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公开(公告)号：US11052137B2
公开(公告)日：2021-07-06
申请号：US16169472
申请日：2018-10-24
发明人： Rob Lavigne , Stefan Miller , Yves Briers , Guido Volckaert , Maarten Walmagh
IPC分类号： A61K38/44 , C07K14/005 , C07K14/47 , C07K14/46 , C12N1/21 , C12N9/36 , C12N15/56 , C07K19/00 , A61K38/47 , A61L2/00 , C12N15/52 , C12N15/62 , C12N9/50 , A61K38/00
摘要： The application relates to antimicrobial agents against Gram-negative bacteria, in particular to fusion proteins composed of an enzyme having the activity of degrading the cell wall of Gram-negative bacteria and a peptide stretch fused to the enzyme at the N- or C-terminus, as well as pharmaceutical compositions comprising the same. Moreover, it relates to nucleic acid molecules encoding such a fusion protein, vectors comprising said nucleic acid molecules and host cells comprising either said nucleic acid molecules or said vectors. In addition, it relates to such a fusion protein for use as a medicament, in particular for the treatment or prevention of Gram-negative bacterial infections, as diagnostic means or as cosmetic substance. The application also relates to the treatment or prevention of Gram-negative bacterial contamination of foodstuff, of food processing equipment, of food processing plants, of surfaces coming into contact with foodstuff, of medical devices, of surfaces in hospitals and surgeries.
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公开(公告)号：US20150118731A1
公开(公告)日：2015-04-30
申请号：US14535457
申请日：2014-11-07
发明人： Rob LAVIGNE , Stefan MILLER , Yves BRIERS , Guido VOLCKAERT , Maarten WALMAGH
CPC分类号： A61K38/47 , A61K38/00 , A61L2/00 , C07K14/005 , C07K14/4723 , C07K2319/00 , C07K2319/20 , C12N9/2462 , C12N9/503 , C12N15/52 , C12N15/62 , C12Y302/01017 , Y02A50/475 , Y02A50/478 , Y02A50/479
摘要： The application relates to antimicrobial agents against Gram-negative bacteria, in particular to fusion proteins composed of an enzyme having the activity of degrading the cell wall of Gram-negative bacteria and a peptide stretch fused to the enzyme at the N- or C-terminus, as well as pharmaceutical compositions comprising the same. Moreover, it relates to nucleic acid molecules encoding such a fusion protein, vectors comprising said nucleic acid molecules and host cells comprising either said nucleic acid molecules or said vectors. In addition, it relates to such a fusion protein for use as a medicament, in particular for the treatment or prevention of Gram-negative bacterial infections, as diagnostic means or as cosmetic substance. The application also relates to the treatment or prevention of Gram-negative bacterial contamination of foodstuff, of food processing equipment, of food processing plants, of surfaces coming into contact with foodstuff, of medical devices, of surfaces in hospitals and surgeries.
摘要翻译： 本申请涉及抗革兰氏阴性细菌的抗微生物剂，特别是由具有降解革兰氏阴性细菌细胞壁的活性的酶和在N-或C-末端与酶融合的肽拉伸组成的融合蛋白 ，以及包含其的药物组合物。 此外，其涉及编码这种融合蛋白的核酸分子，包含所述核酸分子的载体和包含所述核酸分子或所述载体的宿主细胞。 此外，它涉及用作药物，特别是用于治疗或预防革兰氏阴性细菌感染的这种融合蛋白，作为诊断手段或化妆品。 该应用还涉及食品加工设备，食品加工厂，与食品接触的表面，医疗器械，医院和手术中的表面的革兰氏阴性细菌污染的治疗或预防。
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公开(公告)号：US20130052182A1
公开(公告)日：2013-02-28
申请号：US13643900
申请日：2011-04-27
申请人： Stefan Miller
发明人： Stefan Miller
CPC分类号： A61K38/47 , A01N37/46 , A61K45/06 , C12N9/2462 , C12N9/52 , C12N15/62 , C12Y302/01017 , Y02A50/469 , Y02A50/473 , Y02A50/475 , Y02A50/478 , Y02A50/481
摘要： The present invention relates to methods of eliminating, reducing or preventing bacterial biofilms by means of a fusion protein comprising an endolysin, an autolysin or a bacteriocin to which a peptide with membrane or LPS disrupting activity is fused. Further, the present invention relates to fusion proteins for use as a medicament, in particular for the treatment or prevention of Gram-negative and/or Gram-positive bacterial infections associated with bacterial biofilm, as diagnostic means, disinfectant or as cosmetic substance. The present invention also relates to the removal or reduction or prevention of Gram-negative and/or Gram-positive bacterial contamination associated with bacterial biofilm of foodstuff, of food processing equipment, of food processing plants, of surfaces coming into contact with foodstuff, of medical devices, of surfaces in hospitals and surgeries. Furthermore, the present invention relates to the use of said fusion protein as a diagnostic means in medicinal, food or feed or environmental diagnostic associated with bacterial biofilm.
摘要翻译： 本发明涉及通过融合蛋白消除，减少或预防细菌生物膜的方法，所述融合蛋白包含溶解有膜或LPS破坏活性的肽的细胞内溶素，自溶蛋白或细菌素。 此外，本发明涉及用作药物的融合蛋白，特别是用于治疗或预防与细菌生物膜相关的革兰氏阴性和/或革兰氏阳性细菌感染，作为诊断手段，消毒剂或化妆品物质。 本发明还涉及与食品的细菌生物膜，食品加工设备，食品加工设备，与食品接触的表面的革兰氏阴性和/或革兰氏阳性细菌污染的去除或减少或预防， 医疗设备，医院和手术中的表面。 此外，本发明涉及所述融合蛋白作为与细菌生物膜相关的医药，食品或饲料或环境诊断中的诊断方法的用途。
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公开(公告)号：US10167462B2
公开(公告)日：2019-01-01
申请号：US15036583
申请日：2014-11-14
申请人： Lysando AG
发明人： Irina Anosova
摘要： The present invention relates to polypeptides comprising an amino acid sequence exhibiting at least about 90% sequence identity with the sequence of SEQ ID NO: 1. Said polypeptides preferably degrade the peptidoglycan of Gram-negative bacteria, in particular of Pseudomonas and/or Campylobacter bacteria. In addition, the present invention relates to nucleic acids encoding such polypeptides, vectors comprising such nucleic acids, and corresponding host cells. Finally, the present invention relates to compositions comprising such polypeptides, nucleic acids, vectors, and/or host cells according to the present invention.
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公开(公告)号：US09169472B2
公开(公告)日：2015-10-27
申请号：US14475900
申请日：2014-09-03
发明人： Yves Briers , Rob Lavigne , Maarten Walmagh , Stefan Miller
CPC分类号： C12N9/2462 , A01N43/50 , A23L3/3571 , A61K38/00 , A61K38/47 , C07K7/08 , C07K14/195 , C07K14/21 , C07K14/43518 , C07K2319/21 , C07K2319/55 , C12Q1/04 , C12Q1/34 , C12Y302/01017 , G01N2333/928
摘要： The present invention relates to a polypeptide with an amino acid sequence according to SEQ ID NO: 1 and fragments or derivatives thereof. The present invention further relates to fusion proteins comprising said polypeptide and an additional peptide stretch fused to said polypeptide at the N- or C-terminus. Moreover, the present invention relates to nucleic acid molecules encoding said polypeptide or fusion protein, vectors comprising said nucleic acid molecules and host cells comprising either said nucleic acid molecules or said vectors. In addition, the present invention relates to said polypeptide or fusion protein for use as a medicament, in particular for the treatment or prevention of Gram-negative bacterial infections, as diagnostic means, as cosmetic substance or as sanitizing agent. The present invention also relates to the use of said polypeptide or fusion protein for the treatment or prevention of Gram-negative bacterial contamination of foodstuff, of food processing equipment, of food processing plants, of surfaces coming into contact with foodstuff, of medical devices, of surfaces in hospitals and surgeries. Furthermore, the present invention relates to a pharmaceutical composition comprising said polypeptide or fusion protein.
摘要翻译： 本发明涉及具有根据SEQ ID NO：1的氨基酸序列及其片段或衍生物的多肽。 本发明还涉及包含所述多肽的融合蛋白和在N-或C-末端与所述多肽融合的另外的肽拉伸。 此外，本发明涉及编码所述多肽或融合蛋白的核酸分子，包含所述核酸分子的载体和包含所述核酸分子或所述载体的宿主细胞。 此外，本发明涉及用作药物的所述多肽或融合蛋白，特别是用于治疗或预防革兰氏阴性细菌感染，作为诊断手段，作为化妆品或消毒剂。 本发明还涉及所述多肽或融合蛋白用于治疗或预防食品的食品加工设备，食品加工厂，与食品接触的表面，医疗器械的革兰氏阴性细菌污染， 在医院和手术中的表面。 此外，本发明涉及包含所述多肽或融合蛋白的药物组合物。
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公开(公告)号：US20150024469A1
公开(公告)日：2015-01-22
申请号：US14475900
申请日：2014-09-03
发明人： Yves BRIERS , Rob LAVIGNE , Maarten WALMAGH , Stefan MILLER
IPC分类号： C12N9/36 , C07K14/195
CPC分类号： C12N9/2462 , A01N43/50 , A23L3/3571 , A61K38/00 , A61K38/47 , C07K7/08 , C07K14/195 , C07K14/21 , C07K14/43518 , C07K2319/21 , C07K2319/55 , C12Q1/04 , C12Q1/34 , C12Y302/01017 , G01N2333/928
摘要： The present invention relates to a polypeptide with an amino acid sequence according to SEQ ID NO: 1 and fragments or derivatives thereof. The present invention further relates to fusion proteins comprising said polypeptide and an additional peptide stretch fused to said polypeptide at the N- or C-terminus. Moreover, the present invention relates to nucleic acid molecules encoding said polypeptide or fusion protein, vectors comprising said nucleic acid molecules and host cells comprising either said nucleic acid molecules or said vectors. In addition, the present invention relates to said polypeptide or fusion protein for use as a medicament, in particular for the treatment or prevention of Gram-negative bacterial infections, as diagnostic means, as cosmetic substance or as sanitizing agent. The present invention also relates to the use of said polypeptide or fusion protein for the treatment or prevention of Gram-negative bacterial contamination of foodstuff, of food processing equipment, of food processing plants, of surfaces coming into contact with foodstuff, of medical devices, of surfaces in hospitals and surgeries. Furthermore, the present invention relates to a pharmaceutical composition comprising said polypeptide or fusion protein.
摘要翻译： 本发明涉及具有根据SEQ ID NO：1的氨基酸序列及其片段或衍生物的多肽。 本发明还涉及包含所述多肽的融合蛋白和在N-或C-末端与所述多肽融合的另外的肽拉伸。 此外，本发明涉及编码所述多肽或融合蛋白的核酸分子，包含所述核酸分子的载体和包含所述核酸分子或所述载体的宿主细胞。 此外，本发明涉及用作药物的所述多肽或融合蛋白，特别是用于治疗或预防革兰氏阴性细菌感染，作为诊断手段，作为化妆品或消毒剂。 本发明还涉及所述多肽或融合蛋白用于治疗或预防食品的食品加工设备，食品加工厂，与食品接触的表面，医疗器械的革兰氏阴性细菌污染， 在医院和手术中的表面。 此外，本发明涉及包含所述多肽或融合蛋白的药物组合物。
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公开(公告)号：US08906365B2
公开(公告)日：2014-12-09
申请号：US13380312
申请日：2010-06-28
申请人： Rob Lavigne , Stefan Miller , Yves Briers , Guido Volckaert , Maarten Walmagh
发明人： Rob Lavigne , Stefan Miller , Yves Briers , Guido Volckaert , Maarten Walmagh
IPC分类号： C12N9/24 , C07K14/005 , C07K14/47 , C07K19/00 , A61K38/47 , A61L2/00 , C12N15/56 , C12N15/62 , C12N9/50 , C12N15/52 , C12N9/36 , A61K38/00
CPC分类号： A61K38/47 , A61K38/00 , A61L2/00 , C07K14/005 , C07K14/4723 , C07K2319/00 , C07K2319/20 , C12N9/2462 , C12N9/503 , C12N15/52 , C12N15/62 , C12Y302/01017 , Y02A50/475 , Y02A50/478 , Y02A50/479
摘要： The application relates to antimicrobial agents against Gram-negative bacteria, in particular to fusion proteins composed of an enzyme having the activity of degrading the cell wall of Gram-negative bacteria and a peptide stretch fused to the enzyme at the N- or C-terminus, as well as pharmaceutical compositions thereof. Moreover, it relates to nucleic acid molecules encoding such a fusion protein, vectors carrying the nucleic acid molecules and host cells transformed with either the nucleic acid molecules or the vectors. In addition, it relates to such a fusion protein for use as a medicament, in particular for the treatment or prevention of Gram-negative bacterial infections, as diagnostic means or as cosmetic substance. The application also relates to the treatment or prevention of Gram-negative bacterial contamination of foodstuff, of food processing equipment, of food processing plants, of surfaces coming into contact with foodstuff, of medical devices, of surfaces in hospitals and surgeries.
摘要翻译： 本申请涉及抗革兰氏阴性细菌的抗微生物剂，特别是由具有降解革兰氏阴性细菌细胞壁的活性的酶和在N-或C-末端与酶融合的肽拉伸组成的融合蛋白 ，以及其药物组合物。 此外，它涉及编码这种融合蛋白的核酸分子，携带核酸分子的载体和用核酸分子或载体转化的宿主细胞。 此外，它涉及用作药物，特别是用于治疗或预防革兰氏阴性细菌感染的这种融合蛋白，作为诊断手段或化妆品。 该应用还涉及食品加工设备，食品加工厂，与食品接触的表面，医疗器械，医院和手术中的表面的革兰氏阴性细菌污染的治疗或预防。
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公开(公告)号：US11958890B2
公开(公告)日：2024-04-16
申请号：US17057933
申请日：2019-05-29
申请人： LYSANDO AG
发明人： Manfred Biebl , Martin Griessl
CPC分类号： C07K14/4723 , A01N63/50 , A61P31/04 , C07K14/43563 , C12N9/2462 , C12Y302/01017 , A61K38/00 , C07K2319/00
摘要： The present invention relates to a polypeptide comprising a Gram negative endolysin and a peptide selected from the group consisting of an antimicrobial peptide, an amphipathic peptide, a cationic peptide, a sushi peptide or a defensin, wherein the endolysin in turn is selected from the group consisting of SEQ ID NO:1, SEQ ID NO:2, SEQ ID NO:3, SEQ ID NO:4, SEQ ID NO:5, SEQ ID NO:6, SEQ ID NO:7, SEQ ID NO:8, SEQ ID NO:9 and sequences having at least 80% sequence identity with SEQ ID NO:1, SEQ ID NO:2, SEQ ID NO:3, SEQ ID NO:4, SEQ ID NO:5, SEQ ID NO:6, SEQ ID NO:7, SEQ ID NO:8 and/or SEQ ID NO:9. The present invention relates also to corresponding nucleic acids, vectors, bacteriophages, host cells, compositions and kits. The present inventions also relates to the use of said polypeptides, nucleic acids, vectors, bacteriophages, host cells, compositions and kits in methods for treatment of the human or animal body by surgery or therapy or in diagnostic methods practiced on the human or animal body. The polypeptides, nucleic acids, vectors, bacteriophages, host cells, compositions and kits according to the invention may also be used as an antimicrobial in, e.g., food or feed, in cosmetics, or as disinfecting agent.
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公开(公告)号：US20190209663A1
公开(公告)日：2019-07-11
申请号：US16169472
申请日：2018-10-24
发明人： Rob Lavigne , Stefan Miller , Yves Briers , Guido Volckaert , Maarten Walmagh
CPC分类号： A61K38/47 , A61K38/00 , A61L2/00 , C07K14/005 , C07K14/4723 , C07K2319/00 , C07K2319/20 , C12N9/2462 , C12N9/503 , C12N15/52 , C12N15/62 , C12Y302/01017 , Y02A50/475 , Y02A50/478 , Y02A50/479
摘要： The application relates to antimicrobial agents against Gram-negative bacteria, in particular to fusion proteins composed of an enzyme having the activity of degrading the cell wall of Gram-negative bacteria and a peptide stretch fused to the enzyme at the N- or C-terminus, as well as pharmaceutical compositions comprising the same. Moreover, it relates to nucleic acid molecules encoding such a fusion protein, vectors comprising said nucleic acid molecules and host cells comprising either said nucleic acid molecules or said vectors. In addition, it relates to such a fusion protein for use as a medicament, in particular for the treatment or prevention of Gram-negative bacterial infections, as diagnostic means or as cosmetic substance. The application also relates to the treatment or prevention of Gram-negative bacterial contamination of foodstuff, of food processing equipment, of food processing plants, of surfaces coming into contact with foodstuff, of medical devices, of surfaces in hospitals and surgeries.
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公开(公告)号：US10184120B2
公开(公告)日：2019-01-22
申请号：US15036569
申请日：2014-11-14
申请人： Lysando AG
发明人： Stefan Miller , Reinhard Sterner , Heike Stüer
摘要： The present invention relates to polypeptides comprising an amino acid sequence exhibiting at least about 90% sequence identity with the sequence of SEQ ID NO: 1. Said polypeptides preferably degrade the peptidoglycan of Gram-negative bacteria, in particular of Pseudomonas and/or Campylobacter bacteria. In addition, the present invention relates to nucleic acids encoding such polypeptides, vectors comprising such nucleic acids, and corresponding host cells. Finally, the present invention relates to compositions comprising such polypeptides, nucleic acids, vectors, and/or host cells according to the present invention.
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