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公开(公告)号：US20240341803A1
公开(公告)日：2024-10-17
申请号：US18756246
申请日：2024-06-27
发明人： Jenna Gorlewicz , Nnaoma Agwu , Kyle Deprow , Eric Leuthardt
CPC分类号： A61B17/3403 , A61B17/3421 , A61B17/3478 , A61B2017/00331 , A61B2017/00991
摘要： The present disclosure generally relates to systems and methods for guiding surgical tools to a surgical site, and more particularly, to systems and methods for guiding a tool sheath of a delivery system to a surgical site such as a location in a subject's brain and associated surgical procedures.
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公开(公告)号：US20240279236A1
公开(公告)日：2024-08-22
申请号：US18559471
申请日：2022-05-09
IPC分类号： C07D495/04 , A61K31/519 , A61K31/5377 , A61K31/541 , A61K31/695 , A61K45/06 , A61P31/06 , C07D513/04 , C07D519/00 , C07F7/08
CPC分类号： C07D495/04 , A61K31/519 , A61K31/5377 , A61K31/541 , A61K31/695 , A61K45/06 , A61P31/06 , C07D513/04 , C07D519/00 , C07F7/0812
摘要： The present disclosure relates to various compounds and compositions which are useful for the treatment of tuberculosis and other diseases such as infections caused by Mycobacterium tuberculosis. The present disclosure also relates to various methods of using these compounds and compositions to treat tuberculosis and other diseases such as infections caused by Mycobacterium tuberculosis. Further, the present disclosure relates to processes of preparing these compounds and compositions.
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公开(公告)号：US12037327B2
公开(公告)日：2024-07-16
申请号：US17052584
申请日：2019-05-03
IPC分类号： C07D407/04 , A61K31/135 , A61K31/136 , A61K31/137 , A61K45/06 , C07D213/38 , C07D307/52 , C07D333/20 , G01N33/50 , G01N21/64
CPC分类号： C07D407/04 , A61K45/06 , C07D213/38 , C07D307/52 , C07D333/20 , G01N33/502 , G01N21/64
摘要： In one aspect, the present disclosure provides compounds of the formula (I): In other aspects, the present disclosure provides compositions and methods of targeting GPER for the treatment of cancers, such as breast cancers and leukemias, gallstone disease, cardiovascular disease, and for conferring of neuroprotection on a subject. Also disclosed are high throughput assays for identifying antagonists of GPER.
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公开(公告)号：US20240115264A1
公开(公告)日：2024-04-11
申请号：US18480631
申请日：2023-10-04
发明人： Ajay Kumar Jain
CPC分类号： A61B17/1114 , A61F2/2496 , A61B2017/1135 , A61F2002/045
摘要： A recirculation system for recirculating intestinal content within an intestinal tract of a subject including a recirculation pathway extending from a distal portion of the intestinal tract to a proximal portion of the intestinal tract forming a recirculation loop for recirculating the intestinal content through the proximal portion of the intestinal tract to increase nutrient absorption from the intestinal content. A bypass pathway in fluid communication with the recirculation pathway and configured to divert the intestinal content from the recirculation pathway to continue along the intestinal tract.
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公开(公告)号：US20240100133A1
公开(公告)日：2024-03-28
申请号：US18363255
申请日：2023-08-01
发明人： Daniel F. HOFT , Valerio RASI
CPC分类号： A61K38/482 , A61P31/06 , C12N9/6467 , C12Y304/21078
摘要： The present disclosure is directed to recombinant mutant Granzyme A molecules that lack enzymatic activity and their use in inhibiting Mycobacterium tuberculosis and treating the related disease states.
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公开(公告)号：US20240041986A1
公开(公告)日：2024-02-08
申请号：US18028634
申请日：2021-10-05
发明人： Mary S. Morris , Richard J. DiPaolo
摘要： Methods of attenuating an antigenic response in a mammal to one or more Type 1 diabetes related-antigens are provided. The method may result in delaying the onset of decreased pancreatic beta cell function in the mammal and/or at least delaying a reduction in serum C-peptide levels in the mammal The method comprises sublingually administering an effective amount of an insulin-related peptide to the mammal and commonly makes use of a sublingual formulation of an insulin-related peptide that includes an aqueous pharmaceutically acceptable carrier, e.g., an aqueous carrier which comprises at least about 30 vol. % glycerin.
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公开(公告)号：US11890268B2
公开(公告)日：2024-02-06
申请号：US17046896
申请日：2019-04-10
IPC分类号： A61K31/381
CPC分类号： A61K31/381
摘要： In one aspect, the present disclosure provides a compound of the formula: (I) wherein the variables are as defined herein. In another aspect, the present disclosure also provides pharmaceutical compositions and methods of use of the compounds disclosed herein.
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公开(公告)号：US20220370566A1
公开(公告)日：2022-11-24
申请号：US17614035
申请日：2019-11-12
摘要： Disclosed are methods and compositions for treating cognitive decline in subjects in need. More specifically, disclosed are methods of administrating exogenous adropin to subjects suffering from, or at risk of, cognitive decline including the aged and those suffering from traumatic brain injury. Also disclosed are subjects who would benefit from such treatment and pharmaceutical acceptable compositions comprising adropin, adropin34-76, and derivatives or variations thereof.
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公开(公告)号：US20220267312A1
公开(公告)日：2022-08-25
申请号：US17578616
申请日：2022-01-19
申请人： Saint Louis University , United States Government as Represented by the Department of Veterans Affairs
发明人： John K. WALKER , Feng CAO , Terri BOEHM , Kinthada RAMAKUMAR
IPC分类号： C07D417/04 , C07D417/14 , C07D417/12 , A61P31/04
摘要： Provided herein are compounds of the formula: wherein the variables are as defined herein. Pharmaceutical compositions of the compounds are also provided. In some aspects, these compounds may be used for the treatment of diseases or disorders, such as an infection of an antibiotic resistant bacteria.
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公开(公告)号：US11420922B2
公开(公告)日：2022-08-23
申请号：US15735195
申请日：2016-06-10
IPC分类号： A61K31/675 , A61K31/122 , A61K31/7072 , A61K31/522 , A61K31/708 , A61K31/513 , A61K45/06 , A61K9/00 , A61P31/22 , C07C49/733 , C07C69/757 , C07C49/717 , A61K38/21
摘要： The present disclosure relates to inhibitors of herpesvirus nucleic acid metabolism and inhibitors of Hepatitis B virus. Also provided are methods of treatment using these agents.
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