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公开(公告)号：US20100323379A1
公开(公告)日：2010-12-23
申请号：US12680073
申请日：2008-09-25
CPC分类号： G01N33/6893 , A61B5/14546 , A61B5/15003 , A61B5/153 , A61B5/4818 , G01N2800/2864 , Y10T436/143333
摘要： This document relates to methods and materials involved in diagnosing sleep apnea and assessing the effectiveness of a treatment for sleep apnea. For example, methods and materials for using markers to determine whether or not a mammal (e.g., a human) has sleep apnea are provided. In addition, methods and materials that can be used to determine whether or not a mammal (e.g., a human) responds to a sleep apnea treatment are provided.
摘要翻译： 本文件涉及诊断睡眠呼吸暂停和评估治疗睡眠呼吸暂停的有效性的方法和材料。 例如，提供了使用标记来确定哺乳动物（例如，人）是否具有睡眠呼吸暂停的方法和材料。 此外，提供了可以用于确定哺乳动物（例如，人）是否对睡眠呼吸暂停治疗作出响应的方法和材料。
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公开(公告)号：US20080214943A1
公开(公告)日：2008-09-04
申请号：US11720566
申请日：2005-11-17
申请人： Tomas Kara , Jiri Nykodym , Charles J. Bruce , Paul Friedman , Kalpaki L. Venkatachalam , Virend K. Somers
发明人： Tomas Kara , Jiri Nykodym , Charles J. Bruce , Paul Friedman , Kalpaki L. Venkatachalam , Virend K. Somers
IPC分类号： A61B5/026
CPC分类号： A61B5/0261
摘要： Perfused tissue is illuminated and light passing through the tissue or reflected from it is detected to produce an electrical signal. Amplitude pulses corresponding to the subject's heart beat are detected in the electrical signal and the areas of these pulses are calculated to produce blood flow values indicative of the blood volume pumped by the heart. The blood flow values may be used alone or in combination with other measured cardiac parameters to evaluate cardiac function.
摘要翻译： 穿透组织被照亮，并且检测到穿过组织或从其反射的光以产生电信号。 在电信号中检测对应于被检者心跳的幅度脉冲，并且计算这些脉冲的面积，以产生指示由心脏泵送的血容量的血流值。 血流值可以单独使用或与其他测量的心脏参数组合使用以评估心脏功能。
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公开(公告)号：US20180350468A1
公开(公告)日：2018-12-06
申请号：US15778405
申请日：2016-11-23
申请人： Paul A. FRIEDMAN , Kevin E. BENNET , Samuel J. ASIRVATHAM , Charles J. BRUCE , John J. DILLON , Virend K. SOMERS , Dan SADOT , Amir GEVA , Yehu SAPIR , MAYO FOUNDATION FOR MEDICAL EDUCATION AND RESEARCH , B.G. NEGEV TECHNOLOGIES AND APPLICATIONS LTD., AT BEN-GURION UNIVERSITY
发明人： Paul A. FRIEDMAN , Kevin E. BENNET , Samuel J. ASIRVATHAM , Charles J. BRUCE , Michael J. ACKERMAN , John J. DILLON , Virend K. SOMERS , Dan SADOT , Amir GEVA , Yehu SAPIR , Zachi ATTIA
IPC分类号： G16H50/20 , G16H50/70 , A61B5/145 , A61B5/0245 , A61B5/0452
CPC分类号： A61B5/00 , A61B5/02 , A61B5/0205 , A61B5/024 , A61B5/0245 , A61B5/0285 , A61B5/0452 , A61B5/14532 , A61B5/14546 , G06F19/00
摘要： Among the techniques described herein is a method that includes obtaining data indicating electrocardiogram results from a human. A plurality of beats represented in the electrocardiogram results can be identified. For each beat in the plurality of beats represented in the electrocardiogram results, a value for a first feature of the beat can be determined. Statistical analysis can be performed on the values for the first feature of the plurality of beats. An indication of the level of the analyte within the human can be generated based on a result of the statistical analysis performed on the values for the first feature of the plurality of beats. The indication of the level of the analyte within the human can be provided.
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4.发明申请ANALYTE ASSESSMENT AND ARRHYTHMIA RISK PREDICTION USING PHYSIOLOGICAL ELECTRICAL DATA 审中-公开使用生理电气数据分析评估和ARRHYTHMIA风险预测公开(公告)号：US20160256063A1
公开(公告)日：2016-09-08
申请号：US15025158
申请日：2014-09-26
申请人： Paul A. FRIEDMAN , Kevin E. BENNET , Charles J. BRUCE , Virend K. SOMERS , Samuel J. ASIRVATHAM , Michael J. ACKERMAN , John J. DILLION , Dan SADOT , Yehu SAPIR , Amir GEVA , MAYO FOUNDATION FOR MEDICAL EDUCATION AND RESEARCH
发明人： Paul A. Friedman , Kevin E. Bennet , Charles J. Bruce , Virend K. Somers , Samuel J. Asirvatham , Michael J. Ackerman , John J. Dillon , Dan Sadot , Yehu Sapir , Amir Geva
IPC分类号： A61B5/0402 , A61B5/04 , A61B5/00 , A61B5/0456 , A61B5/0472 , A61B5/145 , A61B5/0245 , A61B5/0452
CPC分类号： A61B5/0402 , A61B5/0245 , A61B5/02455 , A61B5/04011 , A61B5/04012 , A61B5/04017 , A61B5/04085 , A61B5/0452 , A61B5/04525 , A61B5/0456 , A61B5/0468 , A61B5/0472 , A61B5/14546 , A61B5/6852 , A61B5/686 , A61B5/6861 , A61B5/7264 , A61B5/7275
摘要： This document describes, among other things, a computer-implemented method that includes accessing, by a computer system, electrogram data for a patient, wherein the electrogram data is obtained using one or more leads that sense physiological electrical activity of the patient. The computer system can identify one or more waveform features from the electrogram data, and one or more correlations between values of the one or more waveform features and analyte levels. One or more estimated analyte levels in the patient are determined based on 1) the one or more waveform features identified from the electrogram data and 2) the one or more correlations. The computer system can output information related to the one or more estimated analyte levels.
摘要翻译： 本文件尤其描述了一种计算机实现的方法，其包括通过计算机系统访问患者的电描记图数据，其中使用感测患者的生理电活动的一个或多个引线获得电描记图数据。 计算机系统可以从电描记图数据中识别一个或多个波形特征，以及一个或多个波形特征和分析物水平的值之间的一个或多个相关性。 基于1）从电描记图数据识别的一个或多个波形特征和2）一个或多个相关性来确定患者中的一个或多个估计的分析物水平。 计算机系统可以输出与一个或多个估计分析物水平相关的信息。
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公开(公告)号：US07228167B2
公开(公告)日：2007-06-05
申请号：US10821778
申请日：2004-04-09
申请人： Tomas Kara , Virend K. Somers
发明人： Tomas Kara , Virend K. Somers
IPC分类号： A61B5/0428
CPC分类号： A61N1/0526 , A61B5/0205 , A61B5/021 , A61B5/0402 , A61B5/0476 , A61B5/0816 , A61B5/4094
摘要： A method and apparatus for monitoring the application of a vagus nerve stimulation signal includes a detection circuit having an amplifier, a filter, and a signal prolongation circuit. The signal prolongation circuit rectifies a detected vagus nerve signal and provides the signal to a Schmitt trigger extending the length of the signal. Because of the prolongation of the signal, the signal can be sampled at a relatively low rate, and real time data illustrating the response of various physiological signals to the application of the vagus nerve signal can be monitored, thereby providing clinical data for monitoring and adjusting the applied stimulation.
摘要翻译： 用于监测迷走神经刺激信号的应用的方法和装置包括具有放大器，滤波器和信号延长电路的检测电路。 信号延长电路对检测到的迷走神经信号进行整流，并将信号提供给延长信号长度的施密特触发器。 由于信号的延长，可以以相对低的速率对信号进行采样，并且可以监视说明各种生理信号对应用迷走神经信号的响应的实时数据，从而提供用于监测和调整的临床数据 应用刺激。
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公开(公告)号：US08948854B2
公开(公告)日：2015-02-03
申请号：US13810064
申请日：2011-07-13
IPC分类号： A61B5/04 , A61B5/145 , A61B5/0452 , A61B5/0472
CPC分类号： A61B5/04012 , A61B5/0006 , A61B5/04525 , A61B5/0472 , A61B5/14532 , A61B5/14546 , A61B5/1477
摘要： This document provides methods and materials related to the non-invasive measurement of analytes in blood.
摘要翻译： 本文档提供了与血液中分析物无创测量相关的方法和材料。
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公开(公告)号：US20130184599A1
公开(公告)日：2013-07-18
申请号：US13810064
申请日：2011-07-13
IPC分类号： A61B5/0452
CPC分类号： A61B5/04012 , A61B5/0006 , A61B5/04525 , A61B5/0472 , A61B5/14532 , A61B5/14546 , A61B5/1477
摘要： This document provides methods and materials related to the non-invasive measurement of analytes in blood.
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公开(公告)号：US20130144190A1
公开(公告)日：2013-06-06
申请号：US13700702
申请日：2011-05-27
IPC分类号： A61B5/00 , A61B5/145 , A61B5/08 , A61B5/0205 , A61B5/0402 , A61B5/087 , A61B5/01 , A61B5/053 , A61B7/00 , A61B5/024
CPC分类号： A61B5/4818 , A61B5/0002 , A61B5/0077 , A61B5/01 , A61B5/02055 , A61B5/024 , A61B5/0402 , A61B5/053 , A61B5/0816 , A61B5/082 , A61B5/087 , A61B5/14542 , A61B5/6898 , A61B5/7257 , A61B5/7282 , A61B7/003 , A61B2505/07 , A61B2562/0204
摘要： This document provides methods and materials (e.g., systems) related to assessing sleep conditions (e.g., sleep apnea).
摘要翻译： 本文件提供了与评估睡眠状况（例如睡眠呼吸暂停）相关的方法和材料（例如系统）。
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