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公开(公告)号：US20110268698A1
公开(公告)日：2011-11-03
申请号：US13158692
申请日：2011-06-13
申请人： Gary M. KARP , Peter Seongwoo HWANG , James J. TAKASUGI , Hongyu REN , Richard Gerald WILDE , Anthony A. TURPOFF , Alexander AREFOLOV , Guangming CHEN , Jeffrey Allen CAMPBELL , Chunshi Li , Steven Paget , Nanjing Zhang , Xiaoyan Zhang , Jin Zhu
发明人： Gary M. KARP , Peter Seongwoo HWANG , James J. TAKASUGI , Hongyu REN , Richard Gerald WILDE , Anthony A. TURPOFF , Alexander AREFOLOV , Guangming CHEN , Jeffrey Allen CAMPBELL , Chunshi Li , Steven Paget , Nanjing Zhang , Xiaoyan Zhang , Jin Zhu
IPC分类号： A61K38/21
CPC分类号： C07D209/30 , C07D209/42 , C07D401/04 , C07D401/14 , C07D403/12 , C07D403/14 , C07D409/12 , C07D413/12 , C07D417/10 , C07D417/12 , C07D417/14
摘要： The present invention provides compounds, pharmaceutical compositions, and methods of using such compounds or compositions for treating infection by a virus, or for affecting viral IBES activity.
摘要翻译： 本发明提供化合物，药物组合物和使用这些化合物或组合物治疗病毒感染或影响病毒IBES活性的方法。
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公开(公告)号：US07781478B2
公开(公告)日：2010-08-24
申请号：US11653450
申请日：2007-01-16
申请人： Gary M. Karp , Peter Seongwoo Hwang , James J. Takasugi , Hongyu Ren , Richard Gerald Wilde , Anthony A. Turpoff , Alexander Arefolov , Guangming Chen , Jeffrey Allen Campbell , Chunshi Li , Steven Paget , Nanjing Zhang , Jin Zhu , Xiaoyan Zhang
发明人： Gary M. Karp , Peter Seongwoo Hwang , James J. Takasugi , Hongyu Ren , Richard Gerald Wilde , Anthony A. Turpoff , Alexander Arefolov , Guangming Chen , Jeffrey Allen Campbell , Chunshi Li , Steven Paget , Nanjing Zhang , Jin Zhu , Xiaoyan Zhang
IPC分类号： C07D209/10 , A61K31/404
CPC分类号： C07D209/30 , C07D209/42 , C07D401/04 , C07D401/14 , C07D403/12 , C07D403/14 , C07D409/12 , C07D413/12 , C07D417/10 , C07D417/12 , C07D417/14
摘要： The present invention provides compounds, pharmaceutical compositions, and methods of using such compounds or compositions for treating infection by a virus, or for affecting viral IRES activity.
摘要翻译： 本发明提供化合物，药物组合物和使用这些化合物或组合物治疗病毒感染或影响病毒IRES活性的方法。
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公开(公告)号：US07973069B2
公开(公告)日：2011-07-05
申请号：US12814755
申请日：2010-06-14
申请人： Gary M. Karp , Peter Seongwoo Hwang , James J. Takasugi , Hongyu Ren , Richard Gerald Wilde , Anthony A. Turpoff , Alexander Arefolov , Guangming Chen , Jeffrey Allen Campbell , Chunshi Li , Steven Paget , Nanjing Zhang , Jin Zhu , Xiaoyan Zhang
发明人： Gary M. Karp , Peter Seongwoo Hwang , James J. Takasugi , Hongyu Ren , Richard Gerald Wilde , Anthony A. Turpoff , Alexander Arefolov , Guangming Chen , Jeffrey Allen Campbell , Chunshi Li , Steven Paget , Nanjing Zhang , Jin Zhu , Xiaoyan Zhang
IPC分类号： C07D209/10 , A61K31/404
CPC分类号： C07D209/30 , C07D209/42 , C07D401/04 , C07D401/14 , C07D403/12 , C07D403/14 , C07D409/12 , C07D413/12 , C07D417/10 , C07D417/12 , C07D417/14
摘要： The present invention provides compounds, pharmaceutical compositions, and methods of using such compounds or compositions for treating infection by a virus, or for affecting viral IRES activity.
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公开(公告)号：US20100292187A1
公开(公告)日：2010-11-18
申请号：US12814755
申请日：2010-06-14
申请人： Gary M. Karp , Peter Seongwoo Hwang , James J. Takasugi , Hongyu Ren , Richard Gerald Wilde , Anthony A. Turpoff , Alexander Arefolov , Guangming Chen , Jeffrey A. Campbell , Chunshi Li , Steven Paget , Nanjing Zhang , Xiaoyan Zhang , Jin Zhu
发明人： Gary M. Karp , Peter Seongwoo Hwang , James J. Takasugi , Hongyu Ren , Richard Gerald Wilde , Anthony A. Turpoff , Alexander Arefolov , Guangming Chen , Jeffrey A. Campbell , Chunshi Li , Steven Paget , Nanjing Zhang , Xiaoyan Zhang , Jin Zhu
IPC分类号： A61K31/675 , A61K31/541 , A61K31/53 , A61K31/497 , A61K31/506 , A61K31/454 , A61K31/4439 , A61K31/433 , A61K31/4245 , A61K31/427 , A61K31/422 , A61K31/41 , A61K31/4196 , A61K31/4155 , A61K31/407 , A61K31/404 , C07D417/12 , C07D413/12 , C07D401/12 , C07D413/04 , C07D417/10 , C07D413/10 , C07F9/572 , C07D491/14 , C07D403/10 , C07D209/14 , C07D403/12 , C07D407/12 , C07D417/04 , C07D403/04 , C07D401/04 , A61P31/12
CPC分类号： C07D209/30 , C07D209/42 , C07D401/04 , C07D401/14 , C07D403/12 , C07D403/14 , C07D409/12 , C07D413/12 , C07D417/10 , C07D417/12 , C07D417/14
摘要： The present invention provides compounds, pharmaceutical compositions, and methods of using such compounds or compositions for treating infection by a virus, or for affecting viral IRES activity.
摘要翻译： 本发明提供化合物，药物组合物和使用这些化合物或组合物治疗病毒感染或影响病毒IRES活性的方法。
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公开(公告)号：US07772271B2
公开(公告)日：2010-08-10
申请号：US11653448
申请日：2007-01-16
申请人： Gary Mitchell Karp , Peter Seongwoo Hwang , James J. Takasugi , Hongyu Ren , Richard Gerald Wilde , Anthony Turpoff , Alexander Arefolov , Guangming Chen , Jeffrey Allen Campbell , Chunshi Li , Steven Paget , Nanjing Zhang , Xiaoyan Zhang , Jin Zhu
发明人： Gary Mitchell Karp , Peter Seongwoo Hwang , James J. Takasugi , Hongyu Ren , Richard Gerald Wilde , Anthony Turpoff , Alexander Arefolov , Guangming Chen , Jeffrey Allen Campbell , Chunshi Li , Steven Paget , Nanjing Zhang , Xiaoyan Zhang , Jin Zhu
IPC分类号： C07D209/10 , A61K31/404
CPC分类号： C07D209/30 , C07D209/14 , C07D209/42 , C07D401/04 , C07D401/12 , C07D401/14 , C07D403/10 , C07D403/12 , C07D403/14 , C07D409/12 , C07D413/10 , C07D413/12 , C07D413/14 , C07D417/10 , C07D417/12 , C07D417/14
摘要： The present invention provides compounds, pharmaceutical compositions, and methods of using such compounds or compositions for treating infection by a virus, or for affecting viral IRES activity.
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公开(公告)号：US20100305100A1
公开(公告)日：2010-12-02
申请号：US12828597
申请日：2010-07-01
申请人： Gary Mitchell Karp , Peter Seongwoo Hwang , James J. Takasugi , Hongyu Ren , Richard Gerald Wilde , Anthony Turpoff , Alexander Arefolov , Guangming Chen , Jeffrey Allen Campbell , Chunshi Li , Steven Paget , Nanjing Zhang , Xiaoyan Zhang , Jin Zhu
发明人： Gary Mitchell Karp , Peter Seongwoo Hwang , James J. Takasugi , Hongyu Ren , Richard Gerald Wilde , Anthony Turpoff , Alexander Arefolov , Guangming Chen , Jeffrey Allen Campbell , Chunshi Li , Steven Paget , Nanjing Zhang , Xiaoyan Zhang , Jin Zhu
IPC分类号： A61K31/55 , C07D209/04 , C07D417/06 , C07D405/12 , C07D271/10 , C07D403/04 , C07D263/30 , C07D401/12 , C07D239/10 , C07D215/00 , C07D223/16 , A61K31/405 , A61K31/40 , A61K31/4155 , A61K31/4245 , A61K31/427 , A61K31/42 , A61K31/4439 , A61K31/497 , A61K31/4725 , A61P31/14 , A61P31/12
CPC分类号： C07D209/30 , C07D209/14 , C07D209/42 , C07D401/04 , C07D401/12 , C07D401/14 , C07D403/10 , C07D403/12 , C07D403/14 , C07D409/12 , C07D413/10 , C07D413/12 , C07D413/14 , C07D417/10 , C07D417/12 , C07D417/14
摘要： The present invention provides compounds, pharmaceutical compositions, and methods of using such compounds or compositions for treating infection by a virus, or for affecting viral IRES activity.
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公开(公告)号：US08735414B2
公开(公告)日：2014-05-27
申请号：US13259717
申请日：2010-04-05
申请人： Malcolm MacCoss , F. George Njoroge , Amin Nomeir , Guangming Chen , Song Xiao Huang , Ramesh Kakarla , Gary Mitchell Karp , William Joseph Lennox , Chunshi Li , Ronggang Liu , Yalei Liu , Christie Morrill , Steven D. Paget , Sean W Smith , James Takasugi , Anthony A. Turpoff , Hongyu Ren , Nanjing Zhang , Xiaoyan Zhang , Jin Zhu
发明人： Malcolm MacCoss , F. George Njoroge , Amin Nomeir , Guangming Chen , Song Xiao Huang , Ramesh Kakarla , Gary Mitchell Karp , William Joseph Lennox , Chunshi Li , Ronggang Liu , Yalei Liu , Christie Morrill , Steven D. Paget , Sean W Smith , James Takasugi , Anthony A. Turpoff , Hongyu Ren , Nanjing Zhang , Xiaoyan Zhang , Jin Zhu
IPC分类号： A61K31/506 , C07D401/02 , C07D405/02 , C07D209/04
CPC分类号： C07D401/04 , C07D401/14 , C07D403/04 , C07D405/14 , C07D409/14 , C07D413/14 , C07D417/14
摘要： The present invention is directed to compounds and forms and pharmaceutical compositions thereof useful for treating a viral infection, or for affecting viral activity by modulating viral replication.
摘要翻译： 本发明涉及用于治疗病毒感染或通过调节病毒复制影响病毒活性的化合物及其形式和药物组合物。
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公开(公告)号：US20120184574A1
公开(公告)日：2012-07-19
申请号：US13259717
申请日：2010-04-05
申请人： Malcolm Maccoss , F. George Njoroge , Amin Nomeir , Guangming Chen , Song Xiao Huang , Ramesh Kakarla , Gary Mitchell Karp , William Joseph Lennox , Chunshi Li , Ronggang Liu , Yalei Liu , Christie Morrill , Steven D. Paget , Sean W. Smith , James Takasugi , Anthony A. Turpoff , Hongyu Ren , Nanjing Zhang , Xiaoyan Zhang , Jin Zhu
发明人： Malcolm Maccoss , F. George Njoroge , Amin Nomeir , Guangming Chen , Song Xiao Huang , Ramesh Kakarla , Gary Mitchell Karp , William Joseph Lennox , Chunshi Li , Ronggang Liu , Yalei Liu , Christie Morrill , Steven D. Paget , Sean W. Smith , James Takasugi , Anthony A. Turpoff , Hongyu Ren , Nanjing Zhang , Xiaoyan Zhang , Jin Zhu
IPC分类号： A61K31/4439 , C07D401/14 , A61K31/444 , A61P31/20 , A61P31/12 , A61P31/22 , A61P31/18 , A61P31/14 , C07D401/04 , A61K31/506
CPC分类号： C07D401/04 , C07D401/14 , C07D403/04 , C07D405/14 , C07D409/14 , C07D413/14 , C07D417/14
摘要： The present invention is directed to compounds and forms and pharmaceutical compositions thereof useful for treating a viral infection, or for affecting viral activity by modulating viral replication.
摘要翻译： 本发明涉及用于治疗病毒感染或通过调节病毒复制影响病毒活性的化合物及其形式和药物组合物。
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公开(公告)号：US20120135999A1
公开(公告)日：2012-05-31
申请号：US13259283
申请日：2010-04-05
申请人： Malcolm Maccoss , F. George Njoroge , Amin Nomeir , Guangming Chen , Gary Mitchell Karp , William Jospeh Lennox , Chunshi Li , Christie Morrill , Steven D. Paget , Hongyu Ren , Nanjing Zhang , Xiaoyan Zhang
发明人： Malcolm Maccoss , F. George Njoroge , Amin Nomeir , Guangming Chen , Gary Mitchell Karp , William Jospeh Lennox , Chunshi Li , Christie Morrill , Steven D. Paget , Hongyu Ren , Nanjing Zhang , Xiaoyan Zhang
IPC分类号： A61K31/501 , C07D487/04 , C12N7/06 , A61K31/437 , A61P31/14 , A61K31/519 , A61K31/497 , A61P31/12 , A61P31/18 , A61P31/22 , C07D471/04 , A61K31/506
CPC分类号： C07D471/04 , A61K31/437 , A61K31/506 , C07D401/04 , C07D401/14 , C07D403/04 , C07D403/14 , C07D487/04
摘要： The present invention is directed to compounds and forms and pharmaceutical compositions thereof useful for treating a viral infection, or for affecting viral activity by modulating viral replication.
摘要翻译： 本发明涉及用于治疗病毒感染或通过调节病毒复制影响病毒活性的化合物及其形式和药物组合物。
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公开(公告)号：US09593108B2
公开(公告)日：2017-03-14
申请号：US13259283
申请日：2010-04-05
申请人： Malcolm Maccoss , F. George Njoroge , Amin Nomeir , Guangming Chen , Gary Mitchell Karp , William Jospeh Lennox , Chunshi Li , Christie Morrill , Steven D. Paget , Hongyu Ren , Nanjing Zhang , Xiaoyan Zhang
发明人： Malcolm Maccoss , F. George Njoroge , Amin Nomeir , Guangming Chen , Gary Mitchell Karp , William Jospeh Lennox , Chunshi Li , Christie Morrill , Steven D. Paget , Hongyu Ren , Nanjing Zhang , Xiaoyan Zhang
IPC分类号： C07D487/04 , C07D401/04 , C07D401/14 , C07D403/04 , C07D403/14 , A61K31/437 , A61K31/506 , A61P31/14 , C07D471/04
CPC分类号： C07D471/04 , A61K31/437 , A61K31/506 , C07D401/04 , C07D401/14 , C07D403/04 , C07D403/14 , C07D487/04
摘要： The present invention is directed to compounds and forms and pharmaceutical compositions thereof useful for treating a viral infection, or for affecting viral activity by modulating viral replication.
摘要翻译： 本发明涉及用于治疗病毒感染或通过调节病毒复制影响病毒活性的化合物及其形式和药物组合物。
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