公开(公告)号：US20220138941A1

公开(公告)日：2022-05-05

申请号：US17510541

申请日：2021-10-26

申请人： National Dong Hwa University

发明人： Shi-Jim YEN ,  Wen-Chih CHEN ,  Xian-Dong CHIU ,  Shi-Cheng YE ,  Yu-Jin LIN ,  Chen-Ling LEE

IPC分类号： G06T7/00 ,  H04L29/08 ,  H04L12/58 ,  H04W4/14 ,  G06K9/00 ,  G06F3/14 ,  A61B5/00 ,  G16H50/20 ,  G16H80/00 ,  G06Q10/10 ,  G16H30/20 ,  G06N3/08

摘要： The invention introduces a method for remotely diagnosing tongues based on deep learning, performed by processing unit, including: obtaining a medical-treatment request and medical-record information containing a shooting photo from a client apparatus over a network; inputting the shooting photo to a plurality of partial-detection convolutional neural networks (CNNs) to obtain a plurality of classification results of a plurality of categories, which are associated with a tongue of the shooting photo; displaying a screen of a remote tongue-diagnosis application on a display unit, which contains the classification results of the categories; obtaining a medical advice corresponding to the classification results of the categories; and replying with the medical advice to the client apparatus over the network.

公开(公告)号：US10314847B2

公开(公告)日：2019-06-11

申请号：US15676102

申请日：2017-08-14

申请人： NATIONAL DONG HWA UNIVERSITY

发明人： Mei-Chin Lu ,  Ping-Jyun Sung ,  Jui-Hsin Su ,  Kuei-Hung Lai ,  Yi-Chang Liu ,  Ying-Chi Du ,  Yu-Ming Hsu ,  Ming-Kai Weng ,  Fu-Wen Kuo

IPC分类号： A61K31/56 ,  A61K35/655 ,  A61K31/122

摘要： The present invention discloses scalarane sesterterpenoids represented by formula (I) and meroditerpenoid represented by formula (II), which are extracted from Carteriospongia sp. sponge: where R1 is —CH3 or —C2H5. The compounds of formula (I) can be used to be an anticancer, act as an inhibitor targeting to topoisomerase II and hsp90 and a pharmaceutical composition for anticancer.

公开(公告)号：US09226950B2

公开(公告)日：2016-01-05

申请号：US14077310

申请日：2013-11-12

申请人： National Dong Hwa University

发明人： Ching-Feng Weng ,  Chin-piao Chen ,  Yi-Chen Chia ,  Chia-Yu Hsu

IPC分类号： A61K38/00 ,  C07K9/00 ,  A61K38/28 ,  A61K31/045

CPC分类号： A61K38/28 ,  A61K31/045 ,  A61K2300/00

摘要： The present invention relates to a method or composition for glycemic control in a subject, which is effective for treating diabetes mellitus, comprising administering the subject with a pharmaceutical composition comprising a therapeutically effective amount of an aliphatic alcohol having a general formula of CH3(CH2)nCH2OH, wherein n is an integer from 10 to 40, such as tetracosanol, and a pharmaceutically acceptable carrier.

摘要翻译： 本发明涉及一种用于治疗糖尿病的受试者血糖控制的方法或组合物，其包括给予受试者药物组合物，所述药物组合物包含治疗有效量的通式为CH 3（CH 2） nCH 2 OH，其中n为10至40的整数，例如二十四烷醇，和药学上可接受的载体。

公开(公告)号：US20130158108A1

公开(公告)日：2013-06-20

申请号：US13331059

申请日：2011-12-20

申请人： Tzyy-Wen CHIOU ,  Horng-Jyh Harn ,  Shinn-Zong Lin

发明人： Tzyy-Wen CHIOU ,  Horng-Jyh Harn ,  Shinn-Zong Lin

IPC分类号： A61K31/365 ,  A61P1/16

CPC分类号： A61K31/343

摘要： Provided is a method for treating a liver injury such as fibrosis, cirrhosis and hepatitis as well as a method for restoring liver function in a subject, which includes administrating to the subject a therapeutically effective amount of n-butylidenephthalide having the formula (I) as an active ingredient, or a pharmaceutically acceptable salt of ester thereof: wherein R is ═CHCH2CH2CH3, and n-butylidenephthalide (I) is E form, Z form or a mixture thereof.

摘要翻译： 本发明提供一种治疗肝损伤如纤维化，肝硬化和肝炎的方法以及恢复受试者的肝功能的方法，其包括向受试者施用治疗有效量的具有式（I）的正丁基联苯醚作为 活性成分或其药学上可接受的酯的酯：其中R为= CHCH 2 CH 2 CH 3，正丁基苯酞（I）为E型，Z型或其混合物。

公开(公告)号：US11719880B2

公开(公告)日：2023-08-08

申请号：US17547434

申请日：2021-12-10

申请人： NATIONAL DONG HWA UNIVERSITY

发明人： Duc-Huy Nguyen ,  Jia-Yuan Sun ,  Chia-Yao Lo ,  Jia-Ming Liu ,  Wan-Shao Tsai ,  Ming-Hung Li ,  Sin-Jhang Yang ,  Cheng-Chia Lin ,  Shien-Der Tzeng ,  Yuan-Ron Ma ,  Ming-Yi Lin ,  Chien-Chih Lai

IPC分类号： G02B6/02 ,  C03C25/105 ,  C03C25/328 ,  C03C25/42 ,  C03C25/47

CPC分类号： G02B6/02395 ,  C03C25/105 ,  C03C25/328 ,  C03C25/42 ,  C03C25/47 ,  C03C2218/111

摘要： A perovskite optical element includes a light guiding unit and a luminescent layer. The light guiding unit is configured to conduct light and serves as a resonant cavity. The luminescent layer is a thin film made of perovskite material and clads the light guiding unit. The luminescent layer is configured to be excited by an excitation module to emit light. The light is conducted and output by the light guiding unit. A manufacturing method of a perovskite optical element includes preparing a dip coating solution; dipping a single crystal optical fiber in the dip coating solution for one hour, removing the single crystal optical fiber out of the dip coating solution, and drying the single crystal optical fiber; and placing the single crystal optical fiber into a tube furnace, heating the crystal optical fiber, and introducing synthetic molecules into the tube furnace.

公开(公告)号：US20150203430A1

公开(公告)日：2015-07-23

申请号：US14161213

申请日：2014-01-22

申请人： National Dong Hwa University

发明人： Ching-Feng Weng ,  Chin-piao Chen ,  Sulake Rohidas Shivaji ,  Chia-Yu Hsu

IPC分类号： C07C49/753 ,  A61K36/07 ,  A61K38/28 ,  C07C41/18 ,  C07F7/18 ,  C07C45/65 ,  C07C41/30 ,  C07C45/51 ,  A61K31/122 ,  C07C47/277

CPC分类号： C07C49/753 ,  A61K31/122 ,  A61K31/343 ,  A61K38/28 ,  C07C45/294 ,  C07C45/65 ,  C07C2101/14 ,  C07C2101/16 ,  C07C2601/14 ,  C07C2601/16 ,  A61K2300/00

摘要： The present invention relates to a method or composition for treating diabetes mellitus, comprising administering a subject with a pharmaceutical composition comprising a therapeutically effective amount of an active compound from Antrodia camphorate, such as antroquinonols, and a pharmaceutically acceptable carrier. In addition, the prevent invention provides a new process for the total synthesis of antroquinonol. Also provided are the new compounds produced during the process for preparing of antroquinonol.

摘要翻译： 本发明涉及用于治疗糖尿病的方法或组合物，其包括给予患者药物组合物，所述药物组合物包含治疗有效量的樟脑酸樟脑磺酸盐如抗醌喹诺酮和可药用载体的活性化合物。 此外，防止发明提供了用于全面合成抗醌喹诺酮的新方法。 还提供了在制备抗喹诺酮的过程中产生的新化合物。

公开(公告)号：US20150133371A1

公开(公告)日：2015-05-14

申请号：US14077310

申请日：2013-11-12

申请人： National Dong Hwa University

发明人： Ching-Feng Weng ,  Chin-piao Chen ,  Yi-Chen Chia ,  Chia-Yu Hsu

IPC分类号： C07C31/125 ,  A61K38/28 ,  C07C31/02 ,  A61K31/045

CPC分类号： A61K38/28 ,  A61K31/045 ,  A61K2300/00

摘要： The present invention relates to a method or composition for glycemic control in a subject, which is effective for treating diabetes mellitus, comprising administering the subject with a pharmaceutical composition comprising a therapeutically effective amount of an aliphatic alcohol having a general formula of CH3(CH2)nCH2OH, wherein n is an integer from 10 to 40, such as tetracosanol, and a pharmaceutically acceptable carrier.

摘要翻译： 本发明涉及一种用于治疗糖尿病的受试者血糖控制的方法或组合物，其包括给予受试者药物组合物，所述药物组合物包含治疗有效量的通式为CH 3（CH 2） nCH 2 OH，其中n为10至40的整数，例如二十四烷醇，和药学上可接受的载体。

公开(公告)号：US08927601B2

公开(公告)日：2015-01-06

申请号：US13331059

申请日：2011-12-20

申请人： Tzyy-Wen Chiou ,  Horng-Jyh Harn ,  Shinn-Zong Lin

发明人： Tzyy-Wen Chiou ,  Horng-Jyh Harn ,  Shinn-Zong Lin

IPC分类号： A61K31/343

CPC分类号： A61K31/343

摘要： Provided is a method for treating a liver injury such as fibrosis, cirrhosis and hepatitis as well as a method for restoring liver function in a subject, which includes administrating to the subject a therapeutically effective amount of n-butylidenephthalide having the formula (I) as an active ingredient, or a pharmaceutically acceptable salt of ester thereof: wherein R is ═CHCH2CH2CH3, and n-butylidenephthalide (I) is E form, Z form or a mixture thereof.

摘要翻译： 本发明提供一种治疗肝损伤如纤维化，肝硬化和肝炎的方法以及恢复受试者的肝功能的方法，其包括向受试者施用治疗有效量的具有式（I）的正丁基联苯醚作为 活性成分或其药学上可接受的酯：其中R为= CHCH2CH2CH3，正丁基苯酞（I）为E型，Z型或其混合物。

公开(公告)号：US20110165201A1

公开(公告)日：2011-07-07

申请号：US12984042

申请日：2011-01-04

申请人： Tzyy-Wen Chiou ,  Horng-Jyh Harn ,  Shinn-Zong Lin

发明人： Tzyy-Wen Chiou ,  Horng-Jyh Harn ,  Shinn-Zong Lin

IPC分类号： A61K31/343 ,  A61K9/00 ,  A61P35/00

CPC分类号： A61K31/343 ,  A61K9/0024 ,  A61K47/34

摘要： This invention relates to a pharmaceutical formulation containing z-butylidenephthalide and a polymer, e.g., a polyanhydride. Also disclosed is use of this formulation to treat tumor.

摘要翻译： 本发明涉及含有叔丁基肾上腺素和聚合物例如聚酐的药物制剂。 还公开了该制剂的用途来治疗肿瘤。

公开(公告)号：US20230023270A1

公开(公告)日：2023-01-26

申请号：US17932549

申请日：2022-09-15

申请人： NATIONAL DONG HWA UNIVERSITY

发明人： Tzyy-Wen Chiou ,  Shinn-Zong Lin ,  Horng-Jyh Harn ,  Hong-Lin Su ,  Shih-Ping Liu ,  Kang-Yun Lu ,  Jeanne Hsieh

IPC分类号： C12N5/077 ,  A61K31/341 ,  A61K35/28 ,  A61P3/04 ,  A61K35/35

摘要： Applications of butylidenephthalide (BP), comprising the use of BP in providing a kit for promoting differentiation of stem cells into brown adipose cells, and the use of BP in preparing a medicament, wherein the medicament is used for inhibiting the accumulation of white adipose cells, promoting the conversion of white adipose cells into brown adipose cells, inhibiting weight gain and/or reducing the content of triglycerides, glucose, and total cholesterol in blood.