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    Stable solid state raman laser and a method of operating same
    2.
    发明授权
    Stable solid state raman laser and a method of operating same 有权
    稳定的固态拉曼激光器和操作方法相同

    公开(公告)号：US06901084B2

    公开(公告)日：2005-05-31

    申请号：US10333672

    申请日：2001-07-26

    申请人： Helen M. Pask ,  James A. Piper

    发明人： Helen M. Pask ,  James A. Piper

    IPC分类号： G02F1/35 ,  G02F1/37 ,  H01S3/08 ,  H01S3/108 ,  H01S3/109 ,  H01S3/11 ,  H01S3/113 ,  H01S3/136 ,  H01S3/139 ,  H01S3/30 ,  H01S3/10

    CPC分类号： H01S3/30 ,  H01S3/08072 ,  H01S3/108 ,  H01S3/117 ,  H01S3/136 ,  H01S3/139

    摘要： The present invention relates to a stable solid-state Raman laser, the solid-state Raman laser including a resonator cavity defined by at least two reflectors, a laser material located in the resonator cavity and capable of generating a cavity laser beam which propagates within the resonator cavity, a solid Raman medium located in the resonator cavity for shifting the frequency of the cavity laser beam to produce a Raman laser beam which propagates within the resonator cavity; and an output coupler for coupling and outputting the Raman laser beam from the resonator cavity, wherein at least one parameter selected from the group consisting of the position of the laser material relative to the position of the Raman medium in the cavity, the length of the cavity and the curvature of at least one of the reflectors, is selected such that changes in the focal lengths of both the laser material and the Raman medium as a result of thermal effects in the laser material and the Raman medium during operation of the laser do not substantially cause instability in the power of the output Raman laser beam. A method of maintaining stable operation of a solid state Raman laser is also described.

    摘要翻译： 本发明涉及一种稳定的固态拉曼激光器，该固态拉曼激光器包括由至少两个反射器限定的谐振腔，位于谐振腔中的激光材料，能够产生在该谐振腔内传播的腔激光束 谐振腔，位于谐振器腔中的固体拉曼介质，用于移动腔激光束的频率，以产生在谐振腔内传播的拉曼激光束; 以及输出耦合器，用于耦合并输出来自谐振腔的拉曼激光束，其中至少一个参数选自激光材料相对于腔中的拉曼介质的位置的位置， 腔和至少一个反射器的曲率被选择为使得激光材料和拉曼介质的焦距在激光材料和拉曼介质中在激光操作期间的热效应的变化 实质上不会导致输出拉曼激光束的功率不稳定。 还描述了保持固态拉曼激光器的稳定操作的方法。

    Prolactin antagonists and uses thereof
    3.
    发明授权
    Prolactin antagonists and uses thereof 失效
    催乳素拮抗剂及其用途

    公开(公告)号：US06890738B2

    公开(公告)日：2005-05-10

    申请号：US09065330

    申请日：1998-04-23

    申请人： Ameae Walker

    发明人： Ameae Walker

    IPC分类号： A61K38/00 ,  C07K14/575 ,  C12N1/21 ,  A61K38/22 ,  C12N15/16 ,  C12N15/63

    CPC分类号： C07K14/57554 ,  A61K38/00 ,  C07K2319/00

    摘要： Recombinant nucleotide sequences encoding mutated prolactin are described. Expression of the sequences result in mimics of a phosphorylated prolactin corresponding to a selected species. A particularly preferred mimic is mutated at serine 179 (corresponding to human PRL) where serine is substituted by an aspartate residue. This aspartate mutant is a very effective antagonist and shows no ability to stimulate Nb2 to cell proliferation.

    摘要翻译： 描述了编码突变催乳素的重组核苷酸序列。 序列的表达导致对应于所选物种的磷酸化催乳素的模拟。 特别优选的模拟物在丝氨酸179（相当于人PRL）突变，丝氨酸被天冬氨酸残基取代。 这种天冬氨酸突变体是非常有效的拮抗剂，并且不显示刺激Nb2对细胞增殖的能力。

    Installation for increasing the light yield on the playing surface in a stadium
    5.
    发明授权
    Installation for increasing the light yield on the playing surface in a stadium 失效
    安装，以增加体育场内的演奏场地的光线产量

    公开(公告)号：US06873465B2

    公开(公告)日：2005-03-29

    申请号：US10240916

    申请日：2001-04-02

    申请人： Cornelis Groot

    发明人： Cornelis Groot

    IPC分类号： A63C19/00 ,  E04D13/03 ,  E04F17/06 ,  E04H3/14 ,  G02B17/00 ,  E04B7/14 ,  E04H3/10 ,  G02B27/00

    CPC分类号： E04H3/14 ,  A63C19/00 ,  E04F17/06

    摘要： An installation for increasing the daylight yield in a stadium provided with a playing surface, stands, and optionally a covering, includes an essentially vertical light-reflecting body to guide the light incident on the body towards the playing surface in the stadium. Preferably the reflecting body is arranged along the free peripheral edge of the covering of the stadium. In one embodiment the reflecting body includes a multi-layer construction of two corrugated sheets with a light-reflecting foil between them. The installation can increase the light yield in a covered stadium by between 30% and 50%.

    摘要翻译： 用于增加设置有游戏表面，支架和可选地覆盖物的体育场内的日光产量的装置包括基本垂直的光反射体，用于将入射在身体上的光引导到体育场内的游戏表面。 优选地，反射体沿着体育场的覆盖物的自由周边边缘布置。 在一个实施例中，反射体包括两层波纹片的多层结构，在它们之间具有光反射箔。 该安装可以将覆盖的体育场的光产量提高30％至50％。

    Automated laser diode test system
    6.
    发明授权
    Automated laser diode test system 有权
    自动激光二极管测试系统

    公开(公告)号：US06873172B2

    公开(公告)日：2005-03-29

    申请号：US10146709

    申请日：2002-05-14

    申请人： Paul Cornelius ,  John Walsh ,  Yong Yim

    发明人： Paul Cornelius ,  John Walsh ,  Yong Yim

    IPC分类号： H01S5/00 ,  H01S5/042 ,  G01R31/26

    CPC分类号： H01S5/0014 ,  H01S5/0021 ,  H01S5/042

    摘要： An automated laser diode testing and burn-in system is disclosed. Initial device data is obtained by applying current to the device at room temperature and measuring the device parameters. The device is then subjected to a burn-in process at higher temperatures. Device performance is monitored throughout the burn-in process. Upon termination of the burn-in process the devices are cooled to room temperature and the post burn-in device power is measured again under the same test conditions. If the device parameters have changed by more than a particular amount the device is rejected. Otherwise, the device is accepted and installed in the next level assembly. The test system disclosed herein achieves significant advantages over prior art in cost and throughput by combining an easy to load laser test fixture with automatic device hold down feature, heating capability, computer program driven test protocol capable of performing initial laser measurements, calibrating each laser and photodetector pair, burn-in test, post burn-in measurements, failed device detection, storage of laser test history records and enabling remote access to such records. The invention eliminates the need for numerous labor intensive ergonomically difficult steps and costly test fixtures.

    摘要翻译： 公开了一种自动化激光二极管测试和老化系统。 通过在室温下将电流施加到器件并测量器件参数来获得初始器件数据。 然后在较高温度下对该装置进行老化过程。 在整个烧录过程中监视器件性能。 在老化过程结束后，将器件冷却至室温，并在相同的测试条件下再次测量后置式老化装置的功率。 如果设备参数已经改变了超过特定的量，则设备被拒绝。 否则，设备被接受并安装在下一级程序集中。 本文所公开的测试系统通过将容易加载的激光测试夹具与自动装置保持特征，加热能力，能够执行初始激光测量的计算机程序驱动测试协议，校准每个激光器以及 光电检测器对，老化测试，后期老化测量，设备检测失败，激光测试历史记录的存储和远程访问这些记录。 本发明消除了对许多劳动密集的人体工程学困难的步骤和昂贵的测试夹具的需要。

    Non-oligomerizing tandem fluorescent proteins
    8.
    发明授权
    Non-oligomerizing tandem fluorescent proteins 有权
    非低聚串联荧光蛋白

    公开(公告)号：US06852849B2

    公开(公告)日：2005-02-08

    申请号：US09866538

    申请日：2001-05-24

    申请人： Roger Y. Tsien ,  Robert E. Campbell

    发明人： Roger Y. Tsien ,  Robert E. Campbell

    IPC分类号： C07K14/435 ,  C12Q1/25 ,  G01N33/58 ,  G01N33/84 ,  C07H21/04 ,  C07K14/00 ,  C12N15/09

    CPC分类号： G01N33/587 ,  C07K14/43595 ,  C12Q1/25 ,  G01N33/84 ,  G01N2500/02

    摘要： Non-oligomerizing fluorescent proteins, which are formed by operatively linking two or more monomers of a fluorescent protein, or which are derived from a fluorescent protein having at least one mutation that reduces or eliminates the ability of the fluorescent protein to oligomerize, are provided. The non-oligomerizing fluorescent proteins can be derived from a naturally occurring green fluorescent protein, a red fluorescent protein, or other fluorescent protein, or a fluorescent protein related thereto. Also provided is a fusion protein, which includes a non-oligomerizing fluorescent protein linked to at least one polypeptide of interest. In addition, a polynucleotide encoding a non-oligomerizing fluorescent protein is provided, as is a recombinant nucleic acid molecule, which includes polynucleotide encoding a non-oligomerizing fluorescent protein operatively linked to at least a second polynucleotide. Vectors and host cells containing such polynucleotides also are provided, as are kits containing one or more non-oligomerizing fluorescent proteins or encoding polynucleotides or constructs derived therefrom. Further provided are methods of making and using the proteins and polynucleotides.

    摘要翻译： 提供了通过可操作地连接两种或更多种荧光蛋白单体或衍生自具有降低或消除荧光蛋白低聚的能力的至少一种突变的荧光蛋白而形成的非低聚荧光蛋白。 非低聚荧光蛋白可以衍生自天然存在的绿色荧光蛋白，红色荧光蛋白或其他荧光蛋白，或与其相关的荧光蛋白。 还提供了融合蛋白，其包括与至少一种目的多肽连接的非低聚荧光蛋白。 此外，提供编码非低聚荧光蛋白的多核苷酸，重组核酸分子也包括编码与至少第二个多核苷酸有效连接的非低聚荧光蛋白的多核苷酸。 还提供了含有这种多核苷酸的载体和宿主细胞，以及含有一种或多种非低聚荧光蛋白或编码多核苷酸或由其衍生的构建体的试剂盒。 进一步提供制备和使用蛋白质和多核苷酸的方法。

    Method and system for managing and providing sales data using world wide web
    9.
    发明授权
    Method and system for managing and providing sales data using world wide web 失效
    使用万维网管理和提供销售数据的方法和系统

    公开(公告)号：US06850896B1

    公开(公告)日：2005-02-01

    申请号：US09429240

    申请日：1999-10-28

    申请人： Ariel Kelman ,  Corey Sommers

    发明人： Ariel Kelman ,  Corey Sommers

    IPC分类号： G06Q10/06 ,  G06Q10/08 ,  G06Q30/02 ,  G06Q30/06 ,  G06F17/60

    CPC分类号： G06Q10/087 ,  G06Q10/0637 ,  G06Q10/0639 ,  G06Q30/0203 ,  G06Q30/06 ,  G06Q30/0601 ,  Y10S707/99952

    摘要： A method and system for managing sales data. One embodiment is a software application that assists in classification, review and approval of data to be stored in a database for the use of a product supplier or seller. In one embodiment, a method includes storing a plurality of data components as groups of data components in a database, wherein the plurality of data components comprises information relating to products, and information relating to customers. The method further includes assigning a subset of the plurality of users to a content review group (“CRG”), and notifying each user in the CRG to provide input regarding individual data components of a group of data components. Input may include indicating whether data components are accurate, entering comments regarding the data components, entering edits to the data components. The method further includes receiving and storing the input, notifying a content director (“CD”) to review the input. Review may include editing the comments entered, deleting the comments entered, and consolidating the input. At least one of the data components is staged to be stored in a central database, based upon the review.

    摘要翻译： 一种用于管理销售数据的方法和系统。 一个实施例是一种软件应用程序，其帮助分类，审查和批准要存储在数据库中以供产品供应商或卖方使用的数据。 在一个实施例中，一种方法包括将多个数据组件作为一组数据组件存储在数据库中，其中多个数据组件包括与产品相关的信息以及与客户有关的信息。 该方法还包括将多个用户的子集分配给内容审查组（“CRG”），并通知CRG中的每个用户提供关于一组数据组件的单个数据组件的输入。 输入可以包括指示数据组件是否准确，输入有关数据组件的注释，输入对数据组件的编辑。 该方法还包括接收和存储输入，通知内容导演（“CD”）来检查输入。 审核可能包括编辑输入的注释，删除输入的注释和合并输入。 基于审查，至少一个数据组件被分段存储在中央数据库中。

    Treatment of inner ear hair cells
    10.
    发明授权
    Treatment of inner ear hair cells 有权
    内耳毛细胞治疗

    公开(公告)号：US06927204B2

    公开(公告)日：2005-08-09

    申请号：US10458039

    申请日：2003-06-09

    申请人： Wei-Qiang Gao

    发明人： Wei-Qiang Gao

    IPC分类号： A61K38/18 ,  A61K38/30 ,  A61K38/00 ,  A61K38/28 ,  A61K39/395 ,  C07K16/00

    CPC分类号： A61K38/1825 ,  A61K38/1841 ,  A61K38/30 ,  Y10S435/81 ,  A61K2300/00

    摘要： Compositions, methods, and devices are provided for inducing or enhancing the growth, proliferation, regeneration of inner ear tissue, particularly inner ear hair cells. In addition, provided are compositions and methods for prophylactic or therapeutic treatment of a mammal afflicted with an inner ear disorder or condition, particularly for hearing impairments involving hair cell damage, loss, or degeneration, by administration of a therapeutically effective amount of IGF-1 or FGF-2, or their agonists, alone or in combination.

    摘要翻译： 提供了组合物，方法和装置，用于诱导或增强内耳组织，特别是内耳毛细胞的生长，增殖，再生。 此外，提供了通过施用治疗有效量的IGF-1来预防或治疗患有内耳障碍或病症的哺乳动物，特别是涉及毛细胞损伤，损失或变性的听力损伤的组合物和方法 或FGF-2，或其激动剂，单独或组合使用。