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公开(公告)号：US12029594B2
公开(公告)日：2024-07-09
申请号：US17269986
申请日：2019-08-21
发明人： Uri Manor , Linjing Fang
CPC分类号： A61B6/4258 , A61B6/4035 , A61B6/5282 , A61B6/5288 , A61B6/542 , G06T11/00 , G06T2210/41
摘要： A method to, is provided for collecting an image from a sample. The method includes selecting a radiation level for a first probe to meet a desired radiation dosage, and providing, with the first probe, a radiation at a selected point within a region of the sample. The method includes identifying a second selected point within the region of the sample based on a down sampling scheme, and providing a second radiation amount at the second selected point within the region of the sample. The method also includes interpolating a first datum and a second datum based on an up sampling scheme to obtain a plurality of data, and forming an image of the region of the sample with the plurality of data. A system to perform the above method and including the first probe is also provided.
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公开(公告)号：US20210321963A1
公开(公告)日：2021-10-21
申请号：US17269986
申请日：2019-08-21
发明人： Uri MANOR , Linjing FANG
IPC分类号： A61B6/00
摘要： A method to, is provided for collecting an image from a sample. The method includes selecting a radiation level for a first probe to meet a desired radiation dosage, and providing, with the first probe, a radiation at a selected point within a region of the sample. The method includes identifying a second selected point within the region of the sample based on a down sampling scheme, and providing a second radiation amount at the second selected point within the region of the sample. The method also includes interpolating a first datum and a second datum based on an up sampling scheme to obtain a plurality of data, and forming an image of the region of the sample with the plurality of data. A system to perform the above method and including the first probe is also provided.
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公开(公告)号：US10891313B2
公开(公告)日：2021-01-12
申请号：US15879396
申请日：2018-01-24
发明人： Todd Prentice Coleman , Rui Ma , Sanggyun Kim , Cheolsoo Park , Ricardo Gil Da Costa , Raynard Fung , Diego Mesa
IPC分类号： A61B5/0484 , G06F16/28 , G06F16/2457 , A61B5/0482 , G16H10/20 , A61B5/00 , A61B5/0488 , A61B5/16
摘要： Methods, devices, and systems are disclosed for producing cognitive and/or sensory profiles. In one aspect, a method to provide a cognitive or sensory assessment of a subject includes selecting a profile category from among a cognitive performance profile, a sensory performance profile, and a cognitive and sensory performance profile, presenting a sequence of stimuli to a subject, the sequence of stimuli based on the selected profile category, acquiring physiological signals of the subject before, during, and after the presenting the sequence of stimuli to produce physiological data, and processing the physiological data to generate an information set including one or more quantitative values associated with the selected profile category.
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公开(公告)号：US20180305403A1
公开(公告)日：2018-10-25
申请号：US16022578
申请日：2018-06-28
发明人： Ronald M. Evans , Michael Downes
IPC分类号： C07K5/062 , C07D417/12 , C07C233/73 , C07D417/10 , C07D417/04 , C07D413/12 , C07D413/04 , C07D409/12 , C07D407/12 , C07D405/12 , C07D405/10 , C07D405/04 , C07D401/12 , C07D401/04 , C07D333/38 , C07D333/24 , C07D309/06 , C07D309/04 , C07D307/83 , C07D307/81 , C07D307/68 , C07D307/54 , C07D305/06 , C07D295/155 , C07D295/13 , C07D271/12 , C07D231/12 , C07D213/64 , C07D213/56 , C07D213/40 , C07D209/34 , C07D205/04 , C07C317/44 , C07C259/06 , C07C255/57 , C07C237/32 , C07C235/84 , C07C235/48 , C07C235/42 , C07C233/87 , C07C233/75
摘要： Provided herein are deuterated compounds and compositions useful in increasing PPARδ activity. The compounds have a formula where L5 comprises at least one deuterium. Exemplary species include The compounds and compositions provided herein are useful for the treatment of PPARδ related diseases (e.g., muscular diseases, vascular disease, demyelinating disease, and metabolic diseases).
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公开(公告)号：US20130251734A1
公开(公告)日：2013-09-26
申请号：US13790191
申请日：2013-03-08
IPC分类号： A61K39/395 , A61K31/4196 , A61K31/519
CPC分类号： A61K39/3955 , A61K31/4196 , A61K31/519 , Y02A50/385 , Y02A50/387 , Y02A50/393 , Y02A50/411
摘要： This disclosure concerns antimicrobial compositions and methods for immunoenhancement, for example methods of increasing production of a type I interferon (IFN) in response to pathogen infection, by administration of a TAM receptor inhibitor. In certain embodiments, the disclosure concerns methods of using a TAM receptor inhibitor to treat a viral or bacterial infection in a subject.
摘要翻译： 本公开涉及抗微生物组合物和免疫增强方法，例如通过施用TAM受体抑制剂增加I型干扰素（IFN）响应于病原体感染的产生的方法。 在某些实施方案中，本公开涉及使用TAM受体抑制剂治疗受试者的病毒或细菌感染的方法。
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公开(公告)号：US08415361B2
公开(公告)日：2013-04-09
申请号：US12741812
申请日：2008-11-07
IPC分类号： C07D471/04 , A61K31/41
CPC分类号： A61K39/3955 , A61K31/4196 , A61K31/519 , Y02A50/385 , Y02A50/387 , Y02A50/393 , Y02A50/411
摘要： This disclosure concerns antimicrobial compositions and methods for immunoenhancement, for example methods of increasing production of a type I interferon (IFN) in response to pathogen infection, by administration of a TAM receptor inhibitor. In certain embodiments, the disclosure concerns methods of using a TAM receptor inhibitor to treat a viral or bacterial infection in a subject.
摘要翻译： 本公开涉及抗微生物组合物和免疫增强方法，例如通过施用TAM受体抑制剂增加I型干扰素（IFN）响应于病原体感染的产生的方法。 在某些实施方案中，本公开涉及使用TAM受体抑制剂治疗受试者的病毒或细菌感染的方法。
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7.发明申请METHODS AND COMPOSITIONS FOR NMR SPECTROSCOPIC ANALYSIS USING ISOTOPIC LABELING SCHEMES 审中-公开使用同位素标记方案的NMR光谱分析的方法和组合物公开(公告)号：US20130078727A1
公开(公告)日：2013-03-28
申请号：US13604509
申请日：2012-09-05
CPC分类号： G01N24/087 , G06F17/00
摘要： Provided herein are methods and compositions for efficient accumulation of structural information (e.g., three dimensional structural information) for amino acid sequences.
摘要翻译： 本文提供了用于氨基酸序列的结构信息（例如，三维结构信息）的有效积累的方法和组合物。
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公开(公告)号：US08404247B2
公开(公告)日：2013-03-26
申请号：US13167627
申请日：2011-06-23
申请人： John Young , Anette Schneemann , Marianne Manchester , Kelly Dryden , John M. Marlett , Darly Joseph Manayani , Godfrey Jonah Anderson Rainey , Vijay Reddy , Marc E. Siladi , Heather M. Scobie , Diane Thomas , Mark Yeager
发明人： John Young , Anette Schneemann , Marianne Manchester , Kelly Dryden , John M. Marlett , Darly Joseph Manayani , Godfrey Jonah Anderson Rainey , Vijay Reddy , Marc E. Siladi , Heather M. Scobie , Diane Thomas , Mark Yeager
IPC分类号： A61K39/385 , A61K39/07 , A61K39/08 , A61K39/116 , A61K39/295
CPC分类号： A61K39/07 , A61K2039/5256 , A61K2039/5258 , C12N2710/14143 , C12N2770/30023
摘要： Antitoxin and vaccine compositions based on nodavirus VLPs are provided. Anthrax antitoxin and vaccine compositions are provided. Methods of treating toxins with VLP-based antitoxins are provided. Methods of raising an immune response with immunogen decorated VLPs are provided.
摘要翻译： 提供了基于转染病毒VLP的抗毒素和疫苗组合物。 提供炭疽毒素抗毒素和疫苗组合物。 提供了使用基于VLP的抗毒素治疗毒素的方法。 提供了用免疫原装饰的VLP提高免疫应答的方法。
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公开(公告)号：US08258099B2
公开(公告)日：2012-09-04
申请号：US11632588
申请日：2005-07-15
申请人： Kun Ping Lu , Robert K. Suto , Janusz M. Sowadski , Gunter S. Fischer , Joseph P. Noel , Mark Verdecia
发明人： Kun Ping Lu , Robert K. Suto , Janusz M. Sowadski , Gunter S. Fischer , Joseph P. Noel , Mark Verdecia
IPC分类号： C07K7/00
CPC分类号： C12Q1/533 , A61K38/00 , C07K7/06 , G01N33/573 , G01N2500/04
摘要： The invention is directed to peptide modulators of Pin1 and Pin1-related proteins and the use of such modulators for treatment of Pin1 associated states, e.g., for the treatment of cancer or neurodegenerative disease.
摘要翻译： 本发明涉及Pin1和Pin1相关蛋白的肽调节剂以及这种调节剂用于治疗Pin1相关状态的用途，例如用于治疗癌症或神经变性疾病。
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10.发明授权Metabolic engineering of lipid metabolism by improving fatty acid binding and transport 有权通过改善脂肪酸结合和转运来代谢脂质代谢工程公开(公告)号：US08252973B2
公开(公告)日：2012-08-28
申请号：US13107558
申请日：2011-05-13
IPC分类号： C12N15/82
CPC分类号： C12N9/90 , C12N15/8247
摘要： CHI like fatty acid binding proteins and genes, recombinant cells and organisms, methods of metabolic pathway engineering to improve lipid production in cells, Crystal structures of CHI like fatty acid binding proteins, methods of engineering CHI like fatty acid binding proteins and systems thereof are provided.
摘要翻译： CHI如脂肪酸结合蛋白和基因，重组细胞和生物体，代谢途径工程方法，以改善细胞中的脂质生成，提供CHI类脂肪酸结合蛋白的晶体结构，工程化CHI如脂肪酸结合蛋白的方法及其系统 。
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