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6 条记录 (耗时 0.015 秒)

    Sample holder for surface plasmon resonance measuring instruments
    1.
    发明授权
    Sample holder for surface plasmon resonance measuring instruments 有权
    表面等离子体共振测量仪器的样品架

    公开(公告)号：US07846396B2

    公开(公告)日：2010-12-07

    申请号：US11141167

    申请日：2005-05-31

    申请人： Daniel B. Roitman ,  Gregory D. VanWiggeren

    发明人： Daniel B. Roitman ,  Gregory D. VanWiggeren

    IPC分类号： B01L3/00

    CPC分类号： G01N21/553 ,  B01L3/5085 ,  B01L3/5088 ,  B01L2300/0822 ,  B01L2300/161 ,  B82Y20/00 ,  G02B5/008 ,  Y10T436/24 ,  Y10T436/25

    摘要： A droplet sample holder, especially a sample holder for use in a measuring instrument utilizing surface plasmon resonance. The sample holder reduces or minimizes the measurement distortion result of the droplet “pherpheral concentration effect” by surrounding the analysis zone with a wettable (hydrophilic) zone that captures the periphery of the droplet to keep the pheriphery of the droplet and the increased concentration of the analyte out of the analysis zone. The wettable zone is surrounded by a nonwettable (hydrophobic) zone that restricts the periphery of the droplet to analysis zone and the wettable zone.

    摘要翻译： 液滴样品架，特别是用于使用表面等离子体共振的测量仪器中的样品架。 样品架通过用可捕获液滴的周边的可湿性（亲水性）区围绕分析区来降低或最小化液滴“pherpheral浓度效应”的测量失真结果，以保持液滴的浓度，并且增加浓度 分析出分析区。 可湿润区域被不可润湿（疏水）区域围绕，该区域将液滴的周边限制到分析区域和可湿性区域。

    Oscillating sensor and fluid sample analysis using an oscillating sensor
    2.
    发明授权
    Oscillating sensor and fluid sample analysis using an oscillating sensor 有权
    振荡传感器和使用振荡传感器的流体样品分析

    公开(公告)号：US07975530B2

    公开(公告)日：2011-07-12

    申请号：US12882658

    申请日：2010-09-15

    申请人： Christopher D. Whalen ,  Klaus Wiehler ,  Sven Kelling

    发明人： Christopher D. Whalen ,  Klaus Wiehler ,  Sven Kelling

    IPC分类号： G01N29/27 ,  G01N29/032

    CPC分类号： G01N29/222 ,  B01L3/502776 ,  B01L2200/146 ,  B01L2300/0627 ,  B01L2300/0877 ,  B01L2300/14 ,  G01N29/022 ,  G01N2291/02466 ,  Y10T29/49002 ,  Y10T29/49826

    摘要： An assembly design for an oscillating resonator-based sensor where an oscillating crystal resonator such as a quartz crystal resonator is rigidly affixed or ‘mounted’ onto a solid substrate in such a fashion that the resonator can either rest flush against the substrate surface or upon a rigid mounting adhesive. Once cured, the mounting adhesive forms a liquid tight seal between the mounted resonator and the substrate such that only the sensing electrode surface will be exposed to fluids applied to the front side of the substrate. The mounted resonator assembly is designed in such a way that it can be interfaced with a fluid delivery system to form a liquid tight chamber or flow cell around the mounted resonator without incurring additional physical impact upon the mounted resonator. The assembled flow cell can in turn be used to direct multiple fluid streams to flow in a laminar manner over the sensing surface of the mounted resonator and by varying the rates of flow for the different laminar flowing fluid streams the total hydraulic pressure exerted on the surface of the mounted resonator can be held constant.

    摘要翻译： 用于基于振荡谐振器的传感器的组装设计，其中诸如石英晶体谐振器的振荡晶体谐振器以这样的方式刚性地固定或“安装”到固体衬底上，使得谐振器可以保持与衬底表面齐平或者在一个 刚性安装胶。 一旦固化，安装粘合剂在安装的谐振器和基板之间形成液密密封，使得只有感测电极表面将暴露于施加到基板的前侧的流体。 安装的谐振器组件被设计成使得其可以与流体输送系统接口以在安装的谐振器周围形成液体密封室或流动池，而不会对安装的谐振器造成额外的物理冲击。 组装的流通池又可用于引导多个流体流以层流方式流过安装的谐振器的感测表面，并且通过改变不同层流流体流的流速来施加在表面上的总液压 安装的谐振器可以保持恒定。

    Oscillating sensor and fluid sample analysis using an oscillating sensor
    3.
    发明授权
    Oscillating sensor and fluid sample analysis using an oscillating sensor 有权
    振荡传感器和使用振荡传感器的流体样品分析

    公开(公告)号：US07802466B2

    公开(公告)日：2010-09-28

    申请号：US11946338

    申请日：2007-11-28

    申请人： Christopher D. Whalen ,  Klaus Wiehler ,  Sven Kelling

    发明人： Christopher D. Whalen ,  Klaus Wiehler ,  Sven Kelling

    IPC分类号： G01N29/27 ,  G01N29/032

    CPC分类号： G01N29/222 ,  B01L3/502776 ,  B01L2200/146 ,  B01L2300/0627 ,  B01L2300/0877 ,  B01L2300/14 ,  G01N29/022 ,  G01N2291/02466 ,  Y10T29/49002 ,  Y10T29/49826

    摘要： An assembly design for an oscillating resonator-based sensor where an oscillating crystal resonator such as a quartz crystal resonator is rigidly affixed or ‘mounted’ onto a solid substrate in such a fashion that the resonator can either rest flush against the substrate surface or upon a rigid mounting adhesive. Once cured, the mounting adhesive forms a liquid tight seal between the mounted resonator and the substrate such that only the sensing electrode surface will be exposed to fluids applied to the front side of the substrate. The mounted resonator assembly is designed in such a way that it can be interfaced with a fluid delivery system to form a liquid tight chamber or flow cell around the mounted resonator without incurring additional physical impact upon the mounted resonator. The assembled flow cell can in turn be used to direct multiple fluid streams to flow in a laminar manner over the sensing surface of the mounted resonator and by varying the rates of flow for the different laminar flowing fluid streams the total hydraulic pressure exerted on the surface of the mounted resonator can be held constant.

    摘要翻译： 用于基于振荡谐振器的传感器的组装设计，其中诸如石英晶体谐振器的振荡晶体谐振器以这样的方式刚性地固定或“安装”到固体衬底上，使得谐振器可以保持与衬底表面齐平或者在一个 刚性安装胶。 一旦固化，安装粘合剂在安装的谐振器和基板之间形成液密密封，使得只有感测电极表面将暴露于施加到基板的前侧的流体。 安装的谐振器组件被设计成使得其可以与流体输送系统接口以在安装的谐振器周围形成液体密封室或流动池，而不会对安装的谐振器造成额外的物理冲击。 组装的流通池又可用于引导多个流体流以层流方式流过安装的谐振器的感测表面，并且通过改变不同层流流体流的流速来施加在表面上的总液压 安装的谐振器可以保持恒定。

    Hydrodynamic isolation method and apparatus
    4.
    发明授权
    Hydrodynamic isolation method and apparatus 有权
    流体动力学隔离方法及装置

    公开(公告)号：US08728398B2

    公开(公告)日：2014-05-20

    申请号：US12964936

    申请日：2010-12-10

    申请人： Christopher D. Whalen

    发明人： Christopher D. Whalen

    IPC分类号： B01L3/00 ,  G01N33/00

    CPC分类号： B01L3/502761 ,  B01L3/5025 ,  B01L2200/0636 ,  B01L2200/141 ,  B01L2300/0816 ,  B01L2300/0819 ,  B01L2300/0874 ,  B01L2300/0877 ,  Y10T436/11 ,  Y10T436/117497 ,  Y10T436/118339 ,  Y10T436/25 ,  Y10T436/2575

    摘要： The present invention is a flow cell and method for use in microfluidic analyses that presents highly discrete and small volumes of fluid to isolated locations on a two-dimensional surface contained within an open fluidic chamber defined by the flow cell that has physical dimensions such that laminar style flow occurs for fluids flowing through the chamber. This process of location specific fluid addressing within the flow cell is facilitated by combining components of hydrodynamic focusing with site specific cell evacuation. The process does not require the use of physical barriers within the flow cell or mechanical valves to control the paths of fluid movement.

    摘要翻译： 本发明是一种用于微流体分析的流动池和方法，其将高度离散和小体积的流体呈现在包含在由流动池限定的开放流体室内的二维表面上的隔离位置上，该二维表面具有物理尺寸，使得层流 发生流经腔室的流体的风流。 通过将流体动力学聚焦的组分与位点特异性细胞排出组合来促进流动池内位置特异性流体寻址的这个过程。 该过程不需要在流动池或机械阀门内使用物理屏障来控制流体运动的路径。