公开(公告)号：US20080269837A1

公开(公告)日：2008-10-30

申请号：US11742442

申请日：2007-04-30

申请人： Christy Ludlow ,  Pamela Reed Kearney ,  Thomas E. Cross ,  Robyn L. Jagler ,  Robert L. Olson ,  James Britton Hissong

发明人： Christy Ludlow ,  Pamela Reed Kearney ,  Thomas E. Cross ,  Robyn L. Jagler ,  Robert L. Olson ,  James Britton Hissong

IPC分类号： A61N1/372

CPC分类号： A61N1/05 ,  A61N1/0526 ,  A61N1/36007

摘要： Implantable leads implantable in a patient, such as patient's neck. The lead includes a first lead segment and a second lead segment. The second lead segment extends from the first lead segment at a first junction point and includes first, second, and third legs each defining a longitudinal length in extension from the first junction point to a distal end. A length of the first leg is greater than a length of the second leg, and a length of the second leg is greater than a length of the third leg. With this configuration, each of the legs are adapted to support at least one electrode at the distal end thereof, and are appropriately dimensioned relative to one another for locating the corresponding electrode at a desired target tissue site in the patient's neck. Targeted tissue can include, for example, muscles of the neck.

摘要翻译： 可植入的导线植入患者，如病人的颈部。 引线包括第一引线段和第二引线段。 第二引线段在第一连接点处从第一引线段延伸并且包括第一，第二和第三引脚，每个引脚限定从第一连接点延伸到远端的纵向长度。 第一腿部的长度大于第二腿部的长度，并且第二腿部的长度大于第三腿部的长度。 利用这种构造，每个腿适于在其远端处支撑至少一个电极，并且相对于彼此适当地确定尺寸，以将相应的电极定位在患者颈部中期望的目标组织部位。 目标组织可以包括例如颈部的肌肉。

公开(公告)号：US20080269716A1

公开(公告)日：2008-10-30

申请号：US11739982

申请日：2007-04-25

申请人： Eric H. Bonde ,  Martin T. Gerber

发明人： Eric H. Bonde ,  Martin T. Gerber

IPC分类号： A61M31/00

CPC分类号： A61N1/0526 ,  A61B17/06109 ,  A61B17/3468 ,  A61B2017/00946 ,  A61B2017/06052 ,  A61N1/0551 ,  A61N1/36071

摘要： The disclosure is directed to a method for implanting a medical device proximate to a target tissue site within an occipital region of a patient, such as proximate to an occipital nerve or a trigeminal nerve. The method comprises introducing an implant tool into a patient to define an insertion path to the target tissue site. The implant tool includes a shape memory cannula and a malleable needle at least partially disposed within an inner lumen of the cannula. The shape of the needle may be changed to accommodate different anatomical structures/features of the patient. Upon withdrawal of the needle from the cannula, the cannula may change shape, thereby changing the shape of the insertion path.

摘要翻译： 本公开涉及一种用于将医疗设备植入接近患者枕骨区域内的目标组织部位（例如靠近枕骨神经或三叉神经）的方法。 该方法包括将植入物工具引入患者以限定到目标组织部位的插入路径。 植入物工具包括形状记忆套管和至少部分地设置在套管的内腔内的有韧性的针。 可以改变针的形状以适应患者的不同解剖结构/特征。 当针从套管中取出时，套管可以改变形状，从而改变插入路径的形状。

公开(公告)号：US20080132979A1

公开(公告)日：2008-06-05

申请号：US11606772

申请日：2006-11-30

申请人： Martin T. Gerber

发明人： Martin T. Gerber

IPC分类号： A61N1/05

CPC分类号： A61N1/0526 ,  A61N1/0504

摘要： A method for implanting one or more implantable medical leads of an electrical stimulation system proximate to an occipital region of a patient comprises utilizing a needle to define an insertion path through tissue of the patient to a target tissue site. The insertion path may be dilated to a size large enough to receive an implantable medical lead. An electrical test signal may be delivered to the patient via the needle, a guide wire or a dilator assembly during the implantation procedure in order to assess the efficacy of stimulation prior to implantation of the lead and/or to establish the location of the needle, guide wire and/or dilator assembly within the patient.

摘要翻译： 用于将邻近患者枕骨区域的电刺激系统的一个或多个可植入医疗引线植入的方法包括利用针来限定通过患者组织到目标组织部位的插入路径。 插入路径可以扩大到足够大以接收可植入医疗引线的尺寸。 在植入过程期间，电测试信号可以经由针，导丝或扩张器组件递送给患者，以便在植入引导之前评估刺激的功效和/或建立针的位置， 导丝和/或扩张器组件在患者体内。

公开(公告)号：US07228167B2

公开(公告)日：2007-06-05

申请号：US10821778

申请日：2004-04-09

申请人： Tomas Kara ,  Virend K. Somers

发明人： Tomas Kara ,  Virend K. Somers

IPC分类号： A61B5/0428

CPC分类号： A61N1/0526 ,  A61B5/0205 ,  A61B5/021 ,  A61B5/0402 ,  A61B5/0476 ,  A61B5/0816 ,  A61B5/4094

摘要： A method and apparatus for monitoring the application of a vagus nerve stimulation signal includes a detection circuit having an amplifier, a filter, and a signal prolongation circuit. The signal prolongation circuit rectifies a detected vagus nerve signal and provides the signal to a Schmitt trigger extending the length of the signal. Because of the prolongation of the signal, the signal can be sampled at a relatively low rate, and real time data illustrating the response of various physiological signals to the application of the vagus nerve signal can be monitored, thereby providing clinical data for monitoring and adjusting the applied stimulation.

摘要翻译： 用于监测迷走神经刺激信号的应用的方法和装置包括具有放大器，滤波器和信号延长电路的检测电路。 信号延长电路对检测到的迷走神经信号进行整流，并将信号提供给延长信号长度的施密特触发器。 由于信号的延长，可以以相对低的速率对信号进行采样，并且可以监视说明各种生理信号对应用迷走神经信号的响应的实时数据，从而提供用于监测和调整的临床数据 应用刺激。

公开(公告)号：US20050159790A1

公开(公告)日：2005-07-21

申请号：US10952536

申请日：2004-09-27

申请人： Alon Shalev

发明人： Alon Shalev

IPC分类号： A61B20060101 ,  A61N1/04 ,  A61N1/18

CPC分类号： A61N1/36046 ,  A61M5/14276 ,  A61M5/1723 ,  A61M2205/3303 ,  A61M2210/0618 ,  A61M2210/0693 ,  A61N1/0526 ,  A61N1/0546 ,  A61N1/0548

摘要： A method is provided for facilitating a diagnosis of a condition of a subject, including applying a current to a site of the subject selected from the list consisting of: a sphenopalatine ganglion (SPG) of the subject, and a neural tract originating in or leading to the SPG, and configuring the current to increase conductance of molecules from brain tissue of the subject through a blood brain barrier (BBB) of the subject into a systemic blood circulation of the subject. The method also includes sensing a quantity of the molecules from a site outside of the brain of the subject, following initiation of application of the current.

摘要翻译： 提供了一种用于促进对受试者的状况的诊断的方法，包括将电流施加到从包括主题的蝶腭神经节（SPG）的列表中选择的对象的部位，以及源自或前导的神经系统 并且配置电流以将分子从受试者的脑组织通过受试者的血脑屏障（BBB）增加到受试者的全身血液循环中。 该方法还包括在开始施用电流之后从受试者脑部外的部位感测一定数量的分子。

公开(公告)号：US06853858B2

公开(公告)日：2005-02-08

申请号：US10294343

申请日：2002-11-14

申请人： Alon Shalev

发明人： Alon Shalev

IPC分类号： A61N1/18 ,  A61N1/40

CPC分类号： A61N1/205 ,  A61M5/14276 ,  A61M5/1723 ,  A61M2205/3303 ,  A61M2210/0618 ,  A61M2210/0693 ,  A61N1/0526 ,  A61N1/0546 ,  A61N1/0548 ,  A61N1/325 ,  A61N1/36017 ,  A61N1/3605 ,  A61N1/36071 ,  A61N1/36082

摘要： Apparatus is provided for delivering a Non Steroidal Anti-Inflammatory Drug (NSAID) supplied to a body of a subject for delivery to at least a portion of a central nervous system (CNS) of the subject via a systemic blood circulation of the subject, including a stimulator adapted to stimulate at least one site of the subject, so as to cause an increase in passage of the NSAID from the systemic blood circulation across a blood brain barrier (BBB) of the subject to the portion of the CNS, during at least a portion of the time that the NSAID is present in the blood, the site selected from the list consisting of: a sphenopalatine ganglion (SPG) of the subject, an anterior ethmoidal nerve of the subject, a posterior ethmoidal nerve of the subject, a communicating branch between an anterior ethmoidal nerve and a retro-orbital branch of an SPG of the subject, a communicating branch between a posterior ethmoidal nerve and a retro-orbital branch of an SPG of the subject, a greater palatine nerve of the subject, a lesser palatine nerve of the subject, a sphenopalatine nerve of the subject, a communicating branch between a maxillary nerve and an SPG of the subject, a nasopalatine nerve of the subject, a posterior nasal nerve of the subject, an infraorbital nerve of the subject, an otic ganglion of the subject, an afferent fiber going into the otic ganglion of the subject, an efferent fiber going out of the otic ganglion of the subject, a vidian nerve of the subject, a greater superficial petrosal nerve of the subject, and a lesser deep petrosal nerve of the subject.

摘要翻译： 提供了用于递送供应给受试者的非甾体抗炎药物（NSAID）的装置，用于经由受试者的全身血液循环递送至受试者的至少一部分中枢​​神经系统（CNS），包括 刺激剂，其适于刺激受试者的至少一个部位，以便使NSAID从至少受试者的血脑屏障（BBB）的全身血液循环通过到CNS的部分，至少在 NSAID存在于血液中的一部分时间，从选自以下的列表中选择的部位：主体的蝶腭神经节（SPG），受试者的前脑膜神经，受试者的后脑膜神经， 在受试者的SPG的前脑膜神经和后眼轨道分支之间的连通分支，在受试者的SPG的后脑膜神经和后视轨分支之间的连通分支，更大的腭神经 受试者的较少的腭神经，受试者的蝶腭神经，受试者的上颌神经和SPG之间的连通分支，受试者的鼻ine神经，受试者的后鼻神经，眶下 受试者的神经，受试者的耳神经节，进入受试者的耳神经节的传入纤维，远离受试者的耳神经节的传出纤维，受试者的维管神经，较大的浅表岩石神经 受试者，以及受试者的较深深的岩石神经。

公开(公告)号：US20030195601A1

公开(公告)日：2003-10-16

申请号：US10160468

申请日：2002-05-01

发明人： Andy Hung ,  Robert Greenberg ,  Dao Min Zhou ,  Jack Judy ,  Neil Talbot

IPC分类号： A61N001/05

CPC分类号： A61N1/05 ,  A61N1/0526 ,  A61N1/0541 ,  A61N1/0543 ,  A61N1/0551

摘要： The present invention is a micro-machined electrode for neural-electronic interfaces which can achieve a ten times lower impedance and higher charge injection limit for a given material and planar area.

摘要翻译： 本发明是用于神经 - 电子接口的微加工电极，其可以为给定材料和平面区域实现十倍低阻抗和更高电荷注入极限。

公开(公告)号：US20030018366A1

公开(公告)日：2003-01-23

申请号：US10198351

申请日：2002-07-17

发明人： John Lamont

IPC分类号： A61N001/34

CPC分类号： A61N1/0526

摘要： A method for modifying cranial electrical potentials utilizes an electrical lead having first and second electrodes. The electrical lead may also include either a resistive component for increasing the resistance of the electrical lead, or a diode for restricting the flow of electricity through the lead to a single direction. The electrical lead is attached between skin surface areas of a human head, such as between ears, or an ear and an area of the scalp or forehead. Preferably, two electrical leads are utilized, one lead extending from a left ear to a right portion of the head, and the other electrical lead extending from the right ear to the left portion of the head. Scalp electrical potentials are altered in a passive manner resulting in beneficial effects on a variety of psychiatric disorders and brain functioning.

摘要翻译： 用于修改颅电位的方法利用具有第一和第二电极的电引线。 电引线还可以包括用于增加电引线的电阻的电阻元件或用于限制通过引线的电流流向单个方向的二极管。 电引线附着在人头部的皮肤表面区域之间，例如耳朵之间，或耳朵与头皮或前额的区域之间。 优选地，使用两个电引线，一个引线从左耳延伸到头部的右部，另一个引线从右耳延伸到头部的左部。 头皮电位以被动方式改变，从而对各种精神障碍和脑功能产生有益的影响。

公开(公告)号：US3562408A

公开(公告)日：1971-02-09

申请号：US3562408D

申请日：1969-03-05

申请人： INST OF MEDICAL SCIENCES THE

发明人： COLLINS CARTER C ,  SAUNDERS FRANK A ,  MADEY JULIUS M

IPC分类号： A61F9/08 ,  A61N1/36 ,  G09B21/00 ,  H04N7/18 ,  H04N9/02

CPC分类号： A61N1/36014 ,  A61F9/08 ,  A61N1/0526 ,  G09B21/003

摘要： A multiple anode photomultiplying image tube is provided employing an image intensifier structure and an array of anodes for converting visible information into patterned electrical signals. A modulating source associated with the tube assures that the electrical signals exhibit particular characteristics; and such signals are conveyed to an array of electrodes in contact with the skin of a subject, to be perceived by the subject as a conceptual image. The photomultiplying image tube can be mounted in or on spectacles, or on the head of the subject. Arrangements are disclosed for providing black and white information, color information, and stereoscopic information to the subject, and for using the eyes to aim the system at any desired object.

公开(公告)号：US490679A

公开(公告)日：1893-01-31

申请号：US490679D

CPC分类号： A61H39/002 ,  A61N1/0526