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公开(公告)号：US09371369B2
公开(公告)日：2016-06-21
申请号：US14168973
申请日：2014-01-30
发明人： Volker Schellenberger , Joshua Silverman , Chia-Wei Wang , Benjamin Spink , Willem P. Stemmer , Nathan Geething , Wayne To , Jeffrey L. Cleland
IPC分类号： A61K38/16 , A61K38/18 , C07K14/61 , C07K14/46 , C07K14/545 , C07K14/00 , C07K14/605 , C07K14/745 , C07K14/47
CPC分类号： C07K14/47 , C07K14/001 , C07K14/545 , C07K14/605 , C07K14/61 , C07K14/745 , C07K2319/31 , C07K2319/35 , C12N9/6437 , C12N9/644
摘要： The present invention relates to compositions comprising biologically active proteins linked to extended recombinant polypeptide (XTEN), isolated nucleic acids encoding the compositions and vectors and host cells containing the same, and methods of using such compositions in treatment of glucose-related diseases, metabolic diseases, coagulation disorders, and growth hormone-related disorders and conditions.
摘要翻译： 本发明涉及包含与延伸的重组多肽（XTEN）连接的生物活性蛋白质的组合物，编码组合物的分离的核酸和载体以及含有它们的宿主细胞，以及使用这些组合物治疗葡萄糖相关疾病，代谢疾病 ，凝血障碍和生长激素相关的疾病和病症。
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2.发明授权Binding fusion proteins, binding fusion protein-drug conjugates, XTEN-drug conjugates and methods of making and using same 有权结合融合蛋白，结合融合蛋白 - 药物偶联物，XTEN-药物共轭物及其制备和使用方法公开(公告)号：US09249211B2
公开(公告)日：2016-02-02
申请号：US13631361
申请日：2012-09-28
发明人： Volker Schellenberger , Joshua Silverman , Chia-wei Wang , Benjamin Spink , Willem P. Stemmer , Nathan Geething
CPC分类号： C12P21/02 , A61K38/00 , C07K14/00 , C07K14/70521 , C07K14/7155 , C07K14/8125 , C07K16/18 , C07K16/241 , C07K16/244 , C07K16/2809 , C07K16/2863 , C07K16/2878 , C07K16/32 , C07K16/40 , C07K2317/31 , C07K2317/569 , C07K2317/622 , C07K2317/92 , C07K2317/94 , C07K2319/31 , C07K2319/70 , C07K2319/74 , C12N15/625
摘要： The present invention relates to binding fusion protein compositions comprising targeting moieties linked to extended recombinant polypeptide (XTEN), binding fusion protein-drug conjugate compositions, and XTEN-drug conjugate compositions, isolated nucleic acids encoding the compositions and vectors and host cells containing the same, and methods of using such compositions in treatment of diseases, disorders, and conditions.
摘要翻译： 本发明涉及包含与延伸重组多肽（XTEN）连接的靶向部分，结合融合蛋白 - 药物共轭组合物和XTEN-药物共轭组合物的结合融合蛋白组合物，编码组合物和载体的分离的核酸和含有该重组多肽的宿主细胞 以及使用这些组合物治疗疾病，病症和病症的方法。
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3.发明申请公开(公告)号：US20150344862A1
公开(公告)日：2015-12-03
申请号：US14710077
申请日：2015-05-12
发明人： Volker SCHELLENBERGER , Willem P. Stemmer , Nathan C. Geething , Wayne To , Joshua Silverman , Chia-wei Wang , Benjamin Spink
IPC分类号： C12N9/64
CPC分类号： C12N9/644 , A61K38/00 , C07K14/001 , C07K2319/00 , C07K2319/31 , C07K2319/50 , C12N9/6437 , C12N15/70 , C12Y304/21022
摘要： The present invention relates to compositions comprising factor IX coagulation factors linked to extended recombinant polypeptide (XTEN), isolated nucleic acids encoding the compositions and vectors and host cells containing the same, and methods of making and using such compositions in treatment of coagulation factor-related diseases, disorders, and conditions.
摘要翻译： 本发明涉及包含与延伸的重组多肽（XTEN）连接的因子IX凝血因子的组合物，编码组合物的分离的核酸和载体以及含有它们的宿主细胞，以及制备和使用这些组合物治疗凝血因子相关的方法 疾病，病症和状况。
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公开(公告)号：US20150037359A1
公开(公告)日：2015-02-05
申请号：US14381199
申请日：2013-02-27
发明人： Volker Schellenberger , Vladimir Podust , Chia-Wei Wang , Bryant McLaughlin , Bee-Cheng Sim , Sheng Ding , Chen Gu
CPC分类号： A61K38/24 , A61K47/64 , A61K49/0032 , A61K49/0052 , A61K49/0056 , C07K5/0205
摘要： The present invention relates to extended recombinant polypeptide (XTEN) compositions, conjugate compositions comprising XTEN and XTEN linked to cross-linkers useful for conjugation to pharmacologically active payloads, methods of making highly purified XTEN, methods of making XTEN-linker and XTEN-payload conjugates, and methods of using the XTEN-cross-linker and XTEN-payload compositions.
摘要翻译： 本发明涉及延伸的重组多肽（XTEN）组合物，包含与用于与药理活性有效载体缀合的交联剂连接的XTEN和XTEN的缀合物组合物，制备高度纯化的XTEN的方法，制备XTEN-接头和XTEN-有效载体缀合物的方法 以及使用XTEN-交联剂和XTEN-有效载体组合物的方法。
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公开(公告)号：US10953073B2
公开(公告)日：2021-03-23
申请号：US16133444
申请日：2018-09-17
发明人： Volker Schellenberger , Vladimir Podust , Chia-Wei Wang , Bryant McLaughlin , Bee-Cheng Sim , Sheng Ding , Chen Gu
摘要： The present invention relates to extended recombinant polypeptide (XTEN) compositions, conjugate compositions comprising XTEN and XTEN linked to cross-linkers useful for conjugation to pharmacologically active payloads, methods of making highly purified XTEN, methods of making XTEN-linker and XTEN-payload conjugates, and methods of using the XTEN-cross-linker and XTEN-payload compositions.
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公开(公告)号：US20190083577A1
公开(公告)日：2019-03-21
申请号：US16133444
申请日：2018-09-17
发明人： Volker Schellenberger , Vladimir Podust , Chia-Wei Wang , Bryant MCLAUGHLIN , Bee-Cheng Sim , Sheng Ding , Chen Gu
摘要： The present invention relates to extended recombinant polypeptide (XTEN) compositions, conjugate compositions comprising XTEN and XTEN linked to cross-linkers useful for conjugation to pharmacologically active payloads, methods of making highly purified XTEN, methods of making XTEN-linker and XTEN-payload conjugates, and methods of using the XTEN-cross-linker and XTEN-payload compositions.
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公开(公告)号：US10172953B2
公开(公告)日：2019-01-08
申请号：US14381199
申请日：2013-02-27
发明人： Volker Schellenberger , Vladimir Podust , Chia-Wei Wang , Bryant McLaughlin , Bee-Cheng Sim , Sheng Ding , Chen Gu
摘要： The present invention relates to extended recombinant polypeptide (XTEN) compositions, conjugate compositions comprising XTEN and XTEN linked to cross-linkers useful for conjugation to pharmacologically active payloads, methods of making highly purified XTEN, methods of making XTEN-linker and XTEN-payload conjugates, and methods of using the XTEN-cross-linker and XTEN-payload compositions.
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公开(公告)号：US20180125988A1
公开(公告)日：2018-05-10
申请号：US15525819
申请日：2015-11-11
发明人： Fan YANG , Volker SCHELLENBERGER , Sheng DING , Desiree THAYER , Chia-Wei WANG
CPC分类号： A61K47/551 , A61K47/6803 , A61K47/6855 , A61P35/00 , C07K14/00 , C07K2319/00 , C07K2319/01 , C07K2319/30 , C07K2319/50 , C07K2319/70 , C12N9/6421 , C12N15/70 , G01N2030/027
摘要： The present disclosure provides drug conjugate compositions, and compositions and methods for preparing and using the same. In some embodiments, the present invention relates to targeted conjugate compositions comprising cysteine-containing domains (CCD) linked to targeting moieties, extended recombinant polypeptides (XTEN)and peptide cleavable moieties, with pharmacologically active payload drugs cross-linked to cysteine residues, resulting in compositions that can be cleaved by proteases associated with target tissues. The invention also provides methods of making the targeted conjugate compositions and methods of using the targeted conjugate compositions.
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公开(公告)号：US20170158748A1
公开(公告)日：2017-06-08
申请号：US15365792
申请日：2016-11-30
发明人： Volker Schellenberger , Joshua Silverman , Willem P. Stemmer , Chia-wei Wang , Nathan Geething , Jeffrey L. Cleland
IPC分类号： C07K14/605
CPC分类号： C07K14/605 , A23V2200/328 , A61K38/00 , C07K14/575 , C07K14/57563 , C07K2319/00 , C07K2319/31 , C07K2319/50 , C12N15/70 , C12P21/02 , Y10S514/866
摘要： The present invention relates to compositions comprising glucose regulating peptides linked to extended recombinant polypeptide (XTEN), isolated nucleic acids encoding the compositions and vectors and host cells containing the same, and methods of making and using such compositions in treatment of glucose regulating peptide-related diseases, disorders, and conditions.
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10.发明申请BINDING FUSION PROTEINS, BINDING FUSION PROTEIN-DRUG CONJUGATES, XTEN-DRUG CONJUGATES AND METHODS OF MAKING AND USING SAME 有权结合融合蛋白，结合融合蛋白 - 药物结合物，XTEN-DRUG结合体及其制备和使用方法公开(公告)号：US20170016042A1
公开(公告)日：2017-01-19
申请号：US14977035
申请日：2015-12-21
发明人： Volker Schellenberger , Joshua Silverman , Chia-wei Wang , Benjamin Spink , Willem P.C. Stemmer , Nathan C. Geething
IPC分类号： C12P21/02 , C07K14/00 , C07K16/32 , C07K14/715 , C07K16/28 , C12N15/62 , C07K14/705
CPC分类号： C12P21/02 , A61K38/00 , C07K14/00 , C07K14/70521 , C07K14/7155 , C07K14/8125 , C07K16/18 , C07K16/241 , C07K16/244 , C07K16/2809 , C07K16/2863 , C07K16/2878 , C07K16/32 , C07K16/40 , C07K2317/31 , C07K2317/569 , C07K2317/622 , C07K2317/92 , C07K2317/94 , C07K2319/31 , C07K2319/70 , C07K2319/74 , C12N15/625
摘要： The present invention relates to binding fusion protein compositions comprising targeting moieties linked to extended recombinant polypeptide (XTEN), binding fusion protein-drug conjugate compositions, and XTEN-drug conjugate compositions, isolated nucleic acids encoding the compositions and vectors and host cells containing the same, and methods of using such compositions in treatment of diseases, disorders, and conditions.
摘要翻译： 本发明涉及包含与延伸重组多肽（XTEN）连接的靶向部分，结合融合蛋白 - 药物共轭组合物和XTEN-药物共轭组合物的结合融合蛋白组合物，编码组合物和载体的分离的核酸和含有该重组多肽的宿主细胞 以及使用这些组合物治疗疾病，病症和病症的方法。
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