Hospital bed with foot egress
    3.
    发明授权

    公开(公告)号:US11759380B2

    公开(公告)日:2023-09-19

    申请号:US17966058

    申请日:2022-10-14

    摘要: A hospital bed having foot egress, including a foot section with a pair of foot panels that can pivot upward and be locked into place to provide a support structure for standing and ambulation. Each of the pair of foot section panels can include a grab handle for assistance in standing. The foot end of the frame of the bed includes a retractable crossbar which supports the foot panels, and which can be reversibly retracted towards the middle of the bed frame and beneath the seat section of the bed to provide a clearing at the distal foot end of the bed for the patient to stand and exit the bed safely and efficiently.

    Steam leakage compact bearing
    4.
    发明授权

    公开(公告)号:US11746827B2

    公开(公告)日:2023-09-05

    申请号:US17766012

    申请日:2020-08-03

    申请人: NIDEC GPM GmbH

    摘要: The invention relates to a shaft bearing having a seal arrangement to prevent steam leakages that can occur in the event of temperature fluctuations or pressure fluctuations between a liquid medium on the one side and a gaseous medium on the other side of the compact bearing, wherein, between a primary radial seal and a rotation bearing portion, a lubrication space surrounding a shaft circumference is arranged that receives a volume of lubricating grease that has a higher viscosity than a lubricating oil and a coolant; and a volume compensator for compensating a temperature-dependent volume fluctuation is provided that comprises a compressible material, and is arranged vertically in interaction with the volume of the lubricating oil and/or the volume of the lubricating grease.

    Engineered aryl sulfate-dependent enzymes

    公开(公告)号:US11708593B2

    公开(公告)日:2023-07-25

    申请号:US17949489

    申请日:2022-09-21

    申请人: OPTIMVIA, LLC

    IPC分类号: C12P19/26 C12N9/10

    摘要: The present invention provides several non-naturally occurring sulfotransferase enzymes that have been engineered to react with aryl sulfate compounds as sulfo group donors, instead of the natural substrate 3′-phosphoadenosine 5′-phosphosulfate (PAPS), and with heparosan-based polysaccharides, particularly heparan sulfate, as sulfo group acceptors. Each of the engineered sulfotransferase enzymes have a biological activity characterized by the position within the heparosan-based polysaccharide that receives the sulfo group, including glucosaminyl N-sulfotransferase activity, hexuronyl 2-O sulfotransferase activity, glucosaminyl 6-O sulfotransferase activity, or glucosaminyl 3-O sulfotransferase activity. Methods of using the engineered sulfotransferases to produce sulfated heparosan-based polysaccharides, including polysaccharides having anticoagulant activity, are also provided.

    Engineered aryl sulfate-dependent enzymes

    公开(公告)号:US11692180B2

    公开(公告)日:2023-07-04

    申请号:US17376341

    申请日:2021-07-15

    申请人: OPTIMVIA, LLC

    IPC分类号: C12N9/10 C12N15/63 C12P19/64

    摘要: The present invention provides several non-naturally occurring sulfotransferase enzymes that have been engineered to react with aryl sulfate compounds as sulfo group donors, instead of the natural substrate 3′-phosphoadenosine 5′-phosphosulfate (PAPS), and with heparosan-based polysaccharides, particularly heparan sulfate, as sulfo group acceptors. Each of the engineered sulfotransferase enzymes have a biological activity characterized by the position within the heparosan-based polysaccharide that receives the sulfo group, including glucosaminyl N-sulfotransferase activity, hexuronyl 2-O sulfotransferase activity, glucosaminyl 6-O sulfotransferase activity, or glucosaminyl 3-O sulfotransferase activity. Methods of using the engineered sulfotransferases to produce sulfated heparosan-based polysaccharides, including polysaccharides having anticoagulant activity, are also provided.

    Feminine cooling apparatus and method

    公开(公告)号:US11590021B2

    公开(公告)日:2023-02-28

    申请号:US16503842

    申请日:2019-07-05

    申请人: Kesha Williams

    发明人: Kesha Williams

    IPC分类号: A61F7/00

    摘要: An apparatus for providing prolonged topical cooling to the external female genitalia as a therapeutic benefit to and relief from female itching and burning is disclosed as a lightweight, portable cooling unit in combination with one or more labial inserts which are specifically designed to conform to the user's anatomy. The cooling unit is typically a container capable of both cooling and transporting the labial inserts during travel, and providing easy access to relief when needed by the user. A cooled labial insert can be applied to the external female genitalia for treatment of the acute symptoms associated with vulvar inflammation and irritation. The inventive apparatus can maintain a cooling temperature to the affected area for an extended period of time, limited only by the life of the cooling power source. The labial inserts can be worn in public with minimum disruption to the user's clothing and mobility.

    Engineered aryl sulfate-dependent enzymes

    公开(公告)号:US11572549B2

    公开(公告)日:2023-02-07

    申请号:US17376322

    申请日:2021-07-15

    申请人: OPTIMVIA, LLC

    IPC分类号: C12N9/10 C12N15/63 C12P19/64

    摘要: The present invention provides several non-naturally occurring sulfotransferase enzymes that have been engineered to react with aryl sulfate compounds as sulfo group donors, instead of the natural substrate 3′-phosphoadenosine 5′-phosphosulfate (PAPS), and with heparosan-based polysaccharides, particularly heparan sulfate, as sulfo group acceptors. Each of the engineered sulfotransferase enzymes have a biological activity characterized by the position within the heparosan-based polysaccharide that receives the sulfo group, including glucosaminyl N-sulfotransferase activity, hexuronyl 2-O sulfotransferase activity, glucosaminyl 6-O sulfotransferase activity, or glucosaminyl 3-O sulfotransferase activity. Methods of using the engineered sulfotransferases to produce sulfated heparosan-based polysaccharides, including polysaccharides having anticoagulant activity, are also provided.