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    SOFT TISSUE IMPLANT
    1.
    发明申请
    SOFT TISSUE IMPLANT 审中-公开
    软组织植入

    公开(公告)号：US20150005234A1

    公开(公告)日：2015-01-01

    申请号：US14320885

    申请日：2014-07-01

    申请人： Amit Prakash Govil

    发明人： Amit Prakash Govil

    IPC分类号： A61K38/18 ,  A61K45/06

    CPC分类号： A61K45/06 ,  A61K8/981 ,  A61K38/18 ,  A61K2800/91 ,  A61L27/3633 ,  A61L27/3683 ,  A61L27/38 ,  A61L27/54 ,  A61L2300/416 ,  A61L2430/34 ,  A61Q19/08

    摘要： Provided herein are soft tissue implants, methods of making, use, and administration thereof. The soft tissue implants can be prepared by harvesting cells or tissue from a donor and selectively lysing the cells or tissue to obtain the intracellular content. Also provided herein are delivery devices for delivering the soft tissue implants described herein and kits that include the soft tissue implants described herein.

    摘要翻译： 本文提供软组织植入物，制备，使用和施用方法。 软组织植入物可以通过从供体中收获细胞或组织并选择性地裂解细胞或组织以获得细胞内含量来制备。 本文还提供用于递送本文所述的软组织植入物的递送装置和包括本文所述的软组织植入物的试剂盒。

    Bioactive Grafts and Composites
    3.
    发明申请
    Bioactive Grafts and Composites 审中-公开
    生物活性接枝和复合材料

    公开(公告)号：US20110118850A1

    公开(公告)日：2011-05-19

    申请号：US12959777

    申请日：2010-12-03

    申请人： Amit Prakash Govil ,  Christian Gamboa

    发明人： Amit Prakash Govil ,  Christian Gamboa

    IPC分类号： A61F2/28

    CPC分类号： A61L27/20 ,  A61F2/4644 ,  A61F2002/4646 ,  A61K35/32 ,  A61L27/12 ,  A61L27/3608 ,  A61L27/365 ,  A61L27/50 ,  A61L27/54 ,  A61L2300/232 ,  A61L2300/404 ,  A61L2300/412 ,  A61L2300/45 ,  A61L2300/60 ,  A61L2300/62 ,  A61L2400/16 ,  A61L2430/02 ,  C08L5/08

    摘要： Disclosed are various bioactive grafts and/or biocompatible materials and methods of making the same. In one embodiment, bone material is harvested from a donor. The harvested bone material is exposed to a lysing agent, the lysing agent configured to release growth factors and bioactive materials from cellular material of the harvested bone material. The harvested bone material is then rinsed with a rinsing agent. The pH of the harvested bone material is substantially neutralized. In another embodiment, an orthopaedic implant includes an antibacterial polysaccharide. The implant may also include an osteostimulative agent.

    摘要翻译： 公开了各种生物活性移植物和/或生物相容性材料及其制备方法。 在一个实施方案中，从供体收获骨材料。 收获的骨材料暴露于裂解剂，裂解剂配置为从收获的骨材料的细胞材料中释放生长因子和生物活性物质。 然后用收集的骨材料用漂洗剂漂洗。 收获的骨材料的pH被基本上中和。 在另一个实施方案中，矫形植入物包括抗菌多糖。 植入物还可以包括骨质疏松剂。

    EXPANDABLE BRACHYTHERAPY DEVICE
    4.
    发明申请
    EXPANDABLE BRACHYTHERAPY DEVICE 有权
    可扩展的BRACHYTHERAPY设备

    公开(公告)号：US20100130807A1

    公开(公告)日：2010-05-27

    申请号：US12694741

    申请日：2010-01-27

    申请人： JACK C. WHITE ,  DAVID WESLEY STEPHENS ,  AMIT PRAKASH GOVIL ,  JOSHUA J. BERGMAN ,  NATHAN CHRISTOPHER GRIFFITH ,  KYLE KEVIN MILLAGE

    发明人： JACK C. WHITE ,  DAVID WESLEY STEPHENS ,  AMIT PRAKASH GOVIL ,  JOSHUA J. BERGMAN ,  NATHAN CHRISTOPHER GRIFFITH ,  KYLE KEVIN MILLAGE

    IPC分类号： A61M36/12

    CPC分类号： A61N5/1015 ,  A61M29/02 ,  A61N5/1007 ,  A61N2005/1008 ,  A61N2005/1018 ,  A61N2005/1024

    摘要： A method for brachytherapy in a lumpectomy cavity of a breast including, positioning a distal end of a brachytherapy device within the cavity, expanding an expandable surface portion located between proximal and distal ends of the device within the cavity, the source lumen tubes defining a curved configuration within the cavity; and positioning a source of radiation sequentially within one or more source lumens of the source lumen tubes according to a brachytherapy treatment plan. The device includes an inner tube, and a plurality of source lumen tubes located around the inner tube and including distal ends secured together with the inner tube at the distal end disposed within the body cavity, the source lumen tubes comprising proximal portions sufficiently long to extend outside the breast.

    摘要翻译： 一种用于乳房肿瘤切除腔的近距离放射治疗方法，包括将近距离放射治疗装置的远端定位在腔内，使位于腔内的装置的近端和远端之间的可扩张表面部分膨胀，源腔管限定弯曲 腔内配置; 以及根据近程放射疗法治疗计划将辐射源依次定位在源腔管的一个或多个源腔内。 所述装置包括内管和位于所述内管周围的多个源管腔，并且包括远端，所述远端与设置在所述体腔内的远端处与所述内管固定在一起，所述源腔管包括足够长以延伸的近端部分 在乳房外面

    EXPANDABLE BRACHYTHERAPY DEVICE
    5.
    发明申请
    EXPANDABLE BRACHYTHERAPY DEVICE 有权
    可扩展的BRACHYTHERAPY设备

    公开(公告)号：US20100121129A1

    公开(公告)日：2010-05-13

    申请号：US12692289

    申请日：2010-01-22

    申请人： JACK C. WHITE ,  DAVID WESLEY STEPHENS ,  AMIT PRAKASH GOVIL ,  JOSHUA J. BERGMAN ,  NATHAN CHRISTOPHER GRIFFITH ,  KYLE KEVIN MILLAGE

    发明人： JACK C. WHITE ,  DAVID WESLEY STEPHENS ,  AMIT PRAKASH GOVIL ,  JOSHUA J. BERGMAN ,  NATHAN CHRISTOPHER GRIFFITH ,  KYLE KEVIN MILLAGE

    IPC分类号： A61M36/12

    CPC分类号： A61N5/1015 ,  A61M29/02 ,  A61N5/1007 ,  A61N2005/1008 ,  A61N2005/1018 ,  A61N2005/1024

    摘要： A brachytherapy device including an elongate member comprising a proximal portion and a distal portion. The device also includes a movable surface portion surrounding at least the distal portion of the elongate member and a plurality of source lumen tubes defining respective source lumens, the source lumen tubes being located around the elongate member, distal ends of the source lumen tubes coupled to the distal portion of the elongate member, the source lumen tubes extending a sufficient distance in a proximal direction such that the source lumen tubes extend outside a body when distal portions of the source lumen tubes are positioned in a body cavity for brachytherapy. The device also has structure coupled to the distal ends of the source lumen tubes for positioning the distal portions of the source lumen tubes at different distances from the elongate member for brachytherapy by exerting a force in a proximal direction on the distal ends of the source lumen tubes, the structure including an actuator for actuating the structure, at least a portion of the actuator being located outside the body when the distal portions of the source lumen tubes are positioned in a body cavity for brachytherapy. The device also includes a ring, tube or manifold securing a portion of the source lumen tubes proximal to the distal portion around the elongate member and a source of radiation suitable for insertion into the source lumens.

    摘要翻译： 一种近距离放射治疗装置，包括包括近端部分和远端部分的细长部件。 该装置还包括围绕细长构件的至少远侧部分的可移动表面部分和限定相应源腔的多个源腔管，源腔管位于细长构件周围，源腔管的远端连接到 细长构件的远端部分，源腔管在近端方向上延伸足够的距离，使得当源管腔的远端位于用于近距离放射治疗的体腔中时，源腔管延伸到身体外部。 该装置还具有耦合到源腔管的远端的结构，用于通过在源腔的远端上沿近端方向施加力来将源腔管的远端部分定位在与细长构件不同的距离处，用于近距离放射治疗 管，该结构包括用于致动结构的致动器，当源腔管的远端位于用于近距离放射治疗的体腔中时，致动器的至少一部分位于身体外部。 该装置还包括环，管或歧管，其将源腔腔管的一部分靠近远端部分固定在细长构件周围，以及适于插入源腔的辐射源。

    Expandable brachytherapy device
    6.
    发明授权
    Expandable brachytherapy device 有权
    可扩展近距离放射治疗装置

    公开(公告)号：US07497820B2

    公开(公告)日：2009-03-03

    申请号：US11688033

    申请日：2007-03-19

    申请人： Jack C. White ,  David Wesley Stephens ,  Amit Prakash Govil ,  Joshua J. Bergman ,  Nathan Christopher Griffith ,  Kyle Kevin Millage

    发明人： Jack C. White ,  David Wesley Stephens ,  Amit Prakash Govil ,  Joshua J. Bergman ,  Nathan Christopher Griffith ,  Kyle Kevin Millage

    IPC分类号： A61N5/00

    CPC分类号： A61N5/1015 ,  A61M29/02 ,  A61N5/1007 ,  A61N2005/1008 ,  A61N2005/1018 ,  A61N2005/1024

    摘要： A brachytherapy device for the provision of brachytherapy is disclosed. The brachytherapy device has at least one source lumen located outside a movable surface of the device. The source lumen may be secured to the movable outer surface in a manner whereby relative movement of the source lumen relative to the movable outer surface is permitted. The brachytherapy device is inserted into a body cavity. After insertion, the movable surface is moved to position the at least one source lumen closer to the tissue boundary of the cavity. One or more sources of radiation are then placed within the at least one source lumen to provide a customizable treatment. Also disclosed are methods for providing brachytherapy via body cavities.

    摘要翻译： 公开了一种用于提供近距离放射治疗的近距离放射治疗装置。 近程放射治疗装置具有位于装置的可移动表面外部的至少一个源腔。 源腔可以以允许源腔相对于可移动外表面的相对运动的方式固定到可移动外表面。 近距离放射治疗装置插入体腔。 在插入之后，可移动表面被移动以使至少一个源管腔更靠近腔的组织边界。 然后将一个或多个辐射源放置在至少一个源腔内以提供可定制的治疗。 还公开了通过体腔提供近距离放射治疗的方法。

    Bioactive Grafts and Composites
    7.
    发明申请
    Bioactive Grafts and Composites 审中-公开

    公开(公告)号：US20200237955A1

    公开(公告)日：2020-07-30

    申请号：US16590467

    申请日：2019-10-02

    申请人： Amit Prakash GOVIL ,  Christian GAMBOA

    发明人： Amit Prakash GOVIL ,  Christian GAMBOA

    IPC分类号： A61L27/20 ,  A61L27/54 ,  A61F2/46 ,  A61L27/50 ,  A61L27/12 ,  A61L27/36 ,  A61K35/32

    摘要： Disclosed are various bioactive grafts and/or biocompatible materials and methods of making the same. In one embodiment, bone material is harvested from a donor. The harvested bone material is exposed to a lysing agent, the lysing agent configured to release growth factors and bioactive materials from cellular material of the harvested bone material. The harvested bone material is then rinsed with a rinsing agent. The pH of the harvested bone material is substantially neutralized. In another embodiment, an orthopaedic implant includes an antibacterial polysaccharide. The implant may also include an osteostimulative agent.

    Expandable brachytherapy device
    9.
    发明授权
    Expandable brachytherapy device 有权
    可扩展近距离放射治疗装置

    公开(公告)号：US07662082B2

    公开(公告)日：2010-02-16

    申请号：US11266994

    申请日：2005-11-04

    申请人： Jack C. White ,  David Wesley Stephens ,  Amit Prakash Govil ,  Joshua J. Bergman ,  Nathan Christopher Griffith ,  Kyle Kevin Millage

    发明人： Jack C. White ,  David Wesley Stephens ,  Amit Prakash Govil ,  Joshua J. Bergman ,  Nathan Christopher Griffith ,  Kyle Kevin Millage

    IPC分类号： A61N5/00

    CPC分类号： A61N5/1015 ,  A61M29/02 ,  A61N5/1007 ,  A61N2005/1008 ,  A61N2005/1018 ,  A61N2005/1024

    摘要： A brachytherapy device for the provision of brachytherapy is disclosed. The brachytherapy device has at least one source lumen located outside a movable surface of the device. The source lumen may be secured to the movable outer surface in a manner whereby relative movement of the source lumen relative to the movable outer surface is permitted. The brachytherapy device is inserted into a body cavity. After insertion, the movable surface is moved to position the at least one source lumen closer to the tissue boundary of the cavity. One or more sources of radiation are then placed within the at least one source lumen to provide a customizable treatment. Also disclosed are methods for providing brachytherapy via body cavities.

    摘要翻译： 公开了一种用于提供近距离放射治疗的近距离放射治疗装置。 近程放射治疗装置具有位于装置的可移动表面外部的至少一个源腔。 源腔可以以允许源腔相对于可移动外表面的相对运动的方式固定到可移动外表面。 近距离放射治疗装置插入体腔。 在插入之后，可移动表面被移动以使至少一个源管腔更靠近腔的组织边界。 然后将一个或多个辐射源放置在至少一个源腔内以提供可定制的治疗。 还公开了通过体腔提供近距离放射治疗的方法。