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    Modulation of endogenous AICAR levels for the treatment of diabetes and obesity
    1.
    发明申请
    Modulation of endogenous AICAR levels for the treatment of diabetes and obesity 审中-公开
    调节内源性AICAR水平治疗糖尿病和肥胖

    公开(公告)号：US20070015720A1

    公开(公告)日：2007-01-18

    申请号：US11347811

    申请日：2006-02-03

    申请人： Karen Bulock ,  Mark Tepper ,  John Zhang ,  Roustem Nabioullin

    发明人： Karen Bulock ,  Mark Tepper ,  John Zhang ,  Roustem Nabioullin

    IPC分类号： A61K31/7056

    CPC分类号： C12N15/1137 ,  A61K31/7056 ,  C12N2310/14 ,  C12Y201/02003

    摘要： The invention relates to methods for treating type 2 diabetes, obesity, metabolic syndrome and conditions associated with these by administering an AICAR-monophosphate (AICAR-MP) enhancing agent that increases endogenous AICAR-MP levels in a cell. Inhibition of AICAR-formyltransferase activity (AICARFT) in a cell that regulates metabolic activity (such as fat, liver, muscle, pancreatic beta or certain brain cells) increases AICAR-monophosphate levels which in turn results in activation of the AMP-kinase (AMPK) pathway, and all of the downstream functions mediated by AMPK including increased fatty acid oxidation, enhanced glucose transport and decreased fatty acid synthesis.

    摘要翻译： 本发明涉及通过施用增加细胞内源性AICAR-MP水平的AICAR-一磷酸（AICAR-MP）增强剂治疗2型糖尿病，肥胖症，代谢综合征和与此相关的病症的方法。 在调节代谢活性的细胞（如脂肪，肝脏，肌肉，胰腺β或某些脑细胞）中抑制AICAR-甲酰转移酶活性（AICARFT）增加AICAR-单磷酸盐水平，这反过来导致AMP-激酶（AMPK ）途径，并且由AMPK介导的所有下游功能包括增加的脂肪酸氧化，增强的葡萄糖转运和降低的脂肪酸合成。

    Sheath for use with an ultrasound element
    5.
    发明授权
    Sheath for use with an ultrasound element 有权
    护套用于超声波元件

    公开(公告)号：US08764700B2

    公开(公告)日：2014-07-01

    申请号：US13332226

    申请日：2011-12-20

    申请人： John Zhang ,  Gary Lichttenegger ,  James E. Rodriguey ,  Katsuro Tachibana

    发明人： John Zhang ,  Gary Lichttenegger ,  James E. Rodriguey ,  Katsuro Tachibana

    IPC分类号： A61B17/20

    CPC分类号： A61M5/14 ,  A61B1/00135 ,  A61B8/12 ,  A61B17/22 ,  A61B17/2202 ,  A61B17/320068 ,  A61B2017/22082 ,  A61B2017/22084 ,  A61B2017/320072 ,  A61B2017/320084 ,  A61B2018/00011 ,  A61M25/007 ,  A61M37/0092 ,  A61M2025/0057 ,  A61M2025/105

    摘要： An apparatus for delivering ultrasound energy and a drug solution to a treatment site in a vessel is disclosed. The apparatus includes an elongate, hollow sheath having a distal opening and an energy delivery section at least partially constructed from a material that transmits ultrasound energy. The apparatus also includes a drug delivery lumen positioned along at least a portion of the sheath, the drug delivery lumen having at least one drug delivery port within the energy delivery section. The apparatus further includes an elongate body having an ultrasound element, the elongate body configured to be movably positioned within the sheath, such that ultrasonic energy can be transmitted from the ultrasound element through the energy delivery section.

    摘要翻译： 公开了一种用于将超声能量和药物溶液输送到容器中的治疗部位的装置。 该装置包括细长的中空护套，其具有远端开口和至少部分地由透射超声能量的材料构成的能量传递部分。 该装置还包括沿护套的至少一部分定位的药物递送腔，药物递送腔具有在能量输送部分内的至少一个药物递送端口。 该装置还包括具有超声波元件的细长主体，细长主体被配置为可移动地定位在护套内，使得超声能量可以从超声波元件通过能量输送部分传递。

    CARTRIDGE FOR A BLOOD VESSEL ACCESS SYSTEM AND DEVICE
    6.
    发明申请
    CARTRIDGE FOR A BLOOD VESSEL ACCESS SYSTEM AND DEVICE 审中-公开
    用于血液容器访问系统和装置的盒子

    公开(公告)号：US20130131597A1

    公开(公告)日：2013-05-23

    申请号：US13681105

    申请日：2012-11-19

    申请人： Michael Blaivas ,  Timothy Chinowsky ,  Kurt Duclos ,  John Zhang

    发明人： Michael Blaivas ,  Timothy Chinowsky ,  Kurt Duclos ,  John Zhang

    IPC分类号： A61M25/00

    CPC分类号： A61M25/0097 ,  A61B17/3403 ,  A61B90/14 ,  A61B2017/3409 ,  A61B2017/3413 ,  A61B2034/107 ,  A61B2090/378 ,  A61M25/0113 ,  A61M25/0606

    摘要： A cartridge for use with a blood vessel access system and device. The cartridge includes a slideable needle mount and a slideable cannula mount, the slideable needle mount having a needle in slideable connection with a lumen of a cannula held by the needle mount. The slideable needle mount and the slideable cannula mount are removeably attachable with separate moveable platforms of a needle injector that is pivotally attached to a handheld ultrasound transceiver in signal communication with a computer processing unit connected with a monitor. Upon insonification of a patient's vasculature using the handheld ultrasound transceiver pressed against the surface of the patient, needle injection and subsequent cannulation of a targeted blood vessel appearing on the monitor is accomplished by deploying the needle and cannula from the cartridge via motorization of the moveable platforms that is initiated by the user operating a controller on the device's needle injector.

    摘要翻译： 用于血管通路系统和装置的药筒。 该盒包括一个可滑动的针座和一个可滑动的套管座，该可滑动的针座具有一个可与针座保持的插管的内腔可滑动连接的针。 可滑动的针座和可滑动的套管安装件可拆卸地附接到针注射器的单独的可移动平台上，所述移动平台可枢转地附接到与监视器连接的计算机处理单元信号通信的手持式超声收发器。 在使用按压患者表面的手持式超声收发器对患者的脉管系统进行神经化时，出现在监视器上的目标血管的针注射和随后的插管通过从可移动平台的机动化部署针筒和套管来实现 这是由用户操作设备的针注射器上的控制器启动的。

    Compositions and methods for the prevention and treatment of circulatory conditions
    7.
    发明申请
    Compositions and methods for the prevention and treatment of circulatory conditions 审中-公开
    用于预防和治疗循环状况的组合物和方法

    公开(公告)号：US20070037756A1

    公开(公告)日：2007-02-15

    申请号：US11202452

    申请日：2005-08-12

    申请人： David Lau ,  John Zhang

    发明人： David Lau ,  John Zhang

    IPC分类号： A61K31/7024 ,  A61K31/353 ,  A61K31/343

    CPC分类号： A61K31/343 ,  A61K31/353 ,  A61K31/7024

    摘要： The present invention relates to compositions and the prevention and treatment of circulatory conditions. In one embodiment, the present invention contemplates a compositions comprising anti-platelet aggregating activity. In another embodiment, the present invention contemplates methods to prevent or treat vascular or cardiovascular diseases. In another embodiment, the present invention relates to a method to prevent or treat cardiovascular disease by administering a glycerol saccharide derivative, an arylpolyphenol, a saccharide substituted with an arylpolyphenol, or a steroid substituted with an arylpolyphenol capable of reducing platelet aggregation. In one embodiment, the invention relates to a method of using the compounds capable of reducing platelet aggregation in order to prevent the recurrence of a heart attack by administration of the compounds to a subject after the subject has experienced a heart attack.

    摘要翻译： 本发明涉及组合物和预防和治疗循环状况。 在一个实施方案中，本发明涉及包含抗血小板聚集活性的组合物。 在另一个实施方案中，本发明考虑了预防或治疗血管或心血管疾病的方法。 在另一个实施方案中，本发明涉及一种通过施用甘油糖衍生物，芳基多酚，被芳基多酚取代的糖或被能够还原血小板聚集的芳基多酚取代的类固醇来预防或治疗心血管疾病的方法。 在一个实施方案中，本发明涉及使用能够减少血小板聚集的化合物的方法，以便在受试者经历心脏病发作之后通过向受试者施用化合物来防止心脏病发作的复发。

    BACNET MS/TP AUTOMATIC MAC ADDRESSING
    8.
    发明申请
    BACNET MS/TP AUTOMATIC MAC ADDRESSING 有权
    BACNET MS / TP自动MAC寻址

    公开(公告)号：US20140025842A1

    公开(公告)日：2014-01-23

    申请号：US13555980

    申请日：2012-07-23

    申请人： Ting Li ,  Yongxi Zhou ,  Hu Zou ,  Jianping Chen ,  John Zhang

    发明人： Ting Li ,  Yongxi Zhou ,  Hu Zou ,  Jianping Chen ,  John Zhang

    IPC分类号： G06F15/16

    CPC分类号： H04L63/0876 ,  H04L12/417 ,  H04L29/12254 ,  H04L41/08 ,  H04L61/103 ,  H04L61/2038 ,  H04L61/6022 ,  H04L67/125

    摘要： A building automation and control network (BACnet) master-slave/token-passing (MS/TP) automatic media access control (MAC) addressing system having a BACnet MS/TP network, a MAC assigner on the network, and one or more MAC assignees on the network. Each assignee may have a global unique identity (GUID) and the assigner may have a pre-defined address. The assigner may gather virtually all GUIDs of the MAC assignees on the network and gather virtually all unused MAC addresses on the network. The assigner may map GUIDs to the unused MAC addresses and send a resulting map to the MAC assignees for assignment of a MAC address to each assignee. Each assignee may be assigned a MAC address according to its GUID, and the assignment of a MAC address to each assignee may occur automatically without manual intervention. In other words, the system may provide auto MAC addressing.

    摘要翻译： 具有BACnet MS / TP网络的建筑物自动化和控制网络（BACnet）主从/令牌传递（MS / TP）自动媒体访问控制（MAC）寻址系统，网络上的MAC分配器以及一个或多个MAC 受理人在网络上。 每个受让人可以具有全局唯一身份（GUID），并且分配者可以具有预定义的地址。 分配器可以几乎收集网络上MAC分配器的所有GUID，并且几乎收集网络上的所有未使用的MAC地址。 分配器可以将GUID映射到未使用的MAC地址，并将得到的映射发送给MAC分配者，以向每个受让人分配MAC地址。 每个受让人可以根据其GUID分配MAC地址，并且每个受让人的MAC地址的分配可以在没有手动干预的情况下自动发生。 换句话说，系统可以提供自动MAC寻址。

    Brachytherapy apparatus for asymmetrical body cavities
    10.
    发明授权
    Brachytherapy apparatus for asymmetrical body cavities 有权
    近距离放射治疗仪用于不对称体腔

    公开(公告)号：US08226539B2

    公开(公告)日：2012-07-24

    申请号：US12554732

    申请日：2009-09-04

    申请人： L. Michael Cutrer ,  Richard A. Terwilliger ,  Fredrick W. Winch ,  John Zhang ,  Wayne Higgins ,  Terence Ellard ,  David Bossi

    发明人： L. Michael Cutrer ,  Richard A. Terwilliger ,  Fredrick W. Winch ,  John Zhang ,  Wayne Higgins ,  Terence Ellard ,  David Bossi

    IPC分类号： A61N5/00

    CPC分类号： A61N5/1015 ,  A61N2005/1018

    摘要： The present disclosure provides a brachytherapy apparatus, system and method that delivers partial breast irradiation treatment for post-lumpectomy patients via introduction of a catheter-like device through a trocar. The apparatus may be introduced post-surgically with local anesthesia under image guidance into the previous excision site and into a cavity by a surgeon. The brachytherapy apparatus includes one or more thin-walled tubes, each of said thin-walled tubes being configured to contain one or more radioactive sources, at least one radiation source configured to deliver a prescribed dose of radiation, a whisk adjuster configured to permit adjustment of each of the one or more thin-walled tubes so that the tubes substantially conform to a size of the body cavity; and an expansion element configured to expand outwardly said one or more thin-walled tubes within the cavity so that the thin-walled tubes substantially conform to a shape and/or size of the body cavity.

    摘要翻译： 本公开提供了一种近距离放射治疗装置，系统和方法，其通过经由套管针引入导管状装置来递送部分乳房外照射治疗肿瘤后切除术患者。 该装置可以在图像引导下用手术后的局部麻醉引入先前的切除部位并由外科医生进入腔中。 近距离放射治疗装置包括一个或多个薄壁管，每个所述薄壁管被构造成容纳一个或多个放射源，至少一个辐射源被配置为传送规定剂量的辐射，构造成允许调节的搅拌器 所述一个或多个薄壁管中的每一个使得所述管基本上符合所述体腔的尺寸; 以及膨胀元件，其构造成向外扩张所述空腔内的所述一个或多个薄壁管，使得所述薄壁管基本上符合所述体腔的形状和/或尺寸。