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公开(公告)号：US20220351371A1
公开(公告)日：2022-11-03
申请号：US17620498
申请日：2020-06-26
申请人： MACQUARIE UNIVERSITY
发明人： Dominic ROWE , Ewa GOLDYS , Martin GOSNELL , Ayad ANWER
摘要： Disclosed is a method for diagnosing a neurodegenerative disease in a subject. The method comprises obtaining from the subject a sample comprising at least one live blood cell, and optionally isolating at least one live blood cell from the sample. The method further comprises generating one or more multispectral or hyperspectral images of the at least one cell, and analysing spectral characteristics of autofluorescence from the at least one cell. Also disclosed is a system configured to aid in the detection or diagnosis of a neurodegenerative disease. Also disclosed is a method for selecting a subject for treatment for a neurodegenerative disease. Also disclosed is a method for monitoring the response of a subject to a therapeutic treatment for a neurodegenerative disease. Also disclosed is a protocol for monitoring the efficacy of a therapeutic treatment for a neurodegenerative disease.
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公开(公告)号：US20220038034A1
公开(公告)日：2022-02-03
申请号：US16944775
申请日：2020-07-31
发明人： Chinthaka Pasan Gooneratne , Subhas Mukhopadhyay , Bodong Li , Guodong Zhan , Arturo Magana-Mora , Timothy Eric Moellendick
摘要： An apparatus includes an outer structure body having an inner surface defining a cavity and an inner structure body rotatably supported within the cavity. The inner structure body has an outer surface in opposing relation to the inner surface and a central bore. Movable elements are positioned along the inner surface and movably coupled to the outer structure body. Ball elements are positioned along the outer surface and coupled to the inner structure body for movement with the inner structure body. The ball elements releasably contact the movable elements and impart motion to the movable elements in response to relative motion between the inner structure body and the outer structure body. Energy harvesters are positioned to generate electrical charges based on piezoelectric effect or magnetostrictive effect when motion is imparted to the movable elements by the ball elements.
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公开(公告)号：US20220038031A1
公开(公告)日：2022-02-03
申请号：US16944745
申请日：2020-07-31
发明人： Chinthaka Pasan Gooneratne , Subhas Mukhopadhyay , Bodong Li , Guodong Zhan , Arturo Magana-Mora , Timothy Eric Moellendick
摘要： An apparatus includes an outer structure body having a cavity and an inner structure body rotatably supported within the cavity. The inner structure body has a central bore. Movable elements are positioned along the inner surface and movably coupled to the outer structure body. Ball elements are positioned along the outer surface and coupled to the inner structure body for movement with the inner structure body. The ball elements are positioned to releasably contact and impart motion to the movable elements in response to relative motion between the inner structure body and the outer structure body. A plurality of triboelectric energy harvesters are positioned to generate electrical charges when motion is imparted to the movable elements by the ball elements.
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公开(公告)号：US20220034198A1
公开(公告)日：2022-02-03
申请号：US16944796
申请日：2020-07-31
发明人： Chinthaka Pasan Gooneratne , Subhas Mukhopadhyay , Bodong Li , Guodong Zhan , Arturo Magana-Mora , Timothy Eric Moellendick
摘要： A system includes sensing modules positioned along a length of a drill string. Each sensing module includes a structure arrangement composed of an outer structure body having a cavity and an inner structure body rotatably supported within the cavity. The structure arrangement is coupled to the drill string such that rotation of the drill string produces a relative rotation between the structure bodies. Ball elements are disposed in a gap between the structure bodies and move along a predetermined path defined in the gap in response to relative rotation between the structure bodies. Movable elements are positioned to physically interact with the ball elements as the ball elements move along the predetermined path. Energy harvesters in the sensor modules generate electrical energy from the mechanical energy produced by physical interaction between the ball elements and movable elements. The sensing modules include sensors to measure parameters in the drill string environment.
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公开(公告)号：US20190388519A1
公开(公告)日：2019-12-26
申请号：US16081384
申请日：2017-03-01
申请人： MACQUARIE UNIVERSITY
摘要： The present invention relates to a method of treating or preventing a neurological condition mediated by a tau-dependent signalling complex in neurons of a subject, comprising treating the subject to: (a) promote phosphorylation of one or more amino acids residues of tau, wherein the phosphorylation of the amino acid residues causes disruption of the tau-dependent signalling complex in neurons of the subject; or (b) introduce a variant of tau that causes disruption of the tau-dependent signalling complex in neurons of the subject. The invention also relates to vectors, compositions and kits for treating or preventing a neurological condition mediated by a tau-dependent signalling complex in neurons of a subject.
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公开(公告)号：US20190229490A1
公开(公告)日：2019-07-25
申请号：US16308085
申请日：2017-06-08
IPC分类号： H01S3/115 , C09K11/77 , H01S3/11 , H01S3/106 , G02F1/141 , H01S3/067 , H01S3/17 , H01S3/16 , H01S3/08 , H01S3/10 , H01S3/105
摘要： A voltage-controllable output coupler for a laser, comprising: a liquid crystal cell that provides a change in birefringence in response to an applied voltage; and a polariser oriented with respect to the liquid crystal cell to collectively form a variable reflectance mirror for the laser; wherein output coupling of the laser is controllable by applying voltage to the liquid crystal cell for a switching interval to switch the variable reflectance mirror from high reflectance to low reflectance, and vice versa, thus actively Q-switching or cavity dumping the laser.
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公开(公告)号：US09972966B2
公开(公告)日：2018-05-15
申请号：US15110212
申请日：2015-01-07
申请人： Macquarie University
发明人： Richard Paul Mildren , Aaron McKay
CPC分类号： H01S3/30 , G02F1/353 , G02F2001/3542 , H01S3/0804 , H01S3/08045 , H01S3/094038 , H01S3/094076 , H01S3/0941 , H01S3/1611 , H01S3/163 , H01S3/1673
摘要： The disclosure herein generally relates to a system (10) for converting an input light (12) into an output light beam (14) that has a spatial beam quality that is greater than that of the input light (12). The system (10) comprises an optical resonator having disposed therein a Raman crystal (20). The Raman crystal (20) is for receiving the input light (12) and the optical resonator is configured to resonate a Stokes light beam (22) generated from the input light (12) by at least one nonlinear interaction within the Raman crystal (20). The at least one nonlinear interaction comprises at least one Raman interaction. The Stokes light beam (22) has a spatial beam quality that is greater than that of the input light (12). The system (10) comprises a light extractor (18) arranged to generate the output light beam (14) by extracting at least some of the Stokes light beam (22) from the optical resonator.
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公开(公告)号：US09658513B2
公开(公告)日：2017-05-23
申请号：US14395751
申请日：2013-04-19
申请人： Macquarie University
IPC分类号： G02F1/35 , G02F1/355 , H01S3/30 , G02F1/365 , H01S3/00 , H01S3/081 , H01S3/083 , H01S3/094 , H01S3/109 , H01S3/042
CPC分类号： G02F1/353 , G02F1/3534 , G02F1/3551 , G02F1/365 , H01S3/0092 , H01S3/042 , H01S3/0816 , H01S3/083 , H01S3/094038 , H01S3/109 , H01S3/30
摘要： Disclosed herein is a device (10) for converting a light (12) received thereby. The device (10) comprises a resonating structure (14) comprising a Raman medium. The resonating structure is arranged to resonate Raman light (18) generated by a Raman interaction between the Raman medium and the light (12) when so received.
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公开(公告)号：US07771974B2
公开(公告)日：2010-08-10
申请号：US10362829
申请日：2001-08-29
CPC分类号： C12N15/1027 , C12Q1/6844 , C12Q2525/179 , C12Q2525/161
摘要： A method for gene shuffling to form a mutant or chimeric gene, the method comprising: (a) assigning one or more segments of one or more genes based on regions of encoded amino acid sequence; (b) amplifying the one or more assigned segments of the gene using primers specific for each segment; and (c) causing recombination of the one or more amplified segments to form a mutant or chimeric gene. An oligonucleotide primer suitable for use in gene shuffling, the primer having a non-degenerate core based on a segment or template of a gene to be amplified, and the core being flanked by both 5′ and 3′ degenerate ends.
摘要翻译： 一种用于基因改组以形成突变体或嵌合基因的方法，所述方法包括：（a）基于编码的氨基酸序列的区域分配一个或多个基因的一个或多个片段; （b）使用对每个片段特异的引物扩增该基因的一个或多个指定片段; 和（c）引起所述一个或多个扩增片段的重组以形成突变体或嵌合基因。 适用于基因改组的寡核苷酸引物，具有基于待扩增基因的片段或模板的非简并核心的引物，以及5'和3'简并末端两侧的核心。
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公开(公告)号：US20100054284A1
公开(公告)日：2010-03-04
申请号：US12297051
申请日：2007-04-05
CPC分类号： H01S3/1086 , H01S3/0014 , H01S3/08 , H01S3/08072 , H01S3/08086 , H01S3/0815 , H01S3/094053 , H01S3/09415 , H01S3/109 , H01S3/1611 , H01S3/1671 , H01S3/1673 , H01S3/1675 , H01S2301/02
摘要： A continuous wave Raman laser for producing visible laser output comprising: a resonator cavity; at least a first reflector and a second reflector said first and second reflectors being located at opposite ends of the resonator cavity; a laser gain medium located in the resonator cavity for generating a continuous wave fundamental beam which resonates within the resonator cavity when pumped by a pump beam from a pump source external to the resonator cavity; a solid Raman-active medium positioned in the resonator cavity for Raman shifting the fundamental beam to produce a continuous wave Raman beam which resonates within the resonator cavity; and a non-linear medium positioned in the resonator cavity for frequency converting the continuous wave Raman beam to a converted wavelength to produce a continuous wave converted beam.
摘要翻译： 一种用于产生可见激光输出的连续波拉曼激光器，包括：谐振腔; 至少第一反射器和第二反射器，所述第一和第二反射器位于谐振器腔的相对端; 激光增益介质，位于所述谐振器腔中，用于产生连续波基本束，所述连续波基本束在通过泵浦光束从所述谐振器腔外部的泵浦源泵浦时在谐振腔内谐振; 位于谐振器腔中的固体拉曼活性介质，用于拉曼移位基波束以产生谐振腔内共振的连续波拉曼光束; 以及位于谐振器腔中的非线性介质，用于将连续波拉曼光束频率转换为转换波长，以产生连续波变换波束。
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