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1.发明申请公开(公告)号：US20100022678A1
公开(公告)日：2010-01-28
申请号：US12408913
申请日：2009-03-23
申请人： Donald Yakimicki , Brian H. Thomas , Alicia Rufner , Dirk Pletcher , Hallie E. Brinkerhuff , Michael E. Hawkins
发明人： Donald Yakimicki , Brian H. Thomas , Alicia Rufner , Dirk Pletcher , Hallie E. Brinkerhuff , Michael E. Hawkins
CPC分类号： B29C71/04 , A61L27/16 , B29C71/02 , B29C2035/0822 , B29C2071/022 , B29C2791/005 , B29K2023/0683 , B29L2031/7532 , C08J3/247 , C08J3/28 , C08J7/08 , C08J2323/06 , C08L23/06
摘要： UHMWPE is exposed to crosslinking radiation and than heated utilizing infrared radiation in an inert environment. In one exemplary embodiment, the infrared radiation is provided by an infrared heater having a tungsten heating element with a quartz tube. In this embodiment, the infrared radiation may have the wavelength from about 1.0 micron to about 1.5 microns. In another exemplary embodiment, the UHMWPE is compression molded into bars prior to exposure to the crosslinking radiation.
摘要翻译： UHMWPE暴露于交联辐射，并且在惰性环境中使用红外辐射加热。 在一个示例性实施例中，红外辐射由具有带有石英管的钨加热元件的红外加热器提供。 在该实施例中，红外辐射可以具有约1.0微米至约1.5微米的波长。 在另一示例性实施例中，UHMWPE在暴露于交联辐射之前被压缩成型。
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2.发明申请ANTIOXIDANT STABILIZED CROSSLINKED ULTRA-HIGH MOLECULAR WEIGHT POLYETHYLENE FOR MEDICAL DEVICE APPLICATIONS 有权用于医疗设备应用的抗氧化稳定交联超高分子量聚乙烯公开(公告)号：US20110028600A1
公开(公告)日：2011-02-03
申请号：US12847741
申请日：2010-07-30
申请人： Alicia Rufner , John Knight , Toni Rowe , Dirk Pletcher , Ray Gsell , Werner Schneider , Hallie E. Brinkerhuff
发明人： Alicia Rufner , John Knight , Toni Rowe , Dirk Pletcher , Ray Gsell , Werner Schneider , Hallie E. Brinkerhuff
CPC分类号： C08J3/247 , A61B17/8085 , A61L27/16 , A61L27/505 , C08J3/28 , C08J2323/26 , C08K5/005 , C08K5/1545 , C08K9/10 , C08L23/06 , C08L2312/06 , Y10T428/31 , Y10T428/315
摘要： An antioxidant combined with UHMWPE prior to subjecting the UHMWPE to crosslinking irradiation. In one exemplary embodiment, the antioxidant is tocopherol. After the antioxidant is combined with the UHMWPE, the resulting blend may be formed into slabs, bar stock, and/or incorporated into a substrate, such as a metal, for example. The resulting product may then be subjected to crosslinking irradiation. In one exemplary embodiment, the UHMWPE blend is preheated prior to subjecting the same to crosslinking irradiation. Once irradiated, the UHMWPE blended product may be machined, packaged, and sterilized in accordance with conventional techniques.
摘要翻译： 在超高分子量聚乙烯（UHMWPE）交联照射之前，与UHMWPE结合使用的抗氧化剂。 在一个示例性实施方案中，抗氧化剂是生育酚。 在将抗氧化剂与UHMWPE组合之后，所得到的共混物可以形成为板坯，棒料，和/或结合到例如金属等基材中。 然后将所得产物进行交联照射。 在一个示例性实施方案中，在对其进行交联照射之前，将UHMWPE共混物预热。 一旦照射，UHMWPE共混产品可以根据常规技术被加工，包装和灭菌。
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公开(公告)号：US08669299B2
公开(公告)日：2014-03-11
申请号：US13403040
申请日：2012-02-23
申请人： Alicia Rufner , John Knight , Toni Rowe , Dirk Pletcher , Ray Gsell , Werner Schneider , Hallie E. Brinkerhuff
发明人： Alicia Rufner , John Knight , Toni Rowe , Dirk Pletcher , Ray Gsell , Werner Schneider , Hallie E. Brinkerhuff
CPC分类号： C08K5/1545 , A61B17/8085 , A61L27/16 , A61L27/505 , A61L31/048 , A61L31/143 , C08J3/24 , C08J3/28 , C08J2323/26 , C08L23/06 , C08L2312/06 , Y10T428/31 , Y10T428/315
摘要： An antioxidant combined with UHMWPE prior to subjecting the UHMWPE to crosslinking irradiation. In one exemplary embodiment, the antioxidant is tocopherol. After the antioxidant is combined with the UHMWPE, the resulting blend may be formed into slabs, bar stock, and/or incorporated into a substrate, such as a metal, for example. The resulting product may then be subjected to crosslinking irradiation. In one exemplary embodiment, the UHMWPE blend is preheated prior to subjecting the same to crosslinking irradiation. Once irradiated, the UHMWPE blended product may be machined, packaged, and sterilized in accordance with conventional techniques.
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4.发明申请Antioxidant Stabilized Crosslinked Ultra-High Molecular Weight Polyethylene For Medical Device Applications 有权抗氧化稳定交联超高分子量聚乙烯用于医疗器械应用公开(公告)号：US20120157591A1
公开(公告)日：2012-06-21
申请号：US13403040
申请日：2012-02-23
申请人： Alicia Rufner , John Knight , Toni Rowe , Dirk Pletcher , Ray Gsell , Hallie E. Brinkerhuff , Werner Schneider
发明人： Alicia Rufner , John Knight , Toni Rowe , Dirk Pletcher , Ray Gsell , Hallie E. Brinkerhuff , Werner Schneider
IPC分类号： C08L23/06 , C08K5/1545
CPC分类号： C08K5/1545 , A61B17/8085 , A61L27/16 , A61L27/505 , A61L31/048 , A61L31/143 , C08J3/24 , C08J3/28 , C08J2323/26 , C08L23/06 , C08L2312/06 , Y10T428/31 , Y10T428/315
摘要： An antioxidant combined with UHMWPE prior to subjecting the UHMWPE to crosslinking irradiation. In one exemplary embodiment, the antioxidant is tocopherol. After the antioxidant is combined with the UHMWPE, the resulting blend may be formed into slabs, bar stock, and/or incorporated into a substrate, such as a metal, for example. The resulting product may then be subjected to crosslinking irradiation. In one exemplary embodiment, the UHMWPE blend is preheated prior to subjecting the same to crosslinking irradiation. Once irradiated, the UHMWPE blended product may be machined, packaged, and sterilized in accordance with conventional techniques.
摘要翻译： 在超高分子量聚乙烯（UHMWPE）交联照射之前，与UHMWPE结合使用的抗氧化剂。 在一个示例性实施方案中，抗氧化剂是生育酚。 在将抗氧化剂与UHMWPE组合之后，所得到的共混物可以形成为板坯，棒料，和/或结合到例如金属等基材中。 然后将所得产物进行交联照射。 在一个示例性实施方案中，在对其进行交联照射之前，将UHMWPE共混物预热。 一旦照射，UHMWPE共混产品可以根据常规技术被加工，包装和灭菌。
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5.发明申请公开(公告)号：US20100022677A1
公开(公告)日：2010-01-28
申请号：US12179170
申请日：2008-07-24
申请人： Donald Yakimicki , Brian H. Thomas , Alicia Rufner , Dirk Pletcher , Hallie E. Brinkerhuff , Michael E. Hawkins
发明人： Donald Yakimicki , Brian H. Thomas , Alicia Rufner , Dirk Pletcher , Hallie E. Brinkerhuff , Michael E. Hawkins
IPC分类号： C08J3/28 , C08F110/02
CPC分类号： C08J3/247 , C08J7/08 , C08J2323/06
摘要： UHMWPE is exposed to crosslinking radiation and than heated utilizing infrared radiation. In one exemplary embodiment, the infrared radiation is provided by an infrared heater having a tungsten heating element with a quartz tube. In this embodiment, the infrared radiation may have the wavelength from about 1.0 micron to about 1.5 microns. In another exemplary embodiment, the UHMWPE is compression molded into bars prior to exposure to the crosslinking radiation.
摘要翻译： UHMWPE暴露于交联辐射，并且使用红外辐射加热。 在一个示例性实施例中，红外辐射由具有带有石英管的钨加热元件的红外加热器提供。 在该实施例中，红外辐射可以具有约1.0微米至约1.5微米的波长。 在另一示例性实施例中，UHMWPE在暴露于交联辐射之前被压缩成型。
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6.发明授权Antioxidant stabilized crosslinked ultra-high molecular weight polyethylene for medical device applications 有权用于医疗器械应用的抗氧化稳定的交联超高分子量聚乙烯公开(公告)号：US08664290B2
公开(公告)日：2014-03-04
申请号：US12847741
申请日：2010-07-30
申请人： Alicia Rufner , John Knight , Toni Rowe , Dirk Pletcher , Ray Gsell , Werner Schneider , Hallie E. Brinkerhuff
发明人： Alicia Rufner , John Knight , Toni Rowe , Dirk Pletcher , Ray Gsell , Werner Schneider , Hallie E. Brinkerhuff
CPC分类号： C08J3/247 , A61B17/8085 , A61L27/16 , A61L27/505 , C08J3/28 , C08J2323/26 , C08K5/005 , C08K5/1545 , C08K9/10 , C08L23/06 , C08L2312/06 , Y10T428/31 , Y10T428/315
摘要： An antioxidant combined with UHMWPE prior to subjecting the UHMWPE to crosslinking irradiation. In one exemplary embodiment, the antioxidant is tocopherol. After the antioxidant is combined with the UHMWPE, the resulting blend may be formed into slabs, bar stock, and/or incorporated into a substrate, such as a metal, for example. The resulting product may then be subjected to crosslinking irradiation. In one exemplary embodiment, the UHMWPE blend is preheated prior to subjecting the same to crosslinking irradiation. Once irradiated, the UHMWPE blended product may be machined, packaged, and sterilized in accordance with conventional techniques.
摘要翻译： 在超高分子量聚乙烯（UHMWPE）交联照射之前，与UHMWPE结合使用的抗氧化剂。 在一个示例性实施方案中，抗氧化剂是生育酚。 在将抗氧化剂与UHMWPE组合之后，所得到的共混物可以形成为板坯，棒料，和/或结合到例如金属等基材中。 然后将所得产物进行交联照射。 在一个示例性实施方案中，在对其进行交联照射之前，将UHMWPE共混物预热。 一旦照射，UHMWPE共混产品可以根据常规技术被加工，包装和灭菌。
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公开(公告)号：US08652212B2
公开(公告)日：2014-02-18
申请号：US12362159
申请日：2009-01-29
申请人： Kirt L. Case , Oludele O. Popoola , Robby Kissling , Brion R. Mimnaugh , Archie W. Newsome , Clarence M. Panchison , Dirk L. Pletcher , Randy L. Schlemmer , Zhibin Fang , Juan Vivanco , Alicia Rufner
发明人： Kirt L. Case , Oludele O. Popoola , Robby Kissling , Brion R. Mimnaugh , Archie W. Newsome , Clarence M. Panchison , Dirk L. Pletcher , Randy L. Schlemmer , Zhibin Fang , Juan Vivanco , Alicia Rufner
IPC分类号： A61F2/32
CPC分类号： B29C70/682 , A61B17/86 , A61F2/30942 , A61F2/34 , A61F2002/30329 , A61F2002/305 , A61F2002/3092 , A61F2002/3096 , A61F2002/30981 , A61F2002/3291 , A61F2002/3401 , A61F2002/3411 , A61F2220/0025 , A61F2310/00131 , A61L27/18 , A61L27/50 , A61L27/56 , B29C43/18 , B29C45/14 , C08L71/00
摘要： An orthopedic component having multiple layers that are selected to provide an overall modulus that is substantially lower than the modulus of known orthopedic components to more closely approximate the modulus of the bone into which the orthopedic component is implanted. In one exemplary embodiment, the orthopedic component is an acetabular shell. For example, the acetabular shell may include an outer layer configured for securement to the natural acetabulum of a patient and an inner layer configured to receive an acetabular liner. The head of a femoral prosthesis articulates against the acetabular liner to replicate the function of a natural hip joint. Alternatively, the inner layer of the acetabular shell may act as an integral acetabular liner against which the head of the femoral prosthesis articulates.
摘要翻译： 具有多个层的整形外科组件被选择以提供基本上低于已知矫形部件的模量的总模量，以更接近地将骨骼部件植入其中的骨的模数近似近似。 在一个示例性实施例中，矫形部件是髋臼壳。 例如，髋臼壳可以包括被配置用于固定到患者的天然髋臼的外层和构造成接收髋臼衬垫的内层。 股骨假体的头部与髋臼衬垫铰接以复制天然髋关节的功能。 或者，髋臼壳的内层可以作为整体的髋臼衬垫，股骨假体的头与该髋臼衬垫铰接。
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公开(公告)号：US20090192610A1
公开(公告)日：2009-07-30
申请号：US12362159
申请日：2009-01-29
申请人： Kirt L. Case , Oludele O. Popoola , Robby Kissling , Brion R. Mimnaugh , Archie W. Newsome , Clarence M. Panchison , Dirk L. Pletcher , Randy L. Schlemmer , Zhibin Fang , Juan Vivanco , Alicia Rufner
发明人： Kirt L. Case , Oludele O. Popoola , Robby Kissling , Brion R. Mimnaugh , Archie W. Newsome , Clarence M. Panchison , Dirk L. Pletcher , Randy L. Schlemmer , Zhibin Fang , Juan Vivanco , Alicia Rufner
IPC分类号： A61F2/28 , A61F2/32 , B29D31/505
CPC分类号： B29C70/682 , A61B17/86 , A61F2/30942 , A61F2/34 , A61F2002/30329 , A61F2002/305 , A61F2002/3092 , A61F2002/3096 , A61F2002/30981 , A61F2002/3291 , A61F2002/3401 , A61F2002/3411 , A61F2220/0025 , A61F2310/00131 , A61L27/18 , A61L27/50 , A61L27/56 , B29C43/18 , B29C45/14 , C08L71/00
摘要： An orthopedic component having multiple layers that are selected to provide an overall modulus that is substantially lower than the modulus of known orthopedic components to more closely approximate the modulus of the bone into which the orthopedic component is implanted. In one exemplary embodiment, the orthopedic component is an acetabular shell. For example, the acetabular shell may include an outer layer configured for securement to the natural acetabulum of a patient and an inner layer configured to receive an acetabular liner. The head of a femoral prosthesis articulates against the acetabular liner to replicate the function of a natural hip joint. Alternatively, the inner layer of the acetabular shell may act as an integral acetabular liner against which the head of the femoral prosthesis articulates.
摘要翻译： 具有多个层的整形外科组件被选择以提供基本上低于已知矫形部件的模量的总模量，以更接近地将骨骼部件植入其中的骨的模数近似近似。 在一个示例性实施例中，矫形部件是髋臼壳。 例如，髋臼壳可以包括被配置用于固定到患者的天然髋臼的外层和构造成接收髋臼衬垫的内层。 股骨假体的头部与髋臼衬垫铰接以复制天然髋关节的功能。 或者，髋臼壳的内层可以作为整体的髋臼衬垫，股骨假体的头与该髋臼衬垫铰接。
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9.发明申请ANTIOXIDANT STABILIZED CROSSLINKED ULTRA-HIGH MOLECULAR WEIGHT POLYETHYLENE FOR MEDICAL DEVICE APPLICATIONS 审中-公开用于医疗器械应用的抗氧化稳定交联超高分子量聚乙烯公开(公告)号：US20080319137A1
公开(公告)日：2008-12-25
申请号：US12100894
申请日：2008-04-10
申请人： Alicia Rufner , John Knight , Toni Rowe , Dirk Pletcher , Ray Gsell , Hallie E. Brinkerhuff , Werner Schneider
发明人： Alicia Rufner , John Knight , Toni Rowe , Dirk Pletcher , Ray Gsell , Hallie E. Brinkerhuff , Werner Schneider
IPC分类号： C08F110/02 , C08F2/46 , B29C35/08 , A61L2/14 , A61L2/02
CPC分类号： C08K5/1545 , A61B17/8085 , A61L27/16 , A61L27/505 , A61L31/048 , A61L31/143 , C08J3/24 , C08J3/28 , C08J2323/26 , C08L23/06 , C08L2312/06 , Y10T428/31 , Y10T428/315
摘要： An antioxidant combined with UHMWPE prior to subjecting the UHMWPE to crosslinking irradiation. In one exemplary embodiment, the antioxidant is tocopherol. After the antioxidant is combined with the UHMWPE, the resulting blend may be formed into slabs, bar stock, and/or incorporated into a substrate, such as a metal, for example. The resulting product may then be subjected to crosslinking irradiation. In one exemplary embodiment, the UHMWPE blend is preheated prior to subjecting the same to crosslinking irradiation. Once irradiated, the UHMWPE blended product may be machined, packaged, and sterilized in accordance with conventional techniques.
摘要翻译： 在超高分子量聚乙烯（UHMWPE）交联照射之前，与UHMWPE结合使用的抗氧化剂。 在一个示例性实施方案中，抗氧化剂是生育酚。 在将抗氧化剂与UHMWPE组合之后，所得到的共混物可以形成为板坯，棒料，和/或结合到例如金属等基材中。 然后将所得产物进行交联照射。 在一个示例性实施方案中，在对其进行交联照射之前，将UHMWPE共混物预热。 一旦照射，UHMWPE共混产品可以根据常规技术被加工，包装和灭菌。
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10.发明授权公开(公告)号：US08178594B2
公开(公告)日：2012-05-15
申请号：US12967581
申请日：2010-12-14
申请人： Alicia Rufner , John Knight , Toni Rowe , Dirk Pletcher , Ray Gsell , Werner Schneider , Hallie E. Brinkerhuff
发明人： Alicia Rufner , John Knight , Toni Rowe , Dirk Pletcher , Ray Gsell , Werner Schneider , Hallie E. Brinkerhuff
IPC分类号： C08F10/02
CPC分类号： C08K5/1545 , A61B17/8085 , A61L27/16 , A61L27/505 , A61L31/048 , A61L31/143 , C08J3/24 , C08J3/28 , C08J2323/26 , C08L23/06 , C08L2312/06 , Y10T428/31 , Y10T428/315
摘要： An antioxidant combined with UHMWPE prior to subjecting the UHMWPE to crosslinking irradiation. In one exemplary embodiment, the antioxidant is tocopherol. After the antioxidant is combined with the UHMWPE, the resulting blend may be formed into slabs, bar stock, and/or incorporated into a substrate, such as a metal, for example. The resulting product may then be subjected to crosslinking irradiation. In one exemplary embodiment, the UHMWPE blend is preheated prior to subjecting the same to crosslinking irradiation. Once irradiated, the UHMWPE blended product may be machined, packaged, and sterilized in accordance with conventional techniques.
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