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公开(公告)号：US09226992B2
公开(公告)日：2016-01-05
申请号：US12063966
申请日：2006-08-17
申请人： Stephen Mann , David Philip Knight , Nicholas James Vavasour Skaer , Caroline Bertram , Richard O. C. Oreffo , Helmtrud I. Roach , Andrew Michael Collins
发明人： Stephen Mann , David Philip Knight , Nicholas James Vavasour Skaer , Caroline Bertram , Richard O. C. Oreffo , Helmtrud I. Roach , Andrew Michael Collins
IPC分类号： A61F2/28 , A61L27/42 , A61L27/52 , A61L27/56 , A61L27/58 , A61F2/38 , A61F2/44 , A61L27/22 , A61F2/30 , A61L27/48
CPC分类号： A61L27/227 , A61F2/30756 , A61F2/3872 , A61F2/442 , A61F2002/30062 , A61F2002/30075 , A61F2002/30766 , A61F2002/3092 , A61F2002/4495 , A61F2210/0004 , A61F2210/0061 , A61L27/46 , A61L27/48 , A61L27/52 , A61L27/56 , A61L27/58 , A61L2430/06 , B29C44/1276 , B29C44/3419 , B29C70/222 , B29C70/30 , B29K2105/041 , B29K2105/0809 , B29K2311/10
摘要： A cartilaginous tissue repair device with a biocompatible, bioresorbable three-dimensional silk or other fiber lay and a biocompatible, bioresorbable substantially porous silk-based or other hydrogel partially or substantially filling the interstices of the fiber lay; with or without an integral means of firmly anchoring the device to a patient's bone.
摘要翻译： 具有生物相容性，生物可再吸收的三维丝或其它纤维布的软骨组织修复装置和部分或基本上填充纤维布的间隙的生物相容的，生物可再吸收的基本上多孔的丝基或其它水凝胶; 具有或不具有将装置牢固地锚定到患者骨骼的整体手段。
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公开(公告)号：US20090171467A1
公开(公告)日：2009-07-02
申请号：US12063966
申请日：2006-08-17
申请人： Stephen Mann , David Philip Knight , Nicholas James Vavasour Skaer , Caroline Bertram , Richard O.C. Oreffo , Helmtrud I. Roach , Andrew Michael Collins
发明人： Stephen Mann , David Philip Knight , Nicholas James Vavasour Skaer , Caroline Bertram , Richard O.C. Oreffo , Helmtrud I. Roach , Andrew Michael Collins
CPC分类号： A61L27/227 , A61F2/30756 , A61F2/3872 , A61F2/442 , A61F2002/30062 , A61F2002/30075 , A61F2002/30766 , A61F2002/3092 , A61F2002/4495 , A61F2210/0004 , A61F2210/0061 , A61L27/46 , A61L27/48 , A61L27/52 , A61L27/56 , A61L27/58 , A61L2430/06 , B29C44/1276 , B29C44/3419 , B29C70/222 , B29C70/30 , B29K2105/041 , B29K2105/0809 , B29K2311/10
摘要： A cartilaginous tissue repair device with a biocompatible, bioresorbable three-dimensional silk or other fibre lay and a biocompatible, bioresorbable substantially porous silk-based or other hydrogel partially or substantially filling the interstices of the fibre lay; with or without an integral means of firmly anchoring the device to a patient's bone.
摘要翻译： 具有生物相容性，生物可再吸收的三维丝或其它纤维布的软骨组织修复装置和部分或基本上填充纤维布的间隙的生物相容的，生物可再吸收的基本上多孔的丝基或其它水凝胶; 具有或不具有将装置牢固地锚定到患者骨骼的整体手段。
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公开(公告)号：US20120142898A1
公开(公告)日：2012-06-07
申请号：US13368707
申请日：2012-02-08
申请人： David Philip Knight , Nicholas James Vavasour Skaer , Andrew Michael Collins , Tom Louis Dirk Gheysens , Christopher Holland
发明人： David Philip Knight , Nicholas James Vavasour Skaer , Andrew Michael Collins , Tom Louis Dirk Gheysens , Christopher Holland
IPC分类号： C07K1/02
CPC分类号： A61L27/3687 , A61L27/3604 , C08H1/00 , C08L89/00
摘要： A method for the preparation of a regenerated silk fibroin solution comprises the steps of: treating silk or silk cocoons with an ionic reagent comprising an aqueous solution of monovalent cations and monovalent anions, the cations and anions having ionic radii of at least 1.05 Angstroms and a Jones-Dole B coefficient of between −0.001 and −0.05 at 25° C.; and subsequently degumming the treated silk or silk cocoons; or alternatively, degumming silk or silk cocoons; and subsequently treating the degummed silk or silk cocoons with an ionic reagent comprising an aqueous solution of monovalent cations and monovalent anions, the cations and anions having ionic radii of at least 1.05 Angstroms and a Jones-Dole B coefficient of between −0.001 and −0.05 at 25° C. The invention also extends to fibroin solution, a fibroin material and an implant useful for cartilage repair.
摘要翻译： 一种制备再生丝素蛋白溶液的方法包括以下步骤：用包含一价阳离子和一价阴离子的水溶液的离子试剂处理丝或丝茧，所述阳离子和阴离子的离子半径至少为1.05埃， Jones-Dole B系数在25℃在-0.001和-0.05之间。 然后使经处理的丝或丝茧脱胶; 或者脱胶丝或丝茧; 并随后用包含一价阳离子和一价阴离子水溶液的离子试剂处理脱胶的丝或丝茧，阳离子和阴离子的离子半径至少为1.05埃，琼斯 - 多尔B系数在-0.001-0.05之间 在25℃下。本发明还延伸到丝心蛋白溶液，丝心蛋白材料和用于软骨修复的植入物。
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公开(公告)号：US08337938B2
公开(公告)日：2012-12-25
申请号：US13368707
申请日：2012-02-08
申请人： David Philip Knight , Nicholas James Vavasour Skaer , Andrew Michael Collins , Tom Louis Dirk Gheysens , Christopher Holland
发明人： David Philip Knight , Nicholas James Vavasour Skaer , Andrew Michael Collins , Tom Louis Dirk Gheysens , Christopher Holland
IPC分类号： A61K6/083
CPC分类号： A61L27/3687 , A61L27/3604 , C08H1/00 , C08L89/00
摘要： A method for the preparation of a regenerated silk fibroin solution comprises the steps of: treating silk or silk cocoons with an ionic reagent comprising an aqueous solution of monovalent cations and monovalent anions, the cations and anions having ionic radii of at least 1.05 Angstroms and a Jones-Dole B coefficient of between −0.001 and −0.05 at 25° C.; and subsequently degumming the treated silk or silk cocoons; or alternatively, degumming silk or silk cocoons; and subsequently treating the degummed silk or silk cocoons with an ionic reagent comprising an aqueous solution of monovalent cations and monovalent anions, the cations and anions having ionic radii of at least 1.05 Angstroms and a Jones-Dole B coefficient of between −0.001 and −0.05 at 25° C. The invention also extends to fibroin solution, a fibroin material and an implant useful for cartilage repair.
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公开(公告)号：US08128984B2
公开(公告)日：2012-03-06
申请号：US12990399
申请日：2009-04-30
申请人： David Philip Knight , Nicholas James Vavasour Skaer , Andrew Michael Collins , Tom Louis Dirk Gheysens , Christopher Holland
发明人： David Philip Knight , Nicholas James Vavasour Skaer , Andrew Michael Collins , Tom Louis Dirk Gheysens , Christopher Holland
IPC分类号： A61K6/083
CPC分类号： A61L27/3687 , A61L27/3604 , C08H1/00 , C08L89/00
摘要： A method for the preparation of a regenerated silk fibroin solution comprises the steps of: treating silk or silk cocoons with an ionic reagent comprising an aqueous solution of monovalent cations and monovalent anions, the cations and anions having ionic radii of at least 1.05 Angstroms and a Jones-Dole B coefficient of between −0.001 and −0.05 at 25° C.; and subsequently degumming the treated silk or silk cocoons; or alternatively, degumming silk or silk cocoons; and subsequently treating the degummed silk or silk cocoons with an ionic reagent comprising an aqueous solution of monovalent cations and monovalent anions, the cations and anions having ionic radii of at least 1.05 Angstroms and a Jones-Dole B coefficient of between −0.001 and −0.05 at 25° C. The invention also extends to fibroin solution, a fibroin material and an implant useful for cartilage repair.
摘要翻译： 一种制备再生丝素蛋白溶液的方法包括以下步骤：用包含一价阳离子和一价阴离子的水溶液的离子试剂处理丝或丝茧，所述阳离子和阴离子的离子半径至少为1.05埃， Jones-Dole B系数在25℃在-0.001和-0.05之间。 然后使经处理的丝或丝茧脱胶; 或者脱胶丝或丝茧; 并随后用包含一价阳离子和一价阴离子水溶液的离子试剂处理脱胶的丝或丝茧，阳离子和阴离子的离子半径至少为1.05埃，琼斯 - 多尔B系数在-0.001-0.05之间 在25℃下。本发明还延伸到丝心蛋白溶液，丝心蛋白材料和用于软骨修复的植入物。
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公开(公告)号：US20110177151A1
公开(公告)日：2011-07-21
申请号：US12990399
申请日：2009-04-30
申请人： David Philip Knight , Nicholas James Vavasour Skaer , Andrew Michael Collins , Tom Louis Dirk Gheysens , Christopher Holland
发明人： David Philip Knight , Nicholas James Vavasour Skaer , Andrew Michael Collins , Tom Louis Dirk Gheysens , Christopher Holland
CPC分类号： A61L27/3687 , A61L27/3604 , C08H1/00 , C08L89/00
摘要： A method for the preparation of a regenerated silk fibroin solution comprises the steps of: treating silk or silk cocoons with an ionic reagent comprising an aqueous solution of monovalent cations and monovalent anions, the cations and anions having ionic radii of at least 1.05 Angstroms and a Jones-Dole B coefficient of between −0.001 and −0.05 at 25° C.; and subsequently degumming the treated silk or silk cocoons; or alternatively, degumming silk or silk cocoons; and subsequently treating the degummed silk or silk cocoons with an ionic reagent comprising an aqueous solution of monovalent cations and monovalent anions, the cations and anions having ionic radii of at least 1.05 Angstroms and a Jones-Dole B coefficient of between −0.001 and −0.05 at 25° C. The invention also extends to fibroin solution, a fibroin material and an implant useful for cartilage repair.
摘要翻译： 一种制备再生丝素蛋白溶液的方法包括以下步骤：用包含一价阳离子和一价阴离子的水溶液的离子试剂处理丝或丝茧，所述阳离子和阴离子的离子半径至少为1.05埃， Jones-Dole B系数在25℃在-0.001和-0.05之间。 然后使经处理的丝或丝茧脱胶; 或者脱胶丝或丝茧; 并随后用包含一价阳离子和一价阴离子水溶液的离子试剂处理脱胶的丝或丝茧，阳离子和阴离子的离子半径至少为1.05埃，琼斯 - 多尔B系数在-0.001-0.05之间 在25℃下。本发明还延伸到丝心蛋白溶液，丝心蛋白材料和用于软骨修复的植入物。
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公开(公告)号：US09539154B2
公开(公告)日：2017-01-10
申请号：US14238307
申请日：2012-08-10
CPC分类号： A61F13/511 , A61F2/06 , A61F13/5116 , A61F2013/00238 , A61F2013/51139 , A61L27/3604 , A61L27/507 , A61L31/005 , A61M1/3655
摘要： The present invention relates to a medical device, particularly a vascular graft or an arteriovenous (AV) graft for haemodialysis. The medical device comprises a layer of porous silk fibroin matrix and a layer of knitted silk fibers. The invention further relates to processes of manufacture of such medical devices and methods of use of such devices.
摘要翻译： 本发明涉及用于血液透析的医疗装置，特别是血管移植物或动静脉（AV）移植物。 该医疗装置包括一层多孔丝素蛋白基质和一层针织丝纤维。 本发明还涉及这种医疗装置的制造方法和这种装置的使用方法。
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公开(公告)号：US06858168B1
公开(公告)日：2005-02-22
申请号：US10148101
申请日：2000-11-24
摘要： An apparatus and method for forming liquid spinning solution into a solid formed product whereby the solution is passed through at least one tubular passage (17) having walls formed at least partly of semipermeable and/or porous material. The semipermeable and/or porous material allows parameters, such as the concentration of hydrogen ions, water, salts and low molecular weight, of the liquid spinning solution to be altered as the spinning solution passes through the tubular passage(s).
摘要翻译： 一种用于将液体纺丝溶液形成固体成形产品的装置和方法，由此溶液通过至少一个具有至少部分由半透性和/或多孔材料形成的壁的管状通道（17）。 半透膜和/或多孔材料允许随纺丝溶液通过管状通道而改变液体纺丝溶液的参数，例如氢离子，水，盐和低分子量的浓度。
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公开(公告)号：US08911761B2
公开(公告)日：2014-12-16
申请号：US11515922
申请日：2006-09-05
申请人： David Philip Knight
发明人： David Philip Knight
IPC分类号： A61F2/00 , C07K14/435 , A61L27/48
CPC分类号： C07K14/43518 , A61L27/48 , C07K14/43586 , C08L89/00
摘要： This application discloses a composite material comprising one or more silk elements in an acrylic or cross-linked protein matrix. The silk elements are made from the group of silk elements consisting of domestic silkworm silk, wild silkworm silk, spider dragline silk, and filaments spun from recombinant silk protein or protein analogs. The composite material is particularly useful for use in-surgical-implants.
摘要翻译： 本申请公开了一种在丙烯酸或交联蛋白质基质中包含一种或多种丝素的复合材料。 丝绸元素由家蚕丝，野蚕丝，蜘蛛丝线丝，以及由重组丝蛋白或蛋白质类似物纺丝的丝组成。 复合材料特别适用于外科手术植入物。
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10.发明授权Methods and apparatus for enhanced growth of peripheral nerves and nervous tissue 有权增加周围神经和神经组织生长的方法和装置公开(公告)号：US08106014B2
公开(公告)日：2012-01-31
申请号：US11575268
申请日：2005-09-08
申请人： John Priestley , Von King , David Philip Knight , Nicholas James Vavasor Skaer , Jessica Hensman
发明人： John Priestley , Von King , David Philip Knight , Nicholas James Vavasor Skaer , Jessica Hensman
CPC分类号： A61L31/047 , A61L27/227 , A61L27/48 , A61L31/129 , A61L2430/32 , Y10T29/49826 , C08L89/00
摘要： A medical device comprises a tubular body having a lumen and a long axis; and a plurality of silk elements laid substantially parallel along the long axis of the lumen of the tubular body. A method of manufacturing the medical device comprises forming the tubular body and introducing the silk elements into the lumen of the tubular body so as to lie substantially parallel along the long axis of the lumen of the tubular body. The device can be used in a method for the regeneration of nerve cells comprising the implantation of a medical device at a site for regeneration of nerves.
摘要翻译： 医疗装置包括具有内腔和长轴的管状体; 以及沿着管状体的内腔的长轴大致平行放置的多个丝元件。 制造医疗装置的方法包括形成管状体并将丝状元件引入管状体的内腔，以便沿着管状体的内腔的长轴基本上平行。 该装置可用于神经细胞再生的方法，包括在用于神经再生的部位植入医疗装置。
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