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公开(公告)号：US20240335510A1
公开(公告)日：2024-10-10
申请号：US18746819
申请日：2024-06-18
申请人： CENTRE HOSPITALIER UNIVERSITAIRE DE NIMES , HUMANITAS MIRASOLE SPA , The University of Sussex , King's College London , Queen Mary University of London , Sorbonne Universite , Assistance Publique-Hopitaux De Paris , The University of Sheffield
发明人： Gilbert Bensimon , Peter Nigel Leigh , Timothy Tree , Cecilia Garlanda , Massimo Locati , Janine Kirby , Pamela Shaw , Andrea Malaspina
IPC分类号： A61K38/20 , A61K31/428 , A61P25/28
CPC分类号： A61K38/2013 , A61K31/428 , A61P25/28
摘要： The present invention is in the field of amyotrophic lateral sclerosis (ALS) and relates to human interleukin-2 (IL-2) for use in the treatment of amyotrophic lateral sclerosis in a human subject, wherein each dose of human IL-2 administered to said subject is between 0.1×106 to 3×106 international units (IU). Human IL-2 is preferably administered in cycles of 3 to 7 days of once-daily sub-cutaneous injection of 0.1×106 to 3×106 IU human IL-2. The treatment does not comprise the administration of regulatory T cells to the subject, who is preferably also under riluzole treatment. The administered human IL-2 is preferably not complexed with anti-hIL-2 antibodies and the treatment also preferably does not comprise the administration of rapamycin or any other suppressive agent of effector T cells (Teffs) to the subject. The treatment permits to decrease plasma CCL2 concentration and to change the polarization of blood macrophages from an M1 inflammatory phenotype to an anti-inflammatory M2 phenotype involved in tissue repair.
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公开(公告)号：US20240270792A1
公开(公告)日：2024-08-15
申请号：US18567846
申请日：2021-06-11
摘要： The present invention relates to novel short antimicrobial peptides derived from SHf, to pharmaceutical compositions comprising said peptides and to the uses thereof, in particular as medicament, disinfectant, preservative, agent preventing biofilm formation or pesticide.
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公开(公告)号：US12037362B2
公开(公告)日：2024-07-16
申请号：US16981086
申请日：2019-04-04
申请人： Genethon , Institut National de la Sante et de la Recherche Medicale , Universite d'Evry Val d'Essonne , Sorbonne Universite , Association Institut de Myologie
IPC分类号： C07K14/005 , A61K48/00 , A61P25/28 , C07K14/075 , C12N7/00 , C12N9/22 , C12N15/11 , C12N15/86
CPC分类号： C07K14/005 , A61P25/28 , C07K14/075 , C12N7/00 , C12N9/22 , C12N15/111 , C12N15/86 , A61K48/00 , C12N2310/20 , C12N2750/14121 , C12N2750/14122 , C12N2750/14143 , C12N2750/14152 , C12N2750/14171
摘要： The invention relates to a recombinant adeno-associated virus (AAV) capsid protein, which is a hybrid between AAV serotype 9 (AAV9) and AAV serotype 74 (AAVrh74) capsid proteins, wherein said recombinant hybrid AAV capsid protein has a reduced liver tropism compared to the parent AAV9 and AAVrh74 capsid proteins. The invention relates also to the derived hybrid AAV serotype vector particles packaging a gene of interest and their use in gene therapy, in particular for treating neuromuscular genetic diseases.
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4.发明公开公开(公告)号：US20240228727A1
公开(公告)日：2024-07-11
申请号：US18408255
申请日：2024-01-09
申请人： Protein Evolution Inc. , PARIS SCIENCES ET LETTRES , Centre National de la Recherche Scientifique , ECOLE SUPERIEURE DE PHYSIQUE ET DE CHIMIE INDUSTRIELLES DE LA VILLE DE PARIS , SORBONNE UNIVERSITE
发明人： Ludwik Leibler , François Tournilhac , Clément Freymond , Hernan Garate , Louise Bréloy , Andrew Griffiths , Yannick Rondelez , Brian Mansaku , Jack Pallis , Benjamin Gibbs
IPC分类号： C08J11/10
CPC分类号： C08J11/105
摘要： Systems, methods, and compositions relating to pretreatment and enzymatic degradation of polymeric materials comprising one or more crystallizable polymers or copolymers are generally described. Certain aspects are directed to methods comprising reacting a polymeric material comprising a crystallizable polymer or copolymer with a reactive agent to produce a pretreated polymeric material and exposing the pretreated polymeric material to a polymer-degrading enzyme. In some embodiments, the reactive agent induces chain extension, branching, and/or cross-linking of the crystallizable polymer or copolymer. In some embodiments, the reactive agent induces chain scissions followed by chain extension, branching, and/or cross-linking of the crystallizable polymer or copolymer. In some cases, the methods further comprise a thermal annealing step following the step of reacting the polymeric material comprising the crystallizable polymer or copolymer with the reactive agent and prior to the step of exposing the pretreated polymeric material to the polymer-degrading enzyme. During the thermal annealing step, further chain reactions (e.g., chain scission, extension, branching, and/or cross-linking) may occur.
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公开(公告)号：US12023366B2
公开(公告)日：2024-07-02
申请号：US17000867
申请日：2020-08-24
申请人： GENETHON , ROYAL HOLLOWAY AND BEDFORD NEW COLLEGE , ASSOCIATION INSTITUT DE MYOLOGIE , INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE , CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE , SORBONNE UNIVERSITE , CENTRE HOSPITALIER UNIVERSITAIRE DE NANTES , NANTES UNIVERSITE
CPC分类号： A61K38/1719 , A61K48/005 , A61K48/0058 , A61K48/0075 , C12N7/00 , C12N15/86 , C12N2750/14132 , C12N2750/14143 , C12N2750/14171 , C12N2840/007
摘要： A composition comprising a gene therapy product for use in the treatment of a dystrophic disease in a subject, advantageously in humans, wherein:
the gene therapy product comprises a nucleic acid sequence encoding a functional microdystrophin;
the composition is systemically administered.-
公开(公告)号：US20240198121A1
公开(公告)日：2024-06-20
申请号：US18287328
申请日：2021-04-28
申请人： SORBONN EUNIVERSITE , ASSISTANCE PUBLIQUE - HOPITAUX DE PARIS , CENTRE NATIONAL DE LARECHERCHE SCIENTIFIQUE , INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE-I.N.S.E.R.M. , ECOLE POLYTECHNIQUE
发明人： Thierry DUFOUR , Laura FOUASSIER , Marine CAMUS , Henri DECAUCHY
IPC分类号： A61N1/44
CPC分类号： A61N1/44
摘要： A tool for generating a plasma, the tool having at least one instrument, the instrument having at least a power supply electrode, an internal dielectric screen, a counter electrode, and a sheath. A device that has such a tool.
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公开(公告)号：US20240159655A1
公开(公告)日：2024-05-16
申请号：US18282176
申请日：2022-02-23
申请人： SAFRAN , CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE , SORBONNE UNIVERSITE , ECOLE NATIONALE SUPERIEURE D'ARTS ET METIERS (ENSAM) , CONSERVATOIRE NATIONAL DES ARTS ET METIERS
IPC分类号： G01N21/17
CPC分类号： G01N21/1702 , G01N2021/1706
摘要： A method for focusing acoustic waves on an interface between two layers of a multilayer structure includes providing laser means able to emit a laser beam toward an exterior surface of the multilayer structure to produce a longitudinal wave from the centre of a laser-beam spot projected onto the exterior surface and a transverse wave from the periphery of said spot, determining the distance between said interface and the exterior surface, determining one or more propagation velocities of each of the longitudinal wave and the transverse wave in the one or more layers passed through by said waves to reach said interface, and determining a radius of the laser-beam spot depending on the one or more propagation velocities and on said distance so that the time taken by the longitudinal wave to reach said interface is equal to three times the time taken by the transverse wave to reach said interface.
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公开(公告)号：US20240130358A1
公开(公告)日：2024-04-25
申请号：US18403061
申请日：2024-01-03
申请人： SORIN GROUP ITALIA S.R.L. , SORBONNE UNIVERSITE , INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE , ASSISTNCE PUBLIQUE- HOPTAUX DE PARIS
IPC分类号： A01N1/02
CPC分类号： A01N1/0247 , A01N1/021 , A01N1/0284
摘要： An organ perfusion and preservation system for use in preserving an organ from a donor, may include a fluid reservoir, a heat exchanger in fluid communication with the fluid reservoir and configured to selectively raise and lower a temperature of a perfusion fluid, an oxygenator configured to oxygenate the perfusion fluid, an inflow pump in fluid communication with the fluid reservoir and the oxygenator, a fluid inflow line configured to transport perfusion fluid from the oxygenator to the organ, a fluid outflow line configured to transport perfusion fluid away from the organ and back to the reservoir, an outflow pump in fluid communication with the fluid outflow line and the fluid reservoir, and a controller operatively connected to the inflow pump, the outflow pump, and the heat exchanger, wherein the controller is configured to select parameters to reversibly heat and reversibly cool the organ.
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公开(公告)号：US20240043867A1
公开(公告)日：2024-02-08
申请号：US18058283
申请日：2022-11-23
申请人： GENETHON , SORBONNE UNIVERSITE
IPC分类号： C12N15/86 , A61K35/34 , A61K35/407
CPC分类号： C12N15/86 , A61K35/34 , A61K35/407 , C12N2510/00 , C12N2750/14143 , C12Y302/0102
摘要： The present invention relates to variants of acid-alpha glucosidase and uses thereof.
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10.发明公开公开(公告)号：US20240036060A1
公开(公告)日：2024-02-01
申请号：US18247718
申请日：2021-10-11
申请人： INSTITUT PASTEUR , ASSISTANCE PUBLIQUE - HOPITAUX DE PARIS , SORBONNE UNIVERSITE , BIO-RAD EUROPE GMBH
发明人： Jean-Marc CAVAILLON , Laetitia VELLY , Pierre HAUSFATER , Catherine FITTING , Stevenn VOLANT , Florian SALIPANTE , Lionel VALERA , Jeannette FAREH
IPC分类号： G01N33/68
CPC分类号： G01N33/6893 , G01N2800/26
摘要： The present invention allows a rapid and early diagnosis of bacterial or viral infection. Such a diagnosis is highly desired among patients admitted in emergency department to allow the initiation of the appropriate treatment. Although no biomarker alone can offer an appropriate diagnosis with sufficient sensitivity and specificity, the present invention defines optimal combinations of biomarkers allowing the diagnosis of infection.
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