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    Modulation of endogenous AICAR levels for the treatment of diabetes and obesity
    1.
    发明申请
    Modulation of endogenous AICAR levels for the treatment of diabetes and obesity 审中-公开
    调节内源性AICAR水平治疗糖尿病和肥胖

    公开(公告)号：US20070015720A1

    公开(公告)日：2007-01-18

    申请号：US11347811

    申请日：2006-02-03

    申请人： Karen Bulock ,  Mark Tepper ,  John Zhang ,  Roustem Nabioullin

    发明人： Karen Bulock ,  Mark Tepper ,  John Zhang ,  Roustem Nabioullin

    IPC分类号： A61K31/7056

    CPC分类号： C12N15/1137 ,  A61K31/7056 ,  C12N2310/14 ,  C12Y201/02003

    摘要： The invention relates to methods for treating type 2 diabetes, obesity, metabolic syndrome and conditions associated with these by administering an AICAR-monophosphate (AICAR-MP) enhancing agent that increases endogenous AICAR-MP levels in a cell. Inhibition of AICAR-formyltransferase activity (AICARFT) in a cell that regulates metabolic activity (such as fat, liver, muscle, pancreatic beta or certain brain cells) increases AICAR-monophosphate levels which in turn results in activation of the AMP-kinase (AMPK) pathway, and all of the downstream functions mediated by AMPK including increased fatty acid oxidation, enhanced glucose transport and decreased fatty acid synthesis.

    摘要翻译： 本发明涉及通过施用增加细胞内源性AICAR-MP水平的AICAR-一磷酸（AICAR-MP）增强剂治疗2型糖尿病，肥胖症，代谢综合征和与此相关的病症的方法。 在调节代谢活性的细胞（如脂肪，肝脏，肌肉，胰腺β或某些脑细胞）中抑制AICAR-甲酰转移酶活性（AICARFT）增加AICAR-单磷酸盐水平，这反过来导致AMP-激酶（AMPK ）途径，并且由AMPK介导的所有下游功能包括增加的脂肪酸氧化，增强的葡萄糖转运和降低的脂肪酸合成。

    TREATMENT OF DIABETIC WOUNDS AND PERIPHERAL NEUROPATHIES
    6.
    发明申请
    TREATMENT OF DIABETIC WOUNDS AND PERIPHERAL NEUROPATHIES 审中-公开
    治疗糖尿病和外周神经病变

    公开(公告)号：US20090227572A1

    公开(公告)日：2009-09-10

    申请号：US12405915

    申请日：2009-03-17

    申请人： Jack R. Barber ,  Shi Chung Ng

    发明人： Jack R. Barber ,  Shi Chung Ng

    IPC分类号： A61K31/5395 ,  A61K31/4545 ,  A61K31/15 ,  C07D413/14 ,  C07D401/12 ,  C07C251/16

    CPC分类号： A61K31/165 ,  A61K31/4545 ,  A61K31/5395

    摘要： The present invention provides methods of enhancing healing of wound associated with diabetes, comprising administering an effective amount of one or more of certain hydroxylamine derivatives to a subject in need thereof. In another aspect, the instant invention provides methods of treating or preventing peripheral nervous system neuropathies. Peripheral nervous system neuropathies may but need not be diabetic neuropathies, and may but need not be associated with a diabetic wound. The invention also provides pharmaceutical compositions comprising a certain hydroxylamine derivative or a pharmaceutically acceptable salt thereof, optionally in combination with one or more additional therapeutic agents. In certain compositions and methods, the additional therapeutic agent is a second hydroxylamine derivative or a pharmaceutically acceptable salt thereof.

    摘要翻译： 本发明提供增强与糖尿病相关的伤口愈合的方法，包括向有需要的受试者施用有效量的一种或多种某些羟胺衍生物。 另一方面，本发明提供治疗或预防周围神经系统神经病的方法。 外周神经系统神经病可能不需要是糖尿病性神经病，并且可能不需要与糖尿病伤口相关联。 本发明还提供药物组合物，其包含某些羟胺衍生物或其药学上可接受的盐，任选地与一种或多种另外的治疗剂组合。 在某些组合物和方法中，另外的治疗剂是第二羟胺衍生物或其药学上可接受的盐。

    ANTHRACYCLINE FORMULATIONS
    10.
    发明申请
    ANTHRACYCLINE FORMULATIONS 审中-公开
    安非他酮制剂

    公开(公告)号：US20150342975A1

    公开(公告)日：2015-12-03

    申请号：US14651898

    申请日：2013-12-13

    申请人： CYTRX CORPORATION

    发明人： Scott Geyer ,  Daniel Levitt ,  Carrie Nodgaard ,  Edward H. Trappler

    IPC分类号： A61K31/704

    CPC分类号： A61K31/704 ,  A61K9/0019 ,  A61K9/19 ,  A61K31/7056 ,  A61K47/26

    摘要： The invention relates to reconstituted formulations comprising an anthracycline compound, ethanol, and water. The invention also relates to injectable compositions comprising the reconstituted formulation and Lactated Ringer's solution. Additionally, the invention relates to methods of using the formulations and compositions.

    摘要翻译： 本发明涉及包含蒽环类化合物，乙醇和水的重组制剂。 本发明还涉及包含重构制剂和乳酸林格氏溶液的可注射组合物。 另外，本发明涉及使用制剂和组合物的方法。