申请
    LIGANDS FOR IMAGING CARDIAC INNERVATION 有权
    用于成像心脏感染的配对

    公开(公告)号：US20100221182A1

    公开(公告)日：2010-09-02

    申请号：US12448575

    申请日：2007-12-21

    申请人： Ajay Purohit ,  Thomas D, Harris ,  Heike S. Radeke ,  Simon P. Robinson ,  Ming Yu ,  David S. Casebier ,  Michael T. Azure

    发明人： Ajay Purohit ,  Thomas D, Harris ,  Heike S. Radeke ,  Simon P. Robinson ,  Ming Yu ,  David S. Casebier ,  Michael T. Azure

    IPC分类号： A61K51/04 ,  C07D233/88 ,  C07C279/08 ,  C07C215/30 ,  C07D295/14

    CPC分类号： A61K51/04 ,  A61K51/0453 ,  A61K51/0459 ,  C07B59/001 ,  C07B2200/05 ,  C07C215/60 ,  C07C217/70 ,  C07C279/06 ,  C07C279/08

    摘要： Novel compounds that find use as imaging agents within nuclear medicine applications (PET imaging) for imaging of cardiac innervation are disclosed. These PET based radiotracers may exhibit increased stability, decreased NE release (thereby reducing side effects), improved quantitative data, and/or high affinity for VMAT over prior radiotracers. Methods of using the compounds to image cardiac innervation are also provided. In some instances the compounds are developed by derivatizing certain compounds with 18F in a variety of positions: aryl, alkyl, a keto, benzylic, beta-alkylethers, gamma-propylalkylethers and beta-proplylalkylethers. Alternatively or additionally, a methyl group a is added to the amine, and/or the catechol functionality is either eliminated or masked as a way of making these compounds more stable.

    摘要翻译： 公开了用于心脏神经支配成像的核医学应用（PET成像）中用作成像剂的新型化合物。 这些基于PET的放射性示踪剂可能表现出增加的稳定性，减少NE释放（从而减少副作用），改进的定量数据，和/或对先前的放射性示踪剂对VMAT的高亲和力。 还提供了使用化合物成像心脏神经支配的方法。 在某些情况下，化合物通过在各种位置上衍生化某些化合物而形成：芳基，烷基，酮基，苄基，β-烷基醚，γ-丙基烷基醚和β-丙基烷基醚。 或者或另外，将甲基a加入到胺中，和/或儿茶酚官能团被消除或掩蔽，作为使这些化合物更稳定的方式。

    Cavity microwave filter assembly with lossy networks
    90.
    发明授权
    Cavity microwave filter assembly with lossy networks 有权
    具有有损网络的腔微波滤波器组件

    公开(公告)号：US07764146B2

    公开(公告)日：2010-07-27

    申请号：US12139121

    申请日：2008-06-13

    申请人： Ming Yu ,  S. Vahid Miraftab

    发明人： Ming Yu ,  S. Vahid Miraftab

    IPC分类号： H01P1/20 ,  H01P1/23 ,  H01P3/08

    CPC分类号： H01P1/2084

    摘要： A cavity microwave filter assembly for filtering an electromagnetic wave including a plurality of cavity resonator assemblies, where each cavity resonator assembly has a bottom and including at least one lossy element for electromagnetically coupling two elements of the filter assembly, where at least one element is a cavity resonator assembly. The lossy elements provide attenuation in the loss variation of the filter and sharper slopes resulting in an improved Q factor for the filter. A method for realizing lossy elements as resistors requires determining an equivalent circuit model that can be manufactured using resistors, coupling elements, and transmission lines. The method includes representing the resistive element with a resistor, unity admittance inverters and coupling elements and then scaling to determine the resistor and coupling values. The method further includes replacing the admittance inverters with transmission lines of the appropriate length to account for the specific design of the filter.

    摘要翻译： 一种空腔微波滤波器组件，用于对包括多个空腔谐振器组件的电磁波进行滤波，其中每个空腔谐振器组件具有底部并且包括用于电磁耦合过滤器组件的两个元件的至少一个有损元件，其中至少一个元件为 空腔谐振器组件。 有损元素在滤波器的损耗变化和更尖锐的斜率上提供衰减，导致滤波器的Q因子提高。 用于实现有损耗元件作为电阻器的方法需要确定可以使用电阻器，耦合元件和传输线制造的等效电路模型。 该方法包括用电阻表示电阻元件，单位导纳反相器和耦合元件，然后缩放以确定电阻器和耦合值。 该方法还包括用适当长度的传输线代替导纳逆变器以考虑滤波器的具体设计。