公开(公告)号：US20050133692A1

公开(公告)日：2005-06-23

申请号：US10990747

申请日：2004-11-17

申请人： Hideo Watanabe ,  Akihiro Kitahara

发明人： Hideo Watanabe ,  Akihiro Kitahara

IPC分类号： G02B21/00 ,  H01J40/14

CPC分类号： G02B21/008

摘要： A first amplification unit amplifies at a predetermined amplification rate an output signal from a photodetection unit for detecting an optical signal from a specimen and detecting it. An offset unit assigns offset to an output signal from the photodetection unit. A second amplification unit amplifies at an amplification rate smaller than the amplification rate of the first amplification unit an output signal from the photodetection unit assigned the offset by the offset unit. A rectification unit rectifies an output signal from the second amplification unit. An addition unit adds an output signal from the first amplification unit to an output signal from the rectification unit.

摘要翻译： 第一放大单元以预定的放大率放大来自用于检测来自样本的光信号的光检测单元的输出信号并进行检测。 偏移单元将偏移分配给来自光电检测单元的输出信号。 第二放大单元以比第一放大单元的放大率更小的放大率放大来自由偏移单元分配了偏移的光检测单元的输出信号。 整流单元对来自第二放大单元的输出信号进行整流。 加法单元将来自第一放大单元的输出信号与来自整流单元的输出信号相加。

公开(公告)号：US20130077158A1

公开(公告)日：2013-03-28

申请号：US13534356

申请日：2012-06-27

申请人： Yusuke MATSUMOTO ,  Akihiro KITAHARA ,  Mika FUKUDA

发明人： Yusuke MATSUMOTO ,  Akihiro KITAHARA ,  Mika FUKUDA

IPC分类号： G02B21/08 ,  G02B21/26 ,  G02B21/30

CPC分类号： G02B21/0088 ,  G02B21/24 ,  G02B21/241 ,  G02B21/30 ,  G02B21/32

摘要： An inverted microscope includes: a stage which places a specimen thereon; a light source unit which has a light source irradiating light to the specimen on the stage; an objective lens which focuses at least observation light from the specimen on the stage; a body unit which holds at least the objective lens; a condenser which is provided on an optical axis of the objective lens; a condenser holding unit which holds the condenser; a condenser moving mechanism which movably supports the condenser holding unit and moves the condenser holding unit along the optical axis; a transmission mechanism which transmits power for moving the condenser to the condenser moving mechanism; and an input unit which inputs the power to the transmission mechanism. The input unit is provided above the condenser holding unit.

摘要翻译： 倒置显微镜包括：将样品放置在其上的阶段; 光源单元，其具有向所述台上的所述样本照射光的光源; 将至少将来自样本的观察光聚焦在舞台上的物镜; 至少保持物镜的主体单元; 设置在所述物镜的光轴上的冷凝器; 保持冷凝器的冷凝器保持单元; 冷凝器移动机构，其可移动地支撑所述电容器保持单元并沿着所述光轴移动所述电容器保持单元; 传递用于将冷凝器移动到冷凝器移动机构的动力的传动机构; 以及输入单元，其将功率输入到所述传输机构。 输入单元设置在冷凝器保持单元的上方。

公开(公告)号：US08041097B2

公开(公告)日：2011-10-18

申请号：US12208536

申请日：2008-09-11

申请人： Shuji Akiyama ,  Akihiro Kitahara

发明人： Shuji Akiyama ,  Akihiro Kitahara

IPC分类号： G06K9/00

CPC分类号： G02B21/008 ,  G02B21/006 ,  G06T5/50 ,  G06T2207/10056

摘要： To provide a confocal microscope for obtaining an extended image by easily determining the capturing range of an observation image without being aware of the shape of a sample to be observed, the confocal microscope comprises confocal image generating unit for generating a confocal image, first counting unit for counting a first number of pixels having a predetermined brightness level or lower among the brightness levels of the pixels of the confocal image, second counting unit for counting a second number of pixels obtained by extracting only a pixel that matches a predetermined condition for the confocal image, and boundary determining unit for detecting a boundary by determining whether or not the observation surface is within the image capturing range based on the first and the second numbers of pixels.

摘要翻译： 为了提供共焦显微镜，通过容易地确定观察图像的捕获范围而不知道要观察的样品的形状来获得扩展图像，共聚焦显微镜包括用于产生共聚焦图像的共焦图像产生单元，第一计数单元 用于计数在共焦图像的像素的亮度级中具有预定亮度级别或更低的第一数量的像素;第二计数单元，用于对仅通过提取与共焦焦点的预定条件匹配的像素而获得的第二数量的像素进行计数; 图像和边界确定单元，用于通过基于第一和第二像素数量确定观察表面是否在图像捕获范围内来检测边界。

公开(公告)号：US07297921B2

公开(公告)日：2007-11-20

申请号：US10990747

申请日：2004-11-17

申请人： Hideo Watanabe ,  Akihiro Kitahara

发明人： Hideo Watanabe ,  Akihiro Kitahara

IPC分类号： H01J43/30 ,  H03F3/08

CPC分类号： G02B21/008

摘要： A first amplification unit amplifies at a predetermined amplification rate an output signal from a photodetection unit for detecting an optical signal from a specimen and detecting it. An offset unit assigns offset to an output signal from the photodetection unit. A second amplification unit amplifies at an amplification rate smaller than the amplification rate of the first amplification unit an output signal from the photodetection unit assigned the offset by the offset unit. A rectification unit rectifies an output signal from the second amplification unit. An addition unit adds an output signal from the first amplification unit to an output signal from the rectification unit.

摘要翻译： 第一放大单元以预定的放大率放大来自用于检测来自样本的光信号的光检测单元的输出信号并进行检测。 偏移单元将偏移分配给来自光电检测单元的输出信号。 第二放大单元以比第一放大单元的放大率更小的放大率放大来自由偏移单元分配了偏移的光检测单元的输出信号。 整流单元对来自第二放大单元的输出信号进行整流。 加法单元将来自第一放大单元的输出信号与来自整流单元的输出信号相加。

公开(公告)号：US20070194206A1

公开(公告)日：2007-08-23

申请号：US11788914

申请日：2007-04-23

申请人： Akihiro Kitahara

发明人： Akihiro Kitahara

IPC分类号： G02B27/40

CPC分类号： G02B21/0024 ,  G02B21/365

摘要： A confocal laser scanning microscope acquires confocal images of a sample. The microscope is provided with an optical-microscope optical system which acquires non-confocal images of the sample by detecting measurement light coming from the sample. The optical-microscope optical system includes optical systems corresponding to at least two observation methods, and one of the optical systems is selected during use.

公开(公告)号：US20050161593A1

公开(公告)日：2005-07-28

申请号：US10992421

申请日：2004-11-18

申请人： Akihiro Kitahara

发明人： Akihiro Kitahara

IPC分类号： G02B21/00 ,  G02B21/36 ,  H01J3/14

CPC分类号： G02B21/0024 ,  G02B21/365

摘要： A confocal laser scanning microscope acquires confocal images of a sample. The microscope is provided with an optical-microscope optical system which acquires non-confocal images of the sample by detecting measurement light coming from the sample. The optical-microscope optical system includes optical systems corresponding to at least two observation methods, and one of the optical systems is selected during use.

摘要翻译： 共焦激光扫描显微镜获取样品的共聚焦图像。 显微镜配备有光学显微镜光学系统，其通过检测来自样品的测量光来获取样品的非共焦图像。 光学显微镜光学系统包括对应于至少两种观察方法的光学系统，并且在使用期间选择一个光学系统。

公开(公告)号：US6072625A

公开(公告)日：2000-06-06

申请号：US14718

申请日：1998-01-28

申请人： Akihiro Kitahara ,  Nobuhiro Kita

发明人： Akihiro Kitahara ,  Nobuhiro Kita

IPC分类号： G02B21/00 ,  G02B26/10 ,  G02B27/64 ,  G02B21/06

CPC分类号： G02B27/642 ,  G02B21/0048 ,  G02B21/0068 ,  G02B26/101

摘要： An optical microscope apparatus includes an illumination optical system for illuminating an observation target object; an observation optical system for introducing an observation image of the observation target object; and an image rotation device provided on a light path common to the illumination optical system and the observation optical system, for rotating the observation image. The image rotation device is arranged so as to reflect a light beam entering thereinto, for odd-numbered times and to thereafter emit the light bean therefrom, and is driven to be rotated around an entering/exiting optical axis, thereby to rotate the observation image. The optical microscope apparatus further includes a scanning optical system provided in the illumination optical system, for deflecting observation light to be irradiated on the observation target object, within a predetermined angle range, so as to enter into the image rotation device, so that the sample is scanned with the observation light; and a control device for controlling a deflection angle of the scanning optical system, based on a rotation amount of the image rotation device, such that a scanning range of the observation light is adjusted to a substantially equal position, with respect to the observation target object, regardless of rotation operation of the image rotation device.

摘要翻译： 光学显微镜装置包括用于照射观察目标物体的照明光学系统; 用于引入观察对象的观察图像的观察光学系统; 以及图像旋转装置，设置在照明光学系统和观察光学系统共用的光路上，用于旋转观察图像。 图像旋转装置被布置成反射入射到其中的光束奇数次，然后从其中发射光束，并被驱动以围绕进/出光轴旋转，从而旋转观察图像 。 光学显微镜装置还包括设置在照明光学系统中的扫描光学系统，用于使预定角度范围内的被观察目标物体照射的观察光偏转，以进入图像旋转装置，使得样本 用观察光扫描; 以及控制装置，用于基于图像旋转装置的旋转量来控制扫描光学系统的偏转角，使得观察光的扫描范围相对于观察目标对象被调节到基本相等的位置 ，而不管图像旋转装置的旋转操作。

公开(公告)号：USD690342S1

公开(公告)日：2013-09-24

申请号：US29432018

申请日：2012-09-12

申请人： Yasuo Funakoshi ,  Kenji Tajima ,  Reisuke Osada ,  Akihiro Kitahara ,  Masayoshi Karasawa

设计人： Yasuo Funakoshi ,  Kenji Tajima ,  Reisuke Osada ,  Akihiro Kitahara ,  Masayoshi Karasawa

公开(公告)号：US07227113B2

公开(公告)日：2007-06-05

申请号：US10992421

申请日：2004-11-18

申请人： Akihiro Kitahara

发明人： Akihiro Kitahara

IPC分类号： G02B21/00 ,  H01J3/14

CPC分类号： G02B21/0024 ,  G02B21/365

摘要： A confocal laser scanning microscope acquires confocal images of a sample. The microscope is provided with an optical-microscope optical system which acquires non-confocal images of the sample by detecting measurement light coming from the sample. The optical-microscope optical system includes optical systems corresponding to at least two observation methods, and one of the optical systems is selected during use.

公开(公告)号：US5932871A

公开(公告)日：1999-08-03

申请号：US744752

申请日：1996-11-06

申请人： Shuji Nakagawa ,  Akihiro Kitahara ,  Asao Uenodai

发明人： Shuji Nakagawa ,  Akihiro Kitahara ,  Asao Uenodai

IPC分类号： G02B21/00 ,  G02B7/28 ,  G02B26/10

CPC分类号： G02B21/0048 ,  G02B21/008

摘要： A microscope includes a light source, an objective lens for converging light emitted from the light source onto a sample, and an optical detector for detecting either light from the sample via a confocal point diaphragm or light from the sample which does not pass through the confocal point diaphragm. A range of a focusing point is detected in accordance with the light which does not pass through the confocal diaphragm, and the focusing point is then detected in accordance with the light detected via the confocal point diaphragm in the detected range of the focusing point.

摘要翻译： 显微镜包括光源，用于将从光源发射的光会聚到样品上的物镜，以及用于检测来自样品的来自共焦点膜的光或来自未通过共焦的样品的光的光学检测器 点隔膜。 根据不通过共聚焦膜的光检测聚焦点的范围，然后根据在聚焦点的检测范围内通过共焦点光圈检测到的光来检测聚焦点。