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39 条记录 (耗时 0.013 秒)

    Switching power supply control
    2.
    发明申请
    Switching power supply control 有权

    公开(公告)号：US20060055385A1

    公开(公告)日：2006-03-16

    申请号：US11109466

    申请日：2005-04-18

    申请人： Tod Schiff

    发明人： Tod Schiff

    IPC分类号： G05F1/40

    CPC分类号： H02M3/1563

    摘要： A switching power supply controller includes a comparator to compare a feedback signal to a first limit and a second limit, one of which includes a ramp. Limit generators may be used to generate limit signals in response to power supply signals, control signals, and/or output signals. An error amplifier may be used to generate the feedback signal in response to an output signal and an input control signal. A switching power supply may alternatively include an oscillator that shifts the switching frequency in response to the input control signal.

    Process for the preparation of paroxetine substantially free of alkoxy impurities
    3.
    发明申请
    Process for the preparation of paroxetine substantially free of alkoxy impurities 审中-公开
    制备基本上不含烷氧基杂质的帕罗西汀的方法

    公开(公告)号：US20050203140A1

    公开(公告)日：2005-09-15

    申请号：US11123753

    申请日：2005-05-05

    申请人： Valerie Niddam ,  Ilya Avrutov

    发明人： Valerie Niddam ,  Ilya Avrutov

    IPC分类号： C07D211/22 ,  C07D405/12 ,  A61K31/445 ,  C07D211/20

    CPC分类号： C07D405/12 ,  C07D211/22

    摘要： The present invention is directed to methods for preparing intermediates useful in the synthesis of paroxetine wherein the intermediates are substantially free of alkoxy impurities as well as to methods for preparing paroxetine and pharmaceutically acceptable salts thereof substantially free of alkoxy impurities. The alkoxy impurity is reacted with an ether cleaving agent to generate the corresponding phenol, which is separated, yielding the desired product substantially free of alkoxy impurities. Paroxetine intermediates such as PMA, paroxetine, and pharmaceutically acceptable salts thereof substantially free of alkoxy impurities also form part of the present invention.

    摘要翻译： 本发明涉及制备可用于合成帕罗西汀的中间体的方法，其中中间体基本上不含烷氧基杂质，以及制备基本上不含烷氧基杂质的帕罗西汀及其药学上可接受的盐的方法。 将烷氧基杂质与醚裂解剂反应以产生相应的苯酚，其分离，得到基本上不含烷氧基杂质的所需产物。 帕罗西汀中间体如PMA，帕罗西汀及其基本上不含烷氧基杂质的药用盐也构成本发明的一部分。

    Racemization and enantiomer separation of clopidogrel
    6.
    发明申请
    Racemization and enantiomer separation of clopidogrel 失效
    氯吡格雷的外消旋化和对映异构体分离

    公开(公告)号：US20050049275A1

    公开(公告)日：2005-03-03

    申请号：US10958072

    申请日：2004-10-04

    申请人： Merli Valeriano ,  Paola Daverio ,  Stefano Bianchi

    发明人： Merli Valeriano ,  Paola Daverio ,  Stefano Bianchi

    IPC分类号： A61K31/4743 ,  C07D513/04 ,  C07D498/02

    CPC分类号： C07D513/04 ,  A61K31/4743 ,  Y02P20/582

    摘要： Processes for separation of enantiomers of clopidogrel, and converting one enantiomer of clopidogrel to another enantiomer of clopidogrel are provided. The enantiomers are separated by crystallizing the (S) enantiomer as camphor sulfonate salt from a hydrocarbon, or a mixture of a hydrocarbon and a co-solvent, preferably DMF:toluene. The (R) enantiomer is then racemized and recycled by reaction with a catalytic amount of a base, preferably with t-butoxide.

    摘要翻译： 提供氯吡格雷的对映异构体分离方法，将氯吡格雷的一种对映异构体转化为氯吡格雷的另一种对映异构体。 通过从烃或烃和共溶剂，优选DMF：甲苯的混合物中结晶（S）对映异构体作为樟脑磺酸盐分离对映异构体。 然后将（R）对映异构体外消旋化并通过与催化量的碱，优选与叔丁醇反应而再循环。