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17 条记录 (耗时 0.017 秒)

    Methods and Apparatus for Segregation of Particles
    2.
    发明申请
    Methods and Apparatus for Segregation of Particles 审中-公开

    公开(公告)号：US20180299425A1

    公开(公告)日：2018-10-18

    申请号：US15870381

    申请日：2018-01-12

    申请人： ANGLE North America, Inc.

    发明人： George Hvichia ,  David Counts ,  Gary Evans

    IPC分类号： G01N33/49 ,  B01L3/00

    摘要： The disclosure relates to an apparatus for segregating particles on the basis of their ability to flow through a stepped passageway. At least some of the particles are accommodated in a passage bounded by a first step, but at least some of the particles are unable to pass through a narrower passage bounded by a second step, resulting in segregation of the particles. The apparatus and methods described herein can be used to segregate particles of a wide variety of types. By way of example, they can be used to segregate fetal-like cells from a maternal blood sample such as maternal arterial blood.

    Microstructure for Particle and Cell SEparation, Identification, Sorting, and Manipulation
    7.
    发明申请
    Microstructure for Particle and Cell SEparation, Identification, Sorting, and Manipulation 有权
    微粒结构和细胞分析，鉴定，分选和操作

    公开(公告)号：US20160340644A9

    公开(公告)日：2016-11-24

    申请号：US14079333

    申请日：2013-11-13

    申请人： ANGLE North America, Inc.

    发明人： Georgi HVICHIA

    IPC分类号： C12N5/073

    CPC分类号： C12N5/0606 ,  B01D35/30 ,  B01L3/502761 ,  B01L2200/10 ,  B01L2300/04 ,  B01L2400/0481 ,  C12M47/02 ,  C12M47/04 ,  C12N5/0603 ,  G01N15/0272 ,  G01N2015/0288

    摘要： The invention relates to microscale cell separating apparatus which are able to separate cells on the basis of size of the cells, interaction of the cells with surfaces of the apparatus, or both. The apparatus comprises a stepped or sloped separation element (16) interposed between an inlet region (20) and an outlet region (22) of a void that can be tilled with fluid. The void can be enclosed within a cover (12) and fluid flow through the void engages cells with the separation element. Only cells which have (or can deform to have) a characteristic dimension smaller than or equal to the distance between a step and the cover or body can pass onto or past a step. Modifications of surfaces within the apparatus can also inhibit passage of cells onto or past a step.

    摘要翻译： 本发明涉及能够根据细胞大小分离细胞的细胞分离装置，细胞与装置表面的相互作用，或两者相互作用。 该装置包括位于入口区域（20）和可与流体填充的空隙的出口区域（22）之间的阶梯式或倾斜分离元件（16）。 空隙可以封闭在盖（12）内，并且通过空隙的流体流动与分离元件接合单元。 只有具有（或可以变形为具有）具有小于或等于台阶与盖或主体之间的距离的特征尺寸的单元可以经过或经过台阶。 装置内的表面的修改也可以抑制细胞通过或经过步骤。