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公开(公告)号：US20140271549A1
公开(公告)日：2014-09-18
申请号：US13999616
申请日：2014-03-11
申请人： Aladar A. Szalay
发明人： Aladar A. Szalay
IPC分类号： A61K38/14 , A61K48/00 , A61K31/431 , A61K31/407 , A61K35/76 , A61K31/7036
CPC分类号： A61K38/14 , A61K31/403 , A61K31/4164 , A61K31/43 , A61K31/431 , A61K31/7036 , A61K31/7048 , A61K35/74 , A61K35/768 , A61K38/162 , A61K45/06 , C12N2710/24132 , C12N2710/24143 , Y02A50/465 , A61K2300/00
摘要： Provided are methods for increasing the therapeutic efficacy of viral therapy by administering an antibiotic effective against commensal bacteria with the viral therapy. Included are methods for treating cancers, tumors and metastases by administering the virus and the antibiotic.
摘要翻译： 提供了通过用病毒治疗施用对共生细菌有效的抗生素来增加病毒治疗的治疗功效的方法。 包括通过施用病毒和抗生素治疗癌症，肿瘤和转移瘤的方法。
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公开(公告)号：US20130129614A9
公开(公告)日：2013-05-23
申请号：US13506738
申请日：2012-05-10
申请人： Aladar A. Szalay , Nanhai Chen , Yong A. Yu , Qian Zhang , Yuman Fong
发明人： Aladar A. Szalay , Nanhai Chen , Yong A. Yu , Qian Zhang , Yuman Fong
CPC分类号： C07K14/705 , A61K35/76 , A61K35/768 , A61K38/00 , C12N7/00 , C12N2710/24132 , C12N2710/24143 , G01N33/574 , Y02A50/471 , Y02A50/473
摘要： Modified viruses encoding transporter proteins and methods for preparing the modified viruses are provided. Vaccines that contain the viruses are provided. The viruses also can be used in diagnostic methods, such detection and imaging of tumors. The viruses also can be used in methods of treatment of diseases, such as proliferative and inflammatory disorders, including as anti-tumor agents.
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3.发明授权公开(公告)号：US08343509B2
公开(公告)日：2013-01-01
申请号：US13199567
申请日：2011-09-01
IPC分类号： A61K39/108 , A61K39/02 , C12Q1/00
CPC分类号： A61K51/0491 , A61K31/7088 , A61K35/74 , A61K51/04 , A61K2035/11 , A61K2300/00 , C12N1/20 , Y02A50/473
摘要： Described herein are methods for detecting a bacteria in a subject and methods for detecting, imaging or diagnosing a site, disease, disorder or condition in a subject using bacteria. The methods can be used in conjunction with methods for treating a disease, disorder or condition. Such sites, diseases and disorders include sites of cellular proliferation, such as tumors, tumor tissues, metastases, areas of inflammation, immunoprivileged sites or tissues, wounds and infections. Further described are bacteria for use in the methods and compositions, combinations and kits, including diagnostic and pharmaceutical compositions, containing a bacterium. Bacteria described herein include those that bind, sequester or accumulate radiolabeled compounds by expression of an endogenous gene product that binds to the radiolabeled compound. Additional imaging and therapeutic agents and methods also are described.
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4.发明申请MICROORGANISMS FOR PREVENTING AND TREATING NEOPLASMS ACCOMPANYING CELLULAR THERAPY 审中-公开用于预防和治疗细胞治疗的神经细胞的微生物公开(公告)号：US20110064650A1
公开(公告)日：2011-03-17
申请号：US12736826
申请日：2009-05-15
申请人： Aladar A. Szalay
发明人： Aladar A. Szalay
CPC分类号： A61K35/17 , A61K35/545 , A61K35/768 , A61K38/19 , A61K45/06 , A61K48/00 , C12N2710/24132 , A61K2300/00
摘要： Provided are methods for using cellular compositions in combination with oncolytic viruses. The methods include administering oncolytic viruses for the inhibition and treatment of tumors caused by administration of cellular therapies, such as stem cell therapies. The methods also include contacting cellular compositions with oncolytic viruses for the removal of neoplastic cells prior to administration of the cellular composition for therapy. Diagnostic methods for monitoring treatment also are provided.
摘要翻译： 提供使用细胞组合物与溶瘤病毒组合的方法。 所述方法包括施用溶瘤病毒用于抑制和治疗由施用细胞疗法引起的肿瘤，例如干细胞疗法。 所述方法还包括将细胞组合物与溶瘤病毒接触以在施用用于治疗的细胞组合物之前去除肿瘤细胞。 还提供了用于监测治疗的诊断方法。
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公开(公告)号：US07588771B2
公开(公告)日：2009-09-15
申请号：US11238025
申请日：2005-09-27
申请人： Aladar A. Szalay , Tatyana Timiryasova , Yong A. Yu , Qian Zhang
发明人： Aladar A. Szalay , Tatyana Timiryasova , Yong A. Yu , Qian Zhang
IPC分类号： A61K39/285 , A61K39/385 , A61K39/12 , A61K39/20
CPC分类号： A61K39/285 , A61K9/0019 , A61K35/74 , A61K35/744 , A61K35/768 , A61K39/00 , A61K45/06 , A61K48/00 , A61K2039/5254 , A61K2039/5256 , C07K16/30 , C07K16/40 , C12N7/00 , C12N15/86 , C12N2710/24132 , C12N2710/24134 , C12N2710/24143 , C12N2710/24161 , C12P19/34 , C12P21/02 , Y02A50/472
摘要： Therapeutic methods and microorganisms therefor are provided. The microorganisms are designed to accumulate in immunoprivileged tissues and cells, such as in tumors and other proliferating tissue and in inflamed tissues, compared to other tissues, cells and organs, so that they exhibit relatively low toxicity to host organisms. The microorganisms also are designed or modified to result in leaky cell membranes of cells in which they accumulate, resulting in production of antibodies reactive against proteins and other cellular products and also permitting exploitation of proliferating tissues, particularly tumors, to produce selected proteins and other products. Vaccines containing the microorganisms are provided. Combinations of the microorganisms and anti-cancer agents and uses thereof for treating cancer also are provided.
摘要翻译： 提供了治疗方法和微生物。 与其他组织，细胞和器官相比，微生物被设计为在免疫缺陷组织和细胞中积累，例如在肿瘤和其他增殖组织和发炎组织中，使得它们对宿主生物体具有相对低的毒性。 微生物也被设计或修饰以产生它们积聚的细胞的泄漏的细胞膜，导致生成对蛋白质和其它细胞产物具有反应性的抗体，并且还允许利用增殖组织，特别是肿瘤来产生选定的蛋白质和其它产物 。 提供含有微生物的疫苗。 还提供了微生物和抗癌剂的组合及其用于治疗癌症的用途。
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6.发明申请公开(公告)号：US20090123382A1
公开(公告)日：2009-05-14
申请号：US11982035
申请日：2007-10-31
CPC分类号： A61K49/0013 , A61K38/1841 , A61K38/39 , A61K49/0047 , A61K49/0097 , A61K49/1896 , C07K14/495 , C07K14/78 , C07K2319/55 , C07K2319/60 , C07K2319/61 , C12N2710/24132 , C12Q1/02 , C12Q1/66
摘要： Provided are diagnostic and pharmaceutical compositions containing a microorganism or a cell containing a DNA molecule encoding a detectable protein or a protein that a detectable signal, such as a luminescent or fluorescent protein. Methods of tumor targeting and tumor imaging using the microorganisms and cells are provided. Also provided are therapeutic methods in which the microorganisms and cells, which can encoded a therapeutic protein, such as a cytotoxic or cytostatic protein, are administered.
摘要翻译： 提供了含有微生物或含有编码可检测蛋白质的DNA分子或可检测信号如发光或荧光蛋白的蛋白质的细胞的诊断和药物组合物。 提供使用微生物和细胞的肿瘤靶向和肿瘤成像的方法。 还提供了其中施用可编码治疗性蛋白质（例如细胞毒性或细胞抑制性蛋白质）的微生物和细胞的治疗方法。
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公开(公告)号：US20090117048A1
公开(公告)日：2009-05-07
申请号：US11982040
申请日：2007-10-31
IPC分类号： A61K49/00
CPC分类号： A61K49/0013 , A61K38/1841 , A61K38/39 , A61K49/0047 , A61K49/0097 , A61K49/1896 , C07K14/495 , C07K14/78 , C07K2319/55 , C07K2319/60 , C07K2319/61 , C12N2710/24132 , C12Q1/02 , C12Q1/66
摘要： Provided are diagnostic and pharmaceutical compositions containing a microorganism or a cell containing a DNA molecule encoding a detectable protein or a protein that a detectable signal, such as a luminescent or fluorescent protein. Methods of tumor targeting and tumor imaging using the microorganisms and cells are provided. Also provided are therapeutic methods in which the microorganisms and cells, which can encoded a therapeutic protein, such as a cytotoxic or cytostatic protein, are administered.
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公开(公告)号：US20090117047A1
公开(公告)日：2009-05-07
申请号：US11981976
申请日：2007-10-31
IPC分类号： A61K49/00
CPC分类号： A61K49/0013 , A61K38/1841 , A61K38/39 , A61K49/0047 , A61K49/0097 , A61K49/1896 , C07K14/495 , C07K14/78 , C07K2319/55 , C07K2319/60 , C07K2319/61 , C12N2710/24132 , C12Q1/02 , C12Q1/66 , Y02A50/472
摘要： Provided are diagnostic and pharmaceutical compositions containing a microorganism or a cell containing a DNA molecule encoding a detectable protein or a protein that a detectable signal, such as a luminescent or fluorescent protein. Methods of tumor targeting and tumor imaging using the microorganisms and cells are provided. Also provided are therapeutic methods in which the microorganisms and cells, which can encoded a therapeutic protein, such as a cytotoxic or cytostatic protein, are administered.
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公开(公告)号：US20090117034A1
公开(公告)日：2009-05-07
申请号：US12157960
申请日：2008-06-13
申请人： Nanhai Chen , Aladar A. Szalay , Yong A. Yu , Qian Zhang , Yuman Fong
发明人： Nanhai Chen , Aladar A. Szalay , Yong A. Yu , Qian Zhang , Yuman Fong
IPC分类号： A61K51/02 , C12N7/01 , A61K35/76 , A61K49/04 , A61K39/395 , A61P35/00 , A61P35/04 , A61P35/02 , A61B10/00 , A61K49/00 , A61K49/06 , A61K39/285
CPC分类号： C07K14/705 , A61K35/76 , A61K35/768 , A61K38/00 , C12N7/00 , C12N2710/24132 , C12N2710/24143 , G01N33/574 , Y02A50/471 , Y02A50/473
摘要： Modified viruses encoding transporter proteins and methods for preparing the modified viruses are provided. Vaccines that contain the viruses are provided. The viruses also can be used in diagnostic methods, such detection and imaging of tumors. The viruses also can be used in methods of treatment of diseases, such as proliferative and inflammatory disorders, including as anti-tumor agents.
摘要翻译： 提供了编码转运蛋白的修饰病毒和用于制备修饰病毒的方法。 提供含有病毒的疫苗。 病毒也可用于诊断方法，如肿瘤的检测和成像。 病毒也可用于治疗诸如增殖性和炎症性疾病的疾病的方法，包括作为抗肿瘤剂。
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10.发明授权Artificial chromosomes, uses thereof and methods for preparing artificial chromosomes 失效人造染色体，其用途和制备人造染色体的方法
公开(公告)号：US6077697A
公开(公告)日：2000-06-20
申请号：US682080
申请日：1996-07-15
申请人： Gyula Hadlaczky , Aladar A. Szalay
发明人： Gyula Hadlaczky , Aladar A. Szalay
IPC分类号： A01H1/00 , A01H5/00 , A01K67/027 , A61K38/00 , A61K48/00 , C12N5/02 , C12N5/10 , C12N15/09 , C12N15/113 , C12N15/62 , C12N15/82 , C12N15/85 , C07H21/04 , C12N15/10
CPC分类号： C12N15/85 , A01K67/0275 , C12N15/113 , C12N15/625 , C12N15/82 , C12N15/8509 , A01K2217/05 , A01K2227/10 , A01K2227/105 , A01K2227/30 , A01K2227/40 , A01K2267/01 , A01K2267/03 , A01K2267/0337 , A61K38/00 , A61K48/00 , C07K2319/036 , C07K2319/61 , C12N2310/111 , C12N2800/20 , C12N2800/206 , C12N2800/208 , C12N2830/002
摘要： Methods for preparing cell lines that contain artificial chromosomes, methods for preparation of artificial chromosomes, methods for purification of artificial chromosomes, methods for targeted insertion of heterologous DNA into artificial chromosomes, and methods for delivery of the chromosomes to selected cells and tissues are provided. Also provided are cell lines for use in the methods, and cell lines and chromosomes produced by the methods. In particular, satellite artificial chromosomes that, except for inserted heterologous DNA, are substantially composed of heterochromatin are provided. Methods for use of the artificial chromosomes, including for gene therapy, production of gene products and production of transgenic plants and animals are also provided.
摘要翻译： 提供了包含人造染色体的细胞系的制备方法，人造染色体的制备方法，纯化人造染色体的方法，将异源DNA靶向插入人造染色体的方法，以及将染色体递送至所选择的细胞和组织的方法。 还提供了用于方法的细胞系，以及通过该方法产生的细胞系和染色体。 特别地，提供除了插入的异源DNA之外，基本上由异染色质组成的卫星人造染色体。 还提供了使用人造染色体的方法，包括用于基因治疗，生产基因产物和转基因植物和动物的生产。
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