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    Method for determining the presence of malignant cells
    3.
    发明授权
    Method for determining the presence of malignant cells 失效
    确定恶性细胞存在的方法

    公开(公告)号：US4782015A

    公开(公告)日：1988-11-01

    申请号：US595073

    申请日：1984-03-30

    申请人： Anthony C. Allison ,  Vera Morhenn ,  Alain B. Schreiber

    发明人： Anthony C. Allison ,  Vera Morhenn ,  Alain B. Schreiber

    IPC分类号： G01N33/574 ,  A61K39/395 ,  C07K14/005 ,  C07K14/195 ,  C07K16/00 ,  C07K16/30 ,  C07K19/00 ,  C12N5/10 ,  C12N15/02 ,  C12P21/08 ,  C12R1/91 ,  G01N33/577

    CPC分类号： C07K16/30 ,  Y10S435/81 ,  Y10S435/975 ,  Y10S436/808 ,  Y10S436/813

    摘要： The present invention is concerned with a method for determining the presence of a malignant condition at a locus of interest. An exfoliative cell specimen obtained from the locus is contacted with an antibody specific for an antigenic site that is usually only found in the specimen when a malignant condition is present. The contact is made under conditions for detectable binding of the antibody to such antigenic site. After contact, the presence of binding of the antibody to the antigenic site is observed. The binding of the antibody is related to the presence of a malignant condition at the locus. The invention finds utility, for example, in the detection of cervical carcinoma.

    摘要翻译： 本发明涉及用于确定感兴趣的基因座处的恶性病症的存在的方法。 将从所述场所获得的剥脱性细胞样品与当存在恶性病症时通常仅在样品中发现的抗原位点特异性抗体接触。 在可检测的抗体与这种抗原位点结合的条件下进行接触。 接触后，观察到抗体与抗原位点结合的存在。 抗体的结合与位点处恶性病症的存在有关。 本发明可用于例如宫颈癌的检测。

    Etianic acids as antiangiogenics
    6.
    发明授权
    Etianic acids as antiangiogenics 失效
    Etianic酸作为抗血管生成剂

    公开(公告)号：US4599331A

    公开(公告)日：1986-07-08

    申请号：US685568

    申请日：1984-12-24

    申请人： Alain B. Schreiber ,  William J. Kowalski ,  Stefan H. Unger

    发明人： Alain B. Schreiber ,  William J. Kowalski ,  Stefan H. Unger

    IPC分类号： A61K31/56

    CPC分类号： A61K31/56

    摘要： This invention provides a method for inhibiting angiogenesis in mammals. A pharmaceutically acceptable formulation containing a compound of the formula ##STR1## where X.sub.1 X.sub.2 and X.sub.3 are H, C1, or F and X.sub.3 must be H if the substituent of R.sub.1 is .alpha.OH;R.sup.1 is chosen from the group consisting of hydroxyl and hydrogen;R.sub.2 is chosen from the group of alkyloxy or thioalkyls wherein said alkyls have less than 5 carbon atomsR.sub.3 is H or an alkyl having less than 6 carbon atoms, is administered to the mammal having undesirable angiogenesis.The wavy line at C-16 refers to either .alpha. or .beta..

    摘要翻译： 本发明提供一种抑制哺乳动物血管发生的方法。 含有下式化合物的药学上可接受的制剂，其中X1 X2和X3是H，C1或F和X3必须是H，如果R1的取代基是αOH; R1选自羟基和氢; R 2选自烷氧基或硫代烷基，其中所述烷基具有少于5个碳原子，R 3为H或具有少于6个碳原子的烷基，被给予具有不期望的血管发生的哺乳动物。 C-16的波浪线是指alpha或beta。