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13 条记录 (耗时 0.017 秒)

    Transport protein which is used to introduce chemical compounds into nerve cells
    2.
    发明授权
    Transport protein which is used to introduce chemical compounds into nerve cells 有权
    用于将化学物质引入神经细胞的运输蛋白质

    公开(公告)号：US08293230B2

    公开(公告)日：2012-10-23

    申请号：US11661849

    申请日：2005-09-06

    申请人： Andreas Rummel

    发明人： Andreas Rummel

    IPC分类号： A61K38/48

    CPC分类号： C07K14/33 ,  A61K8/64 ,  A61K8/66 ,  A61K38/00 ,  A61K38/4893 ,  A61Q19/00 ,  A61Q19/08 ,  C12Y304/24069 ,  Y02A50/469 ,  Y02A50/473

    摘要： The invention relates to a transport protein which can be obtained by modifying the heavy chain of the neurotoxin formed by Clostridium botulinum. The protein binds specifically to nerve cells with a higher affinity as the native neurotoxin. The invention also relates to a method for the production of transport protein, the nucleic acids coding for the transport protein, the transport protein containing pharmaceutical and cosmetic compositions and use thereof.

    摘要翻译： 本发明涉及可通过改变由肉毒梭菌形成的神经毒素的重链获得的转运蛋白。 该蛋白与天然神经毒素具有较高的亲和力特异性结合神经细胞。 本发明还涉及生产运输蛋白的方法，编码运输蛋白的核酸，含运输蛋白的药物和化妆品组合物及其用途。

    CARRIER FOR TARGETING NERVE CELLS
    5.
    发明申请
    CARRIER FOR TARGETING NERVE CELLS 有权

    公开(公告)号：US20130315888A1

    公开(公告)日：2013-11-28

    申请号：US13867740

    申请日：2013-04-22

    申请人： Andreas Rummel ,  Tanja Weil ,  Aleksandrs Gutcaits

    发明人： Andreas Rummel ,  Tanja Weil ,  Aleksandrs Gutcaits

    IPC分类号： C12N9/52

    CPC分类号： C12N9/52 ,  A61K38/00 ,  C07K14/33 ,  C12Y304/24069 ,  Y02A50/469 ,  Y02A50/473

    摘要： The present invention relates to a transport protein which can be obtained by modifying the heavy chain of the neurotoxin formed by Clostridium botulinum wherein (i) the protein binds specifically to nerve cells with a higher or lower affinity as the native neurotoxin; (ii) the protein has an increased or reduced neurotoxicity compared to the native neurotoxin, the neurotoxicity being preferably determined in the hemidiaphragm assay; and/or (iii) the protein comprises a lower affinity against neutralizing antibodies compared to the native neurotoxin. The invention also relates to methods for producing the same and the use thereof in cosmetic and pharmaceutical compositions.

    Carrier for targeting nerve cells
    8.
    发明授权
    Carrier for targeting nerve cells 有权

    公开(公告)号：US08481040B2

    公开(公告)日：2013-07-09

    申请号：US11919302

    申请日：2006-04-26

    申请人： Andreas Rummel ,  Tanja Weil ,  Aleksandrs Gutcaits

    发明人： Andreas Rummel ,  Tanja Weil ,  Aleksandrs Gutcaits

    IPC分类号： C07K14/33

    CPC分类号： C12N9/52 ,  A61K38/00 ,  C07K14/33 ,  C12Y304/24069 ,  Y02A50/469 ,  Y02A50/473

    摘要： The present invention relates to a transport protein which can be obtained by modifying the heavy chain of the neurotoxin formed by Clostridium botulinum wherein (i) the protein binds specifically to nerve cells with a higher or lower affinity as the native neurotoxin; (ii) the protein has an increased or reduced neurotoxicity compared to the native neurotoxin, the neurotoxicity being preferably determined in the hemidiaphragma assay; and/or (iii) the protein comprises a lower affinity against neutralizing antibodies compared to the native neurotoxin. The invention also relates to methods for producing the same and the use thereof in cosmetic and pharmaceutical compositions.

    Carrier for targeting nerve cells
    9.
    发明申请
    Carrier for targeting nerve cells 有权
    用于靶向神经细胞的载体

    公开(公告)号：US20090311275A1

    公开(公告)日：2009-12-17

    申请号：US11919302

    申请日：2006-04-26

    申请人： Andreas Rummel ,  Tanja Weil ,  Aleksandrs Gutcaits

    发明人： Andreas Rummel ,  Tanja Weil ,  Aleksandrs Gutcaits

    IPC分类号： A61K39/44 ,  C07K14/33 ,  C12P21/02 ,  C12N1/21 ,  C12N15/70 ,  C12N1/19 ,  C12N15/75 ,  C12N15/81 ,  A61K38/48

    CPC分类号： C12N9/52 ,  A61K38/00 ,  C07K14/33 ,  C12Y304/24069 ,  Y02A50/469 ,  Y02A50/473

    摘要： The present invention relates to a transport protein which can be obtained by modifying the heavy chain of the neurotoxin formed by Clostridium botulinum wherein (i) the protein binds specifically to nerve cells with a higher or lower affinity as the native neurotoxin; (ii) the protein has an increased or reduced neurotoxicity compared to the native neurotoxin, the neurotoxicity being preferably determined in the hemidiaphragma assay; and/or (iii) the protein comprises a lower affinity against neutralizing antibodies compared to the native neurotoxin. The invention also relates to methods for producing the same and the use thereof in cosmetic and pharmaceutical compositions.

    摘要翻译： 本发明涉及通过改变由肉毒梭菌形成的神经毒素的重链而获得的转运蛋白，其中（i）所述蛋白质以与天然神经毒素更高或更低的亲和力的神经细胞特异性结合; （ii）与天然神经毒素相比，蛋白质具有增加或减少的神经毒性，神经毒性优选在膈肌测定中确定; 和/或（iii）与天然神经毒素相比，蛋白质包含对中和抗体的较低亲和力。 本发明还涉及其制备方法及其在化妆品和药物组合物中的用途。

    Method of pyrolyzing brown coal
    10.
    发明授权
    Method of pyrolyzing brown coal 失效
    热解褐煤的方法

    公开(公告)号：US4533438A

    公开(公告)日：1985-08-06

    申请号：US562504

    申请日：1983-12-16

    申请人： Wolfgang Michel ,  Heinz Paul ,  Andreas Rummel ,  Gero Seher ,  Manfred Ossowski ,  Irmtrud Heberlein

    发明人： Wolfgang Michel ,  Heinz Paul ,  Andreas Rummel ,  Gero Seher ,  Manfred Ossowski ,  Irmtrud Heberlein

    IPC分类号： C10B51/00 ,  C10B47/24 ,  C10F5/00 ,  C10F5/06 ,  C10B49/10

    CPC分类号： C10F5/00 ,  C10B47/24 ,  C10F5/06

    摘要： A two-step method and apparatus, according to the fluidized bed principle, for the production of coke, rich gas and pyrolysis tar, with the object of executing the method in a compact apparatus arrangement, with high energy efficiency and high throughput capacity.This is accomplished by a sequence in which the fine grains removed from the drying vapor mixture are removed from the actual pyrolysis process, and a hot gas, alien to the carbonization, is used as fluidization medium in the pyrolysis reactor, and with a hot gas-high performance separator being used for the dust separation from the pyrolysis gas, with the combustion exhaust gas produced in the combustion chamber being used for the indirect heating of the fluidization medium, for the pre-heating of the gas, which is alien to the carbonization, and for the direct heating in the dryer. The dryer has a double casing in the area of the fluidized bed, and a mixing chamber is arranged directly underneath its initial flow bottom, while the pyrolysis reactor is directly connected to the combustion chamber and the pre-heater.

    摘要翻译： 目的是以紧凑的装置结构执行方法，具有高能量效率和高通量能力，根据流化床原理，用于生产焦炭，富气和热解焦油的两步法和装置。 这是通过从干燥蒸汽混合物中除去的细颗粒从实际热解过程中除去的顺序完成的，并且与碳化不同的热气体用作热解反应器中的流化介质，并且使用热气体 高性能分离器用于与热解气体的灰尘分离，燃烧室中产生的燃烧废气用于间接加热流化介质，用于预热气体，这与 碳化，以及干燥机中的直接加热。 干燥器在流化床区域具有双壳体，并且混合室直接布置在其初始流动底部的下方，而热解反应器直接连接到燃烧室和预热器。