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公开(公告)号：US09821023B2
公开(公告)日：2017-11-21
申请号：US14943885
申请日：2015-11-17
发明人： Victor J. Hruby , Minying Cai
IPC分类号： A61K38/12 , A61K38/10 , A61K47/24 , A61K9/00 , A61K9/107 , A61K9/70 , C07K14/68 , C07K14/685 , C07K14/72 , C07K7/08
CPC分类号： A61K38/12 , A61K9/0014 , A61K9/107 , A61K9/2004 , A61K9/7023 , A61K9/7084 , A61K38/10 , A61K47/24 , C07K7/08 , C07K14/68 , C07K14/685 , C07K14/723
摘要： Methods of treating a central nervous system (CNS) disorder or mood disorder in a subject in need of such treatment are described. A therapeutically effective amount of a composition comprising a melanocortin 5 receptor (MC5R) peptide ligand in a pharmaceutically acceptable carrier is administered to the subject. The MC5R peptide ligand is a selective MC5R antagonist, in which administration thereof to the subject can treat the CNS disorder or mood disorder with clinical improvement observed in a relatively short time.
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公开(公告)号：US09784258B2
公开(公告)日：2017-10-10
申请号：US14029286
申请日：2013-09-17
CPC分类号： F04B19/006 , F04B43/12 , F04B53/10 , F16K99/0015 , F16K99/0034 , F16K99/0059 , F16K2099/0094
摘要： Microfluidic oscillator circuits and pumps for microfluidic devices are provided. The microfluidic pump may include a plurality of fluid valves and a microfluidic oscillator circuit having an oscillation frequency. The fluid valves may be configured to move fluids. Each fluid valve may be connected to a node of the microfluidic oscillator circuit. The pumps may be driven by the oscillator circuits such that fluid movement is accomplished entirely by circuits on a microfluidic chip, without the need for off-chip controls.
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公开(公告)号：US09797524B2
公开(公告)日：2017-10-24
申请号：US14852286
申请日：2015-09-11
发明人： Elliot En-Yu Hui , Siavash Ahrar
CPC分类号： F16K99/0001 , F16K99/0015 , F16K99/0057 , F16K2099/0094
摘要： Pneumatic devices for implementing finite state machines are provided. In some implementations, the pneumatic device comprises a state register component configured to hold one of a set of possible states. The pneumatic device also comprises a next-state logic block component configured to determine a next state for the state register component based at least in part on a current state of the state register component. A pneumatic programmable logic array (PLA) implementing a next state logic block of a finite state machine is also provided. The pneumatic PLA comprises an elastomeric membrane containing a pattern of holes and disposed between two channel layers of a pneumatic device. The PLA receives one or more input values representing a current state of a state register and one or more input values representing a user input and calculates one or more output values representing a next state for the state register.
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公开(公告)号：US09593080B1
公开(公告)日：2017-03-14
申请号：US15224446
申请日：2016-07-29
IPC分类号： C08G59/00 , C07D233/88 , C07D403/12 , C07D405/12 , C07D413/14 , G01N33/68 , A61K47/48 , G01N33/569
CPC分类号： C07D233/88 , A61K47/545 , C07D235/30 , C07D277/50 , C07D277/82 , C07D403/12 , C07D405/12 , C07D413/14 , C09B26/06 , C09J163/00 , G01N33/56983 , G01N33/6845
摘要： Triazabutadiene molecules as cleavable cross-linkers adapted to cross-link components with click chemistry, e.g., clickable triazabutadienes. For example, in some embodiments, the triazabutadienes feature alkyne handles attached to the imidazole portion or the aryl portion of the triazabutadienes, wherein the alkyne handles can link to azide handles (e.g., azide handles disposed on other components) via click chemistry. Also described are methods of producing said clickable triazabutadienes and methods of use of said clickable triazabutadienes. The present invention also features methods of cleaving said clickable triazabutadienes, e.g., for liberating the diazonium species for further chemical reactions.
摘要翻译： 三唑二丁烯分子作为可切割交联剂，其适于使用点击化学交联组分，例如可点击的三氮杂二萘嵌苯。 例如，在一些实施方案中，三唑类物质特征是连接到咪唑部分或三氮杂双环的芳基部分的炔柄，其中炔手柄可以通过点击化学连接到叠氮化物手柄（例如，设置在其它组分上的叠氮化物手柄）。 还描述了生产所述可点击的三氮杂双环网的方法和所述可点击的三氮杂双环网的使用方法。 本发明还具有切割所述可点击的三氮杂异二烯的方法，例如用于释放重氮物质用于进一步的化学反应。
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5.发明授权公开(公告)号：US09562855B1
公开(公告)日：2017-02-07
申请号：US13458650
申请日：2012-04-27
申请人： Jeong-Yeol Yoon , David Jinsoo You
发明人： Jeong-Yeol Yoon , David Jinsoo You
IPC分类号： G01N21/47 , G01N33/58 , B01L3/00 , G01N33/569
CPC分类号： G01N21/47 , B01L3/502 , B01L2300/0816 , G01N33/54313 , G01N33/54373 , G01N33/569 , G01N33/56911 , G01N33/585 , G01N2021/4704 , G01N2021/4707 , G01N2021/4711
摘要： Microfluidic methods and systems for detecting levels of microorganisms via Mie forward light scattering. The systems and methods of the present invention can be customized so as to optionally maximize scatter from the particle immunoagglutination and minimize that of the sample matrix, e.g., via selection of parameters particle diameter d, wavelength of incident λ, and/or scatter angle θ. Methods feature providing beads conjugated with an antibody specific for the microorganism, mixing beads with a sample to form a first mixture; providing a control mixture; irradiating the mixtures with incident light; detecting forward light scattering scattered by the first mixture at a first angle with respect to the incident light and forward scattered light scattered by the control the same first angle with respect to the incident light; determining I and I0 from the light scattering; comparing I with I0; and determining a level of the microorganism.
摘要翻译： 用于通过Mie前向光散射检测微生物水平的微流控方法和系统。 可以定制本发明的系统和方法，以便可选地使颗粒免疫凝集的散射最大化，并使样品基质的散射最小化，例如通过选择参数粒径d，入射λ的波长和/或散射角θ 。 方法特征在于提供与微生物特异性抗体缀合的珠粒，将珠子与样品混合以形成第一混合物; 提供控制混合物; 用入射光照射混合物; 检测由第一混合物散射的相对于入射光的第一角度的向前光散射，并且通过控制散射的向前散射的光相对于入射光具有相同的第一角度; 从光散射确定I和I0; 将I与I0进行比较 并确定微生物的水平。
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6.发明授权Topical application of AMPK activators for pharmacological prevention of chronic pain 有权AMPK激活剂局部应用于慢性疼痛的药理学预防公开(公告)号：US09233085B1
公开(公告)日：2016-01-12
申请号：US14318245
申请日：2014-06-27
发明人： Theodore J. Price , Gregory D. Dussor , Dipti Tillu , Bo Lian
IPC分类号： A61K31/155 , A61K31/05 , A61K9/00
CPC分类号： A61K31/155 , A61K9/0014 , A61K31/05 , A61K2300/00
摘要： A topical composition containing an adenosine monophosphate protein kinase (AMPK) activator and methods of administering the AMPK activator for treating acute pain or preventing the development of chronic pain in a subject. The AMPK activator is resveratrol. A second AMPK activator may also be used. The second AMPK activator is metformin. The topical composition may be administered as a gel, ointment, cream, lotion, suspension, liquid, or transdermal patch.
摘要翻译： 含有腺苷一磷酸蛋白激酶（AMPK）激活剂的局部组合物和施用AMPK活化剂治疗急性疼痛或预防受试者慢性疼痛发展的方法。 AMPK激活剂是白藜芦醇。 也可以使用第二AMPK活化剂。 第二种AMPK活化剂是二甲双胍。 局部组合物可以作为凝胶，软膏，乳膏，洗剂，悬浮液，液体或透皮贴剂施用。
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7.发明授权Generating a subgraph of key entities in a network and categorizing the subgraph entities into different types using social network analysis 有权生成网络中关键实体的子图，并使用社交网络分析将子图实体分类为不同类型公开(公告)号：US09195962B2
公开(公告)日：2015-11-24
申请号：US12877914
申请日：2010-09-08
IPC分类号： G06F15/173 , G06Q10/10 , G06Q30/02
摘要： A method, system and computer-program product for generating a subgraph of key entities in a network and organizing entities in the subgraph are disclosed. The technique uses social network analysis centrality metrics to identify key entities in a network. The technique also uses social network analysis centrality metrics to categorize key entities into different types.
摘要翻译： 公开了一种用于在网络中生成关键实体的子图以及子图中的组织实体的方法，系统和计算机程序产品。 该技术使用社交网络分析中心度量来识别网络中的关键实体。 该技术还使用社会网络分析中心度量将关键实体分类为不同类型。
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公开(公告)号：US10129022B1
公开(公告)日：2018-11-13
申请号：US15439102
申请日：2017-02-22
摘要： A key generation technique exploiting the randomness of a wireless channel to generate secret keys to secure automotive wireless communication using symmetric cryptography is presented. Moreover, the algorithm of the present technique solves the challenging key exchange problem in automotive wireless communication with low costs in terms of performance and code size. As demonstrated, the proposed algorithm can generate secret keys with 67% average min-entropy. Furthermore, the proposed technique can achieve up to 10× performance and 20× code size reduction in comparison to the state-of-the-art hybrid cryptographic algorithms.
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9.发明授权公开(公告)号：US09869617B2
公开(公告)日：2018-01-16
申请号：US14432962
申请日：2013-10-07
发明人： Patricia Carrigan , James Grille , Greg Martin , Mark Robida , Patrick C. Roche
CPC分类号： G01N1/30 , G01N1/312 , G01N2001/302
摘要： Methods, kits, and systems for clarifying obfuscating pigments in histology samples such as an automated method of treating a histology sample with a clarifying reagent so that the clarifying reagent, contacts the sample and the pigments within the sample are decolorized , thus alleviating staining obfuscations associated with pigments. Decolorizing the pigments within the sample enables the histology sample to be interpretable by a qualified reader. An antigen retrieval step is performed after the clarification step.
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公开(公告)号：US09302148B1
公开(公告)日：2016-04-05
申请号：US14338529
申请日：2014-07-23
申请人： Shinn Fu Corporation
发明人： Marko Vujicic , Chien-Chi Su
CPC分类号： A63B22/0605 , A63B21/225 , A63B22/0015 , A63B22/0664 , A63B23/04 , A63B2022/0611 , A63B2022/0641 , A63B2022/0658 , A63B2022/0688 , A63B2225/09 , A63B2225/093 , F16H1/28 , F16H33/02 , F16H2001/2872
摘要： An epicyclic gear system features a cylindrical flywheel with a cylindrical flywheel cavity, a plurality of cylindrical mounting pillars, an annular ring gear mounted on the cylindrical mounting pillars, and an annular sun gear mounted to and extending from the flywheel cavity. The epicyclic gear system features a planet carrier mounted to an axle shaft and a planet gear mounted to the planet carrier. The axle shaft passes through an axle aperture, a ring gear aperture, and a sun gear aperture. The planet gear engages the ring gear and the sun gear to provide a desired gear ratio for rotating the flywheel via rotation of the axle shaft, the planet carrier, the planet gear, and the sun gear.
摘要翻译： 行星齿轮系统具有圆柱形飞轮，其具有圆柱形飞轮腔，多个圆柱形安装柱，安装在圆柱形安装柱上的环形齿圈，以及安装到飞轮腔并从飞轮腔延伸的环形太阳齿轮。 行星齿轮系统具有安装到车轴的行星架和安装到行星架的行星齿轮。 车轴通过车轴孔，环形齿轮孔和太阳齿轮孔。 行星齿轮接合环形齿轮和太阳齿轮，以提供用于通过车轴，行星架，行星齿轮和太阳齿轮的旋转来旋转飞轮的期望的传动比。
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