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公开(公告)号：US20230375404A1
公开(公告)日：2023-11-23
申请号：US18308572
申请日：2023-04-27
CPC分类号： G01J3/0229 , G01J3/4406 , G01J3/0208 , G02B5/04 , G01J3/0218 , G02B3/06 , G02B3/0056
摘要： Various embodiments of a laser illumination system are disclosed. In some examples, a system includes one or more lasers and a beam combiner configured to direct a combined light beam along a path. The system can include a polychroic optical assembly that receives the combined light beam and to output a first beam of the first light of the first wavelength and a second beam of the second light of the second wavelength. The second beam can be offset from the first beam. The polychroic optical assembly can be a prism assembly. The system can include one or more optical elements configured alter a distribution of light of the first beam to output a first output line at a sample plane, and to alter a distribution of light of the second beam to output a second output line at the sample plane.
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公开(公告)号：US20230184642A1
公开(公告)日：2023-06-15
申请号：US18082177
申请日：2022-12-15
发明人： Quan Liu , John Barnacle , Eric Beemer
CPC分类号： G01N1/38 , G01N35/1097 , G01N2001/383
摘要： A method for processing a sample of a cell culture composition includes diluting the sample followed by filtering the diluted sample, wherein the dilution may be at least 10 parts by volume of a diluent to one part sample, and the filter may be a porous membrane with a molecular weight cutoff of less than 20,000 Daltons. The dilution may be carried out at a multiple-port dilution valve having a first condition and a second condition. The sample may be mixed with the diluent at a predetermined dilution ratio when the dilution valve is in the second condition.
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3.发明授权公开(公告)号：US11287600B2
公开(公告)日：2022-03-29
申请号：US14218131
申请日：2014-03-18
发明人： Jozef Sofka , Justin VanTassel , James Moronski
摘要： Presented is a method, apparatus and computer-readable medium for reducing error. The apparatus includes a rotatable element having a plurality of spaced light modifying ports located at set positions in the rotatable element, the rotatable element rotatable about an axis. The apparatus further includes a drive engagedly coupled to the rotatable element to rotate the rotatable element, wherein one periodic cycle of the rotatable element is an integer number of periodic cycles of the drive.
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公开(公告)号：US11187360B2
公开(公告)日：2021-11-30
申请号：US15617792
申请日：2017-06-08
发明人： Eric Beemer , Scott Ellis , Craig Graham , Nathaniel Nienhuis , Troy Sanders
摘要： A fluidic connection assembly and methods for quickly connecting or disconnecting a tube to a port by hand and without the use of tools. A body is adapted to receive a tube therethrough, and may have at least two sides which are hinged. Each of the hinged sides has corresponding latching portions or projections located near a lower end of the body. These projections are adapted to fit into a port or other fitting and be securely held in place. The assembly may include a tube extending through a body and through a spring located between the end of the body and the end of the tube, whereby the spring exerts a force directly or indirectly against the end of the tube and against the body, thus holding the tubing securely and sealingly engaged in the port when the assembly is connected. The body may further comprise an additional body or an adapter, and/or a cap and latch. A second spring may be used to push a projecting member into a groove or notch of an adapter when an end of the adapter is inserted into one end of the latch or the body. The fluidic connection assembly is useful in analytical instrument systems, such as for in vitro applications and/or in high pressure applications, among other things, and may be used in methods for connecting, or disconnecting, tubing or a fluidic connection assembly from a port or other fitting or connection.
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公开(公告)号：US11149890B2
公开(公告)日：2021-10-19
申请号：US15057915
申请日：2016-03-01
发明人： Eric Beemer , Craig Graham , Mark Hahn
IPC分类号： G01N30/88 , F16L37/244 , G01N30/60 , B01L3/00 , F16L19/065 , F16L15/08 , F16L19/02 , F16L21/00
摘要： A torque limited fitting is provided having a head and a body, which in certain embodiments may be assembled by an operator. The body of the torque limited fitting has a passageway therethrough for receiving and removably holding tubing. The torque limited fitting may be adapted for use with a flat bottom port, such as in an analytical instrument, like liquid chromatography, gas chromatography, ion chromatography, or in in vitro diagnostic systems.
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公开(公告)号：US10718939B2
公开(公告)日：2020-07-21
申请号：US15952756
申请日：2018-04-13
发明人： Jozef Sofka
摘要： Presented is a method, apparatus, and computer-readable medium for selectively switching optical paths. The apparatus includes a directing mirror for redirecting light from an incoming path to one of a plurality of input paths and redirecting the light from one of a plurality of output paths to an outgoing path, and a plurality of input mirrors, each one of the plurality of input mirrors operable for redirecting the light from one of the plurality of input paths to one of a plurality of transition paths. The apparatus includes a plurality of light modifying elements, each one of the light modifying elements in a corresponding transition path and a plurality of output mirrors, each one of the plurality of output mirrors operable for redirecting the light from one of the plurality of transition paths to one of a plurality of output paths.
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公开(公告)号：US10677766B2
公开(公告)日：2020-06-09
申请号：US15459080
申请日：2017-03-15
发明人： Carl Sims
IPC分类号： G01N30/32 , B01D15/08 , B01D15/42 , G01N30/20 , G01N30/46 , B01D15/18 , B01D15/22 , G01N30/02
摘要： A multi-dimensional liquid analysis system includes a first dimension system and a second dimension system, wherein outflow from the first dimension system is separated at a flow splitter under controlled conditions. The flow splitter separates the first dimension outflow into first and second split outlet flows, with one of the split outlet flows being metered to a designated flow rate with a flow metering device disposed downstream from the flow splitter. The flow metering device selectively closes or opens an outlet flow path to define a volumetric flow rate along that outlet flow path, so that the other split outlet flow is correspondingly controlled.
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公开(公告)号：US20190091609A1
公开(公告)日：2019-03-28
申请号：US16206216
申请日：2018-11-30
发明人： Quan Lui , Carl Sims , Chris Hankins
摘要： A membrane gas-liquid contactor is arranged to define a fluid flow path for contact with a membrane in a manner to improve degassing efficiency. A degassing module housing the membrane is arranged with flow fields for distributing the fluid flow throughout the membrane contact area. The distributed fluid flow may have a uniform membrane contact opportunity.
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公开(公告)号：US09829140B2
公开(公告)日：2017-11-28
申请号：US14592722
申请日：2015-01-08
IPC分类号： F16L55/04
CPC分类号： F16L55/041 , F16L55/043
摘要： A fluid pulse dampener with automatic pressure-compensation is provided. A system of chambers and channels in the dampener creates an internal feedback mechanism that increases or decreases a compensating pressure on the membrane in response to increases or decreases in the pressure of a fluid moving past the other side of the membrane. Variations of the pulse dampener allow for the input and/or output of gas flow to be restricted or increased as may be desired.
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公开(公告)号：US09764290B2
公开(公告)日：2017-09-19
申请号：US14684219
申请日：2015-04-10
发明人： Daniel M. Hartmann , Carl Sims , David Steckman , Leanne Elson
CPC分类号： B01D63/08 , B01D19/0031 , B01D19/0042 , B01D19/0078 , B01D63/00 , B01D69/10 , B01D2313/20
摘要： A device which includes a pulse dampener and a degasser or de-bubbler. The device includes a fluid flow path and a fluid chamber located within the device. In addition, the device includes a pulse dampening membrane for dampening pulses in the fluid as it flows through the device. The device also includes a degassing membrane for degassing the fluid as it flows through the device, and/or a de-bubbling membrane for removing gas bubbles from the fluid as it flows through the device. The degassing or de-bubbling membrane can be separate and distinct from the dampening membrane. The de-bubbling membrane can be in addition to or in place of the degassing membrane in some embodiments.
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