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    Implantable repair device
    2.
    发明授权
    Implantable repair device 有权

    公开(公告)号：US09943412B2

    公开(公告)日：2018-04-17

    申请号：US14351952

    申请日：2012-10-18

    申请人： ORTHOX LIMITED

    发明人： Nicholas Skaer

    IPC分类号： A61L27/56 ,  A61F2/30 ,  A61L27/22

    CPC分类号： A61F2/30756 ,  A61F2002/30757 ,  A61L27/227 ,  A61L27/56 ,  A61L2430/06

    摘要： An implantable repair device for the repair, augmentation or replacement of tissue, uses silk fibroin and has a smooth surface and a porous surface. The smooth surface has a measured Sa value of less than approximately 0.1 μm when using Atomic Force Microscopy when samples of the repair device are fully hydrated by imaging through fluid in peak force tapping mode. A method of preparing such an implantable repair device includes preparing a gel from a fibroin solution in a mold, preparing a material by subjecting the gel to one or more steps of freezing and thawing the gel, and creating at least a porous surface on the device, wherein a portion of the mold is adapted to provide at least one smooth surface.

    Implantable material and a method for the preparation thereof
    7.
    发明授权
    Implantable material and a method for the preparation thereof 有权
    可植入材料及其制备方法

    公开(公告)号：US08128984B2

    公开(公告)日：2012-03-06

    申请号：US12990399

    申请日：2009-04-30

    申请人： David Philip Knight ,  Nicholas James Vavasour Skaer ,  Andrew Michael Collins ,  Tom Louis Dirk Gheysens ,  Christopher Holland

    发明人： David Philip Knight ,  Nicholas James Vavasour Skaer ,  Andrew Michael Collins ,  Tom Louis Dirk Gheysens ,  Christopher Holland

    IPC分类号： A61K6/083

    CPC分类号： A61L27/3687 ,  A61L27/3604 ,  C08H1/00 ,  C08L89/00

    摘要： A method for the preparation of a regenerated silk fibroin solution comprises the steps of: treating silk or silk cocoons with an ionic reagent comprising an aqueous solution of monovalent cations and monovalent anions, the cations and anions having ionic radii of at least 1.05 Angstroms and a Jones-Dole B coefficient of between −0.001 and −0.05 at 25° C.; and subsequently degumming the treated silk or silk cocoons; or alternatively, degumming silk or silk cocoons; and subsequently treating the degummed silk or silk cocoons with an ionic reagent comprising an aqueous solution of monovalent cations and monovalent anions, the cations and anions having ionic radii of at least 1.05 Angstroms and a Jones-Dole B coefficient of between −0.001 and −0.05 at 25° C. The invention also extends to fibroin solution, a fibroin material and an implant useful for cartilage repair.

    摘要翻译： 一种制备再生丝素蛋白溶液的方法包括以下步骤：用包含一价阳离子和一价阴离子的水溶液的离子试剂处理丝或丝茧，所述阳离子和阴离子的离子半径至少为1.05埃， Jones-Dole B系数在25℃在-0.001和-0.05之间。 然后使经处理的丝或丝茧脱胶; 或者脱胶丝或丝茧; 并随后用包含一价阳离子和一价阴离子水溶液的离子试剂处理脱胶的丝或丝茧，阳离子和阴离子的离子半径至少为1.05埃，琼斯 - 多尔B系数在-0.001-0.05之间 在25℃下。本发明还延伸到丝心蛋白溶液，丝心蛋白材料和用于软骨修复的植入物。

    IMPLANTABLE REPAIR DEVICE
    9.
    发明申请
    IMPLANTABLE REPAIR DEVICE 有权
    可植入维修设备

    公开(公告)号：US20140277452A1

    公开(公告)日：2014-09-18

    申请号：US14351952

    申请日：2012-10-18

    申请人： ORTHOX LIMITED

    发明人： Nicholas Skaer

    IPC分类号： A61F2/30

    CPC分类号： A61F2/30756 ,  A61F2002/30757 ,  A61L27/227 ,  A61L27/56 ,  A61L2430/06

    摘要： An implantable repair device for the repair, augmentation or replacement of tissue, uses silk fibroin and has a smooth surface and a porous surface. The smooth surface has a measured Sa value of less than approximately 0.1 μm when using Atomic Force Microscopy when samples of the repair device are fully hydrated by imaging through fluid in peak force tapping mode. A method of preparing such an implantable repair device includes preparing a gel from a fibroin solution in a mould, preparing a material by subjecting the gel to one or more steps of freezing and thawing the gel, and creating at least a porous surface on the device, wherein a portion of the mould is adapted to provide at least one smooth surface.

    摘要翻译： 用于修复，增加或更换组织的植入式修复装置使用丝素蛋白，并具有光滑的表面和多孔表面。 当使用原子力显微镜时，光滑表面具有小于约0.1μm的测量值，当修补装置的样品通过在峰值强力攻丝模式下通过流体成像而完全水合时。 制备这种可植入修复装置的方法包括从模具中的丝心蛋白溶液制备凝胶，通过使凝胶进行一个或多个步骤来冻结和解冻凝胶，并在该装置上产生至少多孔表面来制备材料 ，其中所述模具的一部分适于提供至少一个光滑表面。

    IMPLANTABLE MATERIAL FOR THE REPAIR, AUGMENTATION, OR REPLACEMENT OF BONE AND A METHOD FOR THE PREPARATION THEREOF
    10.
    发明申请
    IMPLANTABLE MATERIAL FOR THE REPAIR, AUGMENTATION, OR REPLACEMENT OF BONE AND A METHOD FOR THE PREPARATION THEREOF 审中-公开
    用于修复，补充或更换骨的可植入材料及其制备方法

    公开(公告)号：US20110172394A1

    公开(公告)日：2011-07-14

    申请号：US13001287

    申请日：2009-06-24

    申请人： David Knight ,  Nicholas Skaer ,  Andrew Collins ,  Tom Louis Dirk Gheysens

    发明人： David Knight ,  Nicholas Skaer ,  Andrew Collins ,  Tom Louis Dirk Gheysens

    IPC分类号： C07K14/435

    CPC分类号： A61L27/46 ,  A61L27/3604 ,  A61L27/365 ,  A61L27/56 ,  A61L2430/02

    摘要： A method for the preparation of an implantable material for the repair, augmentation or replacement of bone from a fibroin solution, the method comprising the steps of: preparing a gel from the fibroin solution; preparing a material by subjecting the gel to one or more steps of freezing and thawing the gel, wherein the step of preparing the gel from the fibroin solution is performed in the presence of phosphate ions. The material may be treated with calcium ionstoform a fibroin-apatite. A further method comprises the step of treating the material with an isocyanate. The invention also extends to a method for the preparation of an implantable material, wherein a regenerated fibroin solution is used. Also, there is an implantable material and an implant.

    摘要翻译： 一种用于制备用于从丝心蛋白溶液修复，增加或替换骨的可植入材料的方法，所述方法包括以下步骤：从丝心蛋白溶液制备凝胶; 通过使凝胶进行一个或多个步骤来冷冻和解冻凝胶来制备材料，其中在磷酸盐离子存在下从丝心蛋白溶液制备凝胶的步骤。 该材料可以用离子交换丝心蛋白磷灰石来处理。 另一种方法包括用异氰酸酯处理该材料的步骤。 本发明还延伸到制备可植入材料的方法，其中使用再生的丝心蛋白溶液。 此外，还有可植入材料和植入物。