公开(公告)号：US20140113263A1

公开(公告)日：2014-04-24

申请号：US13656688

申请日：2012-10-20

申请人： Bruce Jarrell ,  Sergei Nirenburg ,  Marjorie Joan McShane ,  Stephen Beale ,  George Fantry

发明人： Bruce Jarrell ,  Sergei Nirenburg ,  Marjorie Joan McShane ,  Stephen Beale ,  George Fantry

IPC分类号： G09B19/00

CPC分类号： G09B19/00 ,  G09B23/28

摘要： A method and apparatus for a clinical simulation system targets psychological phenomena that can negatively impact the decision making of both a clinician and a patient. Techniques include identifying an independently reasoning agent in a medical clinical information processing system configured to simulate interactions between a clinician and a patient. The method also includes determining, on the system, psychological profile data that indicates one or more personality traits for the agent. The method further includes storing psychological profile data on the system in a hierarchical data structure for a natural language processing system. The method still further includes determining simulation output from the system based at least in part on the psychological profile data.

摘要翻译： 用于临床模拟系统的方法和装置针对可能对临床医师和患者的决策产生不利影响的心理现象。 技术包括在被配置为模拟临床医生和患者之间的相互作用的医疗临床信息处理系统中识别独立推理剂。 该方法还包括在系统上确定指示代理人的一个或多个人格特征的心理简档数据。 该方法还包括在自然语言处理系统的分层数据结构中在系统上存储心理简档数据。 该方法还包括至少部分地基于心理简档数据来确定来自系统的模拟输出。

公开(公告)号：US20230022767A1

公开(公告)日：2023-01-26

申请号：US17777654

申请日：2020-11-17

申请人： THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVIC ,  THE UNIVERSITY OF MARYLAND, BALTIMORE

发明人： Patrick Joseph Morris ,  Craig Joseph Thomas ,  Stephen J. Byard ,  Martin P. Wilmshurst ,  Todd Gould ,  Carlos Zarate ,  Ruin Moaddel

IPC分类号： C07C225/20

摘要： The disclosure provides salts of (2R,6R)-hydroxynorketamine (HNK), wherein the salt is with an organic acid chosen from malonic acid, salicylic acid, ethane sulfonic acid, glycolic acid, stearic acid, or capric acid, and their crystal forms.

公开(公告)号：US11285293B2

公开(公告)日：2022-03-29

申请号：US16216076

申请日：2018-12-11

申请人： The University of Maryland, Baltimore ,  The United States of America as represented by the Department of Veterans Affairs

发明人： Cha-Min Tang ,  Paul E. Bigeleisen ,  Samuel M. Galvagno, Jr. ,  Mark E. Shirtliff

IPC分类号： A61M25/00 ,  A61M25/04 ,  A61L29/06 ,  A61M27/00

摘要： A device disclosed herein includes a tubular member which is flexible and configured to receive ultraviolet (UV) light from a UV illumination coupler. The tubular member contains a lumen defining a longitudinal interior space within the tubular member, a tubular body bounded by an inner wall defining an outer boundary of the lumen and an outer wall defining an outer surface of the tubular member, at least one optical fiber disposed outside of the interior space not parallel to an axis of the lumen and adapted to receive the UV light from the UV illumination coupler, and a protective component adapted to prevent substantively all of the UV light emitted from the optical fiber from exiting the outer wall. Methods for producing and using such devices are also disclosed herein.

公开(公告)号：US10920194B2

公开(公告)日：2021-02-16

申请号：US15802845

申请日：2017-11-03

申请人： The University of Maryland, Baltimore ,  The United States of America as represented by the Department of Veterans Affairs

发明人： Thomas Hornyak ,  Sandeep Joshi

IPC分类号： C12N5/0797 ,  A61K35/36 ,  C12N5/079 ,  C12N5/071

摘要： Hair follicle bulge region/LLP region CD34(+) MeSCs can be isolated from mammalian skin bearing hair follicles. These cells are multipotent and retain the ability to differentiate into cells of neural crest lineage, including glia-like cells that express the glial marker Gfap, and are able to express myelin basic protein, and to remyelinate naked (unmyelinated or demyelinated) neuronal processes with a functional, dense myelin sheath. These cells of neural crest lineage can be used to produce a dense myelin sheath on neurons which lack myelin due to genetic defect, trauma, toxin, infection, or disease process. Therefore, embodiments of the invention provide methods for preparing such cells, the cells themselves and compositions containing the cells, as well as methods for using the cells.

公开(公告)号：US10571465B2

公开(公告)日：2020-02-25

申请号：US14965560

申请日：2015-12-10

申请人： The University of Maryland, Baltimore

发明人： Henryk Szmacinski ,  Joseph R. Lakowicz

IPC分类号： G01N33/543 ,  G01N33/553 ,  G01N21/64 ,  G01N21/27

摘要： Techniques for metal enhanced fluorescence include determining a calibration curve that relates concentration of a particular analyte to at least one of intensity or lifetime of fluorescent emissions at a plasmonic substrate in response to incident light, for a plurality of known concentrations of the particular analyte mixed with a reagent. The reagent comprises a detection molecule. A concentration of the particular analyte in a vicinity of a cell in a sample is determined directly from the calibration curve and measurements, in response to the incident light, of at least one of intensity or lifetime of fluorescent emissions at the plasmonic substrate in contact with the cell and reagent.

公开(公告)号：US10183144B2

公开(公告)日：2019-01-22

申请号：US14535296

申请日：2014-11-06

申请人： The University of Maryland, Baltimore ,  The United States of America as represented by the Department of Veterans Affairs

发明人： Cha-Min Tang ,  Paul E. Bigeleisen ,  Samuel M. Galvagno, Jr. ,  Mark E. Shirtliff

IPC分类号： A61M1/00 ,  A61M25/00 ,  A61L29/06

摘要： A device disclosed herein includes a tubular member which is flexible and configured to receive ultraviolet (UV) light from a UV illumination coupler. The tubular member contains a lumen defining a longitudinal interior space within the tubular member, a tubular body bounded by an inner wall defining an outer boundary of the lumen and an outer wall defining an outer surface of the tubular member, at least one optical fiber disposed outside of the interior space not parallel to an axis of the lumen and adapted to receive the UV light from the UV illumination coupler, and a protective component adapted to prevent substantively all of the UV light emitted from the optical fiber from exiting the outer wall. Methods for producing and using such devices are also disclosed herein.

公开(公告)号：US20180193666A1

公开(公告)日：2018-07-12

申请号：US15915420

申请日：2018-03-08

申请人： Hao H. Zhang ,  Warren D. D'Souza ,  Nilesh N. Mistry ,  Hamid R. Ghaffari

发明人： Hao H. Zhang ,  Warren D. D'Souza ,  Nilesh N. Mistry ,  Hamid R. Ghaffari

IPC分类号： A61N5/10 ,  A61B6/03 ,  A61B5/055 ,  A61B6/00 ,  G16H30/40 ,  A61B5/00 ,  A61B5/08

CPC分类号： A61N5/1039 ,  A61B5/055 ,  A61B5/08 ,  A61B5/7278 ,  A61B5/743 ,  A61B6/032 ,  A61B6/037 ,  A61B6/486 ,  A61B6/5211 ,  A61B6/5235 ,  A61N5/1081 ,  G06F19/321 ,  G16H30/20 ,  G16H30/40

摘要： A method and apparatus for irradiation therapy using voxel based function measurements of organs-at-risk (OAR). The method includes determining size and location of each voxel of a plurality of voxels in a reference frame of a radiation device. The method further includes obtaining measurements that relate to utility of tissue type at each voxel. The method further includes determining a subset of the voxels that enclose an organ-at-risk (OAR) volume. The method further includes determining a value of a utility measure fj at each voxel of the subset based on a corresponding value of the measurements. The method further includes determining a series of beam shapes and intensities which minimize a value of an objective function that is based on a computed dose delivered to an OAR voxel multiplied by the utility measure fj for that voxel summed over all voxels.

公开(公告)号：US09222558B2

公开(公告)日：2015-12-29

申请号：US14071989

申请日：2013-11-05

申请人： University of Maryland, Baltimore County

发明人： Weidong Zhu ,  Xuefeng Wang

IPC分类号： F16H29/00 ,  F16H29/20 ,  F16H29/04 ,  F16H21/14 ,  F16H21/20 ,  F16H19/04

CPC分类号： F16H29/20 ,  F16H19/043 ,  F16H21/14 ,  F16H21/20 ,  F16H29/04 ,  Y10T74/18408

摘要： A geared infinitely variable transmission (GIVT) to provide a continuous output-to-input speed ratio from zero to a certain value is designed, and its working principle is illustrated. Crank-slider systems are used in the GIVT; the output-to-input speed ratio is changed with the crank length. Racks and pinions, controlled by planetary gear sets, are used to change the crank length when the cranks are rotating. One-way bearings rectify the output speeds from different crank-slider systems to obtain the output speed of the GIVT. Noncircular gears are used to minimize variations since the crank-slider systems can introduce variations of the instantaneous speed ratio. A direction control system is provided using planetary gear sets.

摘要翻译： 设计了一种从零到一定值提供连续输出到输入速度比的齿轮无级变速器（GIVT），并说明了其工作原理。 GIVT中使用曲柄滑块系统; 输出转速比随曲柄长度变化。 由行星齿轮组控制的齿条和小齿轮用于在曲柄旋转时改变曲柄长度。 单向轴承整流不同曲柄滑块系统的输出速度，以获得GIVT的输出速度。 使用非圆形齿轮来最小化变化，因为曲柄滑块系统可以引入瞬时速度比的变化。 使用行星齿轮组提供方向控制系统。

公开(公告)号：US20150338402A1

公开(公告)日：2015-11-26

申请号：US14718479

申请日：2015-05-21

申请人： The University of Maryland, Baltimore

发明人： Joseph R. Lakowicz ,  Ramachandram Badugu

IPC分类号： G01N33/543 ,  G01N21/64

CPC分类号： G01N33/54373 ,  G01N21/6428 ,  G01N21/6456 ,  G01N21/648 ,  G01N2021/6439

摘要： Techniques for enhanced fluorescence include a Tamm substrate for a target optical frequency comprising a metal nanoscale layer deposited on a Bragg grating. The Bragg grating includes multiple dielectric layers including multiple high index of refraction layers alternating with multiple low index of refraction layers. The dielectric layers are parallel to the metal nanoscale layer; and, the thickness of each dielectric layer is about a fourth of a wavelength of the target optical frequency in the layer. The metal nanoscale layer is configured to host a fluorophore such that an S polarized emission from the fluorophore at the target optical frequency propagates out of the substrate perpendicular to the plurality of dielectric layers.

摘要翻译： 用于增强荧光的技术包括用于目标光学频率的Tamm衬底，其包括沉积在布拉格光栅上的金属纳米级层。 布拉格光栅包括多个介电层，包括与多个低折射率折射率层交替的多个高折射率折射层。 电介质层平行于金属纳米层; 并且每层介质层的厚度约为该层中目标光频波长的四分之一。 金属纳米层被配置为承载荧光团，使得来自目标光频率处的荧光团的S极化发射从垂直于多个电介质层的衬底传播出来。

公开(公告)号：US20140288036A1

公开(公告)日：2014-09-25

申请号：US14081910

申请日：2013-11-15

申请人： the University of Maryland, Baltimore

发明人： Angela Brodie ,  Vincent Njar

IPC分类号： C07J43/00

CPC分类号： A61K31/58 ,  C07J43/003

摘要： Described are steroidal C-17 benzoazoles, pyrimidinoazoles (azabenzoazoles) and diazines. Methods for their synthesis are also described, which include methods having a step of nucleophilic vinylic “addition-elimination” substitution reaction of 3β-acetoxy-17-chloro-16-formylandrosta-5,16-diene or analogs thereof and benzoazole or pyrimidinoazole nucleophiles and methods having a palladium catalyzed cross-coupling reaction of 17-iodoandrosta-5,16-dien-3β-ol or analogs thereof with tributylstannyl diazines. The compounds are potent inhibitors of human CYP17 enzyme as well as potent antagonists of both wild type and mutant androgen receptors (AR). The compounds are useful for the treatment of human prostate cancer.

摘要翻译： 描述的是甾体C-17苯并唑，嘧啶并唑（氮杂苯并唑）和二嗪。 还描述了它们的合成方法，其包括具有3'-乙酰氧基-17-氯-16-甲酰基雄甾-5,16-二烯或其类似物和苯并唑或嘧啶并咪唑的亲核乙烯基“加成 - 消除”取代反应步骤的方法 亲核试剂和方法具有钯催化的17-碘雄甾-5,16-二烯-3β-醇或其类似物与三丁基甲锡烷基二嗪的交叉偶联反应。 这些化合物是人CYP17酶的有效抑制剂，以及野生型和突变雄激素受体（AR）的有效拮抗剂。 该化合物可用于治疗人类前列腺癌。