公开(公告)号：US20100166738A1

公开(公告)日：2010-07-01

申请号：US12646703

申请日：2009-12-23

申请人： Alexander Gaiger ,  Martin A. Cheever

发明人： Alexander Gaiger ,  Martin A. Cheever

IPC分类号： A61K39/395 ,  A61K39/00 ,  A61K35/26 ,  C12N5/00 ,  A61K38/02 ,  A61K31/7088 ,  C07K2/00 ,  C07K7/06 ,  C07H21/00

CPC分类号： A61K39/0011 ,  A61K2039/55522 ,  A61K2039/55566 ,  A61K2039/55572 ,  Y10S514/885 ,  Y10S530/806 ,  Y10S530/828

摘要： Compositions and methods for the therapy of malignant diseases, such as leukemia and cancer, are disclosed. The compositions comprise one or more of a WT1 polynucleotide, a WT1 polypeptide, an antigen-presenting cell presenting a WT1 polypeptide, an antibody that specifically binds to a WT1 polypeptide; or a T cell that specifically reacts with a WT1 polypeptide. Such compositions may be used, for example, for the prevention and treatment of metastatic diseases.

摘要翻译： 公开了治疗恶性疾病如白血病和癌症的组合物和方法。 所述组合物包含一种或多种WT1多核苷酸，WT1多肽，呈递WT1多肽的抗原呈递细胞，特异性结合WT1多肽的抗体; 或与WT1多肽特异性反应的T细胞。 这样的组合物可以用于例如预防和治疗转移性疾病。

公开(公告)号：US20100087621A1

公开(公告)日：2010-04-08

申请号：US12629651

申请日：2009-12-02

申请人： Martin A. Cheever ,  Mary L. Disis

发明人： Martin A. Cheever ,  Mary L. Disis

IPC分类号： C07K7/06

CPC分类号： A61K39/0011 ,  A61K38/00 ,  A61K39/00 ,  C07K7/06 ,  C07K14/4705 ,  C07K14/71 ,  G01N33/57407 ,  G01N33/57488 ,  G01N2333/71 ,  G01N2333/82 ,  Y10S530/806 ,  Y10S530/828

摘要： Methods for the detection, monitoring and treatment of malignancies in which the HER-2/neu oncogene is associated are disclosed. Detection of specific T cell activation (e.g., by measuring the proliferation of T cells) in response to in vitro exposure to the HER-2/neu protein, or detection of immunocomplexes formed between the HER-2/neu protein and antibodies in body fluid, allows the diagnosis of the presence of a malignancy in which the HER-2/neu oncogene is associated. The present invention also discloses methods and compositions, including peptides, for treating such malignancies.

摘要翻译： 公开了检测，监测和治疗其中HER-2 / neu致癌基因相关的恶性肿瘤的方法。 通过体外暴露于HER-2 / neu蛋白来检测特异性T细胞活化（例如，通过测量T细胞的增殖），或检测HER-2 / neu蛋白与体液中抗体之间形成的免疫复合物 允许诊断HER-2 / neu致癌基因相关的恶性肿瘤的存在。 本发明还公开了用于治疗这些恶性肿瘤的方法和组合物，包括肽。

公开(公告)号：US07247703B2

公开(公告)日：2007-07-24

申请号：US10647005

申请日：2003-08-21

申请人： Martin A Cheever ,  Mary L Disis

发明人： Martin A Cheever ,  Mary L Disis

IPC分类号： C07K7/08 ,  C07K7/06 ,  A61K38/08 ,  A61K38/10

CPC分类号： A61K39/0011 ,  A61K38/00 ,  A61K39/00 ,  C07K7/06 ,  C07K14/4705 ,  C07K14/71 ,  G01N33/57407 ,  G01N33/57488 ,  G01N2333/71 ,  G01N2333/82 ,  Y10S530/806 ,  Y10S530/828

摘要： Methods for the detection, monitoring and treatment of malignancies in which the HER-2/neu oncogene is associated are disclosed. Detection of specific T cell activation (e.g., by measuring the proliferation of T cells) in response to in vitro exposure to the HER-2/neu protein, or detection of immunocomplexes formed between the HER-2/neu protein and antibodies in body fluid, allows the diagnosis of the presence of a malignancy in which the HER-2/neu oncogene is associated. The present invention also discloses methods and compositions, including peptides, for treating such malignancies.

摘要翻译： 公开了检测，监测和治疗其中HER-2 / neu致癌基因相关的恶性肿瘤的方法。 通过体外暴露于HER-2 / neu蛋白来检测特异性T细胞活化（例如，通过测量T细胞的增殖），或检测HER-2 / neu蛋白与体液中抗体之间形成的免疫复合物 允许诊断HER-2 / neu致癌基因相关的恶性肿瘤的存在。 本发明还公开了用于治疗这些恶性肿瘤的方法和组合物，包括肽。

公开(公告)号：US06942862B2

公开(公告)日：2005-09-13

申请号：US09088951

申请日：1998-06-02

申请人： Martin A. Cheever ,  Mary L. Disis

发明人： Martin A. Cheever ,  Mary L. Disis

IPC分类号： A61K38/00 ,  A61K39/00 ,  C07K14/71 ,  A61K38/17

CPC分类号： A61K39/0005 ,  A61K38/00 ,  A61K39/00 ,  A61K39/0011 ,  C07K14/71 ,  G01N33/57407 ,  G01N33/57488 ,  G01N2333/71 ,  G01N2333/82

摘要： Methods and compositions to elicit or enhance immunity in humans against self tumor antigens are disclosed. Such immunity is generated by immunization with homologous foreign proteins. Self tumor antigens include protein expression products of overexpressed human oncogenes, such as human HER-2/neu protein, and organ-specific or tissue-specific differentiation antigens, such as PAP or PSA, associated with tumor cells.

摘要翻译： 公开了引发或增强人体免疫自身抗体抗原的方法和组合物。 这种免疫通过用同源外源蛋白免疫产生。 自身肿瘤抗原包括与肿瘤细胞相关的过度表达的人癌基因如人HER-2 / neu蛋白和器官特异性或组织特异性分化抗原如PAP或PSA的蛋白质表达产物。

公开(公告)号：US5601989A

公开(公告)日：1997-02-11

申请号：US251590

申请日：1994-05-31

申请人： Martin A. Cheever ,  David J. Peace

发明人： Martin A. Cheever ,  David J. Peace

IPC分类号： G01N33/53 ,  A61K35/14 ,  A61K35/17 ,  A61K39/00 ,  A61K48/00 ,  A61P31/04 ,  A61P35/00 ,  C07K14/47 ,  C07K14/82 ,  C12N5/10 ,  C12N15/00 ,  C12N15/09 ,  C12N15/12 ,  C12P21/02 ,  G01N33/50 ,  G01N33/574

CPC分类号： C07K14/82 ,  A61K35/17 ,  C07K14/4746 ,  G01N33/5091 ,  G01N33/5748 ,  A61K39/00 ,  G01N2800/52 ,  Y10S436/813

摘要： Methods for the detection, monitoring and treatment of malignancies are disclosed. Detection of the proliferation of T cells in response to in vitro exposure to a protein expression product of an activated oncogene or cancer-related gene associated with a malignancy, or detection of immunocomplexes formed between the protein expression product and antibodies in body fluid, allows the diagnosis of the presence of a malignancy. The present invention also discloses methods and compositions for treating a malignancy.

摘要翻译： 公开了检测，监测和治疗恶性肿瘤的方法。 响应于体外暴露于与恶性肿瘤相关的活化致癌基因或癌相关基因的蛋白质表达产物或检测体液中蛋白质表达产物和抗体之间形成的免疫复合物的T细胞增殖的检测允许 诊断恶性肿瘤的存在。 本发明还公开了治疗恶性肿瘤的方法和组合物。

公开(公告)号：US07655239B2

公开(公告)日：2010-02-02

申请号：US11821574

申请日：2007-06-21

申请人： Martin A Cheever ,  Mary L Disis

发明人： Martin A Cheever ,  Mary L Disis

IPC分类号： A61K38/08 ,  C07K7/06

CPC分类号： A61K39/0011 ,  A61K38/00 ,  A61K39/00 ,  C07K7/06 ,  C07K14/4705 ,  C07K14/71 ,  G01N33/57407 ,  G01N33/57488 ,  G01N2333/71 ,  G01N2333/82 ,  Y10S530/806 ,  Y10S530/828

摘要： Methods for the detection, monitoring and treatment of malignancies in which the HER-2/neu oncogene is associated are disclosed. Detection of specific T cell activation (e.g., by measuring the proliferation of T cells) in response to in vitro exposure to the HER-2/neu protein, or detection of immunocomplexes formed between the HER-2/neu protein and antibodies in body fluid, allows the diagnosis of the presence of a malignancy in which the HER-2/neu oncogene is associated. The present invention also discloses methods and compositions, including peptides, for treating such malignancies.

摘要翻译： 公开了检测，监测和治疗其中HER-2 / neu致癌基因相关的恶性肿瘤的方法。 通过体外暴露于HER-2 / neu蛋白来检测特异性T细胞活化（例如，通过测量T细胞的增殖），或检测HER-2 / neu蛋白与体液中抗体之间形成的免疫复合物 允许诊断HER-2 / neu致癌基因相关的恶性肿瘤的存在。 本发明还公开了用于治疗这些恶性肿瘤的方法和组合物，包括肽。

公开(公告)号：US20080241268A1

公开(公告)日：2008-10-02

申请号：US11956201

申请日：2007-12-13

申请人： Alexander Gaiger ,  Martin A. Cheever

发明人： Alexander Gaiger ,  Martin A. Cheever

IPC分类号： A61K9/14 ,  A61K39/39 ,  C12N5/08 ,  A61P37/04

CPC分类号： A61K39/0011 ,  A61K2039/55522 ,  A61K2039/55566 ,  A61K2039/55572 ,  Y10S514/885 ,  Y10S530/806 ,  Y10S530/828

摘要： Compositions and methods for the therapy of malignant diseases, such as leukemia and cancer, are disclosed. The compositions comprise one or more of a WT1 polynucleotide, a WT1 polypeptide, an antigen-presenting cell presenting a WT1 polypeptide, an antibody that specifically binds to a WT1 polypeptide; or a T cell that specifically reacts with a WT1 polypeptide. Such compositions may be used, for example, for the prevention and treatment of metastatic diseases.

摘要翻译： 公开了治疗恶性疾病如白血病和癌症的组合物和方法。 所述组合物包含一种或多种WT1多核苷酸，WT1多肽，呈递WT1多肽的抗原呈递细胞，特异性结合WT1多肽的抗体; 或与WT1多肽特异性反应的T细胞。 这样的组合物可以用于例如预防和治疗转移性疾病。

公开(公告)号：US07144581B2

公开(公告)日：2006-12-05

申请号：US09785019

申请日：2001-02-15

申请人： Alexander Gaiger ,  Martin A. Cheever

发明人： Alexander Gaiger ,  Martin A. Cheever

IPC分类号： A61K38/16 ,  A61K39/00 ,  C07K14/435

CPC分类号： C07K14/4748 ,  A61K38/00 ,  A61K39/00 ,  A61K2039/515 ,  C07K2319/00 ,  Y10S514/885 ,  Y10S530/806

摘要： Compositions and methods for the therapy of malignant diseases, such as leukemia and cancer, are disclosed. The compositions comprise one or more of a WT1 polynucleotide, a WT1 polypeptide, an antigen-presenting cell presenting a WT1 polypeptide, an antibody that specifically binds to a WT1 polypeptide; or a T cell that specifically reacts with a WT1 polypeptide. Such compositions may be used, for example, for the prevention and treatment of metastatic diseases.

公开(公告)号：US5869445A

公开(公告)日：1999-02-09

申请号：US625101

申请日：1996-04-01

申请人： Martin A. Cheever ,  Mary L. Disis

发明人： Martin A. Cheever ,  Mary L. Disis

IPC分类号： A61K38/00 ,  A61K38/08 ,  A61K38/10 ,  A61K39/00 ,  C07K1/00 ,  C07K2/00 ,  C07K4/00 ,  C07K5/00 ,  C07K7/00 ,  C07K7/06 ,  C07K7/08 ,  C07K14/00 ,  C07K14/705 ,  C07K14/71 ,  C07K16/00 ,  C07K17/00 ,  C12N5/08 ,  G01N33/574 ,  A61K38/17

CPC分类号： A61K39/0011 ,  C07K14/71 ,  G01N33/57407 ,  G01N33/57488 ,  A61K38/00 ,  A61K39/00 ,  G01N2333/71 ,  G01N2333/82

摘要： Compounds and compositions for eliciting or enhancing immune reactivity to HER-2/neu protein are disclosed. The compounds include polypeptides and nucleic acid molecules encoding such peptides. The compounds may be used for the prevention or treatment of malignancies in which the HER-2/neu oncogene is associated.

摘要翻译： 公开了引发或增强对HER-2 / neu蛋白的免疫反应性的化合物和组合物。 化合物包括编码这些肽的多肽和核酸分子。 该化合物可用于预防或治疗HER-2 / neu致癌基因相关的恶性肿瘤。

公开(公告)号：US08568733B2

公开(公告)日：2013-10-29

申请号：US12099798

申请日：2008-04-09

申请人： Martin A. Cheever ,  Dirk Gheysen

发明人： Martin A. Cheever ,  Dirk Gheysen

IPC分类号： A61K39/00

CPC分类号： C12N15/62 ,  A61K35/00 ,  A61K35/12 ,  A61K38/00 ,  C07K14/71 ,  C07K2319/02 ,  C07K2319/21 ,  C07K2319/30 ,  C07K2319/32 ,  C07K2319/43 ,  C07K2319/73 ,  C07K2319/75

摘要： The present invention is generally directed to HER-2/neu fusion proteins, nucleic acid molecules encoding HER-2/neu fusion proteins, viral vectors expressing HER-2/neu fusion proteins, and pharmaceutical compositions (e.g., vaccines) comprising the HER-2/neu fusion proteins and/or nucleic acid molecules encoding the HER-2/neu fusion proteins. The present invention is also directed to methods of treating or preventing cancer by eliciting or enhancing an immune response to the HER-2/neu protein, including for uses in the treatment of malignancies associated with the HER-2/neu oncogene.

摘要翻译： 本发明一般涉及HER-2 / neu融合蛋白，编码HER-2 / neu融合蛋白的核酸分子，表达HER-2 / neu融合蛋白的病毒载体和包含HER-2 / neu融合蛋白的药物组合物（例如疫苗） 2 / neu融合蛋白和/或编码HER-2 / neu融合蛋白的核酸分子。 本发明还涉及通过引发或增强对HER-2 / neu蛋白的免疫应答来治疗或预防癌症的方法，包括用于治疗与HER-2 / neu癌基因有关的恶性肿瘤的用途。