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1.发明公开公开(公告)号：US20240339964A1
公开(公告)日：2024-10-10
申请号：US18745582
申请日：2024-06-17
发明人： Matthew David ESCARRA , Luke ARTZT , Yaping JI , Daniel CODD , Matthew BARRIOS , Kazi M. ISLAM , David M. BAR-OR , Jacqueline C. FAILLA , Claire C. DAVIS , Maxwell W. WOODY
IPC分类号： H02S40/44 , F24S10/70 , F24S20/20 , F24S23/72 , F24S30/452 , F24S70/65 , H01L31/0304 , H01L31/0336 , H01L31/05 , H01L31/06
CPC分类号： H02S40/44 , F24S10/744 , F24S20/20 , F24S70/65 , F24S23/72 , F24S30/452 , H01L31/03046 , H01L31/0336 , H01L31/0512 , H01L31/06
摘要： A method for concentrated photovoltaic-thermal power generation includes converting a first portion of concentrated sunlight into electrical power when the first portion of concentrated sunlight illuminates an array of photovoltaic cells; and thermally coupling heat generated by the photovoltaic cells into a heat transfer plate. The method also includes cooling the heat transfer plate by flowing heat transfer fluid through an internal path of a cooling block in direct thermal contact with the heat transfer plate; and flowing the heat transfer fluid through a helical tube to absorb thermal energy from a second portion of concentrated sunlight illuminating the helical tube.
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公开(公告)号：US20240269158A1
公开(公告)日：2024-08-15
申请号：US18566383
申请日：2022-06-02
IPC分类号： A61K31/7052 , A61K31/431 , A61P31/04
CPC分类号： A61K31/7052 , A61K31/431 , A61P31/04
摘要： Disclosed herein are therapeutic agents and combinations of therapeutic agents for use in the treatment of bacterial diseases. Such therapeutic agents and combinations may include azlocillin. Methods of reducing or inhibiting Bartonella bacteria in cells and/or in subjects having Bartonella infections and related disorders by providing therapeutic agents alone or in combination are provided.
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公开(公告)号：US11925681B2
公开(公告)日：2024-03-12
申请号：US18088690
申请日：2022-12-26
CPC分类号： A61K39/02 , A61K39/0002 , A61K39/12 , A61K2039/5254
摘要： Outer membrane vesicles from bacteria of the Burkholderia pseudomallei complex can be used as adjuvants in compositions and methods to potentiate the immune response to immunogens.
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公开(公告)号：US20230406804A1
公开(公告)日：2023-12-21
申请号：US18451630
申请日：2023-08-17
发明人： Jayalakshmi SRIDHAR , Frank JONES , Cheryl STEVENS
IPC分类号： C07C50/12
CPC分类号： C07C50/12
摘要： The present disclosure relates to compounds that act as protein kinase inhibitors, and the synthesis of the same. Further, the present disclosure teaches the utilization of such compounds in a treatment for proliferative diseases, including cancer, particularly breast cancer, and especially ER+ and/or HER2+ breast cancer.
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公开(公告)号：US11835500B2
公开(公告)日：2023-12-05
申请号：US15518658
申请日：2015-10-13
发明人： Wayne F. Reed
IPC分类号： C08F2/00 , B01J19/24 , B01J19/00 , B01F33/81 , B01F33/80 , G01N30/78 , B01J4/00 , B01F35/21 , B01F35/71 , C12M1/34 , G01N1/38 , G01N15/02 , G01N15/00
CPC分类号： G01N30/78 , B01F33/811 , B01F35/2132 , B01F35/2133 , B01F35/7176 , B01J4/00 , B01J19/0093 , B01J19/245 , C12M1/34 , B01D2313/08 , B01F33/834 , B01J2219/00813 , B01J2219/00867 , B01J2219/00871 , B01J2219/00889 , B01J2219/00894 , B01J2219/00952 , B01J2219/00968 , B01J2219/00997 , G01N1/38 , G01N15/02 , G01N2015/0092
摘要： Disclosed herein is a device and method for changing the conditions of a solution flowing in a serial path. In particular, disclosed herein is a device that includes a chemical reactor, a first system, and a second system that are each serial to one another. Each of the first system and the second system include a mixing chamber, a solvent reservoir, a solvent pump, and one or more detectors. Also disclosed herein is a method for changing the condition of a solution that includes flowing a liquid sample in a path, serially mixing the sample with at least two discrete solvents while it flows through the path, and detecting the condition of the sample after it is mixed with each solvent.
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公开(公告)号：US20230146939A1
公开(公告)日：2023-05-11
申请号：US18010731
申请日：2021-06-15
发明人： Gregory Jaye Bix
IPC分类号： A61K31/4178 , A61P31/14
CPC分类号： A61K31/4178 , A61P31/14
摘要： Treating a human coronavirus (hCoV) infection includes administering an effective amount of an inhibitor of an α5- or αv-containing integrin to a subject in need thereof. The integrin inhibitor can be ATN-161. The hCoV can be SARS-CoV or SARS-CoV-2.
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公开(公告)号：US20230087018A1
公开(公告)日：2023-03-23
申请号：US17797425
申请日：2021-02-05
发明人： Tony Ye HU , Bo NING , Zhen HUANG
摘要： The present disclosure describes a method for detecting the presence of Mycobacterium tuberculosis in a bodily fluid sample. The method utilizes CRISPR effector proteins along with a guide RNA and a reporter molecule, such that when the guide RNA hybridizes with a target nucleotide fragment, the CRISPR effector protein cleaves the reporter molecule, resulting in a detectable signal.
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公开(公告)号：US11465978B2
公开(公告)日：2022-10-11
申请号：US15021592
申请日：2014-09-11
发明人： Suravi Chakrabarty , Patrick T. Flaherty , Darlene Monlish , Jane E. Cavanaugh , Matthew E. Burow , Steven Elliott , Van T. Hoang
IPC分类号： C07D295/192 , C07D295/16 , C07C229/58 , C07C237/30 , C07C237/32 , C07C237/34 , C07C237/36
摘要： Disclosed are anthranilic amide derivatives having the formula. Compositions are disclosed that include the anthranilic amide derivatives and the use of the anthranilic amide derivatives for the manufacture of a medicament. Further disclosed are methods of inhibiting or treating cancer, inhibiting or reversing an epithelial to mesenchymal cellular transition, and/or inhibiting MEK1/2 and/or MEK 5 enzymatic activity in a subject by administering to the subject an effective amount of a disclosed anthranilic amide derivative.
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公开(公告)号：US11357866B2
公开(公告)日：2022-06-14
申请号：US16002604
申请日：2018-06-07
发明人： Stephen E. Braun , Debasis Mondal , Bruce A Bunnell , Narae Lee
IPC分类号： C12N5/00 , A61K48/00 , A61K39/42 , C07K16/10 , A61P31/18 , A61K45/06 , A61K31/513 , A61K35/28 , A61K31/683 , A61K39/00
摘要： A composition of matter and method of treating HIV with mesenchymal stem cells (MSC) is disclosed. Specifically, MSCs are transduced with vectors incorporating an anti-viral fusion inhibitor, such as a C46-derived peptide or neutralizing antibody. The transduced MSCs are capable of expression the inhibitor and preventing HIV virus-cell fusion.
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公开(公告)号：US11312895B2
公开(公告)日：2022-04-26
申请号：US16901528
申请日：2020-06-15
发明人： Duy T. Nguyen , Vijay Thomas John
摘要： Surfactants are imbibed into Halloysite nanotubes (HNT) and the imbibed nanotubes are coated with wax on the nanotube outer surface. The wax layer prevents the surfactant from being disgorged from the HNT lumen until a triggering condition exists. Triggering conditions include contact with oil, which dissolves the wax; or exposure to temperatures above a melt transition of the wax, which causes the wax to melt. Upon exposure to a triggering condition, at least some of the imbibed surfactants are disgorged from the HNT and into the surrounding environment. The disgorged surfactants provide a conventional effect of reducing interfacial tension and changing reservoir rock wettability to enhance oil recovery. A range of surfactants and waxes are usefully employed in the compositions and methods described herein.
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