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公开(公告)号：US20170130322A1
公开(公告)日：2017-05-11
申请号：US15194117
申请日：2016-06-27
发明人： Daniel D. SIMS , Jeffrey N. STEINMETZ , Conor P. MULLENS , Alexander Parker WOOD , Christopher E. BANAS
CPC分类号： C23C14/24 , A61F2/07 , A61F2/91 , A61F2/915 , A61F2002/9155 , A61F2002/91575 , A61F2210/0076 , A61F2220/0041 , A61F2220/005 , A61F2220/0058 , A61F2220/0075 , A61F2240/001 , A61F2250/0068 , B29C59/04 , B29C59/043 , Y10T156/10 , Y10T156/1043
摘要： A vacuum deposition substrate comprising at least one of a plurality of patterned recesses, raises, or openings. The at least one of a plurality of patterned recesses, raises, or openings further define a geometry of a medical device.
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2.发明申请DEVICE FOR IN VIVO DELIVERY OF BIOACTIVE AGENTS AND METHOD OF MANUFACTURE THEREOF 审中-公开用于生物体药物输送的装置及其制造方法公开(公告)号：US20150342761A1
公开(公告)日：2015-12-03
申请号：US14825526
申请日：2015-08-13
CPC分类号： A61B5/076 , A61B5/01 , A61B5/02055 , A61B5/021 , A61B5/0215 , A61B5/026 , A61B5/4839 , A61B5/6862 , A61B5/6876 , A61F2/07 , A61F2/82 , A61F2/86 , A61F2/91 , A61F2/915 , A61F2002/91533 , A61F2002/91541 , A61F2002/91558 , A61F2210/0076 , A61F2240/001 , A61F2250/0001 , A61F2250/0067 , A61F2250/0068 , A61L27/04 , A61L27/54 , A61L31/022 , A61L31/16 , A61L2300/602
摘要： The drug eluting device consists of an implantable structural element for in vivo controlled delivery of bioactive active agents to a situs in a body. The implantable structural element may be configured as an implantable prosthesis, such as an endoluminal stent, cardiac valve, osteal implant or the like, which serves a dual function of being prosthetic and a carrier for a bioactive agent. Control over elution of the bioactive agents occurs through a plurality of cantilever-like cover members which prevent drug elution until an endogenous or exogenous stimulus causes the cover members to open and permit drug elution.
摘要翻译： 药物洗脱装置由可植入的结构元件组成，用于体内控制递送生物活性剂到体内的部位。 可植入结构元件可以被配置为可植入假体，例如腔内支架，心脏瓣膜，骨植入物等，其用作假体和用于生物活性剂的载体的双重功能。 控制生物活性剂的洗脱通过多个悬臂状覆盖构件发生，其阻止药物洗脱，直到内源性或外源性刺激使盖构件打开并允许药物洗脱。
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公开(公告)号：US20130334032A1
公开(公告)日：2013-12-19
申请号：US13908933
申请日：2013-06-03
IPC分类号： C23C14/35
CPC分类号： C23C14/35 , A61F2/0077 , A61F2/06 , A61F2/91 , A61F2/915 , A61F2002/91533 , A61F2002/9155 , A61F2002/91558 , A61F2210/0076 , A61F2240/001 , Y10T29/49812 , Y10T29/49885 , Y10T29/4998 , Y10T29/49982 , Y10T29/49995
摘要： Implantable medical grafts fabricated of metallic or pseudometallic films of biocompatible materials having a plurality of microperforations passing through the film in a pattern that imparts fabric-like qualities to the graft or permits the geometric deformation of the graft. The implantable graft is preferably fabricated by vacuum deposition of metallic and/or pseudometallic materials into either single or multi-layered structures with the plurality of microperforations either being formed during deposition or after deposition by selective removal of sections of the deposited film. The implantable medical grafts are suitable for use as endoluminal or surgical grafts and may be used as vascular grafts, stent-grafts, skin grafts, shunts, bone grafts, surgical patches, non-vascular conduits, valvular leaflets, filters, occlusion membranes, artificial sphincters, tendons and ligaments.
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4.发明申请公开(公告)号：US20170049594A1
公开(公告)日：2017-02-23
申请号：US15137746
申请日：2016-04-25
CPC分类号： A61F2/95 , A61B2017/1205 , A61F2/91 , A61F2/915 , A61F2002/91525 , A61F2002/91541 , A61F2002/91558 , A61F2210/0076 , A61M25/0013 , A61M25/0045 , A61M25/09 , A61M2025/0042 , A61M2025/006 , A61M2025/0681 , A61M2025/09108 , A61M2025/09133 , A61M2025/0915 , A61M2025/09166 , A61M2205/0244 , A61M2205/0266
摘要： Guidewires and thin-film catheter-sheaths, fabricated using vacuum deposition techniques, which are monolayer or plural-layer members having ultra-thin wall thicknesses to provide very-low profile delivery assemblies for introduction and delivery of endoluminal devices.
摘要翻译： 使用真空沉积技术制造的导丝和薄膜导管鞘，其是具有超薄壁厚的单层或多层构件，以提供用于引入和递送内腔装置的非常低的轮廓输送组件。
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公开(公告)号：US20130131784A1
公开(公告)日：2013-05-23
申请号：US13673168
申请日：2012-11-09
IPC分类号： A61F2/04
CPC分类号： A61F2/04 , A61F2/06 , A61F2/82 , A61L27/06 , A61L27/50 , A61L31/022 , A61L31/14 , C23C14/0005 , Y10T83/04
摘要： Implantable medical grafts fabricated of metallic or pseudometallic films of biocompatible materials having a plurality of microperforations passing through the film in a pattern that imparts fabric-like qualities to the graft or permits the geometric deformation of the graft. The implantable graft is preferably fabricated by vacuum deposition of metallic and/or pseudometallic materials into either single or multi-layered structures with the plurality of microperforations either being formed during deposition or after deposition by selective removal of sections of the deposited film. The implantable medical grafts are suitable for use as endoluminal or surgical grafts and may be used as vascular grafts, stent-grafts, skin grafts, shunts, bone grafts, surgical patches, non-vascular conduits, valvular leaflets, filters, occlusion membranes, artificial sphincters, tendons and ligaments.
摘要翻译： 可植入的医用移植物由生物相容性材料的金属或假金属膜制成，具有多个微孔穿过膜，该图案赋予移植物类织物质量或允许移植物的几何变形。 可植入移植物优选通过将金属和/或假金属材料真空沉积成单层或多层结构而制成，其中多个微穿孔在沉积期间或沉积后通过选择性去除沉积膜的部分而形成。 可植入的医用移植物适合用作腔内或手术移植物，可用作血管移植物，支架移植物，皮肤移植物，分流器，骨移植物，外科补片，非血管导管，瓣膜小叶，滤器，闭塞膜，人造 括约肌，肌腱和韧带。
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公开(公告)号：US20160135943A1
公开(公告)日：2016-05-19
申请号：US14852371
申请日：2015-09-11
CPC分类号： A61F2/04 , A61F2/06 , A61F2/82 , A61L27/06 , A61L27/50 , A61L31/022 , A61L31/14 , C23C14/0005 , Y10T83/04
摘要： Implantable medical grafts fabricated of metallic or pseudometallic films of biocompatible materials having a plurality of microperforations passing through the film in a pattern that imparts fabric-like qualities to the graft or permits the geometric deformation of the graft. The implantable graft is preferably fabricated by vacuum deposition of metallic and/or pseudometallic materials into either single or multi-layered structures with the plurality of microperforations either being formed during deposition or after deposition by selective removal of sections of the deposited film. The implantable medical grafts are suitable for use as endoluminal or surgical grafts and may be used as vascular grafts, stent-grafts, skin grafts, shunts, bone grafts, surgical patches, non-vascular conduits, valvular leaflets, filters, occlusion membranes, artificial sphincters, tendons and ligaments.
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公开(公告)号：US20150328025A1
公开(公告)日：2015-11-19
申请号：US14571572
申请日：2014-12-16
CPC分类号： C23C14/35 , A61F2/0077 , A61F2/06 , A61F2/91 , A61F2/915 , A61F2002/91533 , A61F2002/9155 , A61F2002/91558 , A61F2210/0076 , A61F2240/001 , Y10T29/49812 , Y10T29/49885 , Y10T29/4998 , Y10T29/49982 , Y10T29/49995
摘要： Implantable medical grafts fabricated of metallic or pseudometallic films of biocompatible materials having a plurality of microperforations passing through the film in a pattern that imparts fabric-like qualities to the graft or permits the geometric deformation of the graft. The implantable graft is preferably fabricated by vacuum deposition of metallic and/or pseudometallic materials into either single or multi-layered structures with the plurality of microperforations either being formed during deposition or after deposition by selective removal of sections of the deposited film. The implantable medical grafts are suitable for use as endoluminal or surgical grafts and may be used as vascular grafts, stent-grafts, skin grafts, shunts, bone grafts, surgical patches, non-vascular conduits, valvular leaflets, filters, occlusion membranes, artificial sphincters, tendons and ligaments.
摘要翻译： 可植入的医用移植物由生物相容性材料的金属或假金属膜制成，具有多个微孔穿过膜，该图案赋予移植物类织物质量或允许移植物的几何变形。 可植入移植物优选通过将金属和/或假金属材料真空沉积成单层或多层结构而制成，其中多个微穿孔在沉积期间或沉积后通过选择性去除沉积膜的部分而形成。 可植入的医用移植物适合用作腔内或手术移植物，可用作血管移植物，支架移植物，皮肤移植物，分流器，骨移植物，外科补片，非血管导管，瓣膜小叶，滤器，闭塞膜，人造 括约肌，肌腱和韧带。
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公开(公告)号：US09132001B2
公开(公告)日：2015-09-15
申请号：US13673168
申请日：2012-11-09
CPC分类号： A61F2/04 , A61F2/06 , A61F2/82 , A61L27/06 , A61L27/50 , A61L31/022 , A61L31/14 , C23C14/0005 , Y10T83/04
摘要： Implantable medical grafts fabricated of metallic or pseudometallic films of biocompatible materials having a plurality of microperforations passing through the film in a pattern that imparts fabric-like qualities to the graft or permits the geometric deformation of the graft. The implantable graft is preferably fabricated by vacuum deposition of metallic and/or pseudometallic materials into either single or multi-layered structures with the plurality of microperforations either being formed during deposition or after deposition by selective removal of sections of the deposited film. The implantable medical grafts are suitable for use as endoluminal or surgical grafts and may be used as vascular grafts, stent-grafts, skin grafts, shunts, bone grafts, surgical patches, non-vascular conduits, valvular leaflets, filters, occlusion membranes, artificial sphincters, tendons and ligaments.
摘要翻译： 可植入的医用移植物由生物相容性材料的金属或假金属膜制成，具有多个微孔穿过膜，该图案赋予移植物类织物质量或允许移植物的几何变形。 可植入移植物优选通过将金属和/或假金属材料真空沉积成单层或多层结构而制成，其中多个微穿孔在沉积期间或沉积后通过选择性去除沉积膜的部分而形成。 可植入的医用移植物适合用作腔内或手术移植物，可用作血管移植物，支架移植物，皮肤移植物，分流器，骨移植物，外科补片，非血管导管，瓣膜小叶，滤器，闭塞膜，人造 括约肌，肌腱和韧带。
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9.发明申请IMPLANTABLE EXPANDABLE MEDICAL DEVICES HAVING REGIONS OF DIFFERENTIAL MECHANICAL PROPERTIES AND METHODS OF MAKING SAME 有权具有不同机械特性的区域的可植入的可扩展医疗装置及其制造方法公开(公告)号：US20140067043A1
公开(公告)日：2014-03-06
申请号：US14019123
申请日：2013-09-05
IPC分类号： A61F2/89
CPC分类号： A61F2/915 , A61F2/89 , A61F2/91 , A61F2002/91541 , A61F2002/91558 , A61F2002/91575 , A61F2210/0014 , A61F2210/0023 , A61F2220/0091 , A61F2250/0042 , A61L31/022 , A61L31/14
摘要： An implantable expandable medical device in which selected regions of the device are in a martensite phase and selected regions are in an austenite phase. The martensitic regions exhibit pseudoplastic behavior in vivo and may be deformed without recovery under in vivo body conditions. In contrast the austenitic regions exhibit superelastic behavior in vivo and will recover their pre-programmed configuration upon deformation or release of an applied strain.
摘要翻译： 一种植入式可扩张医疗装置，其中装置的选定区域处于马氏体相，并且所选择的区域处于奥氏体相。 马氏体区域在体内呈现假塑性行为，并且在体内身体条件下可能变形而不恢复。 相比之下，奥氏体区域在体内表现出超弹性行为，并且在施加的应变变形或释放时将恢复其预编程配置。
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10.发明申请公开(公告)号：US20140054258A1
公开(公告)日：2014-02-27
申请号：US13970475
申请日：2013-08-19
IPC分类号： A61F2/91
CPC分类号： A61F2/91 , A61F2/915 , A61F2002/91541 , C23F1/02 , Y10T83/0304
摘要： Methods for manufacturing intravascular stents are disclosed wherein the intravascular stent has its inner surface treated to promote the migration of endothelial cells onto the inner surface of the intravascular stent. In particular, the inner surface of the intravascular stent has at least one groove formed therein.
摘要翻译： 公开了用于制造血管内支架的方法，其中血管内支架具有其内表面被处理以促进内皮细胞迁移到血管内支架的内表面上。 特别地，血管内支架的内表面具有形成在其中的至少一个凹槽。
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