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公开(公告)号：US20230302040A1
公开(公告)日：2023-09-28
申请号：US18143370
申请日：2023-05-04
发明人： Hiroyuki TANAKA , Hideki YOSHIKAWA , Hideki MOCHIZUKI , Tsuyoshi MURASE , Tsutomu SASAKI , Kousuke BABA , Toru IWAHASHI , Mitsuru NAIKI
IPC分类号： A61K31/714 , A61P25/28 , A61K9/00
CPC分类号： A61K31/714 , A61P25/28 , A61K9/0019
摘要： An object is to provide a drug which is useful in treating a nervous system disease. A drug containing vitamin B12 as an active ingredient according to the present invention has an M2 macrophage/microglia induction promoting effect, an M1 macrophage/microglia induction inhibiting effect, a nerve regeneration promoting effect, and the like and is very useful as a therapeutic agent for a nervous system disease, and particularly useful as a therapeutic agent for a central nervous system disease such as cerebral infarction, dementia, or spinal cord injury.
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公开(公告)号：US12066429B2
公开(公告)日：2024-08-20
申请号：US16913376
申请日：2020-06-26
申请人： National University Corporation Tokyo Medical and Dental University , Nippon Zoki Pharmaceutical Co., Ltd.
发明人： Hiroshi Asahara , Tomoki Chiba , Kentaro Abe
IPC分类号： C12N15/11 , C12N15/10 , C12N15/113 , C12N15/63 , G01N33/50
CPC分类号： G01N33/5023 , C12N15/1086 , C12N15/113 , C12N15/63 , C12N2310/14 , C12N2310/18 , C12N2320/10 , C12N2320/50 , G01N2500/02 , G01N2500/10
摘要： Provided are an expression inhibitor of an inflammation promoting factor based on the discovery of a new factor influencing the expression amount/level of an inflammation promoting factor, and a development tool therefor. Provided are also a diagnostic agent and a diagnosis method for immune diseases, inflammatory diseases, painful conditions and similar. More specifically provided are: an expression inhibitor of an inflammation promoting factor containing at least one kind of inhibitor selected from the group consisting of RBMS2 expression inhibitor and RBMS2 function inhibitor; a screening method using as an indicator the expression or the function of RBMS2; an expression cassette useful for the method; as well as a diagnostic agent containing a product detection agent for RBMS2 gene expression and disease detection method using as an indicator RBMS2 gene expression amount/level.
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公开(公告)号：US20240000853A1
公开(公告)日：2024-01-04
申请号：US18355925
申请日：2023-07-20
发明人： Tomohiro MATSUYAMA , Takayuki NAKAGOMI , Yu FUKUDA
CPC分类号： A61K35/36 , G01N33/15 , G01N33/50 , A61K9/0053
摘要： A lipocalin-type prostaglandin D2 synthase (L-PGDS) production promoting agent, more specifically an L-PGDS production promoting agent in pericytes or ischemia-induced multipotent stem cells (iSCs) dedifferentiated from pericytes. A substance having an L-PGDS production promoting action is contained in an extract from inflamed tissues inoculated with vaccinia virus. An L-PGDS production promoting agent is highly useful as a prophylactic, therapeutic or relapse prophylactic agent for a disease in which the effect by promotion of L-PGDS expression is expected to be effective, including a cerebrovascular disorder such as cerebral infarction, dementia such as Alzheimer's disease, or a sleep disorder.
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公开(公告)号：US20230330042A1
公开(公告)日：2023-10-19
申请号：US18028417
申请日：2021-09-22
发明人： Tsuyoshi ADACHI , Kenji MITSUDA , Hideshi NAKANO
IPC分类号： A61K31/135 , A61K9/00
CPC分类号： A61K31/135 , A61K9/0053
摘要： An oral preparation contains tramadol or a pharmaceutically acceptable salt thereof as an active ingredient and has a low incidence of side effects, such that the blood concentration of unchanged tramadol or an active metabolite thereof, for example, falls within a certain numerical range after administration, so that the incidence of side effects is low while the efficacy is excellent.
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公开(公告)号：US20230066066A1
公开(公告)日：2023-03-02
申请号：US17790451
申请日：2021-01-14
摘要： A medical sheet has a cell infiltration suppressing action, including a nonwoven fabric formed of fiber containing an aliphatic polyester, and having a porosity of 50 to 90%. The sheet is very useful because it has an excellent neuroprotective and/or nerve regeneration promoting action, which protects nerves by suppressing the infiltration of inflammatory cells such as macrophages and not giving stimulation that adversely affects nerves because body fluids pass therethrough, by winding around a nerve at a peripheral nerve injury site.
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公开(公告)号：US11324704B2
公开(公告)日：2022-05-10
申请号：US16082594
申请日：2017-03-06
申请人： OSAKA UNIVERSITY , NATIONAL INSTITUTE FOR MATERIALS SCIENCE , NIPPON ZOKI PHARMACEUTICAL CO., LTD.
IPC分类号： A61K9/70 , A61K47/34 , A61K47/36 , A61K31/714 , A61K35/36 , A61K45/00 , A61K38/18 , A61P25/02 , A61K47/32
摘要： Provided is a sustained release sheet that includes a drug for treating nerve injury, wherein the sheet is applied to a nerve injury site, can maintain a high concentration of the drug over a long period, and promotes nerve regeneration without stimulating the nerves, even when the sheet is implanted in the periphery of the nerve injury site. Also provided is a production method for the sheet. This sustained drug release sheet for treating nerve injury is a sheet comprising a non-woven fabric that is formed from nanofibers each containing a drug such as vitamin B12 and a biocompatible polymer such as a biodegradable aliphatic polyester, and is implanted in the periphery of the nerve injury site to promote nerve regeneration.
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公开(公告)号：US20220079995A1
公开(公告)日：2022-03-17
申请号：US17535784
申请日：2021-11-26
发明人： Daisuke SAKAI , Tomoko NAKAI , Mitsuru NAIKI , Yoji SHIBAYAMA
IPC分类号： A61K35/36 , A61K9/00 , C12Q1/6876 , C12Q1/48 , A61K35/76
摘要： An object of the present invention is to provide an agent for promoting expression of N-acetylgalactosaminyltransferase that contains an extract from inflamed tissues inoculated with vaccinia virus. The present invention demonstrated that the extract from inflamed tissues inoculated with vaccinia virus promotes the expression of N-acetylgalactosaminyltransferase in intervertebral disc cells. Thus, the extract from inflamed tissues inoculated with vaccinia virus or a preparation containing the extract is useful as an agent for promoting the expression of N-acetylgalactosaminyltransferase in intervertebral disc cells.
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公开(公告)号：US20210205234A1
公开(公告)日：2021-07-08
申请号：US17163871
申请日：2021-02-01
申请人： OSAKA UNIVERSITY , NATIONAL INSTITUTE FOR MATERIALS SCIENCE , NIPPON ZOKI PHARMACEUTICAL CO., LTD.
IPC分类号： A61K9/70 , A61K47/34 , A61K47/36 , A61K31/714 , A61K35/36 , A61K45/00 , A61K38/18 , A61P25/02 , A61K47/32
摘要： A sustained release sheet that includes a drug for treating nerve injury, wherein the sheet is applied to a nerve injury site, can maintain a high concentration of the drug over a long period, and promotes nerve regeneration without stimulating the nerves, even when the sheet is implanted in the periphery of the nerve injury site. Also provided is a production method for the sheet. This sustained drug release sheet for treating nerve injury is a sheet including a non-woven fabric that is formed from nanofibers each containing a drug such as vitamin B12 and a biocompatible polymer such as a biodegradable aliphatic polyester, and is implanted in the periphery of the nerve injury site to promote nerve regeneration.
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公开(公告)号：US20210186884A1
公开(公告)日：2021-06-24
申请号：US16761317
申请日：2018-11-08
IPC分类号： A61K9/20 , A61K31/167
摘要： A preparation which contains acetaminophen at a high content, in particular, a miniaturized tablet (conventional tablets, sustained-release tablets, etc.) which have excellent dissolution properties, preferable hardness and high drug content uniformity and a manufacturing method thereof. Acetaminophen has a preset particle size and is used for manufacturing a preparation, the flowability of acetaminophen can be improved so that secondary agglomeration can be suppressed, manufacturing efficiency can be elevated and the cost for manufacturing is also reduced. Thus, an acetaminophen preparation having improved administrability, for example, a reduced size and a manufacturing method thereof are highly useful.
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公开(公告)号：US10703725B2
公开(公告)日：2020-07-07
申请号：US15755275
申请日：2016-08-26
发明人： Taizo Ito , Xiaoming Liao , Zihua Li
IPC分类号： C07D223/04 , A61K31/55 , A61P29/00 , C07D223/14 , C07B51/00
摘要： An object of the present invention is to provide a novel tetrahydroazepine compound and a process for producing the same.The present invention relates to a tetrahydroazepine compound represented by the formula (10) or a salt thereof, anda process for producing the said compound or a salt thereof. (In the formula, R1 is an optionally substituted alkyl group, R2 is an optionally substituted alkyl group and one of the X—Y bond and the Y—Z bond is a carbon-carbon double bond and the other is a carbon-carbon single bond).
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