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    Delivery system for deployment of medical devices
    1.
    发明授权
    Delivery system for deployment of medical devices 有权
    用于部署医疗设备的配送系统

    公开(公告)号：US08986361B2

    公开(公告)日：2015-03-24

    申请号：US12253858

    申请日：2008-10-17

    申请人： Georg Börtlein ,  Edward Pannek

    发明人： Georg Börtlein ,  Edward Pannek

    IPC分类号： A61F2/06 ,  A61F2/95 ,  A61F2/24 ,  A61F2/97 ,  A61F2/966

    CPC分类号： A61F2/95 ,  A61F2/2436 ,  A61F2/97 ,  A61F2002/9534 ,  A61F2002/9665

    摘要： A sheathed catheter system is described where the sheath comprises a distal portion and a proximal portion that are moveable axially relative to each other, and relative to a tube carrying a medical device thereon. The distal and proximal sheath portions can be brought together in order to enclose therewithin the medical device. The distal sheath has a proximal section that is configured to bias radially inwardly to minimize an otherwise exposed annular surface catching on protruding surfaces that may exist on the catheter or other medical tool in use at the time, or to minimize scraping the inner native lumen of the patient upon retrieval.

    摘要翻译： 描述了一种护套导管系统，其中护套包括远侧部分和可相对于彼此轴向移动的近端部分，以及相对于在其上承载医疗装置的管道。 远端和近侧护套部分可以集合在一起，以便在医疗装置内包围。 远侧鞘具有近端部分，该近端部分被配置为径向向内偏置以最小化可能存在于当时使用的导管或其他医疗工具上可能存在的突出表面上的另外暴露的环形表面，或者最小化刮擦内部自然腔 病人检索时。

    Prosthetic valve for transluminal delivery
    2.
    发明授权
    Prosthetic valve for transluminal delivery 有权
    用于经腔输送的假体瓣膜

    公开(公告)号：US07329278B2

    公开(公告)日：2008-02-12

    申请号：US11352614

    申请日：2006-02-13

    申请人： Jacques Seguin ,  Georg Börtlein

    发明人： Jacques Seguin ,  Georg Börtlein

    IPC分类号： A61F2/24

    CPC分类号： A61F2/2436 ,  A61B17/0218 ,  A61F2/2412 ,  A61F2/2418 ,  A61F2/2433 ,  A61F2210/0023 ,  A61F2220/0008 ,  A61F2220/0016 ,  A61F2220/005 ,  A61F2220/0075 ,  A61F2230/005 ,  A61F2230/0054 ,  A61F2230/0067 ,  A61F2250/0003 ,  A61F2250/0039 ,  A61F2250/0048 ,  A61F2250/0069 ,  Y10S623/904

    摘要： A prosthetic valve assembly for use in replacing a deficient native valve comprises a replacement valve supported on an expandable valve support. If desired, one or more anchor may be used. The valve support, which entirely supports the valve annulus, valve leaflets, and valve commissure points, is configured to be collapsible for transluminal delivery and expandable to contact the anatomical annulus of the native valve when the assembly is properly positioned. The anchor engages the lumen wall when expanded and prevents substantial migration of the valve assembly when positioned in place. The prosthetic valve assembly is compressible about a catheter, and restrained from expanding by an outer sheath. The catheter may be inserted inside a lumen within the body, such as the femoral artery, and delivered to a desired location, such as the heart. When the outer sheath is retracted, the prosthetic valve assembly expands to an expanded position such that the valve and valve support expand within the deficient native valve, and the anchor engages the lumen wall.

    摘要翻译： 一种用于替换缺陷天然瓣膜的人工瓣膜组件包括支撑在可扩张瓣膜支架上的置换瓣膜。 如果需要，可以使用一个或多个锚固件。 完全支撑瓣膜环，瓣膜小叶和瓣膜关节点的瓣膜支撑件被构造为可折叠的，用于经腔输送，并且当组件被适当定位时，其可扩张以接触天然瓣膜的解剖环。 当膨胀时，锚固件接合管腔壁，并且当定位就位时防止阀组件的大量迁移。 假体瓣膜组件围绕导管可压缩，并且被外护套限制为扩张。 导管可以插入体内的腔内，例如股动脉，并且被输送到期望的位置，例如心脏。 当外鞘缩回时，假体瓣膜组件膨胀到扩张位置，使得瓣膜和瓣膜支撑件在缺陷的天然瓣膜内膨胀，并且锚固件与腔壁接合。

    Heart Valve Prosthesis and Methods of Manufacture and Use
    4.
    发明申请
    Heart Valve Prosthesis and Methods of Manufacture and Use 审中-公开
    心脏瓣膜假体及其制造和使用方法

    公开(公告)号：US20120259409A1

    公开(公告)日：2012-10-11

    申请号：US13526951

    申请日：2012-06-19

    申请人： Than Nguyen ,  Hung Nguyen ,  Mykim Nguyen ,  Stanley Komatsu ,  Robrecht Michiels

    发明人： Than Nguyen ,  Hung Nguyen ,  Mykim Nguyen ,  Stanley Komatsu ,  Robrecht Michiels

    IPC分类号： A61F2/24

    CPC分类号： A61F2/2418 ,  A61F2/2412 ,  A61F2/2415 ,  A61F2220/005 ,  A61F2220/0058 ,  A61F2220/0075 ,  A61F2230/0054 ,  A61F2230/0067 ,  A61F2230/008 ,  A61F2250/0039 ,  Y10S623/90

    摘要： A heart valve prosthesis is provided having a self-expanding multi-level frame that supports a valve body comprising a skirt and plurality of coapting leaflets. The frame transitions between a contracted delivery configuration that enables percutaneous transluminal delivery, and an expanded deployed configuration having an asymmetric hourglass shape. The valve body skirt and leaflets are constructed so that the center of coaptation may be selected to reduce horizontal forces applied to the commissures of the valve, and to efficiently distribute and transmit forces along the leaflets and to the frame. Alternatively, the valve body may be used as a surgically implantable replacement valve prosthesis.

    摘要翻译： 提供了一种心脏瓣膜假体，其具有支撑包括裙部和多个附着小叶的阀体的自膨胀多层框架。 框架在允许经皮腔内递送的收缩递送构型和具有不对称沙漏形状的扩张部署构型之间转变。 阀体裙部和小叶被构造成使得可以选择接合中心以减小施加到阀的连合处的水平力，并且有效地分布和传递沿着传单和框架的力。 或者，阀体可以用作可手术植入的置换瓣膜假体。

    Heart Valve Prosthesis and Methods of Manufacture and Use
    7.
    发明申请
    Heart Valve Prosthesis and Methods of Manufacture and Use 审中-公开
    心脏瓣膜假体及其制造和使用方法

    公开(公告)号：US20150127095A9

    公开(公告)日：2015-05-07

    申请号：US13526951

    申请日：2012-06-19

    申请人： Than Nguyen ,  Hung Nguyen ,  Mykim Nguyen ,  Stanley Komatsu ,  Robrecht Michiels

    发明人： Than Nguyen ,  Hung Nguyen ,  Mykim Nguyen ,  Stanley Komatsu ,  Robrecht Michiels

    IPC分类号： A61F2/24

    CPC分类号： A61F2/2418 ,  A61F2/2412 ,  A61F2/2415 ,  A61F2220/005 ,  A61F2220/0058 ,  A61F2220/0075 ,  A61F2230/0054 ,  A61F2230/0067 ,  A61F2230/008 ,  A61F2250/0039 ,  Y10S623/90

    摘要： A heart valve prosthesis is provided having a self-expanding multi-level frame that supports a valve body comprising a skirt and plurality of coapting leaflets. The frame transitions between a contracted delivery configuration that enables percutaneous transluminal delivery, and an expanded deployed configuration having an asymmetric hourglass shape. The valve body skirt and leaflets are constructed so that the center of coaptation may be selected to reduce horizontal forces applied to the commissures of the valve, and to efficiently distribute and transmit forces along the leaflets and to the frame. Alternatively, the valve body may be used as a surgically implantable replacement valve prosthesis.

    摘要翻译： 提供了一种心脏瓣膜假体，其具有支撑包括裙部和多个附着小叶的阀体的自膨胀多层框架。 框架在允许经皮腔内递送的收缩递送构型和具有不对称沙漏形状的扩张部署构型之间转变。 阀体裙部和小叶被构造成使得可以选择接合中心以减小施加到阀的连合处的水平力，并且有效地分布和传递沿着传单和框架的力。 或者，阀体可以用作可手术植入的置换瓣膜假体。

    Transapical delivery system with ventruculo-arterial overlfow bypass
    8.
    发明授权
    Transapical delivery system with ventruculo-arterial overlfow bypass 有权
    经腹输送系统，具有腹膜动脉旁路

    公开(公告)号：US08784478B2

    公开(公告)日：2014-07-22

    申请号：US12445824

    申请日：2007-10-16

    申请人： Yosi Tuval ,  Raphael Benary

    发明人： Yosi Tuval ,  Raphael Benary

    IPC分类号： A61F2/24 ,  A61M1/00

    CPC分类号： A61B17/3468 ,  A61B17/3498 ,  A61B2017/00243 ,  A61B2017/00252 ,  A61M25/003

    摘要： Apparatus is provided for implanting a prosthetic device (108) in a patient, the apparatus includes a trocar tube (101), a first portion of which is configured to be placed in a left ventricle (12) of the patient during a procedure for implantation of the prosthetic device (108), and a second portion of which is configured to be placed in an extracardiac location during the procedure. The first portion is shaped so as to define at least one opening to an interior thereof. One or more flexible bypass tubes (103, 104, 106), each of which is coupled to the second portion, and each of which is configured to be coupled to at least one artery (20, 21, 30) of the patient, so as to create a blood flow bypass path during the procedure, from the left ventricle (12), via the opening and the bypass tubes (103, 105, 106), to the at least one artery (20, 21, 30). Other embodiments are also described.

    摘要翻译： 提供了用于在患者体内植入假体装置（108）的装置，该装置包括套管针管（101），其第一部分构造成在植入手术期间放置在患者的左心室（12）中 ，并且其第二部分被配置为在手术期间放置在心外部位置。 第一部分被成形为限定到其内部的至少一个开口。 一个或多个柔性旁路管（103,104,106），其每一个联接到第二部分，并且每个配置管被配置为联接到患者的至少一个动脉（20,21,30），因此 以在手术过程中从左心室（12）经由开口和旁路管（103,105,106）到达至少一个动脉（20,21,30）产生血流旁路。 还描述了其它实施例。

    Heart valve prosthesis and methods of manufacture and use
    9.
    发明授权
    Heart valve prosthesis and methods of manufacture and use 有权
    心脏瓣膜假体及其制造和使用方法

    公开(公告)号：US08226710B2

    公开(公告)日：2012-07-24

    申请号：US13072194

    申请日：2011-03-25

    申请人： Than Nguyen ,  Hung Nguyen ,  Mykim Nguyen ,  Stanley Komatsu ,  Robrecht Michiels

    发明人： Than Nguyen ,  Hung Nguyen ,  Mykim Nguyen ,  Stanley Komatsu ,  Robrecht Michiels

    IPC分类号： A61F2/24

    CPC分类号： A61F2/2418 ,  A61F2/2412 ,  A61F2/2415 ,  A61F2220/005 ,  A61F2220/0058 ,  A61F2220/0075 ,  A61F2230/0054 ,  A61F2230/0067 ,  A61F2230/008 ,  A61F2250/0039 ,  Y10S623/90

    摘要： A heart valve prosthesis is provided having a self-expanding multi-level frame that supports a valve body comprising a skirt and plurality of coapting leaflets. The frame transitions between a contracted delivery configuration that enables percutaneous transluminal delivery, and an expanded deployed configuration having an asymmetric hourglass shape. The valve body skirt and leaflets are constructed so that the center of coaptation may be selected to reduce horizontal forces applied to the commissures of the valve, and to efficiently distribute and transmit forces along the leaflets and to the frame. Alternatively, the valve body may be used as a surgically implantable replacement valve prosthesis.

    摘要翻译： 提供了一种心脏瓣膜假体，其具有支撑包括裙部和多个附着小叶的阀体的自膨胀多层框架。 框架在允许经皮腔内递送的收缩递送构型和具有不对称沙漏形状的扩张部署构型之间转变。 阀体裙部和小叶被构造成使得可以选择接合中心以减小施加到阀的连合处的水平力，并且有效地分布和传递沿着传单和框架的力。 或者，阀体可以用作可手术植入的置换瓣膜假体。

    Apparatus for treating a heart valve, in particular a mitral valve
    10.
    发明授权
    Apparatus for treating a heart valve, in particular a mitral valve 有权
    用于治疗心脏瓣膜，特别是二尖瓣的装置

    公开(公告)号：US08632585B2

    公开(公告)日：2014-01-21

    申请号：US13572226

    申请日：2012-08-10

    申请人： Jacques Seguin ,  Bruno Lecointe ,  Remi Gerriet

    发明人： Jacques Seguin ,  Bruno Lecointe ,  Remi Gerriet

    IPC分类号： A61F2/24

    CPC分类号： A61F2/2466 ,  A61B17/064 ,  A61B2017/00243 ,  A61B2017/0649 ,  A61B2017/081 ,  A61F2/2445

    摘要： An apparatus for treating a heart valve apparatus includes at least two anchoring elements designed to be anchored at the annulus and/or heart wall of the valve to be treated. Each anchoring element has a support surface. At least one linking element includes a central branch and two curved side branches, one of which is designed to be engaged on the support surface of an anchoring element, while the other is designed to be engaged on the support surface of another anchoring element, the linking element then being designed to be pivoted to a position such that the anchoring elements interconnect and in which the ends of the central branch are located in the vicinity of the support surfaces.

    摘要翻译： 用于治疗心脏瓣膜装置的装置包括设计成锚定在待治疗的瓣膜的环空和/或心壁上的至少两个锚定元件。 每个锚固元件具有支撑表面。 至少一个连接元件包括中央分支和两个弯曲的侧分支，其中一个被设计成接合在锚固元件的支撑表面上，而另一个连接元件被设计成接合在另一个锚定元件的支撑表面上， 连接元件然后被设计成枢转到一个位置，使得锚固元件互连，并且其中中心支路的端部位于支撑表面附近。