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    USE OF GANODERMA FUNGAL RNA MOLECULES, DRUG, DRUG COMPOSITION AND DELIVERY CARRIER
    1.
    发明申请
    USE OF GANODERMA FUNGAL RNA MOLECULES, DRUG, DRUG COMPOSITION AND DELIVERY CARRIER 有权

    公开(公告)号：US20250019696A1

    公开(公告)日：2025-01-16

    申请号：US18260789

    申请日：2022-11-17

    Applicant: MACAU UNIVERSITY OF SCIENCE AND TECHNOLOGY

    Inventor： Zhihong JIANG ,  Yuan MA ,  Fei REN

    IPC: C12N15/113 ,  A61K36/074 ,  A61P11/06

    Abstract: A use of ganoderma fungal RNA molecules, a drug, a drug composition and a delivery carrier are provided. It has been proved that the tRFs derived from the ganoderma traditional Chinese medicine has an obvious inhibiting effect on airway smooth muscle cell phenotype change (proliferation, abnormal secretion and the like) induced by TGF-β1 and AHR, inflammation and remodeling of asthma mice induced by Dermatophagoides pteronyssinus in the experiments of the present disclosure, which suggests that the tRFs derived from the ganoderma traditional Chinese medicine and a pharmaceutical composition can be a brand new medicine for treating asthma. The drug comprises the RNA molecule and a pharmaceutically acceptable carrier, diluent and/or excipient. The present disclosure is helpful for the research and development of asthma treatment drugs and provides reference for the research and development of other respiratory system disease treatment drugs.

    Method for improving calculations of surface roughness
    3.
    发明授权
    Method for improving calculations of surface roughness 有权

    公开(公告)号：US10580150B2

    公开(公告)日：2020-03-03

    申请号：US15894956

    申请日：2018-02-13

    Applicant: Macau University of Science and Technology

    Inventor： Zhanchuan Cai ,  Wei Cao

    IPC: G06T7/44 ,  G06T17/05 ,  G06F17/16 ,  G06F17/11

    Abstract: Example embodiments include a method that improves calculations of surface roughness that map a planetary surface. The method includes calculating a V-system matrix with a size of α×α in an interval [0,1]; transforming the V-system matrix into an orthogonal matrix; improving calculations of the surface roughness of the planetary surface by calculating the surface roughness of a digital elevation model generated from data captured from the planetary surface; and generating a map of the planetary surface based on the surface roughness.

    Caffeoylquinic acid-rich extract and preparation as well as use thereof
    4.
    发明授权
    Caffeoylquinic acid-rich extract and preparation as well as use thereof 有权

    公开(公告)号：US10342777B2

    公开(公告)日：2019-07-09

    申请号：US14872198

    申请日：2015-10-01

    Applicant: Macau University of Science and Technology

    Inventor： Pei Luo ,  Zhifeng Zhang ,  Hao Zhang

    IPC: A61K31/357 ,  A61K31/216 ,  A61K36/28

    Abstract: A caffeoylquinic acid-rich extract obtained from Erigeron multiradiatus and a method for producing the same. A caffeoylquinic acid-rich extract includes at least 15% by weight of a mixture of certain caffeoylquinic acids. The extract with the mixture of caffeoylquinic acids is highly efficacious in treating and preventing myocardial ischemia or myocardial ischemia reperfusion injuries. A method for treating or preventing a disease caused by myocardial ischemia or myocardial ischemia reperfusion includes administering a therapeutically effective amount of the caffeoylquinic acid-rich extract to a subject. Pharmaceutical compositions including the caffeoylquinic acid-rich extract are also disclosed.

    Methods and apparatus for image construction
    5.
    发明授权
    Methods and apparatus for image construction 有权

    公开(公告)号：US10332279B2

    公开(公告)日：2019-06-25

    申请号：US15448591

    申请日：2017-03-03

    Applicant: Macau University of Science and Technology

    Inventor： Zhanchuan Cai ,  Ting Lan

    IPC: G06T15/00 ,  G06T11/00 ,  G06T3/40

    Abstract: A method constructs an image with improved peak signal-to-noise ratio (PSNR) from a scattered pixel set. The method generates an approximation function that is a linear combination of a plurality of Many-Knot (MK) spline basis functions, and constructs the image with improved PSNR by conducting a least squares treatment on the approximation function to minimize a residual of each pixel value in the scattered pixel set from the approximation function.

    Methods and apparatus for color image watermarking
    6.
    发明授权
    Methods and apparatus for color image watermarking 有权

    公开(公告)号：US10296999B2

    公开(公告)日：2019-05-21

    申请号：US15431739

    申请日：2017-02-13

    Applicant: Macau University of Science and Technology

    Inventor： Zhanchuan Cai

    IPC: H04L9/00 ,  G06T1/00 ,  H04N19/467 ,  H04N1/32

    Abstract: A method embeds a watermark image into a host image with adaptive rectangular partition and Lower Upper (LU) decomposition such that a watermarked image is generated with improved computational complexity. The method divides a host image into an Red (R) component, a Green (G) component, and a Blue (B) component, and divides each component of the R, G, and B components into a plurality of M×M size blocks, and partitions each of the plurality of M×M size blocks into a plurality of non-overlapping blocks with adaptive rectangular partition. The method selects a plurality of embedding blocks from the plurality of M×M size blocks for each component of the R, G, and B components of the host image to embed watermark information such that the watermarked image is generated.

    Zwitterionic zinc(II) carboxylate compounds and their use
    10.
    发明授权
    Zwitterionic zinc(II) carboxylate compounds and their use 有权

    公开(公告)号：US10023594B2

    公开(公告)日：2018-07-17

    申请号：US15251300

    申请日：2016-08-30

    Applicant: Southern Medical University ,  Macau University of Science and Technology

    Inventor： Jin-Xiang Chen ,  Bin Sun ,  Hai-Qing Zhao ,  Bao-Ping Xie ,  Li-Ping Bai ,  Zhi-Hong Jiang

    IPC: C07F3/06 ,  C12Q1/70

    Abstract: A method of preparing a crystalline zwitterionic zinc(II)-carboxylate compound includes the steps of preparing a mixture of zinc(II) ions and a first pyridyl ligand having three carboxylic acid moieties; subjecting the mixture to conditions under which a precipitate is formed; separating the precipitate; adding a solvent and optionally a second pyridyl ligand to the separated precipitate; subjecting the obtained mixture to conditions under which crystals of the zwitterionic zinc(II)-carboxylate compound are formed; and separating the crystals of the zwitterionic zinc(II)-carboxylate compound. Preferably but not exclusively, the crystalline zwitterionic zinc(II)-carboxylate compound essentially consists of at least one 1D coordination polymer. The compounds are suitable for providing a sensing platform for detecting the presence or amount of target nucleic acid, particularly HIV-1 ds-DNA, with specificity, and, thus, a method of detecting a target nucleic acid sequence in a sample and a kit including the compounds and an oligonucleotide probe are also provided.

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