公开(公告)号：US20190328894A1

公开(公告)日：2019-10-31

申请号：US16309577

申请日：2017-06-21

申请人： SEOUL NATIONAL UNIVERSITY R&DB FOUNDATION

发明人： Junho CHUNG ,  Junyeong JIN ,  Hyori KIM ,  Gunwoo PARK ,  Soohyun KIM

IPC分类号： A61K47/68 ,  C07K16/46 ,  A61K47/65 ,  A61P35/00 ,  A61K31/4188 ,  A61K31/407 ,  C07K16/28

摘要： The present invention relates to an antibody drug conjugate using a bispecific antibody and its use. The antibody drug conjugate of the present invention can easily form a conjugate of an antibody and a drug without a multistep synthetic process though binding of a conjugate of a bivalent cotinine-peptide and a drug, and an anti-cotinine single chain variable fragment. In addition, the antibody drug conjugate can effectively deliver a drug to a target to which the antibody binds specifically, and can enhance a half-life of a drug in the body, thereby improving a therapeutic effect.

公开(公告)号：US20240362343A1

公开(公告)日：2024-10-31

申请号：US18396342

申请日：2023-12-26

申请人： SAMSUNG ELECTRONICS CO., LTD.

发明人： HANBYEUL NA ,  SANGPYO KIM ,  JONGMIN KIM ,  JUNG HO AHN ,  DONG-MIN SHIN

IPC分类号： G06F21/60 ,  G06F5/06 ,  G06F7/523 ,  G06F21/78

CPC分类号： G06F21/602 ,  G06F5/06 ,  G06F7/523 ,  G06F21/78

摘要： A homomorphic operation system according to an embodiment includes a homomorphic encryption device configured to output a first ciphertext data generated based on a first base, a homomorphic encryption server including a storage device storing base conversion table configured to convert ciphertext data based on the first base into a second ciphertext data based on a second base and the first ciphertext data received from the homomorphic encryption device, and a homomorphic encryption operation device configured to perform a predetermined operation using the base conversion table on the first ciphertext data to convert the first ciphertext data into the second ciphertext data based on the second base.

公开(公告)号：US12122812B2

公开(公告)日：2024-10-22

申请号：US16979078

申请日：2019-03-05

申请人： SEOUL NATIONAL UNIVERSITY R&DB FOUNDATION

发明人： Byeong Moon Kim ,  Yan Lee ,  Eun Joung Choi ,  Dongwook Jung

IPC分类号： C07K1/13 ,  A61K47/60 ,  C07K14/505 ,  C07K19/00 ,  A61K38/00

CPC分类号： C07K14/505 ,  A61K47/60 ,  C07K19/00 ,  C12Y304/21001 ,  A61K38/00

摘要： Disclosed are a method for preparing a biomaterial having selectively functionalized tyrosine, a biomaterial having selectively functionalized tyrosine, and a pharmaceutical composition containing same as an active ingredient. The method for preparing a biomaterial to which a compound represented by chemical formula 2 is coupled, of the present invention, allows the compound represented by chemical formula 2 to be selectively coupled, in a high yield in a biomaterial, to tyrosine, which is present on the surface of an aqueous solution such that the coupling thereof to amino acids other than tyrosine does not occur and, when only one tyrosine is present, heterogeneous mixtures are not present and the inherent activity of the biomaterial is maintained, and thus the compound can be effectively used as a pharmaceutical composition containing a biomaterial drug as an active ingredient. In addition, the method can selectively functionalize tyrosine, and thus can be effectively used for tyrosine functionalization in a biomaterial.

公开(公告)号：US20240349512A1

公开(公告)日：2024-10-17

申请号：US18635072

申请日：2024-04-15

申请人： SEOUL NATIONAL UNIVERSITY R&DB FOUNDATION

发明人： Jae-Joon KIM ,  Munhyeon KIM

IPC分类号： H10B53/30

CPC分类号： H10B53/30

摘要： A memory using ferroelectric metal field-effect transistors includes a drain, a source, and a gate formed on a substrate, a gate contact formed on an upper portion of the gate, and a ferroelectric layer disposed between the gate contact and the gate and configured to surround the gate contact, wherein the gate, the ferroelectric layer, and the gate contact operate as a capacitor having a metal-ferroelectric layer-metal (MFM) structure.

公开(公告)号：US20240349477A1

公开(公告)日：2024-10-17

申请号：US18635211

申请日：2024-04-15

申请人： SEOUL NATIONAL UNIVERSITY R&DB FOUNDATION

发明人： Jae-Joon KIM ,  Munhyeon KIM

IPC分类号： H10B12/00

CPC分类号： H10B12/00

摘要： A random access memory includes a first transistor including a first gate extending in a first direction, a second transistor including a second gate extending in a second direction perpendicular to the first direction and formed on an upper portion of the first transistor, and a storage node configured to connect a first gate of the first transistor to a drain of the second transistor and storing data.

公开(公告)号：US20240347105A1

公开(公告)日：2024-10-17

申请号：US18635268

申请日：2024-04-15

申请人： SEOUL NATIONAL UNIVERSITY R&DB FOUNDATION

发明人： Jae-Joon KIM ,  Munhyeon KIM

IPC分类号： G11C11/419 ,  G11C5/06 ,  H01L29/06 ,  H01L29/417 ,  H01L29/423 ,  H01L29/66 ,  H01L29/775 ,  H01L29/786 ,  H10B10/00

CPC分类号： G11C11/419 ,  G11C5/063 ,  H01L29/0673 ,  H01L29/41733 ,  H01L29/42392 ,  H01L29/66439 ,  H01L29/775 ,  H01L29/78696 ,  H10B10/125

摘要： A random access memory includes a first transistor including a first gate extending in a first direction, a second transistor disposed on a same plane as the first transistor and including a second gate extending in the first direction, a third transistor including a third gate extending in a second direction perpendicular to the first direction and formed on the first transistor, a fourth transistor including a fourth gate extending in the second direction and formed on the second transistor, a first storage node connecting the first gate of the first transistor to a drain of the third transistor and storing data, and a second storage node connecting the second gate of the second transistor to a drain of the fourth transistor and storing data.

公开(公告)号：US12117985B2

公开(公告)日：2024-10-15

申请号：US17879511

申请日：2022-08-02

申请人： Samsung Electronics Co., Ltd.

发明人： Jin-Soo Kim ,  Jaehoon Shim ,  Carl Duffy

IPC分类号： G06F16/22 ,  G06F16/901

CPC分类号： G06F16/2246 ,  G06F16/9027

摘要： A host, a storage system, and an operating method of the host are provided. The host includes a host memory configured to store a tree structure including a leaf node and an index node, an index management module configured to manage an index based on the tree structure and generate a first log corresponding to the leaf node based on a first update request corresponding to a first key-value entry included in the leaf node, and a device driver configured to generate a first write command corresponding to the first log and transmit the generated first write command to a key-value storage device, so as to store the first log in the key-value storage device. The index management module is configured to generate a first new key-value entry, the first new-key value entry including a first value updated based on the first update request, as the first log.

公开(公告)号：US20240336690A1

公开(公告)日：2024-10-10

申请号：US18293425

申请日：2022-08-01

申请人： SEOUL NATIONAL UNIVERSITY R&DB FOUNDATION ,  EWHA UNIVERSITY-INDUSTRY COLLABORATION FOUNDATION

发明人： JUN HO CHUNG ,  KYUNG HO CHOI ,  SANG IL KIM ,  YOUNG JAE LEE ,  SU JEONG KIM ,  SEO RYEONG PARK ,  SI WON HWANG ,  DONG MIN KANG ,  SU REE KIM

IPC分类号： C07K16/28 ,  A61K47/68

CPC分类号： C07K16/2875 ,  A61K47/6803 ,  A61K47/68031 ,  A61K47/6849 ,  C07K2317/622 ,  C07K2317/76

摘要： An antibody binds to CD154. The antibody includes HCDR, which includes amino acid sequences of SEQ ID NOs: 1 to 3, and LCDR which includes amino acid sequences of SEQ ID NOs: 4 to 6. A composition including an antibody-drug conjugate in which a drug is conjugated to the antibody may prevent or treat a T cell-mediated autoimmune disease and/or organ transplant rejection.

公开(公告)号：US20240321067A1

公开(公告)日：2024-09-26

申请号：US18612259

申请日：2024-03-21

申请人： POSTECH RESEARCH AND BUSINESS DEVELOPMENT FOUNDATION ,  Seoul National University R&DB Foundation

发明人： Moon Jeong Park ,  Yong-Lae Park ,  Myungsun Park ,  HYEON SEONG HAM

IPC分类号： G08B6/00 ,  G01L1/22

CPC分类号： G08B6/00 ,  G01L1/2287

摘要： Haptic interaction system remotely operated by human hand through real-time haptic feedback, and a sensor-integrated iEAP actuator included in the system are provided, in which when a gripper including the sensor-integrated iEAP actuator that operates in conjunction with the user's finger movements comes into contact with an object, changes in signal of the sensor included in the sensor-integrated iEAP actuator are transmitted to the user as haptic feedback in real time, thereby enabling stable gripping without a visual sensor.

公开(公告)号：US20240311145A1

公开(公告)日：2024-09-19

申请号：US18596194

申请日：2024-03-05

申请人： SEOUL NATIONAL UNIVERSITY R&DB FOUNDATION ,  RESEARCH & BUSINESS FOUNDATION SUNGKYUNKWAN UNIVERSITY

发明人： Yunheung PAEK ,  Hyungjoon KOO ,  Sunwoo AHN ,  Seonggwan AHN

IPC分类号： G06F8/75

CPC分类号： G06F8/751

摘要： A binary code similarity detection device performs a preprocessing operation of generating an assembly expression for the binary code by converting a machine language of an input binary code into an assembly language, extracting an assembly function or a command from the binary code converted to the assembly language, and detects a similarity to the assembly expression of a pre-stored binary code by inputting the assembly expression generated by the preprocessing operation to a trained model based on bidirectional encoder representations from transformers (BERT), and the trained model is generated by performing a pre-training step of causing the assembly expression to be understood and a fine-tuning step of inputting an assembly expression of a first binary code and an assembly expression of a second binary code to a pre-trained model and then fine-tuning the pre-trained model based on a similarity between the first binary code and the second binary code.