-
公开(公告)号：US09278172B2
公开(公告)日：2016-03-08
申请号：US13605678
申请日：2012-09-06
申请人： Judson A. Herrig
发明人： Judson A. Herrig
CPC分类号： A61M1/3655 , A61B17/11 , A61B2017/1132 , A61M1/10 , A61M1/1008 , A61M39/10 , A61M39/1011 , A61M39/12 , A61M2205/32
摘要： A connector for fluidly coupling proximal and distal tubular segments of a fluid conduit is provided. In one embodiment, the connector can include a connector body having an outer surface defining a first outer perimeter and an inner surface defining a lumen. The connector can also include a connecting device having an open configuration and a plurality of closed configurations. The connecting device can include first and second members configured to engage each other to secure the fluid conduit to the connector. The connecting device can also include a plurality of closed configurations for securing fluid conduits of different sizes.
摘要翻译： 提供用于流体连接流体导管的近端和远端管状段的连接器。 在一个实施例中，连接器可以包括具有限定第一外周边的外表面和限定内腔的内表面的连接器主体。 连接器还可以包括具有打开构造和多个封闭构造的连接装置。 连接装置可以包括构造成彼此接合以将流体导管固定到连接器的第一和第二构件。 连接装置还可以包括用于固定不同尺寸的流体管道的多个封闭构造。
-
公开(公告)号：US20120009679A1
公开(公告)日：2012-01-12
申请号：US12831053
申请日：2010-07-06
申请人： Joseph Hamby , Steven Walsh
发明人： Joseph Hamby , Steven Walsh
IPC分类号： C12N5/07
CPC分类号： A61L27/3687 , A61L27/3604 , A61L2430/40
摘要： A method is provided for preparing a tissue implant for implantation. The method includes harvesting a tissue material from a human or an animal donor, treating the tissue material in a nuclease-containing solution, and thereafter treating the tissue material with an alkaline alcohol solution. The nuclease-containing solution includes an antimicrobial. The alkaline alcohol solution comprises sodium hydroxide and ethanol.
摘要翻译： 提供了一种用于制备用于植入的组织植入物的方法。 该方法包括从人或动物供体收集组织材料，在含有核酸酶的溶液中处理组织材料，然后用碱性醇溶液处理组织材料。 含有核酸酶的溶液包括抗微生物剂。 碱性醇溶液包含氢氧化钠和乙醇。
-
公开(公告)号：US08071124B2
公开(公告)日：2011-12-06
申请号：US11042180
申请日：2005-01-26
申请人： K. Umit Yuksel , Ana T. Bird , Kirby S. Black
发明人： K. Umit Yuksel , Ana T. Bird , Kirby S. Black
摘要： Liquid, injectable, aqueous solutions are transformed in situ to an expandable foam-like, space filling, and adherent biomaterial. Preferably, the foam-like biomaterial is the reaction product of a two-part liquid system to achieve the in situ formation thereof. The liquid system is generally comprised of a protein solution and a cross linker solution which may either be premixed and then applied to a site in need of the biomaterial, or simultaneously mixed and delivered through an in-line mixing/dispensing tip directly to the site. In especially preferred embodiments, an expandable foam-like biomaterial includes the reaction product of human or animal-derived protein material and a di- or polyaldehyde in the presence of a bicarbonate and an acidic titrant amounts sufficient to impart a cellular foam structure to the material.
摘要翻译： 将液体，可注射的水溶液原位转化为可膨胀的泡沫样，空间填充和粘附的生物材料。 优选地，泡沫状生物材料是两部分液体体系实现其原位形成的反应产物。 液体系统通常由蛋白质溶液和交联剂溶液组成，其可以预混合，然后施用于需要生物材料的部位，或者同时混合并通过直接混合/分配尖端直接递送到该部位 。 在特别优选的实施方案中，可膨胀泡沫状生物材料包括人或动物衍生的蛋白质材料与二醛或多醛在碳酸氢盐存在下的反应产物和足以赋予材料泡沫结构的酸性滴定剂量 。
-
公开(公告)号：US20110208238A1
公开(公告)日：2011-08-25
申请号：US13033456
申请日：2011-02-23
CPC分类号： A61M25/0009 , A61B17/00491 , A61B50/30 , A61B2017/00495 , A61M25/0097 , A61M2025/0046 , A61M2025/0081 , B29C45/14622 , B29L2031/7544 , B29L2031/7548
摘要： A delivery tip extension communicates an adhesive material from a fluid applicator tip to a site within a patient. The delivery tip extension has an elongated shaft with a proximal end portion, a central body portion, and a tapered distal end portion. The central body portion has a length between about 5 cm and about 45 cm. A lumen is defined within and extends along the elongated shaft from a proximal opening to a distal opening. The elongated shaft is relatively more rigid along the central body portion than along the distal end portion to facilitate driving the elongated shaft through the patient with reduced trauma to the patient by the distal end portion. The lumen is sized and shaped along the proximal end portion for securely receiving the fluid applicator tip inserted through the proximal opening such that a dispensing outlet on the fluid applicator tip is in fluid communication with the lumen. The delivery tip extension is sterilized or sterilizable.
摘要翻译： 递送尖端延伸部将来自流体施用器尖端的粘合剂材料连通到患者体内的部位。 输送尖端延伸部具有细长轴，其具有近端部分，中心主体部分和锥形远端部分。 中心体部分具有约5cm至约45cm之间的长度。 内腔被限定在细长轴内并从近端开口延伸到远端开口。 细长轴沿着中心主体部分比沿着远端部分相对更刚性，以便于通过远端部分减少对患者的创伤来驱动细长轴穿过患者。 内腔的大小和形状沿着近端部分，用于牢固地接收通过近侧开口插入的流体施用器尖端，使得流体施用器尖端上的分配出口与管腔流体连通。 输送尖端延伸部被灭菌或消毒。
-
公开(公告)号：US07226615B2
公开(公告)日：2007-06-05
申请号：US09986124
申请日：2001-11-07
申请人： K. Ümit Yüksel , Ana T. Bird , Kirby S. Black
发明人： K. Ümit Yüksel , Ana T. Bird , Kirby S. Black
摘要： Liquid, injectable, aqueous solutions are transformed in situ to an expandable foam-like, space filling, and adherent biomaterial. Preferably, the foam-like biomaterial is the reaction product of a two-part liquid system to achieve the in situ formation thereof. The liquid system is generally comprised of a protein solution and a cross linker solution which may either be premixed and then applied to a site in need of the biomaterial, or simultaneously mixed and delivered through an in-line mixing/dispensing tip directly to the site. In especially preferred embodiments, an expandable foam-like biomaterial includes the reaction product of human or animal-derived protein material and a di- or polyaldehyde in the presence of a bicarbonate and an acidic titrant amounts sufficient to impart a cellular foam structure to the material.
摘要翻译： 将液体，可注射的水溶液原位转化为可膨胀的泡沫样，空间填充和粘附的生物材料。 优选地，泡沫状生物材料是两部分液体体系实现其原位形成的反应产物。 液体系统通常由蛋白质溶液和交联剂溶液组成，其可以预混合，然后施用于需要生物材料的部位，或者同时混合并通过直接混合/分配尖端直接递送到该部位 。 在特别优选的实施方案中，可膨胀泡沫状生物材料包括人或动物衍生的蛋白质材料与二醛或多醛在碳酸氢盐存在下的反应产物和足以赋予材料泡沫结构的酸性滴定剂量 。
-
公开(公告)号：USRE36132E
公开(公告)日：1999-03-09
申请号：US630464
申请日：1996-04-10
申请人： Albert E. Heacox
发明人： Albert E. Heacox
CPC分类号： A01N1/0268 , A01N1/02 , A01N1/0263 , A61B50/30
摘要： A three-envelope package for preserving tissue specimens or other sterile objects. A sterile tissue sample is sealed within an innermost envelope sterile inside and out. The innermost envelope is sealed within the sterile interior of an intermediate envelope equipped with a peel-back seal for subsequent opening. Both the inside and the outside of the intermediate envelope are sterile. The intermediate envelope is sealed within the sterile interior of an outermost envelope, made of foil or another substance impermeable to a storage medium, such as liquid nitrogen. The outermost envelope provides complete impermeability to liquid nitrogen, eliminating the possibility of nitrogen seepage through the peel-back seal of the intermediate envelope. When the envelope package is removed from storage, the intermediate envelope is removed from the outermost envelope and can be opened in an assumed non-sterile environment, without contaminating the innermost envelope or the tissue specimen therein.
摘要翻译： 用于保存组织标本或其他无菌物体的三包装包装。 将无菌组织样品密封在无菌内部和外部的最内层。 最内层的信封被密封在装有剥离密封件的中间信封的无菌内部，用于随后打开。 中间信封的内部和外部都是无菌的。 中间包层密封在最外层的无菌内部，由箔或另一种不可渗透到存储介质如液氮的物质制成。 最外面的外壳提供了对液氮的完全不渗透性，消除了通过中间包层的剥离密封渗氮的可能性。 当信封包从存储器中取出时，中间信封从最外层信封中取出，并且可以在假设的非无菌环境中打开，而不会污染其中最内层的信封或组织标本。
-
7.发明授权
公开(公告)号：US5071741A
公开(公告)日：1991-12-10
申请号：US182367
申请日：1988-04-18
IPC分类号： A01N1/02
CPC分类号： A01N1/02 , A01N1/0221 , Y10S128/27 , Y10T436/108331
摘要： A novel class of nonpermeating cryoprotectants which, when mixed with certain known penetrating cryoprotectants, provide a useful medium for protection of living cells during a cryopreservation process. Algae-derived polysaccharides such as agarose and alginate are useful as nonpermeating cryoprotectants as they form a gel matrix when cooled, protect against ice crystal formation, and yield improved viability of cells when thawed.
摘要翻译： 一种新型的非渗透性冷冻保护剂，当与某些已知的渗透性冷冻保护剂混合时，提供了在冷冻保存过程中保护活细胞的有用介质。 藻类衍生的多糖如琼脂糖和藻酸盐可用作非渗透性冷冻保护剂，因为它们在冷却时形成凝胶基质，防止冰晶形成，并且在解冻时产生细胞的改善的活力。
-
公开(公告)号：US20230091742A1
公开(公告)日：2023-03-23
申请号：US17863675
申请日：2022-07-13
申请人： CryoLife, Inc.
发明人： Steven GOLDSTEIN , Adam MARTINEZ , Candace LAW
IPC分类号： A61L27/36 , A61P9/10 , A61P17/02 , A61L27/54 , C12M3/00 , F26B5/04 , A61L27/16 , A61L27/24 , A61L27/60
摘要： Provided herein are tissue grafts, and in particular human placenta-derived tissue grafts and methods and articles for the manufacture and use thereof.
-
公开(公告)号：USD726818S1
公开(公告)日：2015-04-14
申请号：US29496838
申请日：2014-07-17
申请人： CryoLife, Inc.
设计人： Mark John Yosick
-
公开(公告)号：US20140271904A1
公开(公告)日：2014-09-18
申请号：US14200422
申请日：2014-03-07
申请人： CryoLife, Inc.
发明人： Joseph Hamby , Steven Goldstein , Valerie Rohde
IPC分类号： A61K35/12
CPC分类号： A61K35/12 , A61L27/362 , A61L27/3687 , A61L2430/40
摘要： A method is provided for preparing a biological tissue for implantation. The method includes providing a biological tissue from a human or animal donor, treating the biological tissue with an antiviral treatment formulation, lysing the biological tissue, decellularizing the biological tissue with a decellularization treatment formulation, and decontaminating the biological tissue with an alkaline alcohol solution. The antiviral treatment formulation may include a solution of peracetic acid and an alcohol, wherein the peracetic acid is present in the antiviral treatment formulation at a concentration from about 0.03% to about 1.2% (v/v). The decellularization solution may include a solution of a polar aprotic solvent, such as dimethyl sulfoxide, benzyl alcohol and ethanol.
摘要翻译： 提供了一种用于制备用于植入的生物组织的方法。 该方法包括从人或动物供体提供生物组织，用抗病毒处理制剂处理生物组织，裂解生物组织，用脱细胞处理制剂脱细胞化生物组织，并用碱性醇溶液去除生物组织。 抗病毒治疗制剂可以包括过乙酸和醇的溶液，其中过氧乙酸以约0.03％至约1.2％（v / v）的浓度存在于抗病毒治疗制剂中。 脱细胞溶液可以包括极性非质子溶剂如二甲基亚砜，苄醇和乙醇的溶液。
-
-
-
-
-
-
-
-
-
搜索结果
67 条记录 (耗时 0.019 秒)
