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    Method for purifying 5' -protected 2' -deoxypurine nucleosides
    82.
    发明申请
    Method for purifying 5' -protected 2' -deoxypurine nucleosides 失效
    5'保护的2'-脱氧嘌呤核苷的纯化方法

    公开(公告)号：US20060009635A1

    公开(公告)日：2006-01-12

    申请号：US11204009

    申请日：2005-08-16

    申请人： Hironori Komatsu ,  Toshiyuki Kouno ,  Katsutoshi Tsuchiya

    发明人： Hironori Komatsu ,  Toshiyuki Kouno ,  Katsutoshi Tsuchiya

    IPC分类号： C07H19/22 ,  C07H19/048

    CPC分类号： C07H19/16 ,  C07H1/06

    摘要： A method for efficiently purifying 5′ protected 2′-deoxypurine nucleosides, efficient production of which has previously been difficult. Impurities can be separated by obtaining the 5′ protected 2′-deoxypurine nucleoside as an inclusion crystal including a solvent such as that having a nitrile structure in order to purify the 5′ protected 2′-deoxypurine nucleoside at a high purity. This invention enables synthesis of highly purified, protected deoxypurine nucleosides easily on a large scale, which has previously been performed by column chromatography method.

    摘要翻译： 一种有效纯化5'保护的2'-脱氧嘌呤核苷的方法，其有效生产以前是困难的。 通过获得5'保护的2'-脱氧嘌呤核苷作为包含具有腈结构的溶剂的夹杂晶体以便以高纯度纯化5'保护的2'-脱氧嘌呤核苷可以分离杂质。 本发明能够容易地大规模合成高纯度的保护的脱氧嘌呤核苷，其先前通过柱色谱法进行。

    Nuclear medical diagnosis apparatus
    88.
    发明授权
    Nuclear medical diagnosis apparatus 有权
    核医学诊断仪器

    公开(公告)号：US07626172B2

    公开(公告)日：2009-12-01

    申请号：US12039270

    申请日：2008-02-28

    申请人： Isao Takahashi ,  Kazuma Yokoi ,  Tsuneaki Kawaguchi ,  Katsutoshi Tsuchiya

    发明人： Isao Takahashi ,  Kazuma Yokoi ,  Tsuneaki Kawaguchi ,  Katsutoshi Tsuchiya

    IPC分类号： G01T1/161

    CPC分类号： G01T1/2985 ,  A61B6/037

    摘要： A nuclear medial diagnosis apparatus is used for performing diagnosis by administering a medicine marked with a radioactive isotope into an examinee and by using an image obtained by detecting gamma rays emitted from a particular organ or tumor where the medicine is accumulated. An image (an image created by an image creation unit) is created by a signal (a signal as an output from a radiation detector) corresponding to the energy of the gamma ray detected by a radiation detector. The image includes a contamination component attributed to gamma scattering in the radiation detector. An image correction operation unit performs a convolution operation to obtain a contamination image. The contamination image is subtracted by a corrected image creation unit. Thus, it is possible to prevent image degradation by the gamma ray scattering in the radiation detector.

    摘要翻译： 核内诊断装置用于通过将标有放射性同位素的药物给予受检者并使用通过检测从药物积聚的特定器官或肿瘤发射的γ射线而获得的图像进行诊断。 图像（由图像创建单元创建的图像）由对应于由辐射检测器检测的伽马射线的能量的信号（作为来自辐射检测器的输出的信号）产生。 图像包括归因于辐射检测器中的伽马散射的污染成分。 图像校正操作单元执行卷积操作以获得污染图像。 污染图像由校正图像创建单元减去。 因此，可以防止辐射检测器中的伽马射线散射引起的图像劣化。