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    Automated standards sampling
    3.
    发明授权
    Automated standards sampling 有权
    自动标准抽样

    公开(公告)号：US08003048B2

    公开(公告)日：2011-08-23

    申请号：US11992566

    申请日：2006-09-30

    申请人： Brian K. Clay ,  Martin B. Tobias ,  Larry Macklin ,  Richard D. Godec ,  Steve Poirier

    发明人： Brian K. Clay ,  Martin B. Tobias ,  Larry Macklin ,  Richard D. Godec ,  Steve Poirier

    IPC分类号： G01N15/06 ,  G01N35/10 ,  G01N33/18

    CPC分类号： G01N35/1095 ,  G01N21/05 ,  G01N33/1846 ,  G01N35/00594 ,  G01N35/085 ,  Y10T436/10 ,  Y10T436/11 ,  Y10T436/117497 ,  Y10T436/235 ,  Y10T436/2575

    摘要： An automated standards sampling apparatus (50) and method for using such, apparatus are described. The apparatus can be integrated with a liquid analyzer to form a compact, integrated liquid analysis unit. When used in combination with a specially adapted vial se of standard liquids, the apparatus provides a system for automated, substantially error-free periodic calibration and accuracy verification for an online TOC analyzer (52). The automated standards sampling apparatus of this invention facilitates the easy introduction of known concentrations of standard solutions and “grab” samples into online TOC analyzers to satisfy regulatory compliance, calibration, and validation requirements. The automated standards sampling apparatus of this invention also provides substantially improved reliability, higher productivity and better performance when running the critical and regulatory driven System Suitability Test than does any conventional sampling equipment, and it is likely to find wide use in a variety of industrial applications other than its principal intended use in the pharmaceutical industry.

    摘要翻译： 描述了一种自动化标准取样装置（50）及其使用方法。 该装置可与液体分析仪集成，形成紧凑的集成液体分析单元。 当与特别适合的标准液体小瓶组合使用时，该装置提供了一种用于在线TOC分析仪（52）的自动化，基本上无错误的周期性校准和精度验证的系统。 本发明的自动标准取样装置有助于将已知浓度的标准溶液和“抓取”样品简单地引入到在线TOC分析仪中以满足合规性，校准和验证要求。 本发明的自动标准取样装置在运行关键和监管驱动的系统适用性测试时，比任何常规采样设备都能提供显着提高的可靠性，更高的生产率和更好的性能，并且可能在各种工业应用中广泛使用 除了主要用于制药行业之外。

    Adhesion of membranes on nitride layer in electrochemical sensors by attachment to underlying oxide layer
    4.
    发明授权
    Adhesion of membranes on nitride layer in electrochemical sensors by attachment to underlying oxide layer 有权
    在电化学传感器中通过附着到下面的氧化物层上的膜在氮化物层上的附着力

    公开(公告)号：US07988838B2

    公开(公告)日：2011-08-02

    申请号：US12092299

    申请日：2006-11-01

    申请人： Frank Dipiazza ,  Glenn B. Martin

    发明人： Frank Dipiazza ,  Glenn B. Martin

    IPC分类号： C25B9/10 ,  G01N27/333

    CPC分类号： G01N27/333

    摘要： An electrochemical sensor is provided that exhibits improved adhesion of the membrane to the nitride layer used as an insulating layer in silicon- or silicon-oxide-based electrochemical sensing devices. The sensing devices include a substrate, an oxide disposed on the substrate, a nitride disposed on the oxide, an electrically conductive structure disposed on the oxide layer, and an electrode disposed on the oxide layer and electrically coupled to the electrically conductive structure. At least one opening is formed in the nitride layer to form at least one adhesion trench that exposes a surface region of an oxide layer underlying the nitride layer. The membrane covers the electrode, and contacts the oxide surface regions exposed by the adhesion trenches. The contact between the membrane and the oxide surface region provides for improved adhesion of the membrane to the electrochemical sensing device.

    摘要翻译： 提供了一种电化学传感器，其在基于硅或氧化硅的电化学感测装置中表现出改进的粘附到用作绝缘层的氮化物层的膜。 感测装置包括衬底，设置在衬底上的氧化物，设置在氧化物上的氮化物，设置在氧化物层上的导电结构，以及设置在氧化物层上并电耦合到导电结构的电极。 在氮化物层中形成至少一个开口以形成暴露氮化物层下面的氧化物层的表面区域的至少一个粘合沟槽。 膜覆盖电极，并接触由粘附沟槽暴露的氧化物表面区域。 膜和氧化物表面区域之间的接触提供了改进的膜与电化学感测装置的粘合性。

    Sensitive detection of urea and related compounds in water
    5.
    发明授权
    Sensitive detection of urea and related compounds in water 有权
    尿素和相关化合物在水中的敏感检测

    公开(公告)号：US07662637B2

    公开(公告)日：2010-02-16

    申请号：US10498180

    申请日：2002-12-02

    申请人： Richard D. Godec

    发明人： Richard D. Godec

    IPC分类号： G01N33/00 ,  C12M1/34 ,  C12M3/00

    CPC分类号： G01N27/021 ,  G01N31/002 ,  G01N33/1846 ,  G01N33/62 ,  Y10T436/117497 ,  Y10T436/171538 ,  Y10T436/23 ,  Y10T436/235

    摘要： Methods and apparatus (FIG. 4a) are disclosed for selective and very sensitive detection of certain hydrolyzable compounds, especially urea, in water by hydrolyzing said hydrolyzable compounds in a sample of the water to one or more carbon dioxide group compounds and determining the difference in the carbon dioxide content of the water and the hydrolyzed sample using conductivity measurements or other carbon dioxide detector outputs.

    摘要翻译： 公开了方法和装置（图4a），用于通过将水样中的所述可水解化合物水解成一种或多种二氧化碳基化合物来选择和非常敏感地检测水中的某些可水解化合物，特别是尿素，并确定 使用电导率测量或其他二氧化碳检测器输出的水和水解样品的二氧化碳含量。

    Systems and methods for fluid quality sensing, data sharing and data visualization
    6.
    发明授权
    Systems and methods for fluid quality sensing, data sharing and data visualization 失效
    流体质量感知，数据共享和数据可视化的系统和方法

    公开(公告)号：US07424399B2

    公开(公告)日：2008-09-09

    申请号：US11450923

    申请日：2006-06-09

    申请人： Malcolm R. Kahn ,  Uwe Michalak ,  Dimitris Papageorgiou

    发明人： Malcolm R. Kahn ,  Uwe Michalak ,  Dimitris Papageorgiou

    IPC分类号： G06F11/00

    CPC分类号： G01N33/18 ,  B01D2313/02 ,  C02F1/008 ,  C02F2209/008

    摘要： A service provider receives fluid test data generated from multiple different entities and permits authorized users affiliated with the different entities, as well as others, to visualize information associated with that data to via the Internet using graphical computer interfaces at respective computers. The fluid test data can be gathered using portable sensor units equipped with GPS and wireless communication to transmit the fluid test data and geographical information to the service provider.

    摘要翻译： 服务提供者接收从多个不同实体产生的流体测试数据，并允许附属于不同实体的授权用户以及其他实体可以通过互联网在相应的计算机上使用图形计算机接口将与该数据相关联的信息可视化。 可以使用配有GPS和无线通信的便携式传感器单元收集流体测试数据，以将流体测试数据和地理信息传输到服务提供商。

    Device to alternately supply a fluid to an analyzer
    9.
    发明授权
    Device to alternately supply a fluid to an analyzer 有权
    将流体交替供给分析仪的装置

    公开(公告)号：US07247498B2

    公开(公告)日：2007-07-24

    申请号：US10352516

    申请日：2003-01-28

    申请人： Richard D. Godec ,  Frank J. Silvester ,  Blaine R. Bateman

    发明人： Richard D. Godec ,  Frank J. Silvester ,  Blaine R. Bateman

    IPC分类号： G01N1/10 ,  G01N31/00 ,  G01N33/18 ,  G01N35/10

    CPC分类号： G01N35/1079 ,  G01N2001/2893 ,  Y10T436/10 ,  Y10T436/11 ,  Y10T436/117497 ,  Y10T436/235 ,  Y10T436/25 ,  Y10T436/2575

    摘要： Apparatus and methods for supplying a portion of a fluid stream and, alternately, a fluid of known composition and concentration to an analyzer are provided. The fluid stream is directed through a series of connected chambers formed in an integral housing. A sampling needle has an inlet in one of the chambers and an outlet in fluid communication with the analyzer. When desired, a tube or vial containing a known fluid may be inserted into a chamber containing the sampling needle, so that the known fluid will be supplied to the analyzer. A second needle provides ventilation to the vial to prevent the formation of a vacuum as the known fluid is drained from the vial.

    摘要翻译： 提供了用于将一部分流体流以及已知组成和浓度的流体供应给分析器的装置和方法。 流体流被引导通过形成在一体式壳体中的一系列连接的腔室。 采样针在其中一个腔室中具有入口和与分析器流体连通的出口。 当需要时，可以将含有已知流体的管或小瓶插入到含有采样针的腔室中，从而将已知的流体供应到分析器。 当已知的流体从小瓶中排出时，第二针针对小瓶提供通气以防止形成真空。