公开(公告)号：US20110245663A1

公开(公告)日：2011-10-06

申请号：US13010044

申请日：2011-01-20

申请人： Michel Schneider ,  Christophe Golay ,  Laurent Jakob ,  Jean Brochot ,  Feng Yan ,  Christian Mathieu

发明人： Michel Schneider ,  Christophe Golay ,  Laurent Jakob ,  Jean Brochot ,  Feng Yan ,  Christian Mathieu

IPC分类号： A61B6/00

CPC分类号： A61M5/1456 ,  A61B2017/22008 ,  A61B2090/3925 ,  A61B2090/3933 ,  A61M5/007 ,  A61M2205/6072 ,  B01F9/0016 ,  B01F11/0002 ,  B01F2003/0035

摘要： A power assisted method and injector device for controllably delivering to patients a dispersion medicament or diagnostically active agent, the homogeneity of which is preserved throughout delivery. Diagnostically active agents disclosed are gas microbubble suspensions useful in ultrasonic diagnostic imaging and liposomal formulations in which liposome vesicles are loaded with iodinated compounds.

摘要翻译： 一种功率辅助方法和注射器装置，用于向患者可控地递送分散药物或诊断活性剂，其均匀性在整个递送期间保留。 所公开的诊断活性剂是用于超声诊断成像的气体微泡悬浮液和其中脂质体囊泡装载碘化化合物的脂质体制剂。

公开(公告)号：US07749485B2

公开(公告)日：2010-07-06

申请号：US11596447

申请日：2005-05-31

申请人： Herve Tournier ,  Roland Hyacinthe ,  Michel Schneider

发明人： Herve Tournier ,  Roland Hyacinthe ,  Michel Schneider

IPC分类号： A61K51/00 ,  A61M36/14 ,  B32B5/16 ,  B01F3/00

CPC分类号： A61K9/1075 ,  A61K9/1271 ,  A61K48/0091 ,  A61K49/1812 ,  C12N15/88 ,  Y10S977/907 ,  Y10T428/2982

摘要： Composition for diagnostic or therapeutic use which comprises an assembly comprising an active agent. The assembly comprises a liposome and a plurality of micellar components associated thereto, said micellar components being associated to the outer surface of the envelope of said liposome through a substantially electrostatic interaction, When an active compound is incorporated into the micelles, a substantial amount of said active compound can be linked to a singe liposome. Furthermore, the presence of the outer micellar layer allows to increase the residence time of said liposome in the blood stream.

摘要翻译： 用于诊断或治疗用途的组合物，其包含包含活性剂的组合物。 组合物包含脂质体和与其相关联的多个胶束组分，所述胶束组分通过基本上静电的相互作用与所述脂质体的外壳的外表面结合。当将活性化合物并入胶束中时，大量的所述 活性化合物可以连接到单个脂质体。 此外，外胶束层的存在允许增加所述脂质体在血流中的停留时间。

公开(公告)号：US20080045919A1

公开(公告)日：2008-02-21

申请号：US11794024

申请日：2005-12-20

申请人： Laurent Jakob ,  Frederic Rivas

发明人： Laurent Jakob ,  Frederic Rivas

IPC分类号： A61B19/00

CPC分类号： A61M5/162 ,  A61M2005/1623

摘要： Liquid transfer device to be used to transfer a liquid into or from a dispensing container, particularly a medical dispensing container like a vial for diagnostic agents and kit comprising a vial, a syringe and a device of the aforementioned type. The transfer device comprises a valve which substantially limits the gaseous exchange between the inside of a vial and the external ambient, when the device is connected to the vial in steady state conditions.

摘要翻译： 用于将液体输送到分配容器中的液体转移装置，特别是用于诊断剂的小瓶的药物分配容器以及包括小瓶，注射器和上述类型的装置的试剂盒。 当装置在稳态条件下连接到小瓶时，转移装置包括基本上限制小瓶内部和外部环境之间的气体交换的阀。

公开(公告)号：US20080008657A1

公开(公告)日：2008-01-10

申请号：US11660188

申请日：2005-08-17

申请人： Philippe Bussat ,  Peter Frinking ,  Christian Guillot ,  Michel Schneider

发明人： Philippe Bussat ,  Peter Frinking ,  Christian Guillot ,  Michel Schneider

IPC分类号： A61K49/22

CPC分类号： A61K49/223

摘要： The present invention relates to a new composition comprising gas-filled microvesicles for contrast imaging which are particularly suitable for providing an effective echo response to at least two selected ultrasound waves having different frequencies. Said composition preferably comprises at least two different preparations of gas-filled microvesicles, which preferably have respective different mean sizes. In particular, said preparations preferably have respective Dv values differing from each other by at least 0.5 μm, more preferably at least 1.0 μm. Alternatively, said composition has a volume size distribution showing a value of Bowley skewness of 0.16 or higher. According to a preferred embodiment, at least 95% of the total volume of gas contained in said microvesicles, calculated on the population of microvesicles up to a diameter of 10 μm, is contained in microvesicles having a diameter of 8 micron or less. The composition of the invention can be effectively employed at rather different ultrasound transmission frequencies differing by about 8 MHz.

摘要翻译： 本发明涉及一种新的组合物，其包括用于对比成像的气体填充微泡，其特别适合于向至少两个具有不同频率的选定超声波提供有效的回波响应。 所述组合物优选包含至少两种气体填充微泡的不同制剂，其优选具有不同的平均尺寸。 特别地，所述制剂优选具有彼此不同的至少0.5μm，更优选至少1.0μm的相应的D V值。 或者，所述组合物具有显示Bowley偏度值为0.16或更高的体积大小分布。 根据一个优选实施方案，所述微泡中包含的气体的总体积的至少95％是以直径为10微米的微泡总数计算的，包含在直径为8微米或更小的微泡中。 本发明的组合物可以以不同于约8MHz的相当不同的超声波传播频率有效地使用。

公开(公告)号：US20070071685A1

公开(公告)日：2007-03-29

申请号：US10584327

申请日：2004-12-21

申请人： Michel Schneider ,  Philippe Bussat ,  Feng Yan ,  Anne Senente

发明人： Michel Schneider ,  Philippe Bussat ,  Feng Yan ,  Anne Senente

IPC分类号： A61K49/22

CPC分类号： A61K47/6925 ,  A61K41/0028 ,  A61K49/225

摘要： Assembly comprising a gas-filled microvesicle and a structural entity which is capable to associate through an electrostatic interaction to the outer surface of said microvesicle (microvesicle associated component—MAC), thereby modifying the physico-chemical properties thereof. Said MAC may optionally comprise a targeting ligand, a bioactive agent, a diagnostic agent or any combination thereof. The assembly of the invention can be formed from gasfilled microbubbles or microballoons and a MAC having a diameter of less than 100 pm, in particular a micelle and is used as an active component in diagnostically and/or therapeutically active formulations, in particular for enhancing the imaging in the field of ultrasound contrast imaging, including targeted ultrasound imaging, ultrasound-mediated drug delivery and other imaging techniques such as molecular resonance imaging (MRI) or nuclear imaging.

摘要翻译： 组件包括充气微泡和结构实体，其能够通过静电相互作用与所述微囊体（微泡相关组分-MAC）的外表面缔合，从而改变其物理化学性质。 所述MAC可以任选地包含靶向配体，生物活性剂，诊断剂或其任何组合。 本发明的组件可以由气体填充的微泡或微球和直径小于100μm的MAC，特别是胶束形成，并且用作诊断和/或治疗活性制剂中的活性成分，特别是用于增强 在超声对比成像领域的成像，包括靶向超声成像，超声介导的药物递送和其他成像技术如分子共振成像（MRI）或核成像。

公开(公告)号：US20040197269A1

公开(公告)日：2004-10-07

申请号：US10831165

申请日：2004-04-26

申请人： Bracco Research S.A.

发明人： Feng Yan ,  Michel Schneider ,  Jean Brochot

IPC分类号： A61K049/00

CPC分类号： A61K49/223 ,  A61K49/225

摘要： The invention relates to injectable media for ultrasonic echography in the form of microbubbles or microballoons comprising at least two biocompatible substances A and B (gaseous at the body temperature) forming a mixture which when in suspension with usual surfactants, additives and stabilisers provides useful ultrasound contrast agents. At least one of the components (B) in the mixture is a gas whose molecular weight is greater than 80 daltons and whose solubility in water is below 0.0283 ml per ml of water at standard conditions. The presence of the first component (B) in the contrast medium may vary between 0.5 and 41 volume percent. The other component (A) of the ultrasound contrast media is a gas or a mixture of gases whose molecular weight is below 80 daltons. The second component is present in a proportion of between 59-99.5% by vol., and is preferably chosen from oxygen, air, nitrogen, carbon dioxide or mixtures thereof. Gas mixtures described are found to be very effective as ultrasound contrast media. The invention also comprises a method of making the ultrasound contrast medium, the contrast agent and the ultrasound agent kit.

摘要翻译： 本发明涉及以微泡或微球形式的超声波回波成像的可注射介质，其包含至少两种生物相容性物质A和B（在体温下为气体）形成混合物，当与通常的表面活性剂悬浮时，添加剂和稳定剂提供有用的超声对比 代理商 混合物中组分（B）中的至少一种是分子量大于80道尔顿且在标准条件下其在水中的溶解度低于0.0283ml / ml水的气体。 造影剂中第一组分（B）的存在可以在0.5和41体积％之间变化。 超声造影剂的另一组分（A）是分子量低于80道尔顿的气体或气体混合物。 第二组分以59-99.5体积％的比例存在，优选选自氧气，空气，氮气，二氧化碳或其混合物。 发现所描述的气体混合物作为超声波造影剂非常有效。 本发明还包括制造超声造影剂，造影剂和超声剂试剂盒的方法。

公开(公告)号：US6042809A

公开(公告)日：2000-03-28

申请号：US132763

申请日：1998-08-12

申请人： Herve Tournier ,  Michel Schneider ,  Feng Yan ,  Jean Brochot

发明人： Herve Tournier ,  Michel Schneider ,  Feng Yan ,  Jean Brochot

IPC分类号： A61K9/48 ,  A61B5/055 ,  A61B8/00 ,  A61K49/00 ,  A61K49/18 ,  A61K49/22

CPC分类号： A61K49/1806 ,  A61K49/223

摘要： The invention relates to the application of hyperpolarized gases to magnetic resonance imaging (MRI) of living subjects. The invention also concerns administrable compositions, formulations, methods of making the compositions and formulations and contrast agents involving hyperpolarized gases, as well as their use in MRI.

摘要翻译： 本发明涉及超极化气体对活体的磁共振成像（MRI）的应用。 本发明还涉及可施用的组合物，制剂，制备组合物和制剂的方法以及涉及超极化气体的造影剂以及它们在MRI中的应用。

公开(公告)号：US5545395A

公开(公告)日：1996-08-13

申请号：US421330

申请日：1995-04-13

申请人： Herve Tournier ,  Roland Hyacinthe ,  Michel Schneider

发明人： Herve Tournier ,  Roland Hyacinthe ,  Michel Schneider

IPC分类号： A61K9/127 ,  A61B5/055 ,  A61K20060101 ,  A61K49/00 ,  A61K49/18

CPC分类号： A61K49/1806 ,  A61K49/1839 ,  Y10S977/838 ,  Y10S977/904 ,  Y10S977/905 ,  Y10S977/927 ,  Y10S977/96 ,  Y10T428/2991 ,  Y10T428/2998 ,  Y10T436/24

摘要： Magnetite particles suitable for injection into the blood stream of patients having enhanced resistance against agglomeration and uptake by the RES of the liver and spleen. The particles essentially consist of an iron oxide core and a phosphoric acid mono alkyl or alkenyl ester or glycerophospholipid/surfactant three dimensional shell surrounding the core. The core and the monoester or a micellar glycerophospholipid form an urchin-like structure which is further interlaced or intertwined with a non-ionic surfactant to produce a protective three dimensional shell which renders particles almost undetectable by the macrophages. Particles prepared according to the invention are kept in the blood circulation for long periods and represent excellent long lasting blood pool agents. Key components in the shell are (a) a polybasic mineral-organic species such as glycero phosphatidic acid in micellar form and (b) a block copolymer having successive hydrophilic and hydrophobic segments.

摘要翻译： 适合于注射到患有肝脏和脾脏的RES的聚集和摄取的抗性的患者血液中的磁铁矿颗粒。 颗粒基本上由氧化铁芯和磷酸单烷基或链烯基酯或包含核心的甘油磷脂/表面活性剂三维壳组成。 核心和单酯或胶束甘油磷脂形成海胆样结构，其进一步与非离子表面活性剂交织或交织在一起，以产生保护性三维壳，其使颗粒几乎不被巨噬细胞检测到。 根据本发明制备的颗粒长时间保持在血液循环中并且代表优异的持久的血液池剂。 壳中的关键组分是（a）多元矿物有机物质，例如胶束形式的甘油磷脂酸，和（b）具有连续亲水和疏水链段的嵌段共聚物。

公开(公告)号：US20110150778A1

公开(公告)日：2011-06-23

申请号：US13018290

申请日：2011-01-31

申请人： Michel Schneider ,  Philippe Bussat ,  Feng Yan ,  Anne Senente

发明人： Michel Schneider ,  Philippe Bussat ,  Feng Yan ,  Anne Senente

IPC分类号： A61B5/055 ,  A61B8/00 ,  A61K39/395 ,  A61K9/00 ,  A61K38/00 ,  A61K38/14 ,  A61K31/70 ,  A61K31/715 ,  A61K31/56 ,  A61K38/22 ,  A61K31/7088 ,  A61P43/00

CPC分类号： A61K41/0028 ,  A61K47/6925 ,  A61K49/225

摘要： Assembly comprising a gas-filled microvesicle and a structural entity which is capable to associate through an electrostatic interaction to the outer surface of said microvesicle (microvesicle associated component—MAC), thereby modifying the physico-chemical properties thereof. Said MAC comprises a targeting ligand a diagnostic agent or any combination thereof. Optionally a bioactive agent can further be associated to the MAC. The assembly of the invention can be formed from gas-filled microbubbles or microballoons and a MAC having preferably nanometric dimensions, e.g. a micelle, and is used as an active component in diagnostically and/or therapeutically active formulations, in particular for enhancing the imaging in the field of ultrasound contrast imaging, including targeted ultrasound imaging, ultrasound-mediated drug delivery and other imaging techniques such as molecular resonance imaging (MRI) or nuclear imaging.

摘要翻译： 组件包括充气微泡和结构实体，其能够通过静电相互作用与所述微囊体（微泡相关组分-MAC）的外表面缔合，从而改变其物理化学性质。 所述MAC包含靶向配体，诊断剂或其任何组合。 可选地，生物活性剂可以进一步与MAC相关联。 本发明的组件可以由气体填充的微泡或微球和具有优选纳米尺度的MAC形成，例如， 胶束，并且用作诊断和/或治疗活性制剂中的活性成分，特别是用于增强超声造影成像领域的成像，包括靶向超声成像，超声介导的药物递送和其他成像技术如分子 共振成像（MRI）或核成像。

公开(公告)号：US20090159485A1

公开(公告)日：2009-06-25

申请号：US12086310

申请日：2006-12-05

申请人： Laurent Jakob ,  Frederic Rivas

发明人： Laurent Jakob ,  Frederic Rivas

IPC分类号： B65D69/00 ,  A61B19/00

CPC分类号： A61M5/162 ,  A61J1/201 ,  A61J1/2075 ,  A61J1/2082 ,  A61J1/2089 ,  A61J1/2096 ,  A61M2005/1623

摘要： A kit comprising a medical dispensing container (402), such as a vial for diagnostic agents, and a liquid transfer device (401) to be used to transfer a liquid into or from said dispensing container. The transfer device allows substantially limiting the gaseous exchange between the inside of a vial and the external ambient, when the device is connected to the vial in steady state conditions.

摘要翻译： 一种药盒，包括用于诊断剂的药物分配容器（402），以及用于将液体转移到所述分配容器中的液体转移装置（401）。 当设备在稳态条件下连接到小瓶时，转移装置允许基本上限制小瓶内部和外部环境之间的气体交换。