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    POST DEPLOYMENT RADIAL FORCE RECOVERY OF BIODEGRADABLE SCAFFOLDS
    1.
    发明申请
    POST DEPLOYMENT RADIAL FORCE RECOVERY OF BIODEGRADABLE SCAFFOLDS 审中-公开

    公开(公告)号：US20180116837A1

    公开(公告)日：2018-05-03

    申请号：US15339335

    申请日：2016-10-31

    申请人： AMARANTH MEDICAL PTE.

    发明人： Kamal RAMZIPOOR ,  Chang Y. LEE

    IPC分类号： A61F2/945 ,  A61F2/915

    CPC分类号： A61F2/945 ,  A61F2/915 ,  A61F2210/0014 ,  A61F2210/0071 ,  A61F2240/001

    摘要： Post deployment radial force recovery of biodegradable scaffolds are described where a high molecular weight polymer may be formed into a high molecular weight scaffold by solution casting into a tubular substrate such that the scaffold retains its mechanical properties through processing. The tubular substrate is laser cut and subsequently crimped onto a catheter for deployment into a body lumen. The polymeric scaffold may retain its mechanical properties and result in increased radial strength post-deployment in a saline environment, e.g., within a body lumen. This scaffold enhancement may be attributable at least in part to entanglement of high molecular weight polymer chains as one factor that effects radial force recovery and also to the design or geometry of the scaffold as another factor that effects radial force recovery after deployment.

    BIOABSORBABLE STENTS
    2.
    发明申请
    BIOABSORBABLE STENTS 审中-公开
    生物耐药性

    公开(公告)号：US20150342764A1

    公开(公告)日：2015-12-03

    申请号：US14714959

    申请日：2015-05-18

    申请人： Amaranth Medical Pte.

    发明人： Kamal RAMZIPOOR ,  Chang Y. LEE

    IPC分类号： A61F2/90 ,  A61F2/915

    CPC分类号： A61F2/915 ,  A61F2002/91558 ,  A61F2002/91575 ,  A61F2210/0004 ,  A61F2210/0076 ,  A61F2250/003 ,  A61F2250/0035 ,  A61F2250/0067 ,  A61L31/06 ,  A61L31/148 ,  A61L2420/08 ,  C08L67/04

    摘要： Tubular casting processes, such as dip-coating, may be used to form substrates from polymeric solutions which may be used to fabricate implantable devices such as stents. The polymeric substrates may have multiple layers which retain the inherent properties of their starting materials and which are sufficiently ductile to prevent brittle fracture. Parameters such as the number of times the mandrel is immersed, the duration of time of each immersion within the solution, as well as the delay time between each immersion or the drying or curing time between dips and withdrawal rates of the mandrel from the solution may each be controlled to result in the desired mechanical characteristics. Additional post-processing may also be utilized to further increase strength of the substrate or to alter its shape.

    摘要翻译： 可以使用诸如浸涂的管状浇铸工艺从聚合物溶液形成基底，其可用于制造可植入装置，例如支架。 聚合物基材可以具有多个层，其保持其起始材料的固有性质，并且其具有足够的延展性以防止脆性断裂。 浸入芯棒的次数，溶液中每次浸渍的持续时间以及每次浸渍之间的延迟时间，浸渍之间的干燥或固化时间以及心轴从溶液中提取速率之类的参数可以 每个都被控制以产生期望的机械特性。 还可以使用额外的后处理来进一步增加基底的强度或改变其形状。

    DETECTION AND CHARACTERIZATION OF LASER-INDUCED HEAT AFFECTED ZONES ON POLYMER BASED DEVICES
    3.
    发明申请
    DETECTION AND CHARACTERIZATION OF LASER-INDUCED HEAT AFFECTED ZONES ON POLYMER BASED DEVICES 审中-公开
    基于聚合物的器件激光诱发热影响区域的检测与表征

    公开(公告)号：US20110302677A1

    公开(公告)日：2011-12-08

    申请号：US13152704

    申请日：2011-06-03

    申请人： Kamal RAMZIPOOR ,  Yiwen TANG

    发明人： Kamal RAMZIPOOR ,  Yiwen TANG

    IPC分类号： G01Q60/24

    CPC分类号： G01Q60/58 ,  G01Q60/02

    摘要： Detection and characterization of laser-induced heat affected zones on polymer based devices, such as polymeric stents, are described where Nano Thermal Analysis may be used with atomic force microscopy to obtain the thermal behavior of materials with a spatial resolution of under, e.g., 100 nm. Heat may be applied locally to the measured polymeric stem via a probe tip and the resulting thermal-mechanical response can be measured.

    摘要翻译： 描述了基于聚合物的装置（例如聚合物支架）上的激光诱导的热影响区域的检测和表征，其中可以使用原子力显微镜来进行纳米热分析以获得空间分辨率低于100的材料的热行为，例如100 nm。 可以通过探针尖端将热量局部施加到所测量的聚合物杆上，并且可以测量所得到的热 - 机械响应。

    STENT FABRICATION VIA TUBULAR CASTING PROCESSES
    5.
    发明申请
    STENT FABRICATION VIA TUBULAR CASTING PROCESSES 审中-公开
    通过管状铸造工艺制造的STENT制造

    公开(公告)号：US20140039600A1

    公开(公告)日：2014-02-06

    申请号：US14030912

    申请日：2013-09-18

    申请人： Amaranth Medical Pte.

    发明人： Kamal RAMZIPOOR ,  Alfred N. K. CHIA ,  Liwei WANG

    IPC分类号： A61F2/82

    CPC分类号： A61F2/82 ,  A61F2/07 ,  A61F2/24 ,  A61F2002/30062 ,  A61F2002/30535 ,  A61F2210/0004 ,  A61F2210/0019 ,  A61F2240/004 ,  A61L31/04 ,  A61L31/06 ,  A61L31/14 ,  A61L31/148 ,  A61L31/16 ,  B29C41/003 ,  B29C41/14 ,  B29C49/00 ,  B29K2105/0035 ,  B29K2995/0056 ,  B29L2031/7532

    摘要： Tubular casting processes, such as dip-coating, may be used to form substrates from polymeric solutions which may be used to fabricate implantable devices such as stents. The polymeric substrates may have multiple layers which retain the inherent properties of their starting materials and which are sufficiently ductile to prevent brittle fracture. Parameters such as the number of times the mandrel is immersed, the duration of time of each immersion within the solution, as well as the delay time between each immersion or the drying or curing time between dips and withdrawal rates of the mandrel from the solution may each be controlled to result in the desired mechanical characteristics. Additional post-processing may also be utilized to further increase strength of the substrate or to alter its shape.

    摘要翻译： 可以使用诸如浸涂的管状浇铸工艺从聚合物溶液形成基底，其可用于制造可植入装置，例如支架。 聚合物基材可以具有多个层，其保持其起始材料的固有性质，并且其具有足够的延展性以防止脆性断裂。 浸入芯棒的次数，溶液中每次浸渍的持续时间以及每次浸渍之间的延迟时间，浸渍之间的干燥或固化时间以及心轴从溶液中提取速率之类的参数可以 每个都被控制以产生期望的机械特性。 还可以使用额外的后处理来进一步增加基底的强度或改变其形状。

    Sterilization methods and apparatus
    9.
    发明授权
    Sterilization methods and apparatus 有权
    灭菌方法和装置

    公开(公告)号：US08858611B2

    公开(公告)日：2014-10-14

    申请号：US13934705

    申请日：2013-07-03

    申请人： Amaranth Medical Pte.

    发明人： Kamal Ramzipoor ,  Chang Y. Lee ,  Fozan O. El-Nounou

    IPC分类号： A61L2/08 ,  A61F2/958 ,  A61L2/20 ,  A61M25/10 ,  A61M25/00

    CPC分类号： A61L2/20 ,  A61F2/958 ,  A61L2/08 ,  A61L2/087 ,  A61L2/206 ,  A61L2/208 ,  A61L2202/10 ,  A61L2202/24 ,  A61M25/0097 ,  A61M25/10 ,  A61M2025/0019

    摘要： Sterilization methods for implantable prostheses are described where a polymeric stent may be sterilized, e.g., via ETO sterilization, at a temperature below a glass transition temperature of the stent. A separate delivery catheter may be sterilized separately and the stent and delivery catheter may then be combined in an aseptic or semi-aseptic environment and sterilized as an assembled system such that the requirements for sterilizing the system are relatively lower. Additionally and/or alternatively, valve and filter assemblies may be used with an optional mandrel assembly for maintaining sterility of the internal components of a catheter system.

    摘要翻译： 描述了可植入假体的灭菌方法，其中可以在低于支架的玻璃化转变温度的温度下，例如经由ETO灭菌将聚合物支架灭菌。 单独的输送导管可以单独灭菌，然后将支架和输送导管组合在无菌或半无菌环境中并作为组装系统消毒，使得对系统消毒的要求相对较低。 另外和/或替代地，阀和过滤器组件可以与可选的心轴组件一起使用，以保持导管系统的内部组件的无菌性。