利索-全球专利检索

  1. 登录
  2. 注册

搜索结果

100 条记录 (耗时 0.038 秒)

    Method for preparing highly stable crystals of aspartame derivative
    81.
    发明授权
    Method for preparing highly stable crystals of aspartame derivative 失效
    制备高稳定性阿斯巴甜衍生物晶体的方法

    公开(公告)号：US06844465B2

    公开(公告)日：2005-01-18

    申请号：US10160000

    申请日：2002-06-04

    申请人： Shigeru Kawahara ,  Akihiro Kishishita ,  Kazutaka Nagashima ,  Tadashi Takemoto

    发明人： Shigeru Kawahara ,  Akihiro Kishishita ,  Kazutaka Nagashima ,  Tadashi Takemoto

    IPC分类号： C07K5/075 ,  C07C229/00

    CPC分类号： C07K5/0613

    摘要： Disclosed in the present application are a method for preparing highly-stable A-type crystals by controlling and maintaining the product temperature of B-type N-(3,3-dimethylbutyl)-APM crystals at 25 to 80° C. under an absolute humidity of 0.203 kg/kg or less environment, thereby effecting crystal transition; and a method for preparing A-type crystals by controlling and maintaining the product temperature of D-type crystals of N-(3,3-dimethylbutyl)-APM at 25 to 80° C. under an absolute humidity of 0.0550 kg/kg or less environment, thereby effecting crystal transition. According to these crystal transition methods, highly stable crystals can be prepared stably and at a low cost.

    摘要翻译： 本申请中公开了一种通过控制并保持B型N-（3,3-二甲基丁基）-APM晶体在25至80℃下的产物温度在绝对值下制备高度稳定的A型晶体的方法 湿度为0.203kg / kg以下的环境，从而进行晶体转变; 以及通过在0.05〜50kg / kg的绝对湿度下在25〜80℃下控制并维持N-（3,3-二甲基丁基）-APM的D-型晶体的产物温度来制备A型晶体的方法或 较少的环境，从而进行晶体转变。 根据这些晶体转变方法，可以稳定且低成本地制备高度稳定的晶体。

    Crystals of aspartame derivative
    83.
    发明授权
    Crystals of aspartame derivative 失效
    阿斯巴甜衍生物晶体

    公开(公告)号：US06818243B2

    公开(公告)日：2004-11-16

    申请号：US10183652

    申请日：2002-06-28

    申请人： Kazutaka Nagashima ,  Yuuichi Aoki ,  Eriko Ono ,  Tadashi Takemoto

    发明人： Kazutaka Nagashima ,  Yuuichi Aoki ,  Eriko Ono ,  Tadashi Takemoto

    IPC分类号： A23L1236

    CPC分类号： C07K5/06113 ,  A23L27/32

    摘要： N-[N-[3-(3-hydroxy-4-methoxyphenyl)propyl]-L-&agr;-aspartyl]-L-phenylalanine 1-methyl ester useful as a sweetener with a high potency of sweetness, is provided in the crystalline form having a high stability and a good purity which is favorable as a commercial product.

    摘要翻译： 在结晶中提供了可用作甜度高的甜味剂的N- [N- [3-（3-羟基-4-甲氧基苯基）丙基] -L-α-天冬氨酰基] -L-苯丙氨酸1-甲基酯 形式具有高稳定性和良好的纯度，作为商业产品是有利的。

    Arylpropyl aldehyde derivatives, processes for producing the same, and methods of using the same
    87.
    发明授权
    Arylpropyl aldehyde derivatives, processes for producing the same, and methods of using the same 失效
    芳基丙醛衍生物，其制备方法及其使用方法

    公开(公告)号：US06689902B2

    公开(公告)日：2004-02-10

    申请号：US10197808

    申请日：2002-07-19

    申请人： Kenichi Mori ,  Shigeru Kawahara ,  Tadashi Takemoto

    发明人： Kenichi Mori ,  Shigeru Kawahara ,  Tadashi Takemoto

    IPC分类号： C07C5900

    CPC分类号： C07C69/734 ,  C07C45/41 ,  C07C47/27 ,  C07C47/277 ,  C07C51/367 ,  C07C59/64 ,  C07C59/52

    摘要： 3-(3-Methyl-4-hydroxyphenyl)-3-methylbutyl aldehyde may be produced from 3-(3-methyl-4-hydroxyphenyl)-3-methylbutyric acid by converting the carboxyl group into a formyl group. N-[N-[3-(3-methyl-4-hydroxyphenyl)-3-methylbutyl]-L-&agr;-aspartyl]-L-phenylalanine 1-methyl ester, which is useful as a sweetener having a high potency of sweetness, can be easily and efficiently prepared on an industrial production from such an aldehyde derivative, via a reductive alkylation reaction with aspartame. Therefore, 3-(3-Methyl-4-hydroxyphenyl)-3-methylbutyl aldehyde is extremely excellent as an intermediate for the production of N-[N-[3-(3-methyl-4-hydroxyphenyl)-3-methylbutyl]-L-&agr;-aspartyl]-L-phenylalanine 1-methyl ester. The above butyric acid derivative is a novel compound, which can be easily produced by subjecting 3-(3-methyl-4-methoxyphenyl)-3-methylbutyric acid obtained by the reaction of 2-methoxytoluene with 3-methylcrotonic acid, to a reaction for converting a methoxy group into a hydroxyl group. The present invention further provides several novel compounds useful as a production intermediate, such as the above aldehyde derivative and the like.

    摘要翻译： 3-（3-甲基-4-羟基苯基）-3-甲基丁醛可以通过将羧基转变为甲酰基而由3-（3-甲基-4-羟基苯基）-3-甲基丁酸制备。 N- [N- [3-（3-甲基-4-羟基苯基）-3-甲基丁基] -L-α-天冬氨酰基] -L-苯丙氨酸1-甲基酯，其可用作具有高效能甜度的甜味剂 可以通过这种醛衍生物通过与阿斯巴甜的还原烷基化反应在工业生产上容易且有效地制备。 因此，3-（3-甲基-4-羟基苯基）-3-甲基丁基醛作为制备N- [N- [3-（3-甲基-4-羟基苯基）-3-甲基丁基] -L-α-天冬氨酰基] -L-苯丙氨酸1-甲酯。上述丁酸衍生物是一种新型化合物，其可以通过使3-（3-甲基-4-甲氧基苯基）-3-甲基丁酸得到 通过2-甲氧基甲苯与3-甲基巴豆酸的反应，将甲氧基转化成羟基的反应。本发明还提供了几种可用作生产中间体的新型化合物，例如上述醛衍生物等。

    Dipeptide derivatives and sweetening agents
    89.
    发明授权
    Dipeptide derivatives and sweetening agents 失效
    二肽衍生物和甜味剂

    公开(公告)号：US5968581A

    公开(公告)日：1999-10-19

    申请号：US37870

    申请日：1998-03-10

    申请人： Ryoichiro Nakamura ,  Yusuke Amino ,  Tadashi Takemoto

    发明人： Ryoichiro Nakamura ,  Yusuke Amino ,  Tadashi Takemoto

    IPC分类号： A23L27/30 ,  C07K5/06 ,  C07K5/072 ,  C07K5/075 ,  A23L1/236 ,  C07C229/00

    CPC分类号： C07K5/06113 ,  A23L27/32 ,  C07K5/06104

    摘要： Novel dipeptide derivatives, such as N-3,3-dimethylbutyl-.alpha.-L-aspartyl-.alpha.-methyl-L-phenylalanine methyl ester and N-3,3-dimethylbutyl-.alpha.-L-aspartyl-.alpha.-methyl-L-tyrosine methyl ester, and sweetening agents comprising, as the active ingredient, anyone of the derivatives and their salts, being low-calorie sweetening agents which are excellent in stability, safety and degree of sweetness, are provided. The products to have been sweetened, comprising such above sweetening agents are also provided.

    摘要翻译： 新型二肽衍生物如N-3,3-二甲基丁基-α-L-天冬氨酰-α-甲基-L-苯丙氨酸甲酯和N-3,3-二甲基丁基-α-L-天冬氨酰-α-甲基-L- 酪氨酸甲酯和甜味剂，其包含作为活性成分的任何衍生物及其盐，它们是稳定性，安全性和甜度优异的低热量甜味剂。 还提供了包含这些上述甜味剂的已经变甜的产品。