公开(公告)号：US20100274330A1

公开(公告)日：2010-10-28

申请号：US12831159

申请日：2010-07-06

申请人： Phillip Burwell ,  Zihong Guo ,  Jennifer K. Matson ,  Steven Ross Daly ,  David B. Shine ,  Gary Lichttenegger ,  Jean M. Bishop ,  Nick Yeo ,  Hugh Narciso ,  James C. Chen ,  William L. Barnard ,  Alexei N. Naimushin

发明人： Phillip Burwell ,  Zihong Guo ,  Jennifer K. Matson ,  Steven Ross Daly ,  David B. Shine ,  Gary Lichttenegger ,  Jean M. Bishop ,  Nick Yeo ,  Hugh Narciso ,  James C. Chen ,  William L. Barnard ,  Alexei N. Naimushin

IPC分类号： A61N5/06

CPC分类号： A61N5/0601 ,  A61B2017/22051 ,  A61N5/062 ,  A61N2005/0602 ,  A61N2005/0652

摘要： Light generating devices for illuminating portions of vascular tissue to administer photodynamic therapy, and usable with, or including a distal protection device. A first device includes a hollow tip, a flushing lumen, a guidewire lumen, and at least one of a light source, and a hollow light transmissive shaft that is adapted to accommodate a light source. If desired, the device can include a balloon, so that a portion of a body lumen between the balloon and the distal protection device is isolated when the balloon is inflated. A second device includes inner and outer catheters, the outer catheter including a balloon, and the inner catheter including a light source encompassed by another balloon. Yet another device is a catheter having two balloons and a sleeve extending there between. Within the sleeve, the catheter includes a light source and an expanding member.

摘要翻译： 用于照射血管组织的部分以施用光动力学治疗并且可用于或包括远侧保护装置的光产生装置。 第一装置包括中空尖端，冲洗腔，导丝管腔以及适于容纳光源的光源和中空透光轴中的至少一个。 如果需要，装置可以包括气囊，使得当球囊膨胀时，球囊和远侧保护装置之间的体腔的一部分被隔离。 第二装置包括内导管和外导管，外导管包括气囊，并且内导管包括由另一球囊包围的光源。 另一种装置是具有两个气囊的导管和在其间延伸的套管。 在套管内，导管包括光源和扩张构件。

公开(公告)号：US07675624B2

公开(公告)日：2010-03-09

申请号：US11398964

申请日：2006-04-05

申请人： Timothy M. Chinowsky ,  Scott D. Soelberg ,  Peter C. Kauffman ,  Clement E. Furlong ,  Jared Tritz ,  Michael S. Grow ,  Alexei N. Naimushin ,  Sinclair S. Yee

发明人： Timothy M. Chinowsky ,  Scott D. Soelberg ,  Peter C. Kauffman ,  Clement E. Furlong ,  Jared Tritz ,  Michael S. Grow ,  Alexei N. Naimushin ,  Sinclair S. Yee

IPC分类号： G01N21/55

CPC分类号： G01N21/553 ,  G01N2201/04

摘要： This specification discloses various improvements in the field of SPR sensing systems. One improvement relates to a portable SPR sensing system, e.g., a system contained within a suitcase that can be hand-carried to a monitoring site. Another improvement relates to a portable, cartridge-based SPR sensing system. In this system, selected portions of the system's electrical and fluidics systems are allocated between a base unit and a removable/disposable cartridge. Other improvements relate to methods or protocols for operating an SPR sensing system. Such methods provide for the elimination of false positives and increased sensitivity, e.g., by using secondary antibodies with specificity for different target epitopes and by sensor element redundancy. In addition, protocols are provided for the detection of small molecules. Such protocols may employ a competition type assay where the presence of the analyte inhibits the binding of antibodies to surface immobilized analyte, or a displacement assay, where antibodies bound to the analyte on the sensor surface are displaced by free analyte.

摘要翻译： 本说明书公开了SPR传感系统领域的各种改进。 一个改进涉及便携式SPR感测系统，例如，可以手提携带到监控地点的手提箱内的系统。 另一项改进涉及一种便携式，基于盒式SPR感测系统。 在该系统中，系统的电和流体系统的选定部分被分配在基本单元和可移动/一次性盒之间。 其他改进涉及用于操作SPR感测系统的方法或协议。 这样的方法提供消除假阳性和提高灵敏度，例如通过使用对不同靶标表位具有特异性的二级抗体以及通过传感器元件冗余。 此外，提供了用于检测小分子的方案。 这样的方案可以采用竞争型测定法，其中分析物的存在抑制抗体与表面固定化分析物的结合，或位移测定法，其中与传感器表面上的分析物结合的抗体被游离分析物置换。

公开(公告)号：US08174700B2

公开(公告)日：2012-05-08

申请号：US13016788

申请日：2011-01-28

申请人： Timothy M. Chinowsky ,  Scott D. Soelberg ,  Peter C. Kauffman ,  Clement E. Furlong ,  Jared Tritz ,  Michael S. Grow ,  Alexei N. Naimushin ,  Sinclair S. Yee

发明人： Timothy M. Chinowsky ,  Scott D. Soelberg ,  Peter C. Kauffman ,  Clement E. Furlong ,  Jared Tritz ,  Michael S. Grow ,  Alexei N. Naimushin ,  Sinclair S. Yee

IPC分类号： G01N21/00

CPC分类号： G01N21/553 ,  G01N2201/04

摘要： This specification discloses various improvements in the field of SPR sensing systems. One improvement relates to a portable SPR sensing system, e.g., a system contained within a suitcase that can be hand-carried to a monitoring site. Another improvement relates to a portable, cartridge-based SPR sensing system. In this system, selected portions of the system's electrical and fluidics systems are allocated between a base unit and a removable/disposable cartridge. Other improvements relate to methods or protocols for operating an SPR sensing system. Such methods provide for the elimination of false positives and increased sensitivity, e.g., by using secondary antibodies with specificity for different target epitopes and by sensor element redundancy. In addition, protocols are provided for the detection of small molecules. Such protocols may employ a competition type assay where the presence of the analyte inhibits the binding of antibodies to surface immobilized analyte, or a displacement assay, where antibodies bound to the analyte on the sensor surface are displaced by free analyte.

摘要翻译： 本说明书公开了SPR传感系统领域的各种改进。 一个改进涉及便携式SPR感测系统，例如，可以手提携带到监控地点的手提箱内的系统。 另一项改进涉及一种便携式，基于盒式SPR感测系统。 在该系统中，系统的电和流体系统的选定部分被分配在基本单元和可移动/一次性盒之间。 其他改进涉及用于操作SPR感测系统的方法或协议。 这样的方法提供消除假阳性和提高灵敏度，例如通过使用对不同靶标表位具有特异性的二级抗体以及通过传感器元件冗余。 此外，提供了用于检测小分子的方案。 这样的方案可以采用竞争型测定法，其中分析物的存在抑制抗体与表面固定化分析物的结合，或位移测定法，其中与传感器表面上的分析物结合的抗体被游离分析物置换。

公开(公告)号：US20110128548A1

公开(公告)日：2011-06-02

申请号：US13016788

申请日：2011-01-28

申请人： Timothy M. Chinowsky ,  Scott D. Soelberg ,  Peter C. Kauffman ,  Clement E. Furlong ,  Jared Tritz ,  Michael S. Grow ,  Alexei N. Naimushin ,  Sinclair S. Yee

发明人： Timothy M. Chinowsky ,  Scott D. Soelberg ,  Peter C. Kauffman ,  Clement E. Furlong ,  Jared Tritz ,  Michael S. Grow ,  Alexei N. Naimushin ,  Sinclair S. Yee

IPC分类号： G01N21/55

CPC分类号： G01N21/553 ,  G01N2201/04

摘要： This specification discloses various improvements in the field of SPR sensing systems. One improvement relates to a portable SPR sensing system, e.g., a system contained within a suitcase that can be hand-carried to a monitoring site. Another improvement relates to a portable, cartridge-based SPR sensing system. In this system, selected portions of the system's electrical and fluidics systems are allocated between a base unit and a removable/disposable cartridge. Other improvements relate to methods or protocols for operating an SPR sensing system. Such methods provide for the elimination of false positives and increased sensitivity, e.g., by using secondary antibodies with specificity for different target epitopes and by sensor element redundancy. In addition, protocols are provided for the detection of small molecules. Such protocols may employ a competition type assay where the presence of the analyte inhibits the binding of antibodies to surface immobilized analyte, or a displacement assay, where antibodies bound to the analyte on the sensor surface are displaced by free analyte.

摘要翻译： 本说明书公开了SPR传感系统领域的各种改进。 一个改进涉及便携式SPR感测系统，例如，可以手提携带到监控地点的手提箱内的系统。 另一项改进涉及一种便携式，基于盒式SPR感测系统。 在该系统中，系统的电和流体系统的选定部分被分配在基本单元和可移动/一次性盒之间。 其他改进涉及用于操作SPR感测系统的方法或协议。 这样的方法提供消除假阳性和提高灵敏度，例如通过使用对不同靶标表位具有特异性的二级抗体以及通过传感器元件冗余。 此外，提供了用于检测小分子的方案。 这样的方案可以采用竞争型测定法，其中分析物的存在抑制抗体与表面固定化分析物的结合，或位移测定法，其中与传感器表面上的分析物结合的抗体被游离分析物置换。

公开(公告)号：US20170246472A1

公开(公告)日：2017-08-31

申请号：US15508844

申请日：2015-09-08

申请人： James C. CHEN ,  Llew KELTNER ,  Alexei N. NAIMUSHIN

发明人： James C. CHEN ,  Llew KELTNER ,  Alexei N. NAIMUSHIN

IPC分类号： A61N5/06 ,  A61M37/00

CPC分类号： A61N5/062 ,  A61M37/0092 ,  A61M2037/0007 ,  A61N5/0601 ,  A61N2005/0602 ,  A61N2005/0612 ,  A61N2005/0626 ,  A61N2005/063 ,  A61N2005/067

摘要： Systems, devices, and methods are described for providing, among other things, improvement in treatment of abnormal tissues including cancer, utilizing light activated drug therapy. Improvements include the use of optical penetration and drug penetration enhancers, in combination with photosensitizing drugs, and the use of localization aids and implements, which enable treatment of larger tissue volumes using minimal tissue access. The cytotoxic photoactivation process is also improved by using internal guidance to direct the light source to and at the lesion site using a naturally occurring orifice or intravascular access route.

公开(公告)号：US20100284012A1

公开(公告)日：2010-11-11

申请号：US12699377

申请日：2010-02-03

申请人： Timothy M. Chinowsky ,  Scott D. Soelberg ,  Peter C. Kauffman ,  Clement E. Furlong ,  Jared Tritz ,  Michael S. Grow ,  Alexei N. Naimushin ,  Sinclair S. Yee

发明人： Timothy M. Chinowsky ,  Scott D. Soelberg ,  Peter C. Kauffman ,  Clement E. Furlong ,  Jared Tritz ,  Michael S. Grow ,  Alexei N. Naimushin ,  Sinclair S. Yee

IPC分类号： G01N21/55

CPC分类号： G01N21/553 ,  G01N2201/04

摘要： This specification discloses various improvements in the field of SPR sensing systems. One improvement relates to a portable SPR sensing system, e.g., a system contained within a suitcase that can be hand-carried to a monitoring site. Another improvement relates to a portable, cartridge-based SPR sensing system. In this system, selected portions of the system's electrical and fluidics systems are allocated between a base unit and a removable/disposable cartridge. Other improvements relate to methods or protocols for operating an SPR sensing system. Such methods provide for the elimination of false positives and increased sensitivity, e.g., by using secondary antibodies with specificity for different target epitopes and by sensor element redundancy. In addition, protocols are provided for the detection of small molecules. Such protocols may employ a competition type assay where the presence of the analyte inhibits the binding of antibodies to surface immobilized analyte, or a displacement assay, where antibodies bound to the analyte on the sensor surface are displaced by free analyte.

摘要翻译： 本说明书公开了SPR传感系统领域的各种改进。 一个改进涉及便携式SPR感测系统，例如，可以手提携带到监控地点的手提箱内的系统。 另一项改进涉及一种便携式，基于盒式SPR感测系统。 在该系统中，系统的电和流体系统的选定部分被分配在基本单元和可移动/一次性盒之间。 其他改进涉及用于操作SPR感测系统的方法或协议。 这样的方法提供消除假阳性和提高灵敏度，例如通过使用对不同靶标表位具有特异性的二级抗体以及通过传感器元件冗余。 此外，提供了用于检测小分子的方案。 这样的方案可以采用竞争型测定法，其中分析物的存在抑制抗体与表面固定化分析物的结合，或位移测定法，其中与传感器表面上的分析物结合的抗体被游离分析物置换。